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ES2082703A1 - Nuevos derivados de ciclopropilo, procedimientos para su preparacion y aplicaciones. - Google Patents

Nuevos derivados de ciclopropilo, procedimientos para su preparacion y aplicaciones.

Info

Publication number
ES2082703A1
ES2082703A1 ES09302303A ES9302303A ES2082703A1 ES 2082703 A1 ES2082703 A1 ES 2082703A1 ES 09302303 A ES09302303 A ES 09302303A ES 9302303 A ES9302303 A ES 9302303A ES 2082703 A1 ES2082703 A1 ES 2082703A1
Authority
ES
Spain
Prior art keywords
new derivatives
procedures
applications
preparation
cyclopropyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES09302303A
Other languages
English (en)
Other versions
ES2082703B1 (es
Inventor
Casanova Maria Jose Verde
Ramos Alvaro Galiano
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Instituto de Investigacion y Desarrollo Quimico Biologico SA
Original Assignee
Instituto de Investigacion y Desarrollo Quimico Biologico SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to ES09302303A priority Critical patent/ES2082703B1/es
Application filed by Instituto de Investigacion y Desarrollo Quimico Biologico SA filed Critical Instituto de Investigacion y Desarrollo Quimico Biologico SA
Priority to CA002153264A priority patent/CA2153264C/en
Priority to RU95115550A priority patent/RU2125045C1/ru
Priority to DK94931597T priority patent/DK0677514T3/da
Priority to AU80620/94A priority patent/AU693123B2/en
Priority to KR1019950702759A priority patent/KR100201346B1/ko
Priority to JP7513030A priority patent/JP2931103B2/ja
Priority to PCT/ES1994/000107 priority patent/WO1995012576A1/es
Priority to FI953290A priority patent/FI953290L/fi
Priority to HU9502005A priority patent/HU217550B/hu
Priority to DE69422386T priority patent/DE69422386T2/de
Priority to AT94931597T priority patent/ATE188211T1/de
Priority to EP94931597A priority patent/EP0677514B1/en
Priority to NZ275120A priority patent/NZ275120A/en
Priority to PT94931597T priority patent/PT677514E/pt
Priority to NO952633A priority patent/NO305433B1/no
Publication of ES2082703A1 publication Critical patent/ES2082703A1/es
Application granted granted Critical
Publication of ES2082703B1 publication Critical patent/ES2082703B1/es
Priority to US08/912,250 priority patent/US5834490A/en
Priority to GR20000400676T priority patent/GR3032976T3/el
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Anesthesiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

NUEVOS DERIVADOS DE CICLOPROPILO, PROCEDIMIENTOS PARA SU PREPARACION Y APLICACIONES. LOS NUEVOS DERIVADOS DE CICLOPROPILO TIENEN LA FORMULA (I) DONDE R=CICLOPROPILO O METILCICLOPROPILO. EL PROCEDIMIENTO COMPRENDE HACER REACCIONAR CLORURO DE 2,6-DIBROMOHEXANOILO CON 2,6-DIMETILANILINA EN PRESENCIA DE UNA BASE A 0 -25 C PARA DAR 2,6-DIBROMOHEXANOIL-2,6-DIMETILANILIDA QUE SEGUIDAMENTE SE HACE REACCIONAR CON R-NH2 (DONDE R ES EL DEFINIDO ANTERIORMENTE) A 70-100 C PARA DAR (I). LOS COMPUESTOS (I) TIENEN APLICACION COMO AGENTES ANTIARRITMICOS Y COMO ANESTESICOS LOCALES.
ES09302303A 1993-11-04 1993-11-04 Nuevos derivados de ciclopropilo, procedimientos para su preparacion y aplicaciones. Expired - Fee Related ES2082703B1 (es)

Priority Applications (18)

