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ES2058023A1 - Derivatives of 4-hydroxybutyric acid - Google Patents

Derivatives of 4-hydroxybutyric acid

Info

Publication number
ES2058023A1
ES2058023A1 ES09202177A ES9202177A ES2058023A1 ES 2058023 A1 ES2058023 A1 ES 2058023A1 ES 09202177 A ES09202177 A ES 09202177A ES 9202177 A ES9202177 A ES 9202177A ES 2058023 A1 ES2058023 A1 ES 2058023A1
Authority
ES
Spain
Prior art keywords
hydroxybutyric acid
ch2oh
treatment
derivatives
carbons
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES09202177A
Other languages
Spanish (es)
Other versions
ES2058023B1 (en
Inventor
Gernot Kohler
Anita Kohler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dr Franz Koehler Chemie GmbH
Original Assignee
Dr Franz Koehler Chemie GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Franz Koehler Chemie GmbH filed Critical Dr Franz Koehler Chemie GmbH
Priority to ES9202177A priority Critical patent/ES2058023B1/en
Publication of ES2058023A1 publication Critical patent/ES2058023A1/en
Application granted granted Critical
Publication of ES2058023B1 publication Critical patent/ES2058023B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Derivatives of 4-hydroxybutyric acid, of formulas I and II, in which R1, R2 and R3 denote the radicals H-, CH3-, C2H5-, CH2OH-CH2- or CH2OH-CHOH-CH2-, or with the nitrogen form a heterocycloalkane with 4 or 5 carbons, R4 being an alcohol or polyalcohol with 1-5 carbons and 1-5 oxygens, linear or branched, or in the form of a ring, and R1 and R4 can be condensed with each other to form a cyclic ether, and R5 and R6 independently are H- or CH2OH- . The salts or amides of gamma-hydroxybutyric acid are obtained by reaction of gamma-butyrolactone with an aminoalcohol or a derivative of morpholine, adjusting the pH to 7.5 These compounds are used in parenteral or oral preparations for narcosis in anaesthesia, for sleep induction or sedation, for alcoholic disintoxication treatment, for treatment of cataplexy or narcolepsy, and for treatment of sleep disorders.
ES9202177A 1992-10-29 1992-10-29 DERIVATIVES OF THE ACID 4-HIDROXI-BUTIRICO. Expired - Fee Related ES2058023B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES9202177A ES2058023B1 (en) 1992-10-29 1992-10-29 DERIVATIVES OF THE ACID 4-HIDROXI-BUTIRICO.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9202177A ES2058023B1 (en) 1992-10-29 1992-10-29 DERIVATIVES OF THE ACID 4-HIDROXI-BUTIRICO.

Publications (2)

Publication Number Publication Date
ES2058023A1 true ES2058023A1 (en) 1994-10-16
ES2058023B1 ES2058023B1 (en) 1995-10-01

Family

ID=8278609

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9202177A Expired - Fee Related ES2058023B1 (en) 1992-10-29 1992-10-29 DERIVATIVES OF THE ACID 4-HIDROXI-BUTIRICO.

Country Status (1)

Country Link
ES (1) ES2058023B1 (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4143159A (en) * 1976-07-12 1979-03-06 Henkel Kommanditgesellschaft Auf Aktien Skin-care agents containing hydroxyalkyl carboxamides and process
ES8306360A1 (en) * 1980-07-17 1983-06-01 Klosa Josef Non hygroscopic salts of 4-hydroxy-butanoic acid, process for their preparation and their use for the manufacture of pharmaceutic agents.
EP0398272A1 (en) * 1989-05-19 1990-11-22 Kao Corporation Amide derivatives and dermatologic preparations containing the same
WO1992019581A1 (en) * 1991-04-29 1992-11-12 Dr. Franz Köhler Chemie GmbH 4-hydroxy butyric acid derivatives

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4143159A (en) * 1976-07-12 1979-03-06 Henkel Kommanditgesellschaft Auf Aktien Skin-care agents containing hydroxyalkyl carboxamides and process
ES8306360A1 (en) * 1980-07-17 1983-06-01 Klosa Josef Non hygroscopic salts of 4-hydroxy-butanoic acid, process for their preparation and their use for the manufacture of pharmaceutic agents.
EP0398272A1 (en) * 1989-05-19 1990-11-22 Kao Corporation Amide derivatives and dermatologic preparations containing the same
WO1992019581A1 (en) * 1991-04-29 1992-11-12 Dr. Franz Köhler Chemie GmbH 4-hydroxy butyric acid derivatives

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
S. BUDAVARI et al.: "The Merck Index, an encyclopedia of Chemicals, Drugs and Biologicals", 11 edición, 1989, Merck & Co., Inc., Rahway, NJ, US, pág. 1365, parágrafo 8603 *

Also Published As

Publication number Publication date
ES2058023B1 (en) 1995-10-01

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Legal Events

Date Code Title Description
FD2A Announcement of lapse in spain

Effective date: 20180806