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ES2068862T3 - Derivado de 3'-hidroxibenzoxazinorifamicina; procedimiento para la preparacion del mismo y agente antibacteriano que contiene el mismo. - Google Patents

Derivado de 3'-hidroxibenzoxazinorifamicina; procedimiento para la preparacion del mismo y agente antibacteriano que contiene el mismo.

Info

Publication number
ES2068862T3
ES2068862T3 ES89117012T ES89117012T ES2068862T3 ES 2068862 T3 ES2068862 T3 ES 2068862T3 ES 89117012 T ES89117012 T ES 89117012T ES 89117012 T ES89117012 T ES 89117012T ES 2068862 T3 ES2068862 T3 ES 2068862T3
Authority
ES
Spain
Prior art keywords
same
derivative
group
hydroxibenzoxazinorifamicina
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89117012T
Other languages
English (en)
Inventor
Takehiko Yamane
Takuji Hashizume
Katsuji Yamashita
Kazunori Hosoe
Fumiyuki Kuze
Kiyoshi Watanabe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kanegafuchi Chemical Industry Co Ltd
Original Assignee
Kanegafuchi Chemical Industry Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kanegafuchi Chemical Industry Co Ltd filed Critical Kanegafuchi Chemical Industry Co Ltd
Application granted granted Critical
Publication of ES2068862T3 publication Critical patent/ES2068862T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

UN DERIVADO DE LA RIFAMICINA QUE TIENE LA FORMULA (I) DONDE A ES UN GRUPO QUE TIENE LA FORMULA (II) EN LA QUE R1 ES UN GRUPO ALKIL QUE TIENE 4 O 5 ATOMOS DE CARBONO O UN GRUPO ALKENIL QUE TIENE ENTRE 3 Y 5 ATOMOS DE CARBONO, O UN GRUPO QUE TIENE LA FORMULA (III) EN LA QUE N ES 3 O 4: O LAS SALES FARMACEUTICAMENTE ACEPTABLES DE LOS MISMOS. EL DERIVADO DE RIFAMICINA (I) EXHIBE UNA FUERTE ACTIVIDAD ANTIBACTERIANA CONTRA LA BACTERIA GRAM POSITIVA Y LA BACTERIA DE ACID RAPIDO Y TAMBIEN EXHIBE UNA FUERTE ACTIVIDAD ANTIBACTERIANA CONTRA "TUBERCLE BACILLI".
ES89117012T 1988-11-01 1989-09-14 Derivado de 3'-hidroxibenzoxazinorifamicina; procedimiento para la preparacion del mismo y agente antibacteriano que contiene el mismo. Expired - Lifetime ES2068862T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP27666188 1988-11-01
JP8039689 1989-03-30

Publications (1)

Publication Number Publication Date
ES2068862T3 true ES2068862T3 (es) 1995-05-01

Family

ID=26421409

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89117012T Expired - Lifetime ES2068862T3 (es) 1988-11-01 1989-09-14 Derivado de 3'-hidroxibenzoxazinorifamicina; procedimiento para la preparacion del mismo y agente antibacteriano que contiene el mismo.

Country Status (6)

Country Link
US (1) US4983602A (es)
EP (1) EP0366914B1 (es)
CN (1) CN1023321C (es)
CA (1) CA1304363C (es)
DE (1) DE68919650T2 (es)
ES (1) ES2068862T3 (es)

