ES2078182B1 - PROCEDURE FOR THE PREPARATION OF BIODEGRADABLE MICROSPHERES WITH CONTROLLED RELEASE AND CORRESPONDING MICROSPHERES. - Google Patents
PROCEDURE FOR THE PREPARATION OF BIODEGRADABLE MICROSPHERES WITH CONTROLLED RELEASE AND CORRESPONDING MICROSPHERES.Info
- Publication number
- ES2078182B1 ES2078182B1 ES9400792A ES9400792A ES2078182B1 ES 2078182 B1 ES2078182 B1 ES 2078182B1 ES 9400792 A ES9400792 A ES 9400792A ES 9400792 A ES9400792 A ES 9400792A ES 2078182 B1 ES2078182 B1 ES 2078182B1
- Authority
- ES
- Spain
- Prior art keywords
- microspheres
- procedure
- emulsion
- preparation
- controlled release
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000004005 microsphere Substances 0.000 title abstract 6
- 238000000034 method Methods 0.000 title abstract 4
- 238000013270 controlled release Methods 0.000 title abstract 3
- 238000002360 preparation method Methods 0.000 title abstract 3
- 239000000839 emulsion Substances 0.000 abstract 4
- 239000013543 active substance Substances 0.000 abstract 3
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- -1 CHLORINE HYDROCARBON Chemical class 0.000 abstract 1
- 239000004215 Carbon black (E152) Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-PWCQTSIFSA-N Tritiated water Chemical compound [3H]O[3H] XLYOFNOQVPJJNP-PWCQTSIFSA-N 0.000 abstract 1
- 239000008346 aqueous phase Substances 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 229920001577 copolymer Polymers 0.000 abstract 1
- 238000004090 dissolution Methods 0.000 abstract 1
- 238000001035 drying Methods 0.000 abstract 1
- 238000001704 evaporation Methods 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- 229930195733 hydrocarbon Natural products 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229920000747 poly(lactic acid) Polymers 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Landscapes
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Manufacturing Of Micro-Capsules (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE MICROESFERAS BIODEGRADABLES CON LIBERACION CONTROLADA Y MICROESFERAS CORRESPONDIENTES, MAS PARTICULARMENTE PARA LA PREPARACION DE UNA COMPOSICION FARMACEUTICA EN FORMA DE MICROESFERAS CON LIBERACION CONTROLADA DE POR LO MENOS UN PRINCIPIO ACTIVO HIDROSOLUBLE. EL PROCEDIMIENTO COMPRENDE LA SUCESION DE LAS ETAPAS SIGUIENTES: - DISOLUCION DEL PRINCIPIO ACTIVO EN AGUA, - EMULSION DE LA SOLUCION ACUOSA DE PRINCIPIO ACTIVO OBTENIDA CON UNA SOLUCION DE POR LO MENOS UN COPOLIMERO MATRICIAL DEL TIPO D,L-LACTIDA-CO-GLICOLIDA EN UN HIDROCARBURO CLORADO QUE CONTIENE UN AGENTE MODULADOR DE LA LIBERACION, POLILACTIDA DE BAJO PESO MOLECULAR, QUE DA LUGAR A UNA PRIMERA EMULSION MICROFINA Y HOMOGENEA. - EMULSION DE DICHA PRIMERA EMULSION ASI OBTENIDA EN UNA FASE ACUOSA EXTERNA QUE CONTIENE UN AGENTE TENSIOACTIVO, - EXTRACCION-EVAPORACION DEL DISOLVENTE PARA OBTENER MICROESFERAS QUE SE RECUPERAN DESPUES DE FILTRACION, LAVADO Y SECADO. LA INVENCION COMPRENDE TAMBIEN LAS MICROESFERAS OBTENIDAS POR DICHO PROCEDIMIENTO.PROCEDURE FOR THE PREPARATION OF BIODEGRADABLE MICROSPHERES WITH CONTROLLED RELEASE AND CORRESPONDING MICROSPHERES, MORE PARTICULARLY FOR THE PREPARATION OF A PHARMACEUTICAL COMPOSITION IN THE FORM OF CONTROLLED RELEASE OF AT LEAST ONE WATER-SOLUBLE ACTIVE SUBSTANCE. THE PROCEDURE INCLUDES THE SUCCESSION OF THE FOLLOWING STAGES: - DISSOLUTION OF THE ACTIVE SUBSTANCE IN WATER, - EMULSION OF THE AQUEOUS SOLUTION OF ACTIVE SUBSTANCE OBTAINED WITH A SOLUTION OF AT LEAST ONE MATRICIAL COPOLYMER OF TYPE D, L-LACTIDE-CO-GLICOLE A CHLORINE HYDROCARBON CONTAINING A MODULATING AGENT OF LIBERATION, A LOW MOLECULAR WEIGHT POLYLACTIDE, WHICH CAUSES A FIRST HOMOGENEOUS MICROPHINE EMULSION. - EMULSION OF SUCH FIRST EMULSION SO OBTAINED IN AN EXTERNAL AQUEOUS PHASE CONTAINING A TENSIOACTIVE AGENT, - EXTRACTION-EVAPORATION OF THE SOLVENT TO OBTAIN MICROSPHERES THAT ARE RECOVERED AFTER FILTRATION, WASHING AND DRYING. THE INVENTION ALSO INCLUDES THE MICROSPHERES OBTAINED BY SUCH PROCEDURE.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES9400792A ES2078182B1 (en) | 1994-04-15 | 1994-04-15 | PROCEDURE FOR THE PREPARATION OF BIODEGRADABLE MICROSPHERES WITH CONTROLLED RELEASE AND CORRESPONDING MICROSPHERES. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES9400792A ES2078182B1 (en) | 1994-04-15 | 1994-04-15 | PROCEDURE FOR THE PREPARATION OF BIODEGRADABLE MICROSPHERES WITH CONTROLLED RELEASE AND CORRESPONDING MICROSPHERES. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2078182A1 ES2078182A1 (en) | 1995-12-01 |
| ES2078182B1 true ES2078182B1 (en) | 1996-07-01 |
Family
ID=8285897
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES9400792A Expired - Fee Related ES2078182B1 (en) | 1994-04-15 | 1994-04-15 | PROCEDURE FOR THE PREPARATION OF BIODEGRADABLE MICROSPHERES WITH CONTROLLED RELEASE AND CORRESPONDING MICROSPHERES. |
Country Status (1)
| Country | Link |
|---|---|
| ES (1) | ES2078182B1 (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6204308B1 (en) | 1999-03-01 | 2001-03-20 | Novartis Ag | Organic compounds |
| BRPI0213226B1 (en) * | 2001-10-10 | 2016-03-01 | Pf Medicament | process of preparing a pharmaceutical composition in the form of extended release microspheres of a water soluble active ingredient, and, microspheres |
| ES2194590B2 (en) * | 2001-10-10 | 2006-02-16 | Pierre Fabre Iberica S.A. | BIODEGRADABLE MICROSPHERES WITH PROLONGED RELEASE AND ITS PREPARATION PROCEDURE. |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5288502A (en) * | 1991-10-16 | 1994-02-22 | The University Of Texas System | Preparation and uses of multi-phase microspheres |
-
1994
- 1994-04-15 ES ES9400792A patent/ES2078182B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ES2078182A1 (en) | 1995-12-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD2A | Announcement of lapse in spain |
Effective date: 20141120 |