ES2063313T3 - Nuevos acidos omega-fenilamino alcanoicos sustituidos en el nucleo aromatico por un radical derivado de 19-noresteroides, sus sales, su procedimiento de preparacion y los compuestos intermedios de este procedimiento, su aplicacion como medicamentos y composiciones que los contien - Google Patents
Nuevos acidos omega-fenilamino alcanoicos sustituidos en el nucleo aromatico por un radical derivado de 19-noresteroides, sus sales, su procedimiento de preparacion y los compuestos intermedios de este procedimiento, su aplicacion como medicamentos y composiciones que los contienInfo
- Publication number
- ES2063313T3 ES2063313T3 ES90402328T ES90402328T ES2063313T3 ES 2063313 T3 ES2063313 T3 ES 2063313T3 ES 90402328 T ES90402328 T ES 90402328T ES 90402328 T ES90402328 T ES 90402328T ES 2063313 T3 ES2063313 T3 ES 2063313T3
- Authority
- ES
- Spain
- Prior art keywords
- procedure
- salts
- denotes
- application
- noresteroids
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title abstract 4
- 150000003839 salts Chemical class 0.000 title abstract 3
- 229940079593 drug Drugs 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title abstract 2
- 239000002253 acid Substances 0.000 title 1
- 150000007513 acids Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical class [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 150000001340 alkali metals Chemical class 0.000 abstract 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 abstract 1
- 150000001342 alkaline earth metals Chemical class 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- -1 amine salt Chemical class 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 238000002483 medication Methods 0.000 abstract 1
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
- C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/42—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of mineralocorticosteroids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
LA INVENCION SE REFIERE A NUEVOS PRODUCTOS DE FORMULA (I), EN LA QUE R1 ES UN RADICAL HIDROCARBONADO ALIFATICO C1-C8; RA Y RB SON HIDROGENO O ALQUILO C1-C4; R2 ES HIDROGENO O ALQUILO C1-C12 EVENTUALMENTE SUSTITUIDO; N ES UNO DE LOS VALORES DE 1-6; Z ES UN GRUPO CARBOXI LIBRE O SALIFICADO EN FORMA DE SAL DE METAL ALCALINO O ALCALINOTERREO, AMONIO O AMINA; X ES EL RESTO DE UN CICLO PENTAGONAL O HEXAGONAL EVENTUALMENTE SUSTITUIDO Y EVENTUALMENTE PORTADOR DE UNA INSATURACION, Y EL TRAZO ONDULADO EN LA POSICION 13 SIGNIFICA QUE R1 SE PUEDE ENCONTRAR EN POSICION (ALFA) O (BETA), SUS SALES, PROCEDIMIENTO PARA SU OBTENCION Y SU APLICACION COMO MEDICAMENTOS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8911173A FR2651233B1 (fr) | 1989-08-23 | 1989-08-23 | Nouveaux acides omega-phenylamino alcanouiques substitues sur le noyau aromatique par un radical derive de 19-norsterouides, leur procede de preparation, leur application a titre de medicaments et les compositions les renfermant. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2063313T3 true ES2063313T3 (es) | 1995-01-01 |
Family
ID=9384880
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES90402328T Expired - Lifetime ES2063313T3 (es) | 1989-08-23 | 1990-08-22 | Nuevos acidos omega-fenilamino alcanoicos sustituidos en el nucleo aromatico por un radical derivado de 19-noresteroides, sus sales, su procedimiento de preparacion y los compuestos intermedios de este procedimiento, su aplicacion como medicamentos y composiciones que los contien |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US5166146A (es) |
| EP (1) | EP0414606B1 (es) |
| JP (1) | JP3026997B2 (es) |
| KR (1) | KR910004655A (es) |
| CN (1) | CN1033808C (es) |
| AT (1) | ATE113605T1 (es) |
| AU (1) | AU634569B2 (es) |
| CA (1) | CA2022648A1 (es) |
| DE (1) | DE69013815T2 (es) |
| DK (1) | DK0414606T3 (es) |
| ES (1) | ES2063313T3 (es) |
| FR (1) | FR2651233B1 (es) |
| HU (1) | HU208154B (es) |
| IE (1) | IE65922B1 (es) |
| IL (1) | IL95451A (es) |
| MX (1) | MX22020A (es) |
| PT (1) | PT95066B (es) |
| RU (1) | RU2041236C1 (es) |
| ZA (1) | ZA906341B (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5780220A (en) * | 1994-05-19 | 1998-07-14 | Trustees Of The University Of Pennsylvania | Methods and compositions for inhibiting HIV replication |
| US5639598A (en) * | 1994-05-19 | 1997-06-17 | The Trustees Of The University Of Pennsylvania | Method and kit for identification of antiviral agents capable of abrogating HIV Vpr-Rip-1 binding interactions |
| US6090798A (en) * | 1997-12-19 | 2000-07-18 | Alcon Laboratories, Inc. | Treatment of GLC1A glaucoma with glucocorticoid antagonists |
| EP2576582B1 (en) | 2010-05-26 | 2019-09-18 | Corcept Therapeutics, Inc. | Treatment of muscular dystrophy |
