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ES2075648T3 - Composicion para frenar la caida de los cabellos, y para inducir y estimular su crecimiento, a base de derivados de pirimidinas-n-oxido trisustituidas en las posiciones 2, 4 y 6 por una funcion amina, y nuevos compuestos de pirimidina-n-oxido. - Google Patents

Composicion para frenar la caida de los cabellos, y para inducir y estimular su crecimiento, a base de derivados de pirimidinas-n-oxido trisustituidas en las posiciones 2, 4 y 6 por una funcion amina, y nuevos compuestos de pirimidina-n-oxido.

Info

Publication number
ES2075648T3
ES2075648T3 ES92401689T ES92401689T ES2075648T3 ES 2075648 T3 ES2075648 T3 ES 2075648T3 ES 92401689 T ES92401689 T ES 92401689T ES 92401689 T ES92401689 T ES 92401689T ES 2075648 T3 ES2075648 T3 ES 2075648T3
Authority
ES
Spain
Prior art keywords
growth
composition
hair loss
trisustituted
pirimidine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92401689T
Other languages
English (en)
Inventor
Michel Hocquaux
Khalid Bakkar
Jean-Baptiste Galey
Eric Terranova
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LOreal SA
Original Assignee
LOreal SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by LOreal SA filed Critical LOreal SA
Application granted granted Critical
Publication of ES2075648T3 publication Critical patent/ES2075648T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4953—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/50—Three nitrogen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Dermatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

COMPOSICION PARA FRENAR LA CAIDA DEL CABELLO Y PARA INDUCIR Y ESTIMULAR SU CRECIMIENTO QUE COMPRENDE UN COMPUESTO DE FORMULA (I): EN LA QUE: R1 Y R2 REPRESENTAN H O ALQUILO Y NO REPRESENTAN SIMULTANEAMENTE H; R3 Y R4 REPRESENTAN H, UN ALQUILO, UN HETEROCICLO CON NITROGENO EN POSICION 6 Y NO REPRESENTAN SIMULTANEAMENTE H; X REPRESENTA H O UN HALOGENO; Y REPRESENTA O U OSO3; ASI COMO SUS SALES DE ADICION DE ACIDOS FISIOLOGICAMENTE ACEPTABLES.
ES92401689T 1991-06-20 1992-06-17 Composicion para frenar la caida de los cabellos, y para inducir y estimular su crecimiento, a base de derivados de pirimidinas-n-oxido trisustituidas en las posiciones 2, 4 y 6 por una funcion amina, y nuevos compuestos de pirimidina-n-oxido. Expired - Lifetime ES2075648T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9107591A FR2677884B1 (fr) 1991-06-20 1991-06-20 Composition pour freiner la chute des cheveux a base de pyrimidines n-oxyde trisubstitues ou leurs derives sulfoconjugues, nouveaux composes pyrimidines n-oxyde ou leurs derives sulfoconjugues.

Publications (1)

Publication Number Publication Date
ES2075648T3 true ES2075648T3 (es) 1995-10-01

Family

ID=9414081

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92401689T Expired - Lifetime ES2075648T3 (es) 1991-06-20 1992-06-17 Composicion para frenar la caida de los cabellos, y para inducir y estimular su crecimiento, a base de derivados de pirimidinas-n-oxido trisustituidas en las posiciones 2, 4 y 6 por una funcion amina, y nuevos compuestos de pirimidina-n-oxido.

Country Status (8)

Country Link
US (1) US5772990A (es)
EP (1) EP0519819B1 (es)
JP (1) JP3238944B2 (es)
AT (1) ATE125148T1 (es)
CA (1) CA2071802A1 (es)
DE (1) DE69203545T2 (es)
ES (1) ES2075648T3 (es)
FR (1) FR2677884B1 (es)

