ES2109858B1 - NEW ACID DERIVATIVES (+) - (S) -2- (3-BENZOILFENIL) PROPIONICO WITH ANALGESIC ACTION AND PROCEDURE FOR ITS OBTAINING. - Google Patents
NEW ACID DERIVATIVES (+) - (S) -2- (3-BENZOILFENIL) PROPIONICO WITH ANALGESIC ACTION AND PROCEDURE FOR ITS OBTAINING.Info
- Publication number
- ES2109858B1 ES2109858B1 ES9402406A ES9402406A ES2109858B1 ES 2109858 B1 ES2109858 B1 ES 2109858B1 ES 9402406 A ES9402406 A ES 9402406A ES 9402406 A ES9402406 A ES 9402406A ES 2109858 B1 ES2109858 B1 ES 2109858B1
- Authority
- ES
- Spain
- Prior art keywords
- benzoilfenil
- propionico
- procedure
- obtaining
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000002253 acid Substances 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 3
- 230000000202 analgesic effect Effects 0.000 title abstract 2
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 abstract 4
- RAXXELZNTBOGNW-UHFFFAOYSA-O Imidazolium Chemical compound C1=C[NH+]=CN1 RAXXELZNTBOGNW-UHFFFAOYSA-O 0.000 abstract 2
- AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 abstract 2
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 abstract 2
- 239000004472 Lysine Substances 0.000 abstract 2
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- SDOFMBGMRVAJNF-SLPGGIOYSA-N (2r,3r,4r,5s)-6-aminohexane-1,2,3,4,5-pentol Chemical compound NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO SDOFMBGMRVAJNF-SLPGGIOYSA-N 0.000 abstract 1
- 239000004475 Arginine Substances 0.000 abstract 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 abstract 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 abstract 1
- MBBZMMPHUWSWHV-BDVNFPICSA-N N-methylglucamine Chemical compound CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO MBBZMMPHUWSWHV-BDVNFPICSA-N 0.000 abstract 1
- AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 abstract 1
- UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Natural products OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 abstract 1
- 229940035676 analgesics Drugs 0.000 abstract 1
- 239000000730 antalgic agent Substances 0.000 abstract 1
- 239000002260 anti-inflammatory agent Substances 0.000 abstract 1
- 229940121363 anti-inflammatory agent Drugs 0.000 abstract 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 abstract 1
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 abstract 1
- 229960001231 choline Drugs 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 1
- 229960003104 ornithine Drugs 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/76—Unsaturated compounds containing keto groups
- C07C59/84—Unsaturated compounds containing keto groups containing six membered aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
NUEVOS DERIVADOS DEL ACIDO (+)-(S)-2-(3-BENZOILFENIL)PROPIONICO CON ACCION ANALGESICA Y PROCEDIMIENTO PARA SU OBTENCION.LA PRESENTE INVENCION SE REFIERE A NUEVAS SALES DEL ACIDO (+)(S)-2-(3-BENZOILFENIL)PROPIONICO DE FORMULA I, FORMULA DONDE B+ ES COLINA O LA FORMA PROTONADA DE LISINA, ARGININA, ORNITINA, D-GLUCAMINA, N-METIL-D-GLUCAMINA O IMIDAZOL. EL PROCEDIMIENTO PARA SU PREPARACION COMPRENDE LA REACCION DEL ACIDO (+)-(S)-2-(3-BENZOILFENIL)PROPIONICO (II) CON LA LISINA, ARGININA, ORNITINA, HIDROXIDO DE COLINA, D-GLUCAMINA, N-METIL-DGLUCAMINA O IMIDAZOL O BIEN LA REACCION DE UNA SAL DEL ACIDO II CON LA APROPIADA SAL ORGANICA. DICHOS COMPUESTOS EXHIBEN UNA ELEVADA ACCION COMO ANALGESICOS Y ANTIINFLAMATORIOS EN TERAPIA HUMANA.NEW ACID DERIVATIVES (+) - (S) -2- (3-BENZOILFENIL) PROPIONICO WITH ANALGESIC ACTION AND PROCEDURE FOR ITS OBTAINING. THIS INVENTION REFERS TO NEW SALTS OF ACID (+) (S) -2- (3 -BENZOILFENIL) PROPIONIC OF FORMULA I, FORMULA WHERE B + IS CHOLINE OR THE PROTONATE FORM OF LYSINE, ARGININE, ORNITHINE, D-GLUCAMINE, N-METHYL-D-GLUCAMINE OR IMIDAZOLE. THE PROCEDURE FOR ITS PREPARATION INCLUDES THE REACTION OF THE ACID (+) - (S) -2- (3-BENZOILFENIL) PROPIONICO (II) WITH THE LYSINE, ARGININA, ORNITINA, COLINA HYDROXIDE, D-GLUCAMINA, N-METTIL-DGLUCAMINA Either IMIDAZOLE OR THE REACTION OF A SALT OF ACID II WITH THE PROPER ORGANIC SALT. SUCH COMPOUNDS EXHIBIT A HIGH ACTION AS ANALGESICS AND ANTI-INFLAMMATORIES IN HUMAN THERAPY.
