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ES2041597B1 - NEW PROCEDURE FOR THE PREPARATION OF LIPOSOMES THAT CAPSULATE PHARMACEUTICAL AND COSMETIC PRODUCTS. - Google Patents

NEW PROCEDURE FOR THE PREPARATION OF LIPOSOMES THAT CAPSULATE PHARMACEUTICAL AND COSMETIC PRODUCTS.

Info

Publication number
ES2041597B1
ES2041597B1 ES9200931A ES9200931A ES2041597B1 ES 2041597 B1 ES2041597 B1 ES 2041597B1 ES 9200931 A ES9200931 A ES 9200931A ES 9200931 A ES9200931 A ES 9200931A ES 2041597 B1 ES2041597 B1 ES 2041597B1
Authority
ES
Spain
Prior art keywords
liposomes
organic solvent
capsulate
pharmaceutical
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES9200931A
Other languages
Spanish (es)
Other versions
ES2041597A1 (en
Inventor
Bazaco Joan Freixas
Coca Concepcion Martorell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to ES9200931A priority Critical patent/ES2041597B1/en
Publication of ES2041597A1 publication Critical patent/ES2041597A1/en
Application granted granted Critical
Publication of ES2041597B1 publication Critical patent/ES2041597B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Abstract

NUEVO PROCEDIMIENTO PARA LA PREPARACION DE LIPOSOMAS QUE ENCAPSULAN PRODUCTOS FARMACEUTICOS Y COSMETICOS. COMPRENDE: A) PREPARAR UNA SOLUCION DEL LIPIDO FORMADOR DE LIPOSOMAS EN UN DISOLVENTE ORGANICO, QUE PUEDE CONTENER DISUELTO EL O LOS INGREDIENTES ACTIVOS; B) EVAPORAR EL DISOLVENTE ORGANICO A SEQUEDAD QUEDANDO UNA MATRIZ QUE CONTIENE EL PRINCIPIO ACTIVO A ENCAPSULAR; C) AÑADIR A LA MATRIZ LIPIDICA ANTERIOR UN DISOLVENTE ORGANICO, PARA SU HOMOGENEIZACION; D) EN EL CASO DE QUE EL(LOS) INGREDIENTE(S) ACTIVO(S) NO PUEDA(N) DISOLVERSE EN EL DISOLVENTE ORGANICO, DISOLVERLO(S) EN UNA SOLUCION TAMPON ADECUADA; E HOMOGENEIZAR LA MEZCLA HETEROGENEA OBTENIDA EN D) A 8.000-15.000 R.P.M. DURANTE UN PERIODO DE TIEMPO DE 15 MINUTOS, OBTENIENDOSE UNA SUSPENSION LIPOSOMAL CONTENIENDO LIPOSOMAS MULTILAMELARES CON UN TAMAÑO MEDIO DE 250-350 NM Y UNA POLIDISPERSIDAD DE 0.17; E) CON EL FIN DE REDUCIR EL TAMAÑO DE PARTICULA DE LOS LIPOSOMAS, ESTOS PUEDEN SOMETERSE A UN PROCESO DE EXTRUSION. APLICACION EN CLINICA HUMANA, CLINICA VETERINARIA Y COSMETICA.NEW PROCEDURE FOR THE PREPARATION OF LIPOSOMES THAT CAPSULATE PHARMACEUTICAL AND COSMETIC PRODUCTS. IT UNDERSTANDS: A) PREPARE A LIPOSOM FORMING LIPID SOLUTION IN AN ORGANIC SOLVENT, WHICH MAY CONTAIN SOLVED THE ACTIVE INGREDIENTS OR INGREDIENTS; B) EVAPORATE THE ORGANIC SOLVENT TO DROUGHT REMAINING A MATRIX CONTAINING THE ACTIVE PRINCIPLE TO ENCAPSULATE; C) ADD TO THE PREVIOUS LIPID MATRIX AN ORGANIC SOLVENT FOR HOMOGENIZATION; D) IN THE EVENT THAT THE ACTIVE INGREDIENT (S) CANNOT BE SOLVED IN THE ORGANIC SOLVENT, SOLVE IT (S) IN AN APPROPRIATE BUFFER SOLUTION; E HOMOGENIZE THE HETEROGENOUS MIXTURE OBTAINED IN D) AT 8,000-15,000 R.P.M. DURING A PERIOD OF TIME OF 15 MINUTES, OBTAINING A LIPOSOMAL SUSPENSION CONTAINING MULTILAMEL LIPOSOMES WITH AN AVERAGE SIZE OF 250-350 NM AND A POLYDISPERSITY OF 0.17; E) IN ORDER TO REDUCE THE PARTICULATE SIZE OF THE LIPOSOMES, THESE MAY BE SUBMITTED TO AN EXTRUSION PROCESS. APPLICATION IN HUMAN CLINIC, VETERINARY CLINIC AND COSMETICS.

ES9200931A 1992-05-05 1992-05-05 NEW PROCEDURE FOR THE PREPARATION OF LIPOSOMES THAT CAPSULATE PHARMACEUTICAL AND COSMETIC PRODUCTS. Expired - Fee Related ES2041597B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES9200931A ES2041597B1 (en) 1992-05-05 1992-05-05 NEW PROCEDURE FOR THE PREPARATION OF LIPOSOMES THAT CAPSULATE PHARMACEUTICAL AND COSMETIC PRODUCTS.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9200931A ES2041597B1 (en) 1992-05-05 1992-05-05 NEW PROCEDURE FOR THE PREPARATION OF LIPOSOMES THAT CAPSULATE PHARMACEUTICAL AND COSMETIC PRODUCTS.

Publications (2)

Publication Number Publication Date
ES2041597A1 ES2041597A1 (en) 1993-11-16
ES2041597B1 true ES2041597B1 (en) 1994-06-01

Family

ID=8276917

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9200931A Expired - Fee Related ES2041597B1 (en) 1992-05-05 1992-05-05 NEW PROCEDURE FOR THE PREPARATION OF LIPOSOMES THAT CAPSULATE PHARMACEUTICAL AND COSMETIC PRODUCTS.

Country Status (1)

Country Link
ES (1) ES2041597B1 (en)

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6058915A (en) * 1983-09-12 1985-04-05 Fujisawa Pharmaceut Co Ltd Lipid microcapsule preparation containing medicament
JPH0753661B2 (en) * 1984-03-08 1995-06-07 フアレス フアーマスーチカル リサーチ エヌブイ Pro-liposome composition and method of making an aqueous dispersion of liposomes
US4753788A (en) * 1985-01-31 1988-06-28 Vestar Research Inc. Method for preparing small vesicles using microemulsification
JPH0751496B2 (en) * 1986-04-02 1995-06-05 武田薬品工業株式会社 Manufacturing method of liposome
AU598002B2 (en) * 1986-07-15 1990-06-14 Cilag Ltd. Method of preparing single bilayered liposomes
GB8704171D0 (en) * 1987-02-23 1987-04-01 Clayton Found Res Multivesicular liposomes
CA2046997C (en) * 1990-07-16 2000-12-12 Hiroshi Kikuchi Liposomal products
AR244546A1 (en) * 1990-10-30 1993-11-30 Gador Y Cia S A C I Lab Dr Procedure for the preparation of liposomes insoluble in oil for in soft completely soluble gelatinous capsules.

Also Published As

Publication number Publication date
ES2041597A1 (en) 1993-11-16

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Effective date: 20110803