ES2052471T3 - Preparado farmaceutico fijador del acido gastrico. - Google Patents
Preparado farmaceutico fijador del acido gastrico.Info
- Publication number
- ES2052471T3 ES2052471T3 ES90912814T ES90912814T ES2052471T3 ES 2052471 T3 ES2052471 T3 ES 2052471T3 ES 90912814 T ES90912814 T ES 90912814T ES 90912814 T ES90912814 T ES 90912814T ES 2052471 T3 ES2052471 T3 ES 2052471T3
- Authority
- ES
- Spain
- Prior art keywords
- acid
- pct
- active substance
- effervescent system
- date mar
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 210000004211 gastric acid Anatomy 0.000 title 1
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- 239000002253 acid Substances 0.000 abstract 6
- 239000013543 active substance Substances 0.000 abstract 3
- 239000008187 granular material Substances 0.000 abstract 3
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 abstract 2
- GJCOSYZMQJWQCA-UHFFFAOYSA-N 9H-xanthene Chemical compound C1=CC=C2CC3=CC=CC=C3OC2=C1 GJCOSYZMQJWQCA-UHFFFAOYSA-N 0.000 abstract 1
- 241000416162 Astragalus gummifer Species 0.000 abstract 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 abstract 1
- 229920002774 Maltodextrin Polymers 0.000 abstract 1
- 239000005913 Maltodextrin Substances 0.000 abstract 1
- 229920001615 Tragacanth Polymers 0.000 abstract 1
- 230000002378 acidificating effect Effects 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 150000001340 alkali metals Chemical class 0.000 abstract 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 abstract 1
- -1 alkaline earth metal carbonate Chemical class 0.000 abstract 1
- 150000001621 bismuth Chemical class 0.000 abstract 1
- 239000007795 chemical reaction product Substances 0.000 abstract 1
- GXGAKHNRMVGRPK-UHFFFAOYSA-N dimagnesium;dioxido-bis[[oxido(oxo)silyl]oxy]silane Chemical compound [Mg+2].[Mg+2].[O-][Si](=O)O[Si]([O-])([O-])O[Si]([O-])=O GXGAKHNRMVGRPK-UHFFFAOYSA-N 0.000 abstract 1
- 239000000416 hydrocolloid Substances 0.000 abstract 1
- 239000000391 magnesium silicate Substances 0.000 abstract 1
- 229940099273 magnesium trisilicate Drugs 0.000 abstract 1
- 229910000386 magnesium trisilicate Inorganic materials 0.000 abstract 1
- 235000019793 magnesium trisilicate Nutrition 0.000 abstract 1
- 229940035034 maltodextrin Drugs 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
- MNQYNQBOVCBZIQ-JQOFMKNESA-A sucralfate Chemical compound O[Al](O)OS(=O)(=O)O[C@@H]1[C@@H](OS(=O)(=O)O[Al](O)O)[C@H](OS(=O)(=O)O[Al](O)O)[C@@H](COS(=O)(=O)O[Al](O)O)O[C@H]1O[C@@]1(COS(=O)(=O)O[Al](O)O)[C@@H](OS(=O)(=O)O[Al](O)O)[C@H](OS(=O)(=O)O[Al](O)O)[C@@H](OS(=O)(=O)O[Al](O)O)O1 MNQYNQBOVCBZIQ-JQOFMKNESA-A 0.000 abstract 1
- 229960004291 sucralfate Drugs 0.000 abstract 1
- 229940116362 tragacanth Drugs 0.000 abstract 1
- 235000010487 tragacanth Nutrition 0.000 abstract 1
- 239000000196 tragacanth Substances 0.000 abstract 1
- 229920001285 xanthan gum Polymers 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/29—Antimony or bismuth compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/245—Bismuth; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0007—Effervescent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Inorganic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