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES9402406A ES2109858B1 (en) | 1994-11-23 | 1994-11-23 | NEW ACID DERIVATIVES (+) - (S) -2- (3-BENZOILFENIL) PROPIONICO WITH ANALGESIC ACTION AND PROCEDURE FOR ITS OBTAINING. |
| AU39835/95A AU3983595A (en) | 1994-11-23 | 1995-11-20 | Novel (+)-(s)-2-(3-benzoylphenyl)propionic acid derivatives with analgesic action and the process for the preparation thereof |
| PCT/EP1995/004554 WO1996016016A1 (en) | 1994-11-23 | 1995-11-20 | Novel (+)-(s)-2-(3-benzoylphenyl)propionic acid derivatives with analgesic action and the process for the preparation thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES9402406A ES2109858B1 (en) | 1994-11-23 | 1994-11-23 | NEW ACID DERIVATIVES (+) - (S) -2- (3-BENZOILFENIL) PROPIONICO WITH ANALGESIC ACTION AND PROCEDURE FOR ITS OBTAINING. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2109858A1 ES2109858A1 (en) | 1998-01-16 |
| ES2109858B1 true ES2109858B1 (en) | 1998-08-16 |
Family
ID=8288066
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES9402406A Expired - Fee Related ES2109858B1 (en) | 1994-11-23 | 1994-11-23 | NEW ACID DERIVATIVES (+) - (S) -2- (3-BENZOILFENIL) PROPIONICO WITH ANALGESIC ACTION AND PROCEDURE FOR ITS OBTAINING. |
Country Status (3)
| Country | Link |
|---|---|
| AU (1) | AU3983595A (en) |
| ES (1) | ES2109858B1 (en) |
| WO (1) | WO1996016016A1 (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2315763A (en) * | 1996-07-31 | 1998-02-11 | Procter & Gamble | Preparation of an agglomerated detergent composition comprising a surfactant a an acid source |
| KR20010013712A (en) * | 1998-04-11 | 2001-02-26 | 엘레카빠 유로테라삐치 에스.피.에이. | Pharmaceutical preparation containing hydrosoluble ketoprofen salts and their application |
| FR2892721B1 (en) | 2005-10-28 | 2009-07-24 | Synkem Sa | NOVEL PROCESS FOR PREPARING QUATERNARY ACID AND AMMONIUM SALTS |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5179097A (en) * | 1991-06-10 | 1993-01-12 | Angres Isaac A | Salts of non-steroidal anti-inflammatory carboxylic acids and anti-lipidemic carboxylic acids |
| WO1994020449A1 (en) * | 1993-03-09 | 1994-09-15 | Dompe'farmaceutici Spa | Salts of 2-(3-benzoylphenyl)propionic acid with achiral and chiral organic bases and pharmaceutical compositions thereof |
-
1994
- 1994-11-23 ES ES9402406A patent/ES2109858B1/en not_active Expired - Fee Related
-
1995
- 1995-11-20 WO PCT/EP1995/004554 patent/WO1996016016A1/en active Application Filing
- 1995-11-20 AU AU39835/95A patent/AU3983595A/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU3983595A (en) | 1996-06-17 |
| WO1996016016A1 (en) | 1996-05-30 |
| ES2109858A1 (en) | 1998-01-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EC2A | Search report published |
Date of ref document: 19980116 Kind code of ref document: A1 Effective date: 19980116 |
|
| FD1A | Patent lapsed |
Effective date: 20051124 |