Application Number Priority Date Filing Date Title
ES09302303A ES2082703B1 (es) 1993-11-04 1993-11-04 Nuevos derivados de ciclopropilo, procedimientos para su preparacion y aplicaciones.
AT94931597T ATE188211T1 (de) 1993-11-04 1994-11-03 Cyclopropyl-derivate, verfahren zur herstellung und anwendungen
DK94931597T DK0677514T3 (da) 1993-11-04 1994-11-03 Cyclopropylderivater, fremgangsmåde til fremstilling deraf og anvendelser deraf
AU80620/94A AU693123B2 (en) 1993-11-04 1994-11-03 New cyclopropyl derivatives, preparation method thereof and applications
KR1019950702759A KR100201346B1 (ko) 1993-11-04 1994-11-03 신규시클로프로필유도체, 그 제조방법 및 용도
JP7513030A JP2931103B2 (ja) 1993-11-04 1994-11-03 新規メチルシクロプロピル誘導体類、その調製法および応用
PCT/ES1994/000107 WO1995012576A1 (es) 1993-11-04 1994-11-03 Nuevos derivados de ciclopropilo, procedimientos para su preparacion y aplicaciones
FI953290A FI953290L (fi) 1993-11-04 1994-11-03 Uusia syklopropyylijohdannaisia, menetelmä niiden valmistamiseksi ja niiden käyttö
HU9502005A HU217550B (hu) 1993-11-04 1994-11-03 N-(Metil-ciklopropil)-piperidinkarbonsavanilid-származékok, eljárás előállításukra, valamint alkalmazásuk gyógyszerkészítmények előállítására
NZ275120A NZ275120A (en) 1993-11-04 1994-11-03 1-(methyl) cyclopropyl-2-(2,6-dimethylphenylaminocarbonyl)piperidine, preparation and use
CA002153264A CA2153264C (en) 1993-11-04 1994-11-03 New cyclopropyl derivatives, preparation method thereof and applications
RU95115550A RU2125045C1 (ru) 1993-11-04 1994-11-03 2,6-диметиланилиды n-циклопропилпиперидин-2-карбоновых кислот и фармацевтически приемлемые соли с кислотами и способ их получения
DE69422386T DE69422386T2 (de) 1993-11-04 1994-11-03 Cyclopropyl-derivate, verfahren zur herstellung und anwendungen
PT94931597T PT677514E (pt) 1993-11-04 1994-11-03 Derivados de ciclopropilo processo para a sua preparacao e suas aplicacoes
EP94931597A EP0677514B1 (en) 1993-11-04 1994-11-03 Cyclopropyl derivatives, preparation method thereof and applications
NO952633A NO305433B1 (no) 1993-11-04 1995-07-03 Syklopropylderivat samt anvendelse av dette
US08/912,250 US5834490A (en) 1993-11-04 1997-08-15 Cyclopropyl derivatives, preparation method there-of and applications
GR20000400676T GR3032976T3 (en) 1993-11-04 2000-03-16 New cyclopropyl derivatives, preparation method thereof and applications.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES09302303A ES2082703B1 (es) 1993-11-04 1993-11-04 Nuevos derivados de ciclopropilo, procedimientos para su preparacion y aplicaciones.

Publications (2)

Publication Number Publication Date
ES2082703A1 true ES2082703A1 (es) 1996-03-16
ES2082703B1 ES2082703B1 (es) 1996-12-16

Family

ID=8283511

Family Applications (1)

Application Number Title Priority Date Filing Date
ES09302303A Expired - Fee Related ES2082703B1 (es) 1993-11-04 1993-11-04 Nuevos derivados de ciclopropilo, procedimientos para su preparacion y aplicaciones.

Country Status (17)

Country Link
EP (1) EP0677514B1 (es)
JP (1) JP2931103B2 (es)
KR (1) KR100201346B1 (es)
AT (1) ATE188211T1 (es)
AU (1) AU693123B2 (es)
CA (1) CA2153264C (es)
DE (1) DE69422386T2 (es)
DK (1) DK0677514T3 (es)
ES (1) ES2082703B1 (es)
FI (1) FI953290L (es)
GR (1) GR3032976T3 (es)
HU (1) HU217550B (es)
NO (1) NO305433B1 (es)
NZ (1) NZ275120A (es)
PT (1) PT677514E (es)
RU (1) RU2125045C1 (es)
WO (1) WO1995012576A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5986141A (en) * 1998-09-29 1999-11-16 Eastman Chemical Company Process for the production of cyclopropanemethylamine
RU2504538C2 (ru) * 2012-04-17 2014-01-20 Государственное бюджетное образовательное учреждение высшего профессионального образования "Пермская государственная фармацевтическая академия" Министерства здравоохранения и социального развития Российской Федерации (ГБОУ ВПО ПГФА Минздравсоцразвития России) 2,6-диметиланилид n-циклогексилпирролидин-2-карбоновой кислоты гидрохлорид, проявляющий активность при поверхностной, инфильтрационной и проводниковой анестезии
CN106699744B (zh) * 2015-11-18 2021-05-11 四川海思科制药有限公司 一种杂环类酰胺衍生物及其制备方法和在药学上的应用
CN108218846A (zh) * 2016-12-22 2018-06-29 四川海思科制药有限公司 噻吩衍生物的新固态形式及其制备方法和用途