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FR2732597B1 (fr) * 1995-04-05 1997-05-16 Oreal Utilisation dans une composition en tant qu'activateur et/ou stabilisateur de cyclooxygenase d'au moins un derive de pyrimidine substitue en 6
FR2753378B1 (fr) * 1996-09-17 1998-11-20 Oreal Utilisation dans une composition en tant que stimulateur de tyrosinase d'au moins un derive de pyrimidine 3-oxyde, substitue en 6
US6187796B1 (en) 1998-06-03 2001-02-13 Gpi Nil Holdings, Inc. Sulfone hair growth compositions and uses
US6274602B1 (en) 1998-06-03 2001-08-14 Gpi Nil Holdings, Inc. Heterocyclic thioester and ketone hair growth compositions and uses
US6187784B1 (en) 1998-06-03 2001-02-13 Gpi Nil Holdings, Inc. Pipecolic acid derivative hair growth compositions and uses
US6271244B1 (en) 1998-06-03 2001-08-07 Gpi Nil Holdings, Inc. N-linked urea or carbamate of heterocyclic thioester hair growth compositions and uses
US5945441A (en) * 1997-06-04 1999-08-31 Gpi Nil Holdings, Inc. Pyrrolidine carboxylate hair revitalizing agents
US6136799A (en) * 1998-04-08 2000-10-24 Abbott Laboratories Cosolvent formulations
US6331537B1 (en) 1998-06-03 2001-12-18 Gpi Nil Holdings, Inc. Carboxylic acids and carboxylic acid isosteres of N-heterocyclic compounds
US6172087B1 (en) 1998-06-03 2001-01-09 Gpi Nil Holding, Inc. N-oxide of heterocyclic ester, amide, thioester, or ketone hair growth compositions and uses
JP2002516843A (ja) 1998-06-03 2002-06-11 ジー・ピー・アイ ニイル ホールディングス インコーポレィティッド ヘテロサイクリックエステルおよびアミド発毛組成物およびその使用
JP2002516904A (ja) 1998-06-03 2002-06-11 ジーピーアイ ニル ホールディングス インコーポレイテッド Ｎ−複素環式カルボン酸またはカルボン酸等配電子体のｎ−結合スルホンアミド
US6429215B1 (en) 1998-06-03 2002-08-06 Gpi Nil Holdings, Inc. N-oxide of heterocyclic ester, amide, thioester, or ketone hair growth compositions and uses
US6159950A (en) * 1998-10-16 2000-12-12 Cornell Research Foundation, Inc. Method of modulating hair growth
FR2791671B1 (fr) 1999-04-01 2001-05-11 Oreal Nouveaux composes derives d'esters d'acide benzoique, composition les comprenant et utilisation
CN1662229B (zh) 2002-06-21 2010-05-26 奥里尔股份有限公司 牛磺酸和/或亚牛磺酸在制备治疗秃头症的药物中的应用
US7326717B2 (en) * 2003-05-06 2008-02-05 L'oreal Pyrimidine n-oxide compounds for stimulating the growth of keratin fibers and/or reducing loss thereof
US20060193804A1 (en) * 2005-02-24 2006-08-31 L'oreal Haircare use of cyclic amine derivatives
BRPI0719509A2 (pt) * 2006-09-28 2013-12-31 Follica Inc Métodos, kits e composições para geração de novos folículos pilosos e crescimento de cabelos
FR2915747B1 (fr) * 2007-05-04 2011-02-25 Scras Derives de tri-amino-pyrimidine comme inhibiteurs de phosphatase cdc25
FR2920309B1 (fr) 2007-08-28 2010-05-28 Galderma Res & Dev Utilisation de travoprost pour traiter la chute des cheveux
FR2949052B1 (fr) 2009-08-13 2015-03-27 Oreal Procede de traitement cosmetique du cuir chevelu.
FR2953722B1 (fr) 2009-12-16 2012-03-09 Expanscience Lab Composition comprenant au moins un sucre en c7 pour le traitement de l'alopecie, pour le traitement cosmetique des phaneres, et pour le soin des cheveux, cils ou ongles
PL2838533T3 (pl) 2012-04-16 2018-03-30 Case Western Reserve University Kompozycje i sposoby modulowania aktywności 15-PGDH
JP6517197B2 (ja) 2013-10-15 2019-05-22 ケース ウエスタン リザーブ ユニバーシティ 短鎖デヒドロゲナーゼ活性を調節する組成物および方法
AU2014361754B2 (en) 2013-12-12 2020-04-30 Cellmid Limited Method of treatment of alopecia with monoterpenoids
AU2015357489A1 (en) 2014-12-05 2017-07-06 Case Western Reserve University Compositions and methods of modulating S-nitrosylation
US10688037B1 (en) 2015-12-31 2020-06-23 Nutraceutical Wellness Inc. Compositions and method for hair regrowth
US11690847B2 (en) 2016-11-30 2023-07-04 Case Western Reserve University Combinations of 15-PGDH inhibitors with corticosteroids and/or TNF inhibitors and uses thereof
JP2020514323A (ja) 2017-02-06 2020-05-21 ケース ウエスタン リザーブ ユニバーシティ 短鎖デヒドロゲナーゼ活性を調節する組成物と方法
EP3883577A4 (en) 2018-11-21 2022-06-15 Case Western Reserve University COMPOSITIONS AND METHODS FOR MODULATION OF SHORT CHAIN DEHYDROGENASE ACTIVITY
EP3895685A1 (en) 2020-04-14 2021-10-20 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Natural composition for hair growth stimulation and hair loss prevention and treatment without preservatives
EP3895686A1 (en) 2020-04-14 2021-10-20 FRAUNHOFER-GESELLSCHAFT zur Förderung der angewandten Forschung e.V. Natural composition for hair growth stimulation and hair loss prevention and treatment
AU2021275122A1 (en) 2020-05-20 2022-12-15 Board Of Regents Of The University Of Texas System Compositions and methods of modulating short-chain dehydrogenase activity

