ES2053578T3 - Pirrolidinonas substituidas. - Google Patents
Pirrolidinonas substituidas.Info
- Publication number
- ES2053578T3 ES2053578T3 ES87810045T ES87810045T ES2053578T3 ES 2053578 T3 ES2053578 T3 ES 2053578T3 ES 87810045 T ES87810045 T ES 87810045T ES 87810045 T ES87810045 T ES 87810045T ES 2053578 T3 ES2053578 T3 ES 2053578T3
- Authority
- ES
- Spain
- Prior art keywords
- radical
- formula
- image
- phenyl
- represents hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000004040 pyrrolidinones Chemical class 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000001118 alkylidene group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 150000002431 hydrogen Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 230000001777 nootropic effect Effects 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- IYABWNGZIDDRAK-UHFFFAOYSA-N allene Chemical group C=C=C IYABWNGZIDDRAK-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- CCGKOQOJPYTBIH-UHFFFAOYSA-N ethenone Chemical group C=C=O CCGKOQOJPYTBIH-UHFFFAOYSA-N 0.000 abstract 1
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical class O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Steroid Compounds (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
PIRROLIDIN-2-ONAS SUSTITUIDAS DE LA FORMULA (I) EN LA QUE R1 SIGNIFICA UN RESTO FENILO O NAFTILO NO SUSTITUIDO O SUSTITUIDO POR UN ALQUILO INFERIOR, UN ALCOXI INFERIOR, HALOGENO Y/O TRIFLUOROMETILO; X1 ES UN ALQUILIDENO INFERIOR, X2 ES METILENO, ETILENO U OXOETILENO Y R2 ES HIDROGENO, ALQUILO IINFERIOR O UN RESTO DE LA FORMULA (IA), EN LA QUE X4 ES ALQUILIDENO INFERIOR Y R3 ES HIDROGENO O UN RESTO FENILO O NAFTILO NO SUSTITUIDO O SUSTITUIDO POR ALQUILO INFERIOR, ALCOXI INFERIOR, HALOGENO U/O TRIFLUOROMETILO, Y SUS SALES TIENEN APLICACION FARMACEUTICA CON PROPIEDADES NOOTROPICAS Y PUEDEN SER UTILES COMO FARMACOS NOOTROPICOS. SON OBTENIDOS COMPUESTOS DE LAS FORMULAS (II) Y (III) EN LA QUE Z1 ES UN GRUPO DE LA FORMULA -X1-C(=O)-Z3 (IIA) Y Z2 ES HIDROGENO O Z1 ES HIDROGENO Y Z2 UN GRUPO DE LA FORMULA -C(=O)-X1-Z4 (IIIA) DONDE Z3 Y Z4 SON RESTOS SEPARABLES Y R12 ES UN RESTO R2 O UN GRUPO PROTECTOR AMINO, O CUYAS SALES CONDENSAN JUNTAS Y SE DESDOBLA UN GRUPO PROTECTOR AMINO R12 PRESENTE.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH34686 | 1986-01-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2053578T3 true ES2053578T3 (es) | 1994-08-01 |
Family
ID=4184917
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES87810045T Expired - Lifetime ES2053578T3 (es) | 1986-01-30 | 1987-01-26 | Pirrolidinonas substituidas. |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US4945092A (es) |
| EP (1) | EP0236263B1 (es) |
| JP (1) | JPS62185068A (es) |
| KR (1) | KR870007159A (es) |
| AT (1) | ATE84033T1 (es) |
| AU (1) | AU599951B2 (es) |
| CA (1) | CA1312081C (es) |
| DD (1) | DD260066A5 (es) |
| DE (1) | DE3783247D1 (es) |
| DK (1) | DK47187A (es) |
| ES (1) | ES2053578T3 (es) |
| FI (1) | FI870329A (es) |
| GR (1) | GR3007411T3 (es) |
| HU (1) | HU202862B (es) |
| IE (1) | IE61100B1 (es) |
| IL (1) | IL81394A (es) |
| NO (1) | NO870374L (es) |
| NZ (1) | NZ219101A (es) |
| PH (1) | PH23078A (es) |
| PT (1) | PT84204B (es) |
| ZA (1) | ZA87650B (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI95572C (fi) * | 1987-06-22 | 1996-02-26 | Eisai Co Ltd | Menetelmä lääkeaineena käyttökelpoisen piperidiinijohdannaisten tai sen farmaseuttisen suolan valmistamiseksi |
| US20040180925A1 (en) * | 2000-12-27 | 2004-09-16 | Kenji Matsuno | Dipeptidylpeptidase-IV inhibitor |
