[go: up one dir, main page]

ES2060180T3 - Procedimiento de separacion del acido treo-3-((2-aminofenilo)-tio)-2-hidroxi-3-(4-metoxifenilo) propionico. - Google Patents

Procedimiento de separacion del acido treo-3-((2-aminofenilo)-tio)-2-hidroxi-3-(4-metoxifenilo) propionico.

Info

Publication number
ES2060180T3
ES2060180T3 ES90909482T ES90909482T ES2060180T3 ES 2060180 T3 ES2060180 T3 ES 2060180T3 ES 90909482 T ES90909482 T ES 90909482T ES 90909482 T ES90909482 T ES 90909482T ES 2060180 T3 ES2060180 T3 ES 2060180T3
Authority
ES
Spain
Prior art keywords
acid
threo
propionico
metoxifenilo
aminofenilo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90909482T
Other languages
English (en)
Inventor
Elemer Fogassy
Maria Acs
Tibor Gizur
Kalman Harsanyi
Tischler Zsuzsanna Aracsne
Katalin Berki
Laszlo Toke
Jaszay Zsuzsa Martonffyne
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Richter Gedeon Vegyeszeti Gyar Nyrt
Original Assignee
Richter Gedeon Vegyeszeti Gyar RT
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from HU333589A external-priority patent/HU205896B/hu
Priority claimed from HU333689A external-priority patent/HU204774B/hu
Application filed by Richter Gedeon Vegyeszeti Gyar RT filed Critical Richter Gedeon Vegyeszeti Gyar RT
Application granted granted Critical
Publication of ES2060180T3 publication Critical patent/ES2060180T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/26—Separation; Purification; Stabilisation; Use of additives
    • C07C319/28—Separation; Purification

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

LA INVENCION SE REFIERE A UN NUEVO PROCESO PARA LA RESOLUCION DE UN ACIDO MEZCLA (EN ADELANTE: TRIACIDO MEZCLA) QUE CONTIENE ACIDO (+) -TRIO-3-[(2-AMINOFENIL) TIO] -2-HIDROXI-3-(4-METOXIFENIL) PROPIONICO [EN ADELANTE: ACIDO (+) -TRIO] Y ACIDO (-) -TRIO-3-[(2-AMINOFENIL) TIO] -2-HIDROXI-3(4-METOXIFENIL) PROPIONICO [EN ADELANTE: ACIDO (-) -TRIO]. EL PROCESO PARA LA INVENCION COMPRENDE A) I) PREPARANDO UNA SOLUCION QUE CONTENGA (-) -FENILGLICINAMIDA [EN ADELANTE: (-) -PGA] PARTIENDO DE UNA MEZCLA QUE CONTIENE L-(+) -FENILGLICINAMIDA [EN ADELANTE: (+) -PGA] Y (-) -PGA Y MEDIANTE EL ACIDO (-) -TRIO COMO AGENTE DE RESOLUCION Y UTILIZANDO LA SOLUCION OBTENIDA COMO AGENTE DE RESOLUCION PARA LA RESOLUCION DE LA MEZCLA DEL ACIDO (-) -TRIO; O II) UTILIZANDO UNA SAL CON ADICION DE ACIDO DE (-) -PGA EN UN SOLIDO O EN UNA FORMA DISUELTA COMO AGENTE DE RESOLUCION PARA OBTENER ACIDO (-) TRIO; B) I) PREPARANDO UNA SOLUCION QUE CONTENGA (+) -FENILGLICINAMIDA [EN ADELANTE:(+) -PGA] DE UNA MEZCLA DE QUE CONTENGA (+) -PGA Y (-) -FENILGLICINAMIDA [EN ADELANTE: (-) -PGA ] MEDIANTE EL ACIDO (+) -TRIO COMO AGENTE DE RESOLUCION Y UTILIZANDO LA SOLUCION OBTENIDA COMO AGENTE DE RESOLUCION DE LA MEZCLA DEL ACIDO TRIO; O II) UTILIZANDO UNA SAL CON ADICION DE ACIDO DE (+) -PGA EN UN SOLIDO O FORMA DISUELTA COMO AGENTE DE RESOLUCION PARA OBTENER ACIDO (+) -TRIO.
ES90909482T 1989-06-30 1990-06-29 Procedimiento de separacion del acido treo-3-((2-aminofenilo)-tio)-2-hidroxi-3-(4-metoxifenilo) propionico. Expired - Lifetime ES2060180T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU333589A HU205896B (en) 1989-06-30 1989-06-30 Process for resolving treo-3-//2-amino-phenyl/-thio/-2-hydroxy-3-/4-methoxy-phenyl/-propionic acid
HU333689A HU204774B (en) 1989-06-30 1989-06-30 Process for resolving alpha-phenylglycineamide

