ES2075797B1 - DERIVATIVES OF THERAPEUTICALLY ACTIVE HYDROXAMIC ACIDS, PROCEDURE FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND THE USE OF SUCH COMPOUNDS IN MEDICINE. - Google Patents
DERIVATIVES OF THERAPEUTICALLY ACTIVE HYDROXAMIC ACIDS, PROCEDURE FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND THE USE OF SUCH COMPOUNDS IN MEDICINE.Info
- Publication number
- ES2075797B1 ES2075797B1 ES9301818A ES9301818A ES2075797B1 ES 2075797 B1 ES2075797 B1 ES 2075797B1 ES 9301818 A ES9301818 A ES 9301818A ES 9301818 A ES9301818 A ES 9301818A ES 2075797 B1 ES2075797 B1 ES 2075797B1
- Authority
- ES
- Spain
- Prior art keywords
- compounds
- medicine
- derivatives
- contain
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- NEAQRZUHTPSBBM-UHFFFAOYSA-N 2-hydroxy-3,3-dimethyl-7-nitro-4h-isoquinolin-1-one Chemical class C1=C([N+]([O-])=O)C=C2C(=O)N(O)C(C)(C)CC2=C1 NEAQRZUHTPSBBM-UHFFFAOYSA-N 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- 229920006395 saturated elastomer Polymers 0.000 abstract 4
- 150000002430 hydrocarbons Chemical class 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- -1 AMINO GROUP Chemical group 0.000 abstract 1
- 239000004215 Carbon black (E152) Substances 0.000 abstract 1
- 229930195733 hydrocarbon Natural products 0.000 abstract 1
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical group [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
DERIVADOS DE ACIDOS HIDROXAMICOS TERAPEUTICAMENTE ACTIVOS, PROCEDIMIENTOS PARA SU PREPARACION, COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN Y EL USO DE DICHOS COMPUESTOS EN MEDICINA. LA PRESENTE INVENCION SE REFIERE A DERIVADOS DE ACIDO HIDROXAMICOS TERAPEUTICOS ACTIVOS, A PROCEDIMIENTOS PARA SU PREPARACION, COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN Y AL USO DE DICHOS COMPUESTOS EN MEDICINA, CONCRETAMENTE COMPUESTOS DE FORMULA (I): EN LA QUE - R2 ES UN GRUPO R6-A- DONDE A REPRESENTA UNA CADENA DIVALENTE HIDROCARBONADA, SATURADA O NO SATURADA, LINEAL O RAMIFICADA; - R3 ES UN GRUPO R7-(BN)-, EN DONDE N ES 0 O 1, B ES UNA CADENA DIVALENTE HIDROCARBONADA SATURADA O NO SATURADA, LINEAL O RAMIFICADA; - R4 ES HIDROGENO O METILO; - R5 ES HIDROGENO, O UN GRUPO ALQUILO O AMINO - O R3 Y R5, TOMADOS CONJUNTAMENTE, REPRESENTAN UNA CADENA DIVALENTE HIDROCARBONADA; ESTOS COMPUESTOS INHIBEN LA ACCION DE METALOPROTEINASAS Y SON UTILES PARA EL TRATAMIENTO O PROFILAXIS DE ESTADOS QUE OCASIONAN LA DESINTEGRACION DE TEJIDOS.DERIVATIVES OF THERAPEUTICALLY ACTIVE HYDROXAMIC ACIDS, PROCEDURES FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND THE USE OF SUCH COMPOUNDS IN MEDICINE. THE PRESENT INVENTION REFERS TO DERIVATIVES OF ACTIVE THERAPEUTIC HYDROXAMIC ACIDS, TO PROCEDURES FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM, AND TO THE USE OF SUCH COMPOUNDS IN MEDICINE, WHICH IS A6 - I: R2: -A- WHERE A HYDROCARBON DIVALENT, SATURATED OR NOT SATURATED, LINEAR OR BRANCHED REPRESENTS; - R3 IS A GROUP R7- (BN) -, WHERE N IS 0 O 1, B IS A DIVALENT HYDROCARBON CHAIN SATURATED OR NOT SATURATED, LINEAR OR BRANCHED; - R4 IS HYDROGEN OR METHYL; - R5 IS HYDROGEN, OR AN ALKYL OR AMINO GROUP - OR R3 AND R5, TAKEN TOGETHER, REPRESENT A DIVALENT HYDROCARBON CHAIN; THESE COMPOUNDS INHIBIT THE ACTION OF METALOPROTEINASES AND ARE USEFUL FOR THE TREATMENT OR PROPHYLAXIS OF STATES THAT CAUSE THE DISINTEGRATION OF TISSUES.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES9301818A ES2075797B1 (en) | 1993-08-18 | 1993-08-18 | DERIVATIVES OF THERAPEUTICALLY ACTIVE HYDROXAMIC ACIDS, PROCEDURE FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND THE USE OF SUCH COMPOUNDS IN MEDICINE. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES9301818A ES2075797B1 (en) | 1993-08-18 | 1993-08-18 | DERIVATIVES OF THERAPEUTICALLY ACTIVE HYDROXAMIC ACIDS, PROCEDURE FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND THE USE OF SUCH COMPOUNDS IN MEDICINE. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2075797A1 ES2075797A1 (en) | 1995-10-01 |
| ES2075797B1 true ES2075797B1 (en) | 1996-05-16 |
Family
ID=8282876
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES9301818A Expired - Fee Related ES2075797B1 (en) | 1993-08-18 | 1993-08-18 | DERIVATIVES OF THERAPEUTICALLY ACTIVE HYDROXAMIC ACIDS, PROCEDURE FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND THE USE OF SUCH COMPOUNDS IN MEDICINE. |
Country Status (1)
| Country | Link |
|---|---|
| ES (1) | ES2075797B1 (en) |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8919251D0 (en) * | 1989-08-24 | 1989-10-04 | British Bio Technology | Compounds |
| GB9215665D0 (en) * | 1992-07-23 | 1992-09-09 | British Bio Technology | Compounds |
-
1993
- 1993-08-18 ES ES9301818A patent/ES2075797B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ES2075797A1 (en) | 1995-10-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC2A | Transfer granted |
Owner name: BRITISH BIOTECH PHARMACEUTICALS LIMITED |
|
| FD1A | Patent lapsed |
Effective date: 20100528 |