[go: up one dir, main page]

ES2031096T3 - Una composicion de implante mejorada a base de estradiol y metodo para su preparacion. - Google Patents

Una composicion de implante mejorada a base de estradiol y metodo para su preparacion.

Info

Publication number
ES2031096T3
ES2031096T3 ES198787111218T ES87111218T ES2031096T3 ES 2031096 T3 ES2031096 T3 ES 2031096T3 ES 198787111218 T ES198787111218 T ES 198787111218T ES 87111218 T ES87111218 T ES 87111218T ES 2031096 T3 ES2031096 T3 ES 2031096T3
Authority
ES
Spain
Prior art keywords
estradiol
preparation
improved based
implant composition
composition improved
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198787111218T
Other languages
English (en)
Inventor
Mimi Yih-Pei Chou Schaaf
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Application granted granted Critical
Publication of ES2031096T3 publication Critical patent/ES2031096T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A61K9/204—Polyesters, e.g. poly(lactide-co-glycolide)

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
  • Prostheses (AREA)
  • Materials For Medical Uses (AREA)

Abstract

LA INVENCION SE REFIERE A COMPOSICIONES BIODEGRADABLES QUE LIBERAN CONTINUAMENTE ESTRADIOL DE UNA FORMA UNIFORME DURANTE EXTENSOS PERIODOS DE TIEMPO Y NO MUESTRA LIBERACION INICIAL DE NIVELES ALTOS NO DESEADOS DE INGREDIENTE ACTIVO. LA INVENCION TAMBIEN SE REFIERE A UN METODO PARA LA PREPARACION DE LA COMPOSICION A ANIMALES DE MUCHA ALIMENTACION DE UNA FORMA CONTINUA Y UNIFORME DURANTE EXTENSOS PERIODOS DE TIEMPO.
ES198787111218T 1986-08-11 1987-08-04 Una composicion de implante mejorada a base de estradiol y metodo para su preparacion. Expired - Lifetime ES2031096T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/895,415 US4758435A (en) 1986-08-11 1986-08-11 Estradiol implant composition and method for preparation

Publications (1)

Publication Number Publication Date
ES2031096T3 true ES2031096T3 (es) 1992-12-01

Family

ID=25404471

Family Applications (1)

Application Number Title Priority Date Filing Date
ES198787111218T Expired - Lifetime ES2031096T3 (es) 1986-08-11 1987-08-04 Una composicion de implante mejorada a base de estradiol y metodo para su preparacion.

Country Status (10)

