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ES2060188T3 - Amino-alquenil-fenil-alcanosulfonamidas terciarias antiarritmicas. - Google Patents

Amino-alquenil-fenil-alcanosulfonamidas terciarias antiarritmicas.

Info

Publication number
ES2060188T3
ES2060188T3 ES90911059T ES90911059T ES2060188T3 ES 2060188 T3 ES2060188 T3 ES 2060188T3 ES 90911059 T ES90911059 T ES 90911059T ES 90911059 T ES90911059 T ES 90911059T ES 2060188 T3 ES2060188 T3 ES 2060188T3
Authority
ES
Spain
Prior art keywords
alkyl
hydroxy
hydrogen
substituted
alkenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90911059T
Other languages
English (en)
Inventor
Jackson Boling Hester Jr
Salvatore Charles Perricone
John Kenneth Gibson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Application granted granted Critical
Publication of ES2060188T3 publication Critical patent/ES2060188T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

COMPUESTOS QUE TIENEN LA FORMULA (I) Y LAS SALES FARMACOLOGICAMENTE ACEPTABLES DE LOS MISMOS EN DONDE: N ES DE 1 A 3, R ES UN ALQUILO, R SUB 1 ES HIDROGENO O ALQUILO, R SUB 2 ES ALQUILO, R SUB 3 ES UN ALQUILO; B) ALQUILO SUSTITUIDO POR UN ARILO, HETEROARILO O CICLOALQUILO; C) ALQUILO SUSTITUIDO POR UNO A OCHO ATOMOS DE FLUOR; D) CICLOALQUILO; E) ALQUENILO; F) ALQUILO SUSTITUIDO POR UNO A TRES SUSTITUYENTES HIDROXI, ACILOXI O ALCOXI Y DONDE LA SUMA DE CARBONOS DE R SUB 2 Y R SUB 3 ES MAYOR DE CINCO O DONDE R SUB 2 Y R SUB 3 JUNTO CON EL ATOMO DE NITROGENO FORMAN UN GRUPO HETEROCICLICO SATURADO QUE TIENE UN NITROGENO Y FORMA DE 4 A 8 ATOMOS DE CARBONO O UN GRUPO DE PIPERAZINA SUSTITUIDO EN LA POSICION 4 EN QUE EL SUSTITUYENTE DE LA POSICION 4 PUEDE SER ALQUILO, ARILO, BENZILO O HETEROARILO Y X ES HIDROGENO, HIDROXI, ALCOXI, ALQUILO, TRIFLUORURO DE CARBONO O UN HALOGENO O COMPUESTOS QUE TIENEN LA FORMULA (I'') Y LAS SALES FARMACOLOGICAMENTE ACEPTABLES DE LOS MISMOS EN DONDE: N ES DE 1 A 3, R ESUN ALQUILO, R SUB 1 ES HIDROGENO O ALQUILO, R SUB 2 ES UN ALQUILO, R SUB 3 ES UN ALQUILO SUSTITUIDO POR UN ARILO, HETEROARILO O CICLOALQUILO O UN ALQUILO SUSTITUIDO POR DE UNO A OCHO ATOMOS DE FLUOR, UNA A TRES SUSTITUYENTES HIDROXI, ACILOXI O ALCOXI Y DONDE LA SUMA DE CARBONOS DE R SUB 2 Y R SUB 3 ES MAYOR DE CINCO; X ES HIDROGENO, HIDROXI, ALCOXI, ALQUILO, TRIFLUORURO DE CARBONO O UN HALOGENO, UTILES COMO LA CLASE DE AGENTES ANTIARRITMICOS III.
ES90911059T 1989-07-25 1990-07-19 Amino-alquenil-fenil-alcanosulfonamidas terciarias antiarritmicas. Expired - Lifetime ES2060188T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US38533589A 1989-07-25 1989-07-25

Publications (1)

Publication Number Publication Date
ES2060188T3 true ES2060188T3 (es) 1994-11-16

Family

ID=23520988

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90911059T Expired - Lifetime ES2060188T3 (es) 1989-07-25 1990-07-19 Amino-alquenil-fenil-alcanosulfonamidas terciarias antiarritmicas.

Country Status (11)

Country Link
EP (1) EP0484378B1 (es)
JP (1) JP3065659B2 (es)
KR (1) KR100190256B1 (es)
AT (1) ATE111447T1 (es)
AU (1) AU641676B2 (es)
CA (1) CA2060326C (es)
DE (1) DE69012570T2 (es)
DK (1) DK0484378T3 (es)
ES (1) ES2060188T3 (es)
HK (1) HK1000507A1 (es)
WO (1) WO1991001299A1 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2691064B3 (fr) * 1992-05-14 1996-01-12 Beecham Laboratoires Nouveau medicament pour le traitement de l'arythmie.
US5753659A (en) * 1993-03-29 1998-05-19 Zeneca Limited Heterocyclic compouds
US5750754A (en) * 1993-03-29 1998-05-12 Zeneca Limited Heterocyclic compounds
DK0825184T3 (da) * 1993-03-29 2001-09-10 Astrazeneca Ab Heterocykliske derivater som blodpladeaggregeringsinhibitorer
ZW4194A1 (en) * 1993-03-29 1994-12-21 Zeneca Ltd Heterocyclic compounds
US5652242A (en) * 1993-03-29 1997-07-29 Zeneca Limited Heterocyclic derivatives
JPH09510985A (ja) * 1994-03-31 1997-11-04 スミスクライン・ビーチャム・ラボラトワール・ファルマソーティク 第ｉｉｉ群抗不整脈薬および第ｉｖ群抗不整脈薬を含有する医薬組成物
JPH10505829A (ja) * 1994-09-12 1998-06-09 ファルマシア・アンド・アップジョン・カンパニー 抗不整脈活性を有する４−（４−メタンスルホンアミドフェニル）ブチルアミン誘導体
US5874475A (en) * 1995-12-21 1999-02-23 Pharmacia & Upjohn Company Antiarrhythmic (S)-enantiomers of methanesulfonamides
JP3846899B2 (ja) * 1995-01-10 2006-11-15 ファルマシア・アンド・アップジョン・カンパニー メタンスルホンアミドの抗不整脈（ｓ）−エナンチオマー
US6468098B1 (en) 1999-08-17 2002-10-22 Formfactor, Inc. Electrical contactor especially wafer level contactor using fluid pressure
US7262611B2 (en) 2000-03-17 2007-08-28 Formfactor, Inc. Apparatuses and methods for planarizing a semiconductor contactor
AU8964201A (en) * 2000-07-18 2002-01-30 Hoffmann La Roche Novel aniline derivatives
US7396236B2 (en) 2001-03-16 2008-07-08 Formfactor, Inc. Wafer level interposer

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3758692A (en) * 1969-04-14 1973-09-11 Mead Johnson & Co Ylamines sympathomimetic process and compositions employing sulfonamidophenalk
US3785692A (en) * 1972-03-20 1974-01-15 Marvel Industries Drum lifting attachment
DE3566886D1 (en) * 1984-05-04 1989-01-26 Upjohn Co N-(aminoalkylphenyl)sulfonamides their preparation and therapeutic use
PH25458A (en) * 1987-08-24 1991-07-01 Eisai Co Ltd Piperidine derivatives, therapeutic, preventive agents
DE69600110T2 (de) * 1996-04-22 1998-06-04 Steelcase Strafor Sa Verbesserungen an Verstell- und Bedienungsvorrichtungen von bewegenden und verformbaren Teilen eines Bürostuhls

Also Published As

Publication number Publication date
AU641676B2 (en) 1993-09-30
CA2060326A1 (en) 1991-01-26
EP0484378A1 (en) 1992-05-13
JP3065659B2 (ja) 2000-07-17
KR100190256B1 (en) 1999-06-01
ATE111447T1 (de) 1994-09-15
JPH04506959A (ja) 1992-12-03
CA2060326C (en) 2003-10-21
DK0484378T3 (da) 1995-02-20
WO1991001299A1 (en) 1991-02-07
HK1000507A1 (en) 1998-04-03
DE69012570D1 (de) 1994-10-20
AU6055490A (en) 1991-02-22
DE69012570T2 (de) 1995-02-23
EP0484378B1 (en) 1994-09-14

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