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US5981522A (en) * 1995-09-01 1999-11-09 Kaneka Corporation Treatment of disease caused by infection of Helicobacter
DE69632677T2 (de) * 1995-09-01 2005-06-16 Kaneka Corp. Verwendung eines Rifamycin-Derivates zur Herstellung eines Medikamentes zur Behandlung von Krankheiten verursacht durch Helicobacter pylori-Infektionen
JP3963976B2 (ja) * 1995-12-08 2007-08-22 株式会社カネカ クラミジア感染症治療剤
TW534813B (en) * 1997-02-28 2003-06-01 Kaneka Corp Treating agent for diseases due to infection with helicobacter
WO1999006047A1 (en) * 1997-07-29 1999-02-11 Kaneka Corporation Use of rifamycin derivative for treating mastitis in a domestic animal
US6486161B1 (en) 1998-07-29 2002-11-26 Kaneka Corporation Use of rifamycin derivative for treating mastitis in a domestic animal
US6316433B1 (en) * 1998-12-18 2001-11-13 Kaneka Corporation Method for treatment of bacterial infections with once or twice-weekly administered rifalazil
US6900204B2 (en) * 2001-09-06 2005-05-31 Activbiotics, Inc. Antimicrobial agents and uses thereof
WO2003045319A2 (en) * 2001-11-21 2003-06-05 Activbiotics, Inc. Targeted therapeutics and uses thereof
US20040014750A1 (en) * 2001-12-13 2004-01-22 Michaelis Arthur F. Metal complexes and formulations of rifamycin analogues and uses thereof
US7078399B2 (en) * 2001-12-13 2006-07-18 Activbiotics, Inc. Sulfhydryl rifamycins and uses thereof
US20090149453A1 (en) * 2002-05-23 2009-06-11 Activbiotics Pharma Llc Methods and compositions for treating bacterial infections and diseases associated therewith
AU2003265241A1 (en) * 2002-05-23 2003-12-12 Activbiotics, Inc. Methods of treating bacterial infections and diseases associated therewith
US20040077533A1 (en) * 2002-05-23 2004-04-22 Sayada Chalom B. Methods and compositions for treating bacterial infections and diseases associated therewith
AU2003268330A1 (en) * 2002-08-29 2004-03-19 Activbiotics, Inc. Methods and reagents for treating infections of clostridium difficile and diseases associated therewith
TW200418485A (en) * 2002-09-23 2004-10-01 Activbiotics Inc Rifalazil compositions and therapeutic regimens
AU2003297916A1 (en) * 2002-12-12 2004-07-09 Activbiotics, Inc. Method and reagents for treating or preventing atherosclerosis and diseases associated therewith
AU2003296963A1 (en) * 2002-12-12 2004-07-09 Activbiotics, Inc. Methods and compositions for treating and preventing ear infections
CN1894259A (zh) * 2003-08-22 2007-01-10 活跃生物工艺学公司 利福霉素类似物及其应用
US7820652B2 (en) * 2003-09-24 2010-10-26 Activbiotics Pharma, Llc Regimen for the administration of rifamycin-class antibiotics
US20050123602A1 (en) * 2003-09-25 2005-06-09 Michaelis Arthur F. Rifalazil formulations
WO2005058231A2 (en) * 2003-12-10 2005-06-30 Activbiotics, Inc. Rifamycin analogs and uses thereof
JP2007516291A (ja) * 2003-12-23 2007-06-21 アクティブバイオティクス インコーポレイティッド リファマイシンアナログおよびその使用法
US7202246B2 (en) * 2004-06-09 2007-04-10 Cumbre Pharmaceuticals Inc. Spiro-rifamycin derivatives targeting RNA polymerase
KR101327635B1 (ko) 2005-08-11 2013-11-12 타간타 테라퓨틱스 인크. 포스폰산화 리파마이신, 및 그의 뼈 및 관절 감염의 저지및 치료 용도
AU2007235379A1 (en) * 2006-04-06 2007-10-18 Activbiotics Pharma Llc Pharmaceutical compositions and uses thereof
WO2008008480A2 (en) * 2006-07-12 2008-01-17 Cumbre Pharmaceuticals Inc. Nitroheteroaryl-containing rifamycin derivatives
WO2009064792A1 (en) * 2007-11-16 2009-05-22 Cumbre Pharmaceuticals Inc. Quinolone carboxylic acid-substituted rifamycin derivatives
MX2011000319A (es) * 2008-07-07 2011-09-29 Activbiotics Pharma Llc Uso de rifalazil para tratar trastornos colonicos.
EP2324041A4 (en) 2008-08-13 2012-06-13 Targanta Therapeutics Corp PHOSPHONIZED RIFAMYCINS AND ITS APPLICATION FOR THE PREVENTION AND TREATMENT OF BONE AND JOINT INFECTIONS
RU2496475C2 (ru) 2011-10-26 2013-10-27 Александр Васильевич Иващенко Фармацевтическая композиция и набор для лечения бактериальных инфекций
KR20160015286A (ko) 2013-05-31 2016-02-12 제넨테크, 인크. 항-세포벽 테이코산 항체 및 접합체
US9803002B2 (en) 2013-05-31 2017-10-31 Genentench, Inc. Anti-wall teichoic antibodies and conjugates
CN105358573B (zh) 2013-05-31 2020-10-30 基因泰克公司 抗壁磷壁酸抗体和缀合物
JP6867288B2 (ja) 2014-07-21 2021-04-28 エーエムディー セラピューティックス エルエルシー リファマイシンの眼科用組成物およびその使用
MX2017007231A (es) 2014-12-03 2017-11-08 Genentech Inc Conjugados de rifamicina y anticuerpos contra el staphylococcuss aureus y usos de estos.
CN107206102A (zh) 2014-12-03 2017-09-26 豪夫迈·罗氏有限公司 抗金黄色葡萄球菌抗体利福霉素缀合物及其用途
SG11201807537RA (en) 2016-03-04 2018-09-27 Genentech Inc Process for the preparation of an antibody-rifamycin conjugate
CN108047249A (zh) * 2017-12-21 2018-05-18 中国医药集团总公司四川抗菌素工业研究所 一种新型利福霉素衍生物及其制备方法和用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL130099C (es) * 1963-10-11
US4005077A (en) * 1965-08-24 1977-01-25 Ciba-Geigy Corporation Antibiotically active compounds
JPS59231092A (ja) * 1983-06-11 1984-12-25 Kanebo Ltd フエノチアジン型リフアマイシンおよびその医薬用途
US4690919A (en) * 1984-01-04 1987-09-01 Kanegafuchi Kagaku Kogyo Kabushiki Kaisha Benzoxazinorifamycin derivative, process for preparing the same and antibacterial agent containing the same
JPS63183587A (ja) * 1985-02-05 1988-07-28 Kanegafuchi Chem Ind Co Ltd ベンゾキサジノリフアマイシン誘導体
JP2544375B2 (ja) * 1986-07-14 1996-10-16 鐘淵化学工業株式会社 アルキル置換ベンゾキサジノリフアマイシン誘導体

Also Published As

Publication number Publication date
DE68919650D1 (de) 1995-01-12
CN1042357A (zh) 1990-05-23
EP0366914B1 (en) 1994-11-30
CA1304363C (en) 1992-06-30
EP0366914A3 (en) 1991-07-17
CN1023321C (zh) 1993-12-29
US4983602A (en) 1991-01-08
DE68919650T2 (de) 1995-04-06
EP0366914A2 (en) 1990-05-09

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