ES2065273B1 - PROCEDURE FOR THE PURIFICATION OF CYCLOSPORINE A. - Google Patents
PROCEDURE FOR THE PURIFICATION OF CYCLOSPORINE A.Info
- Publication number
- ES2065273B1 ES2065273B1 ES9301128A ES9301128A ES2065273B1 ES 2065273 B1 ES2065273 B1 ES 2065273B1 ES 9301128 A ES9301128 A ES 9301128A ES 9301128 A ES9301128 A ES 9301128A ES 2065273 B1 ES2065273 B1 ES 2065273B1
- Authority
- ES
- Spain
- Prior art keywords
- cyclosporin
- result
- purification
- procedure
- chromatography
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title abstract 4
- 229930105110 Cyclosporin A Natural products 0.000 title abstract 4
- 108010036949 Cyclosporine Proteins 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 3
- 238000000746 purification Methods 0.000 title abstract 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 abstract 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 4
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 abstract 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 abstract 3
- 229960001265 ciclosporin Drugs 0.000 abstract 3
- 238000004587 chromatography analysis Methods 0.000 abstract 2
- 229930182912 cyclosporin Natural products 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 108010036941 Cyclosporins Proteins 0.000 abstract 1
- 238000004440 column chromatography Methods 0.000 abstract 1
- 238000002844 melting Methods 0.000 abstract 1
- 230000008018 melting Effects 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Landscapes
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
PROCEDIMIENTO PARA LA PURIFICACION DE CICLOSPORINA A DE MEZCLAS QUE CONTIENEN ESPECIALMENTE CICLOSPORINAS A, B, C Y OTROS COMPONENTES DE CICLOSPORINA MAS POLARES O MAS APOLARES QUE LA CICLOSPORINA A O CONTAMINACIONES SIMILARES A ELLOS, QUE COMPRENDE CALENTAR LA MEZCLA O UN RESIDUO DE EVAPORACION DE ELLA A UNA TEMPERATURA ENTRE 80GC Y 115GC ANTES DE LA CROMATOGRAFIA DE COLUMNA, FUNDIRLA Y SOMETER LA MASA FUNDIDA A CROMATOGRAFIA MEDIANTE METODOS CONOCIDOS PER SE. LA CROMATOGRAFIA SE LLEVA A CABO CON LA UTILIZACION SUCESIVA DE LAS SIGUIENTES MEZCLAS DE DISOLVENTES: CLOROFORMO : DICLOROMETANO : ETANOL = 48:50:2 Y CLOROFORMO : ACETATO DE ETILO : ETANOL = 48:50PROCEDURE FOR THE PURIFICATION OF CYCLOSPORIN A FROM MIXTURES CONTAINING ESPECIALLY CYCLOSPORINS A, B, C AND OTHER COMPONENTS OF CYCLOSPORIN MORE POLAR OR MORE APOLAR THAN THE CYCLOSPORIN A RESULTS TO RESULT IN A RESULT OF WARMING AND RESULTING IN A RESULT OF WARMING AND RESULTING IN HEALTH. TEMPERATURE BETWEEN 80GC AND 115GC BEFORE THE COLUMN CHROMATOGRAPHY, MELT IT AND SUBMIT THE MELTING MASS TO CHROMATOGRAPHY THROUGH KNOWN METHODS PER SE. CHROMATOGRAPHY IS CARRIED OUT WITH THE SUCCESSIVE USE OF THE FOLLOWING MIXTURES OF SOLVENTS: CHLOROFORM: DICHLOROMETHANE: ETHANOL = 48: 50: 2 AND CHLOROFORM: ETHYL ACETATE: ETHANOL = 48:50
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES9301128A ES2065273B1 (en) | 1993-05-25 | 1993-05-25 | PROCEDURE FOR THE PURIFICATION OF CYCLOSPORINE A. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES9301128A ES2065273B1 (en) | 1993-05-25 | 1993-05-25 | PROCEDURE FOR THE PURIFICATION OF CYCLOSPORINE A. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2065273A1 ES2065273A1 (en) | 1995-02-01 |
| ES2065273B1 true ES2065273B1 (en) | 1995-09-16 |
Family
ID=8281939
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES9301128A Expired - Fee Related ES2065273B1 (en) | 1993-05-25 | 1993-05-25 | PROCEDURE FOR THE PURIFICATION OF CYCLOSPORINE A. |
Country Status (1)
| Country | Link |
|---|---|
| ES (1) | ES2065273B1 (en) |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH614931A5 (en) * | 1975-11-04 | 1979-12-28 | Sandoz Ag | |
| SE448386B (en) * | 1978-10-18 | 1987-02-16 | Sandoz Ag | NEW CYCLOSPORIN DERIVATIVES, PROCEDURE FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITION CONTAINING THEM |
| DE69124459T3 (en) * | 1990-11-02 | 2001-05-31 | Novartis Ag, Basel | Cyclosporine |
-
1993
- 1993-05-25 ES ES9301128A patent/ES2065273B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ES2065273A1 (en) | 1995-02-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD2A | Announcement of lapse in spain |
Effective date: 20180806 |