Publications (1)

Publication Number Publication Date
ES2060180T3 true ES2060180T3 (es) 1994-11-16

Family

ID=26317626

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90909482T Expired - Lifetime ES2060180T3 (es) 1989-06-30 1990-06-29 Procedimiento de separacion del acido treo-3-((2-aminofenilo)-tio)-2-hidroxi-3-(4-metoxifenilo) propionico.

Country Status (10)

Country Link
US (1) US5292933A (es)
EP (1) EP0431121B1 (es)
JP (1) JPH04500528A (es)
AT (1) ATE93516T1 (es)
DE (1) DE69002924T2 (es)
DK (1) DK0431121T3 (es)
ES (1) ES2060180T3 (es)
IE (1) IE62410B1 (es)
IL (1) IL94914A (es)
WO (1) WO1991000270A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1240651B (it) * 1990-05-17 1993-12-17 Zambon Spa Processo per la risoluzione di derivati glicidici
JP2022526893A (ja) * 2019-03-22 2022-05-27 タイム，インコーポレーテッド Ｄ－メチロシン組成物およびそれを調製するための方法
EP3968785A4 (en) 2019-05-14 2023-01-11 Tyme, Inc. COMPOSITIONS AND METHODS FOR TREATMENT OF CANCER
US10905698B1 (en) 2020-05-14 2021-02-02 Tyme, Inc. Methods of treating SARS-COV-2 infections
WO2022006366A1 (en) * 2020-07-01 2022-01-06 Tyme, Inc. Crystalline forms of metyrosine

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7413843A (nl) * 1974-10-23 1976-04-27 Stamicarbon Optische scheiding van fenylglycine-amide.
SE449611B (sv) * 1982-07-09 1987-05-11 Tanabe Seiyaku Co Sett att framstella 1,5-bensotiazepinderivat
IT1152721B (it) * 1982-10-15 1987-01-07 Luso Farmaco Inst Risoluzione ottica dell'acido dl-alfa-2-idrossi-3-(4-metossifenil)-3-(2-amminofeniltio)propionico
EP0320532A1 (en) * 1986-07-15 1989-06-21 Nihon Iyakuhin Kogyo Co., Ltd. Novel optically active carboxylic acid derivative l-lysine salt and process for production thereof
IT1217988B (it) * 1988-01-28 1990-03-30 Ind Chimica Profarmaco Spa Procedimento per la risoluzione ottica di un pacemo
FR2630107B1 (fr) * 1988-04-19 1990-06-08 Synthelabo Procede de preparation du (+) - (2s,3s) (amino-2 phenyl)thio)-3 hydroxy-2 (methoxy-4 phenyl)-3 propionate de methyle
US5008433A (en) * 1988-05-18 1991-04-16 Marion Laboratories, Inc. 2-hydroxy-3-(4-methoxyphenyl)-3-(2-aminophenylthio)propionic acid, 8'-phenylmenthyl ester, especially for diltiazem
FR2637285B1 (fr) * 1988-10-03 1991-04-12 Synthelabo Procede de preparation de derives de l'acide propionique et produits obtenus

