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ES2067916T3 - Matriz con celulas fijadas por adherencia y procedimiento de produccion de virus/antigenos de virus. - Google Patents

Matriz con celulas fijadas por adherencia y procedimiento de produccion de virus/antigenos de virus.

Info

Publication number
ES2067916T3
ES2067916T3 ES91900666T ES91900666T ES2067916T3 ES 2067916 T3 ES2067916 T3 ES 2067916T3 ES 91900666 T ES91900666 T ES 91900666T ES 91900666 T ES91900666 T ES 91900666T ES 2067916 T3 ES2067916 T3 ES 2067916T3
Authority
ES
Spain
Prior art keywords
virus
cells
matrix
viruses
antigens
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91900666T
Other languages
English (en)
Inventor
Wolfgang Mundt
Noel Barrett
Friedrich Dorner
Johann Eibl
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oesterreichisches Institut fuer Haemoderivate
Original Assignee
Immuno AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immuno AG filed Critical Immuno AG
Application granted granted Critical
Publication of ES2067916T3 publication Critical patent/ES2067916T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2531/00—Microcarriers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
    • C12N2770/24151—Methods of production or purification of viral material
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)

Abstract

MATRIZ CON CELULAS UNIDAS ADHERENTES A ELLA, ASI COMO PROCEDIMIENTO PARA LA PRODUCCION DE VIRUS/ANTIGENOS DE VIRUS. LA INVENCION CONSTA DE UNA MATRIZ, ES DECIR UN MATERIAL DE SOPORTE, CON CELULAS HUMANAS O ANIMALES UNIDAS ADHERENTEMENTE A ELLA, ESTANDO LAS CELULAS INFECTADAS CON VIRUS. SE HA MOSTRADO QUE LAS CELULAS DEPENDIENTES DE LA SUPERFICIE, QUE SON APROPIADAS PARA LA MULTIPLICACION DE LOS VIRUS, INCLUSO EN ESTADO INFECTADO POR VIRUS PERMANECEN ADHERIDAS A UNA MATRIZ, PRODUCEN ANTIGENOS DE VIRUS DE FORMA CONSTANTE A LO LARGO DE UN TIEMPO RELATIVAMENTE LARGO Y LOS CEDEN AL MEDIO DE CULTIVO. PARA LA PRODUCCION DEL ANTIGENO DEL VIRUS DE LA MENINGOENCEFALITIS ESTIVAL (FSME) MEDIANTE CULTIVO DEL VIRUS FSME EN CULTIVOS CELULARES SE VACUNA CON EL VIRUS FSME UNA LINEA CELULAR PERMANENTE DEPENDIENTE DE LA SUPERFICIE, PREFERENTEMENTE LA LINEA CELULAR VERO ATTC CCL 81, Y LAS CELULAS SE MANTIENEN UNIDAS A SOPORTES CONSERVANDO EL CRECIMIENTO CELULAR EN UN SISTEMA SIN SUERO NO LITICO, PARA CONSERVARLA FORMACION DE ANTIGENOS, SEPARANDO A CONTINUACION EL MEDIO QUE CONTIENE LOS ANTIGENOS DE LAS CELULAS UNIDAS AL SOPORTE Y DE FORMA CONOCIDA MEDIANTE CONCENTRACION, INACTIVACION Y PURIFICACION SE PREPARA UN COMPUESTO GALENICO ACEPTABLE.
ES91900666T 1989-12-22 1990-12-21 Matriz con celulas fijadas por adherencia y procedimiento de produccion de virus/antigenos de virus. Expired - Lifetime ES2067916T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AT2928/89A AT393356B (de) 1989-12-22 1989-12-22 Verfahren zur herstellung von fsme-virus-antigen

Publications (1)

Publication Number Publication Date
ES2067916T3 true ES2067916T3 (es) 1995-04-01

Family

ID=3542524

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91900666T Expired - Lifetime ES2067916T3 (es) 1989-12-22 1990-12-21 Matriz con celulas fijadas por adherencia y procedimiento de produccion de virus/antigenos de virus.

