[go: up one dir, main page]

ES2029885T3 - Metodo para preparar acidos ariltioalquilfenil-carboxilicos. - Google Patents

Metodo para preparar acidos ariltioalquilfenil-carboxilicos.

Info

Publication number
ES2029885T3
ES2029885T3 ES198888305654T ES88305654T ES2029885T3 ES 2029885 T3 ES2029885 T3 ES 2029885T3 ES 198888305654 T ES198888305654 T ES 198888305654T ES 88305654 T ES88305654 T ES 88305654T ES 2029885 T3 ES2029885 T3 ES 2029885T3
Authority
ES
Spain
Prior art keywords
chem
aryltioalkylphenyl
preparing
carboxylic acids
arylthioalkylphenylcarboxylic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198888305654T
Other languages
English (en)
Inventor
Steven E Hall
Philip D Stein
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ER Squibb and Sons LLC
Original Assignee
ER Squibb and Sons LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ER Squibb and Sons LLC filed Critical ER Squibb and Sons LLC
Application granted granted Critical
Publication of ES2029885T3 publication Critical patent/ES2029885T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

SE PROPORCIONAN ACIDOS ARILTIOALQUILFENIL CARBOXILICOS, QUE TIENEN LA ESTRUCTURA: (FIG. A), DONDE AR ES UN GRUPO ARILO QUE INCLUYE ARIL O NAFTIL, QUE PUEDE TENER O NO UNO O MAS SUSTITUYENTES, A ES -C(R2)(R3)-, -C(R2)(R3)C(R2)(R3)- O -C(R2)=C(R3)-, DONDE R ES HIDROGENO, METAL ALCALINO O ALQUILO INFERIOR; M ES 0 O 1-3; N ES 0, 1 O 2; P ES 1-5; Y Q Y R SON 0 O 1-3. ESTOS COMPUESTOS SON AGENTES CARDIOVASCULARES QUE TIENEN ACTIVIDAD ANTAGONISTA AL TROMBOXANO Y POR ELLO SON UTILES EN EL TRATAMIENTO DE ENFERMEDAD TROMBOTICA.
ES198888305654T 1987-06-29 1988-06-20 Metodo para preparar acidos ariltioalquilfenil-carboxilicos. Expired - Lifetime ES2029885T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/067,199 US4752616A (en) 1987-06-29 1987-06-29 Arylthioalkylphenyl carboxylic acids, compositions containing same and method of use

Publications (1)

Publication Number Publication Date
ES2029885T3 true ES2029885T3 (es) 1992-10-01

Family

ID=22074375

Family Applications (1)

Application Number Title Priority Date Filing Date
ES198888305654T Expired - Lifetime ES2029885T3 (es) 1987-06-29 1988-06-20 Metodo para preparar acidos ariltioalquilfenil-carboxilicos.

Country Status (7)

Country Link
US (1) US4752616A (es)
EP (1) EP0297768B1 (es)
JP (1) JPS6426548A (es)
AT (1) ATE65500T1 (es)
DE (1) DE3863857D1 (es)
ES (1) ES2029885T3 (es)
GR (1) GR3003015T3 (es)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3724923A1 (de) * 1987-07-28 1989-02-09 Boehringer Mannheim Gmbh Neue schwefelverbindungen, verfahren zu ihrer herstellung sowie arzneimittel
US4931460A (en) * 1987-09-17 1990-06-05 E. R. Squibb & Sons, Inc. Post-ischemic myocardial dysfunction using thromboxane A2 antagonists
US4925873A (en) * 1988-09-01 1990-05-15 E. R. Squibb & Sons, Inc. Method of treating skin injuries using thromboxane A2 receptor antagonists
US5070099A (en) * 1988-10-31 1991-12-03 E. R. Squibb & Sons, Inc. Arylthioalkylphenyl carboxylic acids, derivatives thereof, compositions containing same method of use
US4959383A (en) * 1988-10-31 1990-09-25 E. R. Squibb & Sons, Inc. Phenylsulfone alkenoic acids, derivatives thereof, compositions containing same and method of use
US5106991A (en) * 1989-06-02 1992-04-21 E. R. Squibb & Sons, Inc. Geminally substituted thiaheterocyclic carboxylic acids and derivatives thereof
US4975452A (en) * 1989-06-02 1990-12-04 E. R. Squibb & Sons, Inc. Geminally substituted thiaheterocyclic carboxylic acids and derivatives thereof
US5177069A (en) * 1989-12-13 1993-01-05 Kissei Pharmaceutical Co., Ltd. Naphthysulfonylalkanoic acid compounds and pharmaceutical compositions thereof
AU1742492A (en) * 1991-04-05 1992-11-02 Smithkline Beecham Corporation Disubstituted naphthalenes
US5280034A (en) * 1991-08-23 1994-01-18 E. R. Squibb & Sons, Inc. Bis-heterocyclic prostaglandin analogs
US5827868A (en) * 1991-10-07 1998-10-27 E. R. Squibb & Sons, Inc. Prostaglandin analogs
PL194329B1 (pl) * 1997-05-14 2007-05-31 Atherogenics Inc Zastosowanie monoestru probukolu kwasu bursztynowego lub jego farmaceutycznie dopuszczalnej soli dowytwarzania leku do leczenia choroby, której mediatorem jest VCAM-1
US6670398B2 (en) 1997-05-14 2003-12-30 Atherogenics, Inc. Compounds and methods for treating transplant rejection
US6852878B2 (en) * 1998-05-14 2005-02-08 Atherogenics, Inc. Thioketals and thioethers for inhibiting the expression of VCAM-1
JP2002511878A (ja) * 1997-07-01 2002-04-16 アセロジエニクス・インコーポレイテツド 抗酸化剤による過増殖状態の治療の増強
AU2002320025A1 (en) * 2001-04-11 2002-11-11 Atherogenics, Inc. Probucol monoesters and their use to increase plasma hdl cholesterol levels and improve hdl functionality
AU2002322720B2 (en) 2001-07-25 2008-11-13 Raptor Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
WO2004024094A2 (en) * 2002-09-13 2004-03-25 Samford University Methods and compositons for the use of d-malic acid to decrease serum triglyceride, cholesterol, and lipoprotein levels
CA2512980A1 (en) * 2003-01-13 2004-07-29 Atherogenics, Inc