| EP3265127B1 (en) | 2015-03-02 | 2024-02-21 | Corcept Therapeutics, Inc. | Mifepristone and octreotide for use in the treatment of cushing's syndrome in a patient having an adrenocorticotropic hormone (acth)-secreting pancreatic neuroendocrine tumor |
| MX383353B (es) | 2015-03-30 | 2025-03-13 | Corcept Therapeutics Inc | Uso de antagonistas de receptores de glucocorticoides en combinacion con glucocorticoides para tratar la insuficiencia adrenal. |
| AU2016305092B2 (en) | 2015-08-13 | 2022-01-27 | Corcept Therapeutics, Inc. | Method for differentially diagnosing ACTH-dependent Cushing's syndrome |
| KR102197526B1 (ko) | 2016-01-19 | 2020-12-31 | 코어셉트 쎄라퓨틱스 인코포레이티드 | 이소성 쿠싱 증후군의 감별 진단 |
| US20180148471A1 (en) | 2016-11-30 | 2018-05-31 | Arno Therapeutics, Inc. | Methods for onapristone synthesis dehydration and deprotection |
| UA127409C2 (uk) | 2017-03-31 | 2023-08-16 | Корцепт Терап'Ютікс, Інк. | Модулятори глюкокортикоїдного рецептора для лікування раку шийки матки |
| JP2020524152A (ja) | 2017-06-20 | 2020-08-13 | コーセプト セラピューティクス， インコーポレイテッド | 選択的グルココルチコイドレセプターモジュレーターを使用して神経上皮腫瘍を処置する方法 |
| EP4263807A2 (en) | 2020-12-18 | 2023-10-25 | Instil Bio (Uk) Limited | Processing of tumor infiltrating lymphocytes |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2566779B2 (fr) * | 1984-06-29 | 1987-03-06 | Roussel Uclaf | Nouveaux derives steroides substitues en 11b, leur procede de preparation et leur application comme medicaments |
| FR2596395B1 (fr) * | 1986-03-26 | 1989-05-26 | Roussel Uclaf | Nouveaux steroides comportant un cycle spirannique en position 17, leur procede de preparation, leur application comme medicaments et les compositions les renfermant |
| DE3619413C2 (de) * | 1986-06-10 | 2000-04-06 | Schering Ag | 9alpha, 10alpha-Methylen-Estrene, deren Herstellung und diese enthaltende pharmazeutische Präparate |
| FR2620707B1 (fr) * | 1987-09-18 | 1989-12-08 | Roussel Uclaf | Nouveaux steroides comportant un cycle spirannique a 3, 4 ou 6 chainons en position 17, leur procede et des intermediaires de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant |
-
1989
- 1989-08-23 FR FR8911173A patent/FR2651233B1/fr not_active Expired - Fee Related
-
1990
- 1990-08-03 CA CA002022648A patent/CA2022648A1/fr not_active Abandoned
- 1990-08-10 ZA ZA906341A patent/ZA906341B/xx unknown
- 1990-08-16 US US07/568,597 patent/US5166146A/en not_active Expired - Lifetime
- 1990-08-20 MX MX2202090A patent/MX22020A/es unknown
- 1990-08-20 JP JP02217281A patent/JP3026997B2/ja not_active Expired - Lifetime
- 1990-08-21 IL IL9545190A patent/IL95451A/en not_active IP Right Cessation
- 1990-08-22 KR KR1019900012958A patent/KR910004655A/ko active IP Right Grant
- 1990-08-22 ES ES90402328T patent/ES2063313T3/es not_active Expired - Lifetime
- 1990-08-22 EP EP90402328A patent/EP0414606B1/fr not_active Expired - Lifetime
- 1990-08-22 DK DK90402328.0T patent/DK0414606T3/da active
- 1990-08-22 IE IE303190A patent/IE65922B1/en not_active IP Right Cessation
- 1990-08-22 HU HU905275A patent/HU208154B/hu not_active IP Right Cessation
- 1990-08-22 DE DE69013815T patent/DE69013815T2/de not_active Expired - Lifetime
- 1990-08-22 PT PT95066A patent/PT95066B/pt not_active IP Right Cessation
- 1990-08-22 AT AT90402328T patent/ATE113605T1/de not_active IP Right Cessation
- 1990-08-22 AU AU61189/90A patent/AU634569B2/en not_active Ceased
- 1990-08-23 CN CN90107161A patent/CN1033808C/zh not_active Expired - Fee Related
-
1992
- 1992-05-18 RU SU925011511A patent/RU2041236C1/ru active
Also Published As
| Publication number | Publication date |
|---|---|
| AU6118990A (en) | 1991-02-28 |
| IL95451A (en) | 1995-07-31 |
| DE69013815T2 (de) | 1995-03-16 |
| IE65922B1 (en) | 1995-11-29 |
| CA2022648A1 (fr) | 1991-02-24 |
| JPH0390097A (ja) | 1991-04-16 |
| IL95451A0 (en) | 1991-06-30 |
| AU634569B2 (en) | 1993-02-25 |
| DE69013815D1 (de) | 1994-12-08 |
| EP0414606A2 (fr) | 1991-02-27 |
| CN1051362A (zh) | 1991-05-15 |
| ATE113605T1 (de) | 1994-11-15 |
| JP3026997B2 (ja) | 2000-03-27 |
| US5166146A (en) | 1992-11-24 |
| CN1033808C (zh) | 1997-01-15 |
| PT95066B (pt) | 1997-05-28 |
| HUT54706A (en) | 1991-03-28 |
| IE903031A1 (en) | 1991-02-27 |
| KR910004655A (ko) | 1991-03-29 |
| FR2651233A1 (fr) | 1991-03-01 |
| MX22020A (es) | 1993-11-01 |
| HU208154B (en) | 1993-08-30 |
| RU2041236C1 (ru) | 1995-08-09 |
| FR2651233B1 (fr) | 1991-12-13 |
| EP0414606A3 (en) | 1991-07-24 |
| HU905275D0 (en) | 1991-02-28 |
| EP0414606B1 (fr) | 1994-11-02 |
| ZA906341B (en) | 1991-10-30 |
| DK0414606T3 (da) | 1995-02-27 |
| PT95066A (pt) | 1991-04-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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