Country Link
US (1) US4758435A (es)
EP (1) EP0257369B1 (es)
AT (1) ATE74751T1 (es)
AU (1) AU599406B2 (es)
CA (1) CA1297020C (es)
DE (1) DE3778244D1 (es)
ES (1) ES2031096T3 (es)
GR (1) GR3004370T3 (es)
NZ (1) NZ221390A (es)
ZA (1) ZA875897B (es)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4846844A (en) * 1987-08-31 1989-07-11 Eli Lilly And Company Antimicrobial coated implants
DE3734223A1 (de) * 1987-10-09 1989-04-20 Boehringer Ingelheim Kg Implantierbares, biologisch abbaubares wirkstofffreigabesystem
US5250584A (en) * 1988-08-31 1993-10-05 G-C Dental Industrial Corp. Periodontium-regenerative materials
FR2654337B1 (fr) * 1989-11-15 1994-08-05 Roussel Uclaf Nouvelles microspheres injectables biodegradables procede de preparation et suspensions injectables les renfermant.
US5198220A (en) * 1989-11-17 1993-03-30 The Procter & Gamble Company Sustained release compositions for treating periodontal disease
US5350580A (en) * 1990-03-05 1994-09-27 Minnesota Mining And Manufacturing Company Device and method for extended delivery of pharmacologically active agents to the ear
EP0447719B1 (en) * 1990-03-05 1993-11-03 Minnesota Mining And Manufacturing Company Device for extended delivery of pharmacologically active agents to the ear
US5288496A (en) * 1990-05-15 1994-02-22 Stolle Research & Development Corporation Growth promoters for animals
US5643595A (en) * 1992-11-24 1997-07-01 Alkermes Controlled Therapeutics Inc. Ii Growth promoters for animals
FR2756493B1 (fr) * 1996-12-02 2001-04-13 Delab Dispositif d'administration locale de formulations solides ou semi-solides
US20020111603A1 (en) 1996-12-02 2002-08-15 Societe De Conseils De Recherches Et D'application Device for local administration of solid or semi-solid formulations and delayed-release formulations for proposal parental administration and preparation process
DE19744135C1 (de) * 1997-09-29 1999-03-25 Schering Ag Beschichtete medizinische Implantate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Restenoseprophylaxe
US6022554A (en) * 1997-12-15 2000-02-08 American Home Products Corporation Polymeric microporous film coated subcutaneous implant
ES2359973T3 (es) * 1998-03-19 2011-05-30 MERCK SHARP & DOHME CORP. Composiciones poliméricas líquidas para la liberación controlada de sustancias bioactivas.
FR2770134B1 (fr) * 1998-10-28 2002-06-07 Delab Formulations solides ou semi-solides pour administration locale
US7767708B2 (en) * 1998-11-04 2010-08-03 Schering-Plough Animal Health Corp. Growth stimulant compositions
US6498153B1 (en) 1998-12-31 2002-12-24 Akzo Nobel N.V. Extended release growth promoting two component composition
US6787342B2 (en) 2000-02-16 2004-09-07 Merial Limited Paste formulations
US6953586B1 (en) * 2000-06-08 2005-10-11 Ivy Animal Health, Inc. Growth promoting pharmaceutical implant
WO2007011707A2 (en) 2005-07-15 2007-01-25 Micell Technologies, Inc. Polymer coatings containing drug powder of controlled morphology
WO2007011708A2 (en) 2005-07-15 2007-01-25 Micell Technologies, Inc. Stent with polymer coating containing amorphous rapamycin
US8362086B2 (en) 2005-08-19 2013-01-29 Merial Limited Long acting injectable formulations
EP2019657B1 (en) 2006-04-26 2015-05-27 Micell Technologies, Inc. Coatings containing multiple drugs
DE602007008125D1 (de) * 2006-10-31 2010-09-09 Surmodics Pharmaceuticals Inc Kugelförmige polymer-teilchen
US11426494B2 (en) 2007-01-08 2022-08-30 MT Acquisition Holdings LLC Stents having biodegradable layers
CA2679712C (en) 2007-01-08 2016-11-15 Micell Technologies, Inc. Stents having biodegradable layers
SG192523A1 (en) 2008-04-17 2013-08-30 Micell Technologies Inc Stents having bioabsorbable layers
WO2009132050A2 (en) 2008-04-21 2009-10-29 Otonomy, Inc. Auris formulations for treating otic diseases and conditions
AU2009270849B2 (en) 2008-07-17 2013-11-21 Micell Technologies, Inc. Drug delivery medical device
US9510856B2 (en) 2008-07-17 2016-12-06 Micell Technologies, Inc. Drug delivery medical device
AU2009270695A1 (en) 2008-07-17 2010-01-21 Ap Pharma Methods for enhancing the stability of polyorthoesters and their formulations
JP5421366B2 (ja) 2008-07-21 2014-02-19 オトノミ―，インク． 制御放出性の耳の構造体調節および生来の免疫システム調節化合物および耳の障害の処置のための方法
US8784870B2 (en) * 2008-07-21 2014-07-22 Otonomy, Inc. Controlled release compositions for modulating free-radical induced damage and methods of use thereof
EP2413847A4 (en) 2009-04-01 2013-11-27 Micell Technologies Inc COATED STENTS
WO2010121187A2 (en) 2009-04-17 2010-10-21 Micell Techologies, Inc. Stents having controlled elution
US11369498B2 (en) 2010-02-02 2022-06-28 MT Acquisition Holdings LLC Stent and stent delivery system with improved deliverability
WO2011133655A1 (en) 2010-04-22 2011-10-27 Micell Technologies, Inc. Stents and other devices having extracellular matrix coating
RU2013103740A (ru) * 2010-06-30 2014-08-10 Эвоник Дегусса Корпорэйшн Способы обработки имплантатов для термически неустойчивых и других биологически активных агентов и полученные из них имплантаты
WO2012009684A2 (en) 2010-07-16 2012-01-19 Micell Technologies, Inc. Drug delivery medical device
US10117972B2 (en) 2011-07-15 2018-11-06 Micell Technologies, Inc. Drug delivery medical device
US10188772B2 (en) 2011-10-18 2019-01-29 Micell Technologies, Inc. Drug delivery medical device
CA2857958C (en) * 2011-12-02 2020-08-25 Merial Limited Long-acting injectable moxidectin formulations and moxidectin crystal forms
EP2967803B1 (en) 2013-03-12 2023-12-27 Micell Technologies, Inc. Bioabsorbable biomedical implants
KR20180059584A (ko) 2013-05-15 2018-06-04 미셀 테크놀로지즈, 인코포레이티드 생흡수성 생체의학적 임플란트
US10226419B2 (en) 2014-09-08 2019-03-12 ProMed Pharma, LLC Methods for manufacturing implants
JP7023461B2 (ja) 2015-07-28 2022-02-22 オトノミ―，インク． 耳の疾病の処置のためのｔｒｋｂ又はｔｒｋｃアゴニスト組成物及び方法
CA3029281A1 (en) 2016-06-29 2018-01-04 Otonomy, Inc. Triglyceride otic formulations and uses thereof
CN112165860A (zh) 2018-01-09 2021-01-01 奥德纳米有限公司 生长因子耳用制剂
US20230355542A1 (en) * 2022-05-04 2023-11-09 Yasin Oduk Drug-eluting device with genetic and chemical therapeutics for treating or preventing vascular access dysfunctions

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) * 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
CA1076480A (en) * 1975-04-28 1980-04-29 John S. Kent Inert core implant pellet
US4191741A (en) * 1978-09-22 1980-03-04 Eli Lilly And Company Removable drug implant
US4293539A (en) * 1979-09-12 1981-10-06 Eli Lilly And Company Controlled release formulations and method of treatment
DK119884A (da) * 1983-03-18 1984-09-19 Lilly Co Eli Fast, cylindrisk, subkutan implantation og dens anvendelse
CA1256638A (en) * 1984-07-06 1989-06-27 Motoaki Tanaka Polymer and its production

Also Published As

Publication number Publication date
AU599406B2 (en) 1990-07-19
ZA875897B (en) 1988-05-25
EP0257369B1 (en) 1992-04-15
GR3004370T3 (es) 1993-03-31
US4758435A (en) 1988-07-19
CA1297020C (en) 1992-03-10
DE3778244D1 (de) 1992-05-21
ATE74751T1 (de) 1992-05-15
EP0257369A1 (en) 1988-03-02
NZ221390A (en) 1990-10-26
AU7672487A (en) 1988-02-18

Similar Documents

Publication Publication Date Title
ES2031096T3 (es) Una composicion de implante mejorada a base de estradiol y metodo para su preparacion.
MY113488A (en) Compounds with growth hormone releasing properties
ES2068999T3 (es) Composiciones para la liberacion retardada de clorhexidina.
MY107500A (en) Preparation process of sustained release compositions and the compositions thus obtained
ES2055845T3 (es) Composicion farmaceutica para el tratamiento de la osteoporosis.
DK0486563T3 (da) Tyggegummipræparat med fremskyndet reguleret frigivelse af virksomme stoffer
ATE89161T1 (de) Zubereitungen mit verzoegerter freisetzung sowie deren herstellung.
BR8801242A (pt) Processo de preparar uma composicao para fornecer uma quantidade efetiva de uma dose constante de um ingrediente ativo a um animal e a respectiva composicao
DE3486409D1 (de) Zusammensetzung zur kontrollierten Abgabe eines Wirkstoffs.
IL78826A (en) Precursor composition for the preparation of a biodegradable implant for the sustained release of an active material and such implants prepared therefrom
HUT52083A (en) Herbicidal compositions comprising cyclohexenone oxymetres as active ingredient and process for producing the active ingredients
IL115138A0 (en) Implantable polymer-containing molded articles for the administration of active substances to plants and processes for the preparation thereof
ES491307A0 (es) Un procedimiento para la preparacion de una composicion de liberacion controlada de un compuesto biologicamente activo para su administracion a un animal
HUT60245A (en) Insecticidal compositions comprising 2-aryl-1-(alkoxymethyl)-4-halogen-5-(trifluoromethyl)-pyrrole derivatives as active ingredient and process for producing the active ingredient
DE69314463D1 (de) Hautregenerierende kosmetische zusammensetzung
GB8603964D0 (en) Compositions
HUT50787A (en) Process for producing pharmaceutical compositions comprising 4-aryl-4-piperidine-, pyrrolidine- or hexahydroazepincarbinol derivatives or heterocyclic analogs thereof as active ingredient and process for producing the new compounds
HUT54289A (en) Fungicidal compositions comprising guanidine derivatives as active ingredient and process for producing the active ingredients
MX170055B (es) , "composicion insecticida y procedimiento para su obtencion
IT1229223B (it) Composizioni veterinarie sinergisticamente attive e procedimento per la loro preparazione.
GB2341782A (en) Environmentally friendly chewing gum bases
ES2029462T3 (es) Empleo de 2-terc.-butil-4-metil-ciclohexanol como perfumantes asi como a modo de componente de composiciones perfumantes.
HUT57743A (en) Herbicidal compositions comprising new, substituted sulfonyl amidinohydrazone derivatives as active ingredient and process for producing the active ingredients
MY102265A (en) An acaricidal composition
IT8921608A0 (it) Composizioni a base di tessuti vegetali od animali e procedimento per la loro preparazione.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 257369

Country of ref document: ES