Country Status (16)

Country Link
EP (1) EP0506714B1 (es)
JP (1) JP2633391B2 (es)
AT (2) AT393356B (es)
CA (1) CA2071954C (es)
CZ (1) CZ281804B6 (es)
DE (1) DE59007659D1 (es)
DK (1) DK0506714T3 (es)
ES (1) ES2067916T3 (es)
FI (1) FI98377C (es)
HR (1) HRP921354A2 (es)
HU (1) HU213886B (es)
NO (1) NO310305B1 (es)
RU (1) RU2082757C1 (es)
SK (1) SK659090A3 (es)
WO (1) WO1991009935A1 (es)
YU (1) YU242390A (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2290053A1 (en) * 1994-11-10 2011-03-02 Baxter Healthcare S.A. Method for producing Influenza virus in protein-free cell culture medium
JPH11510151A (ja) * 1995-08-01 1999-09-07 パストゥール メリユ セリュム エ ヴァサン ソシエテ アノニム 日本脳炎ワクチンの工業的製造方法と、それによって得られるワクチン
FR2737412B1 (fr) * 1995-08-01 1997-10-24 Pasteur Merieux Serums Vacc Procede de production d'un vaccin contre le virus de l'encephalite japonaise et vaccin obtenu par ce procede
CA2311336C (en) * 1998-10-05 2007-01-02 The Research Foundation For Microbial Diseases Of Osaka University Enhanced immunogen for inactivated vaccine for infection with japanese encephalitis viruses and process for producing the same
AT409379B (de) 1999-06-02 2002-07-25 Baxter Ag Medium zur protein- und serumfreien kultivierung von zellen
US6855535B2 (en) * 2001-12-10 2005-02-15 Baxter Healthcare S.A. Method of large scale production of Hepatitis A virus
US6951752B2 (en) 2001-12-10 2005-10-04 Bexter Healthcare S.A. Method for large scale production of virus antigen
JP2007068401A (ja) * 2003-08-07 2007-03-22 Chemo Sero Therapeut Res Inst 西ナイルウイルスワクチン
BR122019022434B8 (pt) * 2007-12-27 2021-07-27 Baxalta GmbH método para cultivar células de mamífero que secretam proteína heteróloga em um sobrenadante de cultura celular

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT358167B (de) * 1978-12-22 1980-08-25 Immuno Ag Verfahren zur herstellung von fruehsommer- -meningoenzephalitis-virus (fsme-virus)- -vakzinen
SE445116B (sv) * 1979-09-12 1986-06-02 Pharmacia Fine Chemicals Ab Sett att odla celler pa mikroberare med fibronektinytskikt
NO161446C (no) * 1981-03-13 1989-08-16 Damon Biotech Inc Fremgangsmaate for dyrking av celler som er avhengige av forankring.
SE8103138L (sv) * 1981-05-19 1982-11-20 Pharmacia Fine Chemicals Ab Mikroberare for odling av forankringsberoende celler
CA1206900A (en) * 1981-12-21 1986-07-02 Raymond L. Downs Hollow glass shell microcarrier for growth of cell cultures, and method of shell manufacture
AT385203B (de) * 1985-04-26 1988-03-10 Immuno Ag Verfahren zur herstellung einer fruehsommermeningoenzephalitis-virus (fsme-virus)-vakzine
DD274336A3 (de) * 1985-10-03 1989-12-20 Npo Biolar Verfahren zur Gewinnung einer Mikroträgersubstanz für die Zellkultivierung

Also Published As

Publication number Publication date
AT393356B (de) 1991-10-10
FI98377C (fi) 1997-06-10
CA2071954C (en) 1996-06-18
HRP921354A2 (en) 1996-02-29
NO922422D0 (no) 1992-06-19
HU213886B (en) 1997-11-28
CZ281804B6 (cs) 1997-02-12
CZ659090A3 (en) 1996-11-13
HUT65410A (en) 1994-06-28
NO922422L (no) 1992-08-17
NO310305B1 (no) 2001-06-18
DK0506714T3 (da) 1995-04-18
FI922851A (fi) 1992-06-18
ATE113652T1 (de) 1994-11-15
ATA292889A (de) 1991-03-15
YU242390A (sh) 1993-05-28
SK279236B6 (sk) 1998-08-05
FI98377B (fi) 1997-02-28
HU9202009D0 (en) 1992-10-28
CA2071954A1 (en) 1991-06-23
JP2633391B2 (ja) 1997-07-23
DE59007659D1 (de) 1994-12-08
RU2082757C1 (ru) 1997-06-27
WO1991009935A1 (de) 1991-07-11
EP0506714B1 (de) 1994-11-02
JPH05502581A (ja) 1993-05-13
EP0506714A1 (de) 1992-10-07
SK659090A3 (en) 1998-08-05
FI922851A0 (fi) 1992-06-18

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