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ES2078182A1 - Procedimiento para la preparacion de microesferas biodegradables con liberacion controlada y microesferas correspondientes. - Google Patents

Procedimiento para la preparacion de microesferas biodegradables con liberacion controlada y microesferas correspondientes.

Info

Publication number
ES2078182A1
ES2078182A1 ES09400792A ES9400792A ES2078182A1 ES 2078182 A1 ES2078182 A1 ES 2078182A1 ES 09400792 A ES09400792 A ES 09400792A ES 9400792 A ES9400792 A ES 9400792A ES 2078182 A1 ES2078182 A1 ES 2078182A1
Authority
ES
Spain
Prior art keywords
microspheres
preparation
controlled release
active principle
emulsification
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES09400792A
Other languages
English (en)
Other versions
ES2078182B1 (es
Inventor
Rosa Arola
Amadeo Perez
Miguel Angel Asin
Eulalia Ferret
Eric Goutay
Pere Tarin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pierre Fabre Iberica SA
Original Assignee
Pierre Fabre Iberica SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pierre Fabre Iberica SA filed Critical Pierre Fabre Iberica SA
Priority to ES9400792A priority Critical patent/ES2078182B1/es
Publication of ES2078182A1 publication Critical patent/ES2078182A1/es
Application granted granted Critical
Publication of ES2078182B1 publication Critical patent/ES2078182B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE MICROESFERAS BIODEGRADABLES CON LIBERACION CONTROLADA Y MICROESFERAS CORRESPONDIENTES, MAS PARTICULARMENTE PARA LA PREPARACION DE UNA COMPOSICION FARMACEUTICA EN FORMA DE MICROESFERAS CON LIBERACION CONTROLADA DE POR LO MENOS UN PRINCIPIO ACTIVO HIDROSOLUBLE. EL PROCEDIMIENTO COMPRENDE LA SUCESION DE LAS ETAPAS SIGUIENTES: - DISOLUCION DEL PRINCIPIO ACTIVO EN AGUA, - EMULSION DE LA SOLUCION ACUOSA DE PRINCIPIO ACTIVO OBTENIDA CON UNA SOLUCION DE POR LO MENOS UN COPOLIMERO MATRICIAL DEL TIPO D,L-LACTIDA-CO-GLICOLIDA EN UN HIDROCARBURO CLORADO QUE CONTIENE UN AGENTE MODULADOR DE LA LIBERACION, POLILACTIDA DE BAJO PESO MOLECULAR, QUE DA LUGAR A UNA PRIMERA EMULSION MICROFINA Y HOMOGENEA. - EMULSION DE DICHA PRIMERA EMULSION ASI OBTENIDA EN UNA FASE ACUOSA EXTERNA QUE CONTIENE UN AGENTE TENSIOACTIVO, - EXTRACCION-EVAPORACION DEL DISOLVENTE PARA OBTENER MICROESFERAS QUE SE RECUPERAN DESPUES DE FILTRACION, LAVADO Y SECADO. LA INVENCION COMPRENDE TAMBIEN LAS MICROESFERAS OBTENIDAS POR DICHO PROCEDIMIENTO.
ES9400792A 1994-04-15 1994-04-15 Procedimiento para la preparacion de microesferas biodegradables con liberacion controlada y microesferas correspondientes. Expired - Fee Related ES2078182B1 (es)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES9400792A ES2078182B1 (es) 1994-04-15 1994-04-15 Procedimiento para la preparacion de microesferas biodegradables con liberacion controlada y microesferas correspondientes.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9400792A ES2078182B1 (es) 1994-04-15 1994-04-15 Procedimiento para la preparacion de microesferas biodegradables con liberacion controlada y microesferas correspondientes.

Publications (2)

Publication Number Publication Date
ES2078182A1 true ES2078182A1 (es) 1995-12-01
ES2078182B1 ES2078182B1 (es) 1996-07-01

Family

ID=8285897

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9400792A Expired - Fee Related ES2078182B1 (es) 1994-04-15 1994-04-15 Procedimiento para la preparacion de microesferas biodegradables con liberacion controlada y microesferas correspondientes.

Country Status (1)

Country Link
ES (1) ES2078182B1 (es)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6204308B1 (en) 1999-03-01 2001-03-20 Novartis Ag Organic compounds
ES2194590A1 (es) * 2001-10-10 2003-11-16 Pierre Fabre Iberica S A Microesferas biodegradables con liberacion prolongada y su procedimiento de preparacion.
AU2002358831B2 (en) * 2001-10-10 2007-09-06 Pierre Fabre Medicament Prolonged release biodegradable microspheres and method for preparing same

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993007861A1 (en) * 1991-10-16 1993-04-29 Board Of Regents, The University Of Texas System Preparation and uses of multi-phase microspheres

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993007861A1 (en) * 1991-10-16 1993-04-29 Board Of Regents, The University Of Texas System Preparation and uses of multi-phase microspheres

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6204308B1 (en) 1999-03-01 2001-03-20 Novartis Ag Organic compounds
ES2194590A1 (es) * 2001-10-10 2003-11-16 Pierre Fabre Iberica S A Microesferas biodegradables con liberacion prolongada y su procedimiento de preparacion.
AU2002358831B2 (en) * 2001-10-10 2007-09-06 Pierre Fabre Medicament Prolonged release biodegradable microspheres and method for preparing same

Also Published As

Publication number Publication date
ES2078182B1 (es) 1996-07-01

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