UN GRANULADO, POSIBLEMENTE COMPRIMIDO A MODO DE PASTILLAS, CONTIENE AL MENOS UN ENLACE COMPLEJO, INDISOLUBLE O UN MATERIAL A PENAS DISOLUBLE EN POLVO, QUE PUEDE FIJAR O NEUTRALIZAR ACIDOS, Y QUE NO REACCIONA CON EL ACIDO DEL SISTEMA EFERVESCENTE, Y UN SISTEMA EFERVESCENTE, QUE CONSISTE EN AL MENOS UN ACIDO COMESTIBLE, ORGANICO Y AL MENOS UN CARBONATO ALCALINO O ALCALINOTERREO Y/O BICARBONATO. EL MATERIAL ACTIVO SE ENCUENTRA PRESENTE EN UNA CANTIDAD DEL 5 AL 50%, PREFERENTEMENTE DEL 8 AL 30%, Y EN PARTICULAR DEL 12 AL 25% EN PESO. TIENE UN POLVO FIJADOR DE ACIDO DE ENTRE 2 Y 40, PREFERENTEMENTE 3,5 A 25 MEQ/G, NO REACCIONA CON EL ACIDO DEL SISTEMA EFERVESCENTE Y ELEVA EL VALOR DEL PH EN 0,1 N HCL DURANTE 2 MIN. HASTA UN MAXIMO DE 0,5. CONSISTE EN PARTICULAR EN TRISILICATO DE MAGNESIO, SUCRALFATO Y/O UNA SAL DE BISMUTO. CADA GRANULO CONTIENE AL MENOS UN COMPONENTE ACIDO, AL MENOS UN COMPONENTE DE CARBONATO Y AL MENOS UN MATERIAL ACTIVO ENLAZADO A OTRO. LA FIJACION DE LOS COMPONENTES GRANULADOS ENTRE SI ES EFECTUADA POR UN PRODUCTO DE REACCION DE UN ACIDO CON UN COMPONENTE DE CARBONATO Y/O POR AL MENOS UN HIDROCOLOIDE, EN PARTICULAR XANTANO, MALTODEXTRINA, GALACTOMANANO Y/O TRAGACANTO.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH326089 | 1989-09-07 | ||
| CH336689 | 1989-09-15 | ||
| CH53290 | 1990-02-20 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2052471T1 ES2052471T1 (es) | 1994-07-16 |
| ES2052471T3 true ES2052471T3 (es) | 1994-12-16 |
Family
ID=27172187
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES90912814T Expired - Lifetime ES2052471T3 (es) | 1989-09-07 | 1990-09-06 | Preparado farmaceutico fijador del acido gastrico. |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5260304A (es) |
| EP (1) | EP0490920B1 (es) |
| JP (1) | JP2907299B2 (es) |
| AT (1) | ATE98122T1 (es) |
| DE (1) | DE59003811D1 (es) |
| DK (1) | DK0490920T3 (es) |
| ES (1) | ES2052471T3 (es) |
| FI (1) | FI100855B (es) |
| WO (1) | WO1991003241A1 (es) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5629016A (en) * | 1991-01-30 | 1997-05-13 | Glaxo Wellcome Inc. | Water-dispersible tablets |
| DE69207656T2 (de) * | 1991-01-30 | 1996-10-17 | The Wellcome Foundation Ltd., London | Wasserlösliche tabletten |
| GB9215908D0 (en) * | 1992-07-27 | 1992-09-09 | Wellcome Found | Water dispersible tablets |
| US5447918A (en) * | 1992-07-27 | 1995-09-05 | Mccullough; Ricky W. | Gastrointestinal anti-irritant composition comprising sucralfate and methods of use |
| FR2703250A1 (fr) * | 1993-03-30 | 1994-10-07 | Chicouri Marcel | Nouvelles compositions pharmaceutiques à base de bismuth et leur procédé de préparation. |
| US5993860A (en) * | 1993-06-17 | 1999-11-30 | Venture Lending | NSADI delivery employing a powdered hydrocolloid gum obtainable from higher plants |
| US5698226A (en) * | 1993-07-13 | 1997-12-16 | Glaxo Wellcome Inc. | Water-dispersible tablets |
| US5399356A (en) * | 1994-03-24 | 1995-03-21 | The Procter & Gamble Company | Process for making solid dose forms containing bismuth |
| US5834002A (en) | 1994-05-02 | 1998-11-10 | Josman Laboratories, Inc. | Chewing gum containing colloidal bismuth subcitrate |
| US6426085B1 (en) | 1994-05-02 | 2002-07-30 | Josman Laboratories Inc. | Use of bismuth-containing compounds in topical oral dosage forms for the treatment of halitosis |
| US6902738B2 (en) * | 1994-05-02 | 2005-06-07 | Josman Laboratories, Inc. | Topical oral dosage forms containing bismuth compounds |
| GB9501560D0 (en) | 1995-01-26 | 1995-03-15 | Nycomed Imaging As | Contrast agents |
| CN1177357A (zh) * | 1995-01-26 | 1998-03-25 | 耐克麦德英梅金公司 | 铋化合物 |
| TR199700741T2 (xx) * | 1995-02-02 | 1998-07-21 | Chugai Seiyaku Kabushiki Kaisha | Sukralfat preparatlar. |
| US6379651B1 (en) | 1995-02-07 | 2002-04-30 | Josman Laboratories | Oral-topical dosage forms for delivering antibacterials/antibiotics to oral cavity to eradicate H. pylori as a concomitant treatment for peptic ulcers and other gastro-intestinal diseases |