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB889225A (es) * 1959-07-01
GB775749A (en) * 1955-04-06 1957-05-29 Bofors Ab Method of preparing amides of n-alkyl piperidine monocarboxylic acid and n-alkyl pyrrolidine -a-monocarboxylic acid
GB869978A (en) * 1958-03-13 1961-06-07 Bofors Ab Method of producing n-alkyl-and-cycloalkyl-piperidine carboxylic acid amides
ES460315A1 (es) * 1976-06-22 1978-04-01 Bofors Ab Metodo para la fabricacion del cloruro de la n-metil piperi-din-2-acido carboxilixo-2,6-xilidida.
EP0239710A1 (en) * 1986-01-03 1987-10-07 Astra Läkemedel Aktiebolag (S)-(-)-1-propyl-2',6'-pipecoloxylidide hydrochloride monohydrate, process for its preparation and pharmaceutical preparation containing it

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3379266D1 (en) * 1983-08-01 1989-04-06 Astra Laekemedel Ab L-n-n-propylpipecolic acid-2,6-xylidide and method for preparing the same
US4695576A (en) * 1984-07-09 1987-09-22 Astra Lake Medel Aktiebolag L-N-n-propylpipecolic acid-2,6-xylidide
SU1579455A3 (ru) * 1987-07-01 1990-07-15 Астра Лекемедель Актиеболаг (Фирма) Способ получени оптически чистого моногидрата S-(-)-1-пропил-2 @ ,6 @ -пипеколоксилидид гидрохлорида

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB775749A (en) * 1955-04-06 1957-05-29 Bofors Ab Method of preparing amides of n-alkyl piperidine monocarboxylic acid and n-alkyl pyrrolidine -a-monocarboxylic acid
GB869978A (en) * 1958-03-13 1961-06-07 Bofors Ab Method of producing n-alkyl-and-cycloalkyl-piperidine carboxylic acid amides
GB889225A (es) * 1959-07-01
ES460315A1 (es) * 1976-06-22 1978-04-01 Bofors Ab Metodo para la fabricacion del cloruro de la n-metil piperi-din-2-acido carboxilixo-2,6-xilidida.
EP0239710A1 (en) * 1986-01-03 1987-10-07 Astra Läkemedel Aktiebolag (S)-(-)-1-propyl-2',6'-pipecoloxylidide hydrochloride monohydrate, process for its preparation and pharmaceutical preparation containing it

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CHEM. ABS. Vol. 52, n‘ 17, 10 Septiembre 1958 (Columbus, Ohio, U.S.A.), columnas 14609-14610, resumen n‘ 14609e, BO T. et al.: "N-alkylpyrrolidine and N-alkyl-piperidinecarboxylic acid amides", Acta Chem. Scand. 1957, 11, 1183-90 (Eng) * Resumen * *
CHEM. ABS. Vol. 97, n‘ 21, 22 Noviembre 1982 (Columbus, Ohio, U.S.A.), pßgina 28, resumen n‘ 174482b, CHERNYAKOVA, I.V "Relationship between the anesthetic and antiarrhythmic activity of alfa-azacycloalkanecarboxylic acid derivatives and their effect on the permeability of bilayer phospholipid membranes", Byull. Eskp. Biol. Med. 1982, 94 (8), 56-8 (Russ) * Resumen * *

Also Published As

Publication number Publication date
NO305433B1 (no) 1999-05-31
HUT72899A (en) 1996-06-28
DE69422386D1 (de) 2000-02-03
KR100201346B1 (ko) 1999-06-15
PT677514E (pt) 2000-06-30
EP0677514A1 (en) 1995-10-18
JPH08508044A (ja) 1996-08-27
ES2082703B1 (es) 1996-12-16
FI953290A0 (fi) 1995-07-03
WO1995012576A1 (es) 1995-05-11
FI953290A7 (fi) 1995-08-25
NZ275120A (en) 1999-09-29
FI953290L (fi) 1995-08-25
AU8062094A (en) 1995-05-23
AU693123B2 (en) 1998-06-25
DK0677514T3 (da) 2000-06-13
EP0677514B1 (en) 1999-12-29
KR960700232A (ko) 1996-01-19
NO952633L (no) 1995-09-01
ATE188211T1 (de) 2000-01-15
GR3032976T3 (en) 2000-07-31
RU95115550A (ru) 1997-06-10
RU2125045C1 (ru) 1999-01-20
NO952633D0 (no) 1995-07-03
HU217550B (hu) 2000-02-28
CA2153264A1 (en) 1995-05-11
JP2931103B2 (ja) 1999-08-09
DE69422386T2 (de) 2000-07-27
CA2153264C (en) 1999-09-14
HU9502005D0 (en) 1995-09-28

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