ES2080703B1 - STABILIZATION METHODS OF DRUG SUBSTANCES INCORPORATED IN CHEWING PILLS. - Google Patents
STABILIZATION METHODS OF DRUG SUBSTANCES INCORPORATED IN CHEWING PILLS.Info
- Publication number
- ES2080703B1 ES2080703B1 ES9401862A ES9401862A ES2080703B1 ES 2080703 B1 ES2080703 B1 ES 2080703B1 ES 9401862 A ES9401862 A ES 9401862A ES 9401862 A ES9401862 A ES 9401862A ES 2080703 B1 ES2080703 B1 ES 2080703B1
- Authority
- ES
- Spain
- Prior art keywords
- chewing
- pills
- isooctane
- water
- substances incorporated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 230000001055 chewing effect Effects 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 239000006187 pill Substances 0.000 title abstract 2
- 230000006641 stabilisation Effects 0.000 title abstract 2
- 238000011105 stabilization Methods 0.000 title abstract 2
- 229940088679 drug related substance Drugs 0.000 title 1
- NHTMVDHEPJAVLT-UHFFFAOYSA-N Isooctane Chemical compound CC(C)CC(C)(C)C NHTMVDHEPJAVLT-UHFFFAOYSA-N 0.000 abstract 3
- JVSWJIKNEAIKJW-UHFFFAOYSA-N dimethyl-hexane Natural products CCCCCC(C)C JVSWJIKNEAIKJW-UHFFFAOYSA-N 0.000 abstract 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- XLYOFNOQVPJJNP-PWCQTSIFSA-N Tritiated water Chemical compound [3H]O[3H] XLYOFNOQVPJJNP-PWCQTSIFSA-N 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 229910021529 ammonia Inorganic materials 0.000 abstract 1
- 238000007796 conventional method Methods 0.000 abstract 1
- 239000008367 deionised water Substances 0.000 abstract 1
- 229910021641 deionized water Inorganic materials 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000000839 emulsion Substances 0.000 abstract 1
- 239000003094 microcapsule Substances 0.000 abstract 1
- 239000000047 product Substances 0.000 abstract 1
- 239000012265 solid product Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Landscapes
- Confectionery (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
Abstract
METODO DE ESTABILIZACION DE SUSTANCIAS MEDICAMENTOSAS INCORPORADAS A PASTILLAS DE CHICLE. CONSISTE EN LA MICROENCAPSULACION DEL O LOS PRINCIPIOS ACTIVOS, MEDICAMENTOSOS, MEDIANTE UN PRODUCTO DE MICROENCAPSULADO CUYO COMPONENTE FUNDAMENTAL ES ALBUMINA DE HUEVO Y EN EL QUE PARTICIPAN TAMBIEN GLICIRRICINATO AMONICO, ASPARTAMO, ISOOCTANO, AGUA DESIONIZADA Y SPAN. LOS PRINCIPIOS ACTIVOS SE DISUELVEN POR SEPARADO, CONJUNTAMENTE CON LA ALBUMINA, EL GLICIRRICINATO AMONICO Y EL ASPARTAMO EN AGUA DESIONIZADA, AÑADIENDOSE SEGUIDAMENTE EL ISOOCTANO Y EL SPAN Y AGITANDOSE PARA FORMAR UNA EMULSION QUE SE CALIENTA A 60 C DURANTE UNA HORA. SEGUIDAMENTE SE DECANTA EL ISOOCTANO Y SE LAVA EL PRODUCTO SOLIDO OBTENIDO, LAS MICROCAPSULAS, CON ETANOL. FINALMENTE SE SECA A 60 C Y SE PASA POR UN TAMIZ DE ABERTURA CUADRADA, QUEDANDO EN CONDICIONES DE SER APORTADO, POR METODOS CONVENCIONALES, A LA MASA DE CHICLE.STABILIZATION METHOD OF MEDICATION SUBSTANCES INCORPORATED IN CHEWING PILLS. IT CONSISTS OF THE MICROENCAPSULATION OF THE ACTIVE PRINCIPLE (S), MEDICINES, BY MEANS OF A MICROENCAPSULATED PRODUCT WHICH IS A FUNDAMENTAL COMPONENT OF EGG ALBUMINE AND IN WHICH ALSO AMYCHRICHINATE, ASPARTAMO, WATER, ISOOCTANE, WATER. THE ACTIVE SUBSTANCES ARE DISSOLVED SEPARATELY, TOGETHER WITH ALBUMINE, GLYCUMRICINATE AMMONIA AND ASPARTAMO IN DEIONIZED WATER, FURTHER ADDING THE ISOOCTANE AND SPAN AND WAVING TO FORM AN EMULSION THAT IS WARMING TO 60 DUR. THEN THE ISOOCTANE IS DECANTS AND THE SOLID PRODUCT OBTAINED, THE MICROCAPSULES, IS WASHED WITH ETHANOL. FINALLY DRY AT 60 C AND GO THROUGH A SQUARE OPENING SIEVE, REMAINING IN CONDITION OF BEING CONTRIBUTED, BY CONVENTIONAL METHODS, TO THE CHEWING MASS.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES9401862A ES2080703B1 (en) | 1994-08-25 | 1994-08-25 | STABILIZATION METHODS OF DRUG SUBSTANCES INCORPORATED IN CHEWING PILLS. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES9401862A ES2080703B1 (en) | 1994-08-25 | 1994-08-25 | STABILIZATION METHODS OF DRUG SUBSTANCES INCORPORATED IN CHEWING PILLS. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2080703A1 ES2080703A1 (en) | 1996-02-01 |