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FR1477048A (fr) * 1965-04-23 1967-04-14 Oreal Nouveaux agents tensio-actifs non ioniques et leur procédé de préparation
LU60900A1 (es) * 1970-05-12 1972-02-10
BE791534A (es) * 1971-11-18 1973-05-17 Oreal
US4596812A (en) * 1976-05-24 1986-06-24 The Upjohn Company Methods and solutions for treating male pattern alopecia
US4287338A (en) * 1980-03-10 1981-09-01 The Upjohn Company Sulfooxy-pyrimidinium, -pyridinium, and -triazinium hydroxide inner salts
US4308271A (en) * 1980-06-23 1981-12-29 The Upjohn Company Animal feed and process
FR2504535B1 (fr) * 1981-04-28 1987-08-14 Choay Sa Disaccharides derives d'un acide uronique et d'une glucosamine et compositions pharmaceutiques les contenant pour le controle de la coagulation sanguine
EP0177581A4 (en) * 1984-04-06 1987-08-10 Gail S Bazzano COMPOSITIONS FOR HAIR GROWTH.
WO1986000616A1 (en) * 1984-07-13 1986-01-30 Gail Sansone Bazzano Substituted pyrimidine oxides useful for hair growth promotion
WO1986004231A1 (en) * 1985-01-25 1986-07-31 The Upjohn Company Pyrimidine sulfates for hair growth
FR2581542B1 (fr) * 1985-05-07 1988-02-19 Oreal Compositions topiques destinees au traitement de la peau a base de derives de l'acide salicylique
GB8519416D0 (en) * 1985-08-01 1985-09-04 Unilever Plc Oligosaccharides
LU86574A1 (fr) * 1986-09-08 1988-04-05 Oreal Composition pour induire et stimuler la croissance des cheveux et freiner leur chute,a base d'esters nicotiniques et de derives de pyrimidine
LU86959A1 (fr) * 1987-07-31 1989-03-08 Oreal Nouveaux derives d'ureylene triamino-2,4,6 pyrimidine oxyde-3,leur preparation et leur utilisation en cosmetique et dermopharmacie
GB8806892D0 (en) * 1988-03-23 1988-04-27 Unilever Plc Lactams their synthesis & use in cosmetic compositions
GB8830019D0 (en) * 1988-12-22 1989-02-15 Unilever Plc Cosmetic composition
GB8913708D0 (en) * 1989-06-14 1989-08-02 Unilever Plc Cosmetic composition
FR2651122B1 (fr) * 1989-08-29 1994-10-28 Oreal Compositions destinees a etre utilisees pour freiner la chute des cheveux et pour induire et stimuler leur croissance, contenant des derives de l'amino-2 pyrimidine oxyde-3 et nouveaux composes derives de l'amino-2 pyrimidine oxyde-3.

Also Published As

Publication number Publication date
EP0519819A1 (fr) 1992-12-23
EP0519819B1 (fr) 1995-07-19
JP3238944B2 (ja) 2001-12-17
US5772990A (en) 1998-06-30
ATE125148T1 (de) 1995-08-15
FR2677884A1 (fr) 1992-12-24
DE69203545D1 (de) 1995-08-24
CA2071802A1 (fr) 1992-12-21
FR2677884B1 (fr) 1993-07-09
DE69203545T2 (de) 1996-01-11
JPH05186315A (ja) 1993-07-27

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