| US6372784B1 (en) | 1995-02-07 | 2002-04-16 | Josman Laboratories, Inc. | Bismuth-containing compounds in topical dosage forms for treatment of corneal and dermal wounds |
| AU5123396A (en) * | 1995-04-03 | 1996-10-23 | Chugai Seiyaku Kabushiki Kaisha | Pharmaceutical composition containing sucralfate |
| KR20000019144A (ko) * | 1998-09-09 | 2000-04-06 | 이수근 | 태양전지를이용한휴대용다중전원장치 |
| US6683043B1 (en) * | 1998-12-08 | 2004-01-27 | The Procter & Gamble Company | Process for manufacturing effervescence components |
| US20040142903A1 (en) * | 2003-01-16 | 2004-07-22 | Par Pharmaceutical Inc. | Bioavailable fenofibrate compositions, methods for treating hyperlipidemia and hypercholesterolemia and processes for the preparation of such compositions |
| US8216610B2 (en) | 2004-05-28 | 2012-07-10 | Imaginot Pty Ltd. | Oral paracetamol formulations |
| EP1954298A4 (en) | 2005-11-28 | 2012-10-31 | Imaginot Pty Ltd | DISPENSING SYSTEM FOR ORAL THERAPEUTIC CONNECTION |
| DE102006054260A1 (de) * | 2006-02-28 | 2007-09-27 | Lohmann Animal Health Gmbh & Co. Kg | Wasser stabilisierende Zusammensetzung, Verfahren zu deren Herstellung und deren Verwendung |
| KR20170003414A (ko) * | 2015-06-30 | 2017-01-09 | (주)아모레퍼시픽 | 속붕해형 과립환 모발 세정용 조성물 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB514888A (en) * | 1937-03-20 | 1939-11-21 | Alfred Washington Pauley | Effervescent composition containing magnesium hydroxide and method of making same |
| GB524756A (en) * | 1938-03-17 | 1940-08-14 | Chas H Phillips Chemical Co | Medicinal preparations of magnesium hydroxide and precess of obtaining the same |
| AU1087883A (en) * | 1982-02-02 | 1983-08-11 | Bayer Aktiengesellschaft | Water dispersible, soluble granules |
| US4678661A (en) * | 1983-09-28 | 1987-07-07 | Gerhard Gergely | Effervescent composition and method of making same |
| DE3440288C2 (de) * | 1984-11-05 | 1987-03-12 | Gergely, Gerhard, Dr.-Ing., Wien | Pharmazeutische Zubereitung mit einem Gehalt an Ibuprofen sowie Verfahren zu ihrer Herstellung |
| DE3627475A1 (de) * | 1986-06-26 | 1988-01-14 | Gergely Gerhard | Verfahren zum herstellen eines brausegranulates, danach hergestelltes brausegranulat sowie dessen verwendung |
| US4801454A (en) * | 1986-07-17 | 1989-01-31 | The Proctor & Gamble Company | Processes for making colored pharmaceutical compositions |
| DK179687D0 (da) * | 1987-04-08 | 1987-04-08 | Farma Food As | Praeparat |
-
1990
- 1990-09-06 WO PCT/EP1990/001503 patent/WO1991003241A1/de active IP Right Grant
- 1990-09-06 DK DK90912814.2T patent/DK0490920T3/da not_active Application Discontinuation
- 1990-09-06 AT AT90912814T patent/ATE98122T1/de not_active IP Right Cessation
- 1990-09-06 JP JP2512153A patent/JP2907299B2/ja not_active Expired - Fee Related
- 1990-09-06 DE DE90912814T patent/DE59003811D1/de not_active Expired - Lifetime
- 1990-09-06 ES ES90912814T patent/ES2052471T3/es not_active Expired - Lifetime
- 1990-09-06 EP EP90912814A patent/EP0490920B1/de not_active Expired - Lifetime
- 1990-09-06 US US07/838,435 patent/US5260304A/en not_active Expired - Lifetime
-
1991
- 1991-02-19 FI FI910802A patent/FI100855B/fi active
Also Published As
| Publication number | Publication date |
|---|---|
| FI910802A0 (fi) | 1991-02-19 |
| ATE98122T1 (de) | 1993-12-15 |
| US5260304A (en) | 1993-11-09 |
| WO1991003241A1 (de) | 1991-03-21 |
| JP2907299B2 (ja) | 1999-06-21 |
| ES2052471T1 (es) | 1994-07-16 |
| EP0490920B1 (de) | 1993-12-08 |
| EP0490920A1 (de) | 1992-06-24 |
| FI100855B (fi) | 1998-03-13 |
| DK0490920T3 (da) | 1994-04-25 |
| JPH05500052A (ja) | 1993-01-14 |
| DE59003811D1 (de) | 1994-01-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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