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ES2075851T3 - Metodo para analisis inmunocromatografico. - Google Patents

Metodo para analisis inmunocromatografico.

Info

Publication number
ES2075851T3
ES2075851T3 ES89304913T ES89304913T ES2075851T3 ES 2075851 T3 ES2075851 T3 ES 2075851T3 ES 89304913 T ES89304913 T ES 89304913T ES 89304913 T ES89304913 T ES 89304913T ES 2075851 T3 ES2075851 T3 ES 2075851T3
Authority
ES
Spain
Prior art keywords
component
embedding
zone
liquid
medium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89304913T
Other languages
English (en)
Inventor
Vartan Ghazarossian
Armen B Shanafelt
Carl N Skold
Edwin F Ullman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syntex USA LLC
Original Assignee
Syntex USA LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex USA LLC filed Critical Syntex USA LLC
Application granted granted Critical
Publication of ES2075851T3 publication Critical patent/ES2075851T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54386—Analytical elements
    • G01N33/54387—Immunochromatographic test strips
    • G01N33/54388—Immunochromatographic test strips based on lateral flow
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/97—Test strip or test slide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/971—Capture of complex after antigen-antibody reaction
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/972—Modified antibody, e.g. hybrid, bifunctional
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/975—Kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/807—Apparatus included in process claim, e.g. physical support structures
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/807—Apparatus included in process claim, e.g. physical support structures
    • Y10S436/81—Tube, bottle, or dipstick
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/815—Test for named compound or class of compounds
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/815—Test for named compound or class of compounds
    • Y10S436/816—Alkaloids, amphetamines, and barbiturates
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/819—Multifunctional antigen or antibody
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/822—Identified hapten

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

SE DESCRIBEN METODOS PARA EFECTUAR ENSAYOS. UN METODO TAL CONSISTE EN PROPORCIONAR EN COMBINACION UNA PRIMERA ZONA DE UN MIEMBRO EMBEBEDOR ("PRIMERA ZONA") Y UN MEDIO LIQUIDO QUE CONTIENE UN COMPONENTE. LA PRIMERA ZONA TIENE ENLAZADO A ELLA NO DIFUSIVAMENTE UN REACTIVO NO INTERREACTIVO CON EL COMPONENTE. SE ELIGEN LAS CONDICIONES SEGUN LAS CUALES EL MEDIO LIQUIDO Y POR LO MENOS UNA PARTE DEL COMPONENTE CONTENIDO EN EL RECORRE TODA LA PRIMERA ZONA Y EMIGRA A UNA SEGUNDA ZONA DE MIEMBRO EMBEBEDOR ("SEGUNDA ZONA"), DE COMPOSICION DIFERENTE A LA PRIMERA ZONA, POR MIGRACION CAPILAR. SE DETERMINA LA DISTANCIA QUE HA EMIGRADO EL COMPONENTE A LA SEGUNDA ZONA, O LA DIFERENCIA EN LAS DISTANCIAS QUE HAN EMIGRADO EL MEDIO Y EL COMPONENTE A LA SEGUNDA ZONA, ESTANDO RELACIONADAS LA DISTANCIA O LA DIFERENCIA CON LA CANTIDAD DE COMPONENTE EN EL MEDIO LIQUIDO, O LA CANTIDAD DE REACTIVO. OTRO METODO CONSISTE EN HACER QUE UN MIEMBRO PAR ENLAZANTE ESPECIFICO EN EL PRIMER MEDIO LIQUIDO LLEGUE A ENLAZAR A UN PRIMER MIEMBRO EMBEBEDOR PONIENDO EN CONTACTO UNA PARTE DEL PRIMER MIEMBRO EMBEBEDOR CON EL MEDIO. EL PRIMER MIEMBRO EMBEBEDOR ESTA EN RELACION DE ACEPTAR LIQUIDO CON UN MIEMBRO ABSORBENTE. EL CONTACTO SE LLEVA A CABO EN CONDICIONES EN QUE EL PRIMER MEDIO ATRAVIESA EL PRIMER MIEMBRO EMBEBEDOR Y POR LO MENOS UNA PARTE DEL MIEMBRO ABSORBENTE POR ACCION CAPILAR. ADEMAS, EL METODO CONSISTE EN HACER QUE EL PRIMER MIEMBRO EMBEBEDOR ENTRE EN RELACION DE ACEPTOR LIQUIDO CON UN SEGUNDO MIEMBRO EMBEBEDOR. UN COMPONENTE EN UN SEGUNDO MEDIO LIQUIDO ES TRANSPORTADO Y PREFERIBLEMENTE LLEGA A SER ENLAZADO NO DIFUSIVAMENTE AL SEGUNDO MIEMBRO EMBEBEDOR EN RELACION CON LA PRESENCIA DE ANALITO EN EL PRIMER MEDIO. ESTO SE LLEVA A CABO POR CONTACTO DE UNA PARTE DEL PRIMER MIEMBRO EMBEBEDOR CON EL SEGUNDO MEDIO EN CONDICIONES EN QUE EL SEGUNDO MEDIO RECORRE EL PRIMER MIEMBRO EMBEBEDOR POR ACCION CAPILAR, Y POR LO MENOS UNA PARTE DEL SEGUNDO MIEMBRO EMBEBEDOR. A CONTINUACION SE DETERMINA LA PRESENCIA DEL COMPONENTE SOBRE UNA PARTE AL MENOS DEL SEGUNDO MIEMBRO EMBEBEDOR.
ES89304913T 1988-05-17 1989-05-16 Metodo para analisis inmunocromatografico. Expired - Lifetime ES2075851T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/194,708 US5039607A (en) 1988-05-17 1988-05-17 Method for immunochromatographic analysis

Publications (1)

Publication Number Publication Date
ES2075851T3 true ES2075851T3 (es) 1995-10-16

Family

ID=22718623

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89304913T Expired - Lifetime ES2075851T3 (es) 1988-05-17 1989-05-16 Metodo para analisis inmunocromatografico.

Country Status (7)

Country Link
US (3) US5039607A (es)
EP (1) EP0342913B1 (es)
JP (1) JP3009155B2 (es)
AT (1) ATE126893T1 (es)
CA (1) CA1334164C (es)
DE (1) DE68923907T2 (es)
ES (1) ES2075851T3 (es)

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Also Published As

Publication number Publication date
US5039607A (en) 1991-08-13
US5248619A (en) 1993-09-28
JPH0249161A (ja) 1990-02-19
US5468647A (en) 1995-11-21
EP0342913B1 (en) 1995-08-23
CA1334164C (en) 1995-01-31
DE68923907T2 (de) 1996-03-28
JP3009155B2 (ja) 2000-02-14
EP0342913A3 (en) 1991-01-16
EP0342913A2 (en) 1989-11-23
DE68923907D1 (de) 1995-09-28
ATE126893T1 (de) 1995-09-15

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