| ES2080703B1 true ES2080703B1 (en) | 1996-10-16 |
Family
ID=8287340
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES9401862A Expired - Fee Related ES2080703B1 (en) | 1994-08-25 | 1994-08-25 | STABILIZATION METHODS OF DRUG SUBSTANCES INCORPORATED IN CHEWING PILLS. |
Country Status (1)
| Country | Link |
|---|---|
| ES (1) | ES2080703B1 (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7727565B2 (en) | 2004-08-25 | 2010-06-01 | Cadbury Adams Usa Llc | Liquid-filled chewing gum composition |
| US7851000B2 (en) | 2005-05-23 | 2010-12-14 | Cadbury Adams Usa Llc | Taste potentiator compositions and edible confectionery and chewing gum products containing same |
| US7851005B2 (en) | 2005-05-23 | 2010-12-14 | Cadbury Adams Usa Llc | Taste potentiator compositions and beverages containing same |
| US7851006B2 (en) | 2005-05-23 | 2010-12-14 | Cadbury Adams Usa Llc | Taste potentiator compositions and beverages containing same |
| US7955630B2 (en) | 2004-09-30 | 2011-06-07 | Kraft Foods Global Brands Llc | Thermally stable, high tensile strength encapsulated actives |
| US9198448B2 (en) | 2005-02-07 | 2015-12-01 | Intercontinental Great Brands Llc | Stable tooth whitening gum with reactive ingredients |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2014008314A (en) * | 2014-07-07 | 2016-01-06 | Andres Abelino Choza Romero | Nebulisation-based method for mixing substances. |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1189727B (en) * | 1985-08-30 | 1988-02-04 | Roberto Cappellari | CHEWING RUBBER WITH DIFFERENT EFFECT IN THE TASTE AND TIME |
| US4822621A (en) * | 1987-07-30 | 1989-04-18 | Warner-Lambert Company | Method and product for increased aspartame stability in chewing gum |
-
1994
- 1994-08-25 ES ES9401862A patent/ES2080703B1/en not_active Expired - Fee Related
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7727565B2 (en) | 2004-08-25 | 2010-06-01 | Cadbury Adams Usa Llc | Liquid-filled chewing gum composition |
| US7955630B2 (en) | 2004-09-30 | 2011-06-07 | Kraft Foods Global Brands Llc | Thermally stable, high tensile strength encapsulated actives |
| US8524295B2 (en) | 2004-09-30 | 2013-09-03 | Intercontinental Great Brands Llc | Thermally stable, high tensile strength encapsulated actives |
| US9198448B2 (en) | 2005-02-07 | 2015-12-01 | Intercontinental Great Brands Llc | Stable tooth whitening gum with reactive ingredients |
| US7851000B2 (en) | 2005-05-23 | 2010-12-14 | Cadbury Adams Usa Llc | Taste potentiator compositions and edible confectionery and chewing gum products containing same |
| US7851005B2 (en) | 2005-05-23 | 2010-12-14 | Cadbury Adams Usa Llc | Taste potentiator compositions and beverages containing same |
| US7851006B2 (en) | 2005-05-23 | 2010-12-14 | Cadbury Adams Usa Llc | Taste potentiator compositions and beverages containing same |
| US7879376B2 (en) | 2005-05-23 | 2011-02-01 | Cadbury Adams Usa Llc | Taste potentiator compositions and edible confectionery and chewing gum products containing same |
| US8455033B2 (en) | 2005-05-23 | 2013-06-04 | Kraft Foods Global Brands Llc | Taste potentiator compositions and edible confectionery and chewing gum products containing same |
Also Published As
| Publication number | Publication date |
|---|---|
| ES2080703A1 (en) | 1996-02-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EC2A | Search report published |
Date of ref document: 19940825 Kind code of ref document: B1 Effective date: 19940825 |
|
| FD2A | Announcement of lapse in spain |
Effective date: 20180806 |