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ES2100768T3 - Agente activo sobre el sistema nervioso central, procedimiento para su preparacion y composiciones farmaceuticas que lo contienen. - Google Patents

Agente activo sobre el sistema nervioso central, procedimiento para su preparacion y composiciones farmaceuticas que lo contienen.

Info

Publication number
ES2100768T3
ES2100768T3 ES95907014T ES95907014T ES2100768T3 ES 2100768 T3 ES2100768 T3 ES 2100768T3 ES 95907014 T ES95907014 T ES 95907014T ES 95907014 T ES95907014 T ES 95907014T ES 2100768 T3 ES2100768 T3 ES 2100768T3
Authority
ES
Spain
Prior art keywords
procedure
contain
preparation
pharmaceutical compositions
active agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95907014T
Other languages
English (en)
Inventor
Ges Jose Maria Caldero
Clotet Joan Huguet
Olondriz Francisco Marquillas
Barjoan Pere Dalmases
Rovira Anna Bosch
Acin Joan Roca
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vita Invest SA
Original Assignee
Vita Invest SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vita Invest SA filed Critical Vita Invest SA
Application granted granted Critical
Publication of ES2100768T3 publication Critical patent/ES2100768T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

EL AGENTE ES EL COMPUESTO 3- 2-[4-(6-FLUO-BENZO[D]ISOXAZOL-3IL)3,6-DIHIDRO-2H-PIRIDIN-1-IL]-ETIL}2-METIL-6,7,8,9TETRAHIDROPIRIDO[1,2-A]PIRIMIDIN-4-ONA QUE TIENE LA FORMULA (I) Y LAS SALES FARMACEUTICAMENTE ACEPTABLES DEL MISMO; EL PROCESO SE BASA EN LA REDUCCION DE UNA SAL DE PIRIDINA SELECCIONADA MEDIANTE UN BOROHIDRURO METALICO; SU APLICACION PREFERENTE ES COMO AGENTE ANTIPSICOTICO.
ES95907014T 1994-02-24 1995-02-02 Agente activo sobre el sistema nervioso central, procedimiento para su preparacion y composiciones farmaceuticas que lo contienen. Expired - Lifetime ES2100768T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES09400362A ES2085234B1 (es) 1994-02-24 1994-02-24 Agente activo sobre el sistema nervioso central, procedimiento para su preparacion y composiciones farmaceuticas que lo contienen.

Publications (1)

Publication Number Publication Date
ES2100768T3 true ES2100768T3 (es) 1997-06-16

Family

ID=8285331

Family Applications (2)

Application Number Title Priority Date Filing Date
ES09400362A Expired - Fee Related ES2085234B1 (es) 1994-02-24 1994-02-24 Agente activo sobre el sistema nervioso central, procedimiento para su preparacion y composiciones farmaceuticas que lo contienen.
ES95907014T Expired - Lifetime ES2100768T3 (es) 1994-02-24 1995-02-02 Agente activo sobre el sistema nervioso central, procedimiento para su preparacion y composiciones farmaceuticas que lo contienen.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES09400362A Expired - Fee Related ES2085234B1 (es) 1994-02-24 1994-02-24 Agente activo sobre el sistema nervioso central, procedimiento para su preparacion y composiciones farmaceuticas que lo contienen.

Country Status (12)

Country Link
US (1) US5658916A (es)
EP (1) EP0695751B1 (es)
JP (1) JP2848707B2 (es)
AT (1) ATE150752T1 (es)
AU (1) AU677146B2 (es)
CA (1) CA2160717A1 (es)
DE (1) DE69500198T2 (es)
DK (1) DK0695751T3 (es)
ES (2) ES2085234B1 (es)
GR (1) GR3023800T3 (es)
RU (1) RU2126005C1 (es)
WO (1) WO1995023144A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2138908B1 (es) * 1997-08-14 2000-09-16 Vita Invest Sa Polimorfos de la 3-(2-(4-(6-fluorobenzo(d)isoxazol-3-il) 3,6. dihidro-2h-piridin-1-il)-etil)-2-metil-6,7,8,9-tetrahidropirido (1,2-a) pirimidin-4-ona y procedimientos para su obtencion.
ES2141671B1 (es) * 1997-12-26 2001-01-01 Vita Invest Sa Compuesto pirimidinico activo sobre el sistema nervioso central, procedimiento para su preparacion y composiciones farmaceuticas que lo contienen.
HU227118B1 (en) * 2001-11-13 2010-07-28 Egis Gyogyszergyar Nyilvanosan Process for the preparation of 3-{2-[4-(6-fluoro-1,2-benzizoxazol-3-yl)-1-piperidinyl]-ethyl}-6,7,8,9-tetrahydro-2-methyl-4h-pyrido[1,2-a]pyrimidin-4-one
US8314110B2 (en) * 2007-04-19 2012-11-20 Youxin Li Compounds for treating mental disorders, and preparation and uses thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4342870A (en) * 1980-03-28 1982-08-03 Janssen Pharmaceutica N.V. Novel 3-(1-piperidinylalkyl)-4H-pyrido[1,2-a]pyrimidin-4-one derivatives
US4804663A (en) * 1985-03-27 1989-02-14 Janssen Pharmaceutica N.V. 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles
KR910000165B1 (ko) * 1985-03-27 1991-01-21 쟈안센 파아마슈우티카 엔. 부이. 1,2-벤즈이소옥사졸-3-일과 1,2-벤즈이소티아졸-3-일 유도체의 제조방법
US5158952A (en) * 1988-11-07 1992-10-27 Janssen Pharmaceutica N.V. 3-[2-[4-(6-fluoro-1,2-benzisoxozol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9 tetrahydro-9-hydroxy-2-methyl-4H-pyrido [1,2-a]pyrimidin-4-one, compositions and method of use
CA2000786C (en) * 1988-11-07 1999-01-26 Cornelus G. M. Janssen 3-piperidinyl-1,2-benzisoxazoles
GB9008850D0 (en) * 1990-04-19 1990-06-13 Janssen Pharmaceutica Nv Novel 2,9-disubstituted-4h-pyridol(1,2-a)pyrimidin-4-ones

Also Published As

Publication number Publication date
JPH08509505A (ja) 1996-10-08
EP0695751B1 (en) 1997-03-26
RU2126005C1 (ru) 1999-02-10
ATE150752T1 (de) 1997-04-15
AU1538195A (en) 1995-09-11
ES2085234A1 (es) 1996-05-16
WO1995023144A1 (es) 1995-08-31
AU677146B2 (en) 1997-04-10
DK0695751T3 (da) 1997-09-29
DE69500198D1 (de) 1997-04-30
CA2160717A1 (en) 1995-08-31
US5658916A (en) 1997-08-19
GR3023800T3 (en) 1997-09-30
ES2085234B1 (es) 1997-01-16
JP2848707B2 (ja) 1999-01-20
DE69500198T2 (de) 1997-10-16
EP0695751A1 (en) 1996-02-07

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