Also Published As

Publication number Publication date
EP0431121A1 (en) 1991-06-12
JPH04500528A (ja) 1992-01-30
IE902360L (en) 1990-12-30
IE902360A1 (en) 1991-06-19
EP0431121B1 (en) 1993-08-25
ATE93516T1 (de) 1993-09-15
DK0431121T3 (da) 1993-10-11
DE69002924T2 (de) 1993-12-23
US5292933A (en) 1994-03-08
WO1991000270A1 (en) 1991-01-10
IL94914A0 (en) 1991-04-15
IE62410B1 (en) 1995-01-25
DE69002924D1 (en) 1993-09-30
IL94914A (en) 1994-07-31

Similar Documents

Publication Publication Date Title
DE59407237D1 (de) Nitrato-aminosäure-disulfide zur therapie von erkrankungen des herz-kreislauf-systems
ES2000216A6 (es) Procedimiento para preparar un polipeptido purificado que tiene propiedades inhibidoras de la coagulacion de la sangre.
ES2036192T3 (es) Derivados del acido (met)-acrilico, que contienen grupos uretano, de triciclo (5.2.1.0.2.6) decano.
DK354084A (da) Fremgangsmaade til fremstilling af et aromatiseringsmiddel
DE3667059D1 (en) Benzodipyrroles, processes for their preparation and pharmaceutical compositions containing these compounds
DE3477927D1 (en) Substituted 5,11-dihydro-6h-dibenzûb,e¨azepin-6-ones, method for their preparation and these compounds containing medicines
ES2060180T3 (es) Procedimiento de separacion del acido treo-3-((2-aminofenilo)-tio)-2-hidroxi-3-(4-metoxifenilo) propionico.
ES534798A0 (es) Procedimiento para la preparacion de derivados de insulina
ZA855124B (en) Phenol-naphthyridines,process for preparing them,drugs containing them,particularly anti-ulcer drugs
ES2045215T3 (es) (+)-o (+)-1-(2-n-aminoetil sustituido) -1-metil-7-metoxi-1,2,3,4-tetrahidronaftaleno, y procedimiento para su produccion.
DE3378413D1 (en) Spiro-2-aza-alkane-3-carbonitriles, process for their preparation and their use
IL65597A (en) Preparation of 1alpha,24,25-trihydroxy-and 24,25-dihydroxy-cholesterol and certain novel intermediates used therein
SE8404006L (sv) Aspartam-syntes
ES537558A0 (es) Un procedimiento para la preparacion del isomero r (dextrogiro)
CA1268468C (en) PROSTAGLANDIN ANALOGS WITH SUBSTITUTE THIABICYCLOHEPTAN GROUP
ZA951013B (en) Novel indane-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase
GR3018765T3 (en) Process for the preparation of N-(2-hydroxyethyl)-2-hydroxymethyl-3,4,5-trihydroxy-piperidine and of intermediates.
DE3463143D1 (en) 1-0-alkyl-3-amino-propan-1.2-diol-2-0-phospholipids, process for producing the same and pharmaceutical preparations containing the same
ATE104313T1 (de) Neue 9-g(a)-hydroxy-3-oxo-4,24(25)-stigmastadien26-s|urederivate,verfahren zur herstellung und heilmittel daraus.
ES2006784A6 (es) Procedimiento para preparar derivados de acidos hidroximicos de eteres y tioteres de prostaglandinas
IT1240869B (it) Processo per la produzione di perossido di idrogeno (i)
MY106583A (en) Process for making 3-aroyl-2-oxindole-1-carboxamides.
GR82161B (es)
IT1123138B (it) Processo per la preparazione di 2,2'-bis(fenol 4-sostituito)solfuri
DE69405507D1 (de) Zwischenprodukte zur Herstellung von Vitamin A und von Carotenoiden und Verfahren zu deren Herstellung

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 431121

Country of ref document: ES