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ES2075798B1 - DERIVATIVES OF NATURAL AMINO ACIDS AS METALOPROTEINASE INHIBITORS, PROCEDURE FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND THE USE OF SUCH COMPOUNDS IN MEDICINE. - Google Patents

DERIVATIVES OF NATURAL AMINO ACIDS AS METALOPROTEINASE INHIBITORS, PROCEDURE FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND THE USE OF SUCH COMPOUNDS IN MEDICINE.

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Publication number
ES2075798B1
ES2075798B1 ES9301819A ES9301819A ES2075798B1 ES 2075798 B1 ES2075798 B1 ES 2075798B1 ES 9301819 A ES9301819 A ES 9301819A ES 9301819 A ES9301819 A ES 9301819A ES 2075798 B1 ES2075798 B1 ES 2075798B1
Authority
ES
Spain
Prior art keywords
compounds
derivatives
medicine
preparation
pharmaceutical compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES9301819A
Other languages
Spanish (es)
Other versions
ES2075798A1 (en
Inventor
Jonathon Philip Dickens
Michael John Crimmin
Raymond Paul Beckett
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vernalis R&D Ltd
Original Assignee
British Bio Technology Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by British Bio Technology Ltd filed Critical British Bio Technology Ltd
Priority to ES9301819A priority Critical patent/ES2075798B1/en
Publication of ES2075798A1 publication Critical patent/ES2075798A1/en
Application granted granted Critical
Publication of ES2075798B1 publication Critical patent/ES2075798B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

DERIVADOS DE AMINOACIDOS NATURALES COMO INHIBIDORES DE METALOPROTEINASAS, PROCEDIMIENTO PARA SU PREPARACION, COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN Y EL USO DE DICHOS COMPUESTOS EN MEDICINA. LA PRESENTE INVENCION SE REFIERE A DERIVADOS DE ACIDOS HIDROXAMICOS TERAPEUTICAMENTE ACTIVOS, A PROCEDIMIENTOS PARA SU PREPARACION, COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN Y AL USO DE DICHOS COMPUESTOS EN MEDICINA, CONCRETAMENTE COMPUESTOS DE FORMULA (I) EN LA QUE: - R2 ES UN GRUPO DE R6-A- EN DONDE A REPRESENTA UNA CADENA DIVALENTE HIDROCARBONADA, SATURADA O NO SATURADA, LINEAL O RAMIFICADA, DE HASTA SEIS ATOMOS DE C; - R3 REPRESENTA LA CADENA LATERAL CARACTERISTICA DE UN ALFAAMINOACIDO NATURAL DISTINTO DE PROLINA; - R4 REPRESENTA HIDROGENO O METILO; - R5 REPRESENTA HIDROGENO, O UN GRUPO ALQUILO O AMINO;- O R3 Y R5, TOMADOS CONJUNTAMENTE, REPRESENTAN UNA CADENA DIVALENTE HIDROCARBONADA. ESTOS COMPUESTOS TIENEN LA PROPIEDAD DE INHIBIR LA ACCION DE METALOPROTEINASAS Y SON UTILES PARA EL TRATAMIENTO O PROFILAXIS DE ESTADOS QUE OCASIONAN LA DESINTEGRACION DE TEJIDOS.DERIVATIVES OF NATURAL AMINO ACIDS AS METALOPROTEINASE INHIBITORS, PROCEDURE FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND THE USE OF SUCH COMPOUNDS IN MEDICINE. THE PRESENT INVENTION REFERS TO DERIVATIVES OF THERAPEUTICALLY ACTIVE HYDROXAMIC ACIDS, TO PROCEDURES FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND TO THE USE OF SUCH MEDICINE COMPOUNDS, WHICH ARE: R6-A- WHERE A REPRESENTS A DIVALENT HYDROCARBON CHAIN, SATURATED OR NOT SATURATED, LINEAR OR BRANCHED, UP TO SIX ATOMS OF C; - R3 REPRESENTS THE CHARACTERISTIC SIDE CHAIN OF A NATURAL ALPHA AMINO ACID DIFFERENT FROM PROLIN; - R4 REPRESENTS HYDROGEN OR METHYL; - R5 REPRESENTS HYDROGEN, OR AN ALKYL OR AMINO GROUP; - OR R3 AND R5, TAKEN TOGETHER, REPRESENT A DIVALENT HYDROCARBON CHAIN. THESE COMPOUNDS HAVE THE PROPERTY OF INHIBITING THE ACTION OF METALOPROTEINASES AND ARE USEFUL FOR THE TREATMENT OR PROPHYLAXIS OF STATES THAT CAUSE THE DISINTEGRATION OF TISSUES.

ES9301819A 1993-08-18 1993-08-18 DERIVATIVES OF NATURAL AMINO ACIDS AS METALOPROTEINASE INHIBITORS, PROCEDURE FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND THE USE OF SUCH COMPOUNDS IN MEDICINE. Expired - Lifetime ES2075798B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES9301819A ES2075798B1 (en) 1993-08-18 1993-08-18 DERIVATIVES OF NATURAL AMINO ACIDS AS METALOPROTEINASE INHIBITORS, PROCEDURE FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND THE USE OF SUCH COMPOUNDS IN MEDICINE.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9301819A ES2075798B1 (en) 1993-08-18 1993-08-18 DERIVATIVES OF NATURAL AMINO ACIDS AS METALOPROTEINASE INHIBITORS, PROCEDURE FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND THE USE OF SUCH COMPOUNDS IN MEDICINE.

Publications (2)

Publication Number Publication Date
ES2075798A1 ES2075798A1 (en) 1995-10-01
ES2075798B1 true ES2075798B1 (en) 1996-03-01

Family

ID=8282878

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9301819A Expired - Lifetime ES2075798B1 (en) 1993-08-18 1993-08-18 DERIVATIVES OF NATURAL AMINO ACIDS AS METALOPROTEINASE INHIBITORS, PROCEDURE FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND THE USE OF SUCH COMPOUNDS IN MEDICINE.

Country Status (1)

Country Link
ES (1) ES2075798B1 (en)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8919251D0 (en) * 1989-08-24 1989-10-04 British Bio Technology Compounds
GB9215665D0 (en) * 1992-07-23 1992-09-09 British Bio Technology Compounds

Also Published As

Publication number Publication date
ES2075798A1 (en) 1995-10-01

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