| EP4101561A1 (de) | 2021-06-08 | 2022-12-14 | Meusburger Georg GmbH & Co. KG | Zentriereinrichtung für ein formwerkzeug mit gleichzeitig tragenden wälzkörpereinheiten |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1039113A (en) * | 1964-08-06 | 1966-08-17 | Ucb Sa | New n-substituted lactams |
| US4144246A (en) * | 1976-11-15 | 1979-03-13 | Parke, Davis & Company | Pyrrolidineacetic acid esters |
| BE864269A (fr) * | 1977-03-03 | 1978-06-16 | Parke Davis & Co | Nouveaux n-(aminoalkyl substitue)-2-oxo-1-pyrrolidine-acetamides et procedes pour les produire |
| DE2757680A1 (de) * | 1977-12-23 | 1979-06-28 | Troponwerke Gmbh & Co Kg | Neue 2-oxo-1-pyrrolidinessigsaeurederivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| EP0089900B1 (en) * | 1982-03-24 | 1985-12-27 | Prodes S.A. | New n-((2-oxo-1-pyrrolidinyl)acetyl)piperazines, the methods of producing such new compounds and their salts as well as pharmaceutical preparations for therapeutic use containing these compounds or salts |
-
1987
- 1987-01-21 PH PH34749A patent/PH23078A/en unknown
- 1987-01-26 DE DE8787810045T patent/DE3783247D1/de not_active Expired - Fee Related
- 1987-01-26 FI FI870329A patent/FI870329A/fi not_active IP Right Cessation
- 1987-01-26 ES ES87810045T patent/ES2053578T3/es not_active Expired - Lifetime
- 1987-01-26 AT AT87810045T patent/ATE84033T1/de not_active IP Right Cessation
- 1987-01-26 EP EP87810045A patent/EP0236263B1/de not_active Expired - Lifetime
- 1987-01-27 IL IL81394A patent/IL81394A/xx not_active IP Right Cessation
- 1987-01-28 DD DD87299511A patent/DD260066A5/de unknown
- 1987-01-28 PT PT84204A patent/PT84204B/pt not_active IP Right Cessation
- 1987-01-28 CA CA000528330A patent/CA1312081C/en not_active Expired - Lifetime
- 1987-01-29 NZ NZ219101A patent/NZ219101A/xx unknown
- 1987-01-29 DK DK047187A patent/DK47187A/da not_active Application Discontinuation
- 1987-01-29 ZA ZA87650A patent/ZA87650B/xx unknown
- 1987-01-29 AU AU68097/87A patent/AU599951B2/en not_active Ceased
- 1987-01-29 NO NO870374A patent/NO870374L/no unknown
- 1987-01-29 HU HU87277A patent/HU202862B/hu not_active IP Right Cessation
- 1987-01-29 IE IE23087A patent/IE61100B1/en not_active IP Right Cessation
- 1987-01-30 KR KR870000728A patent/KR870007159A/ko not_active Application Discontinuation
- 1987-01-30 JP JP62018790A patent/JPS62185068A/ja active Granted
-
1989
- 1989-06-19 US US07/370,093 patent/US4945092A/en not_active Expired - Fee Related
-
1993
- 1993-03-19 GR GR920402948T patent/GR3007411T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IE61100B1 (en) | 1994-10-05 |
| HU202862B (en) | 1991-04-29 |
| IL81394A (en) | 1991-08-16 |
| FI870329A0 (fi) | 1987-01-26 |
| ATE84033T1 (de) | 1993-01-15 |
| EP0236263A2 (de) | 1987-09-09 |
| HUT43058A (en) | 1987-09-28 |
| NZ219101A (en) | 1990-03-27 |
| PH23078A (en) | 1989-04-10 |
| DE3783247D1 (de) | 1993-02-11 |
| PT84204B (pt) | 1989-09-14 |
| NO870374D0 (no) | 1987-01-29 |
| JPS62185068A (ja) | 1987-08-13 |
| CA1312081C (en) | 1992-12-29 |
| AU599951B2 (en) | 1990-08-02 |
| EP0236263A3 (en) | 1989-04-19 |
| ZA87650B (en) | 1987-09-30 |
| AU6809787A (en) | 1987-08-06 |
| EP0236263B1 (de) | 1992-12-30 |
| DK47187A (da) | 1987-07-31 |
| DD260066A5 (de) | 1988-09-14 |
| FI870329A (fi) | 1987-07-31 |
| IE870230L (en) | 1987-07-30 |
| DK47187D0 (da) | 1987-01-29 |
| IL81394A0 (en) | 1987-08-31 |
| GR3007411T3 (es) | 1993-07-30 |
| NO870374L (no) | 1987-07-31 |
| US4945092A (en) | 1990-07-31 |
| PT84204A (en) | 1987-02-01 |
| KR870007159A (ko) | 1987-08-17 |
| JPH0558631B2 (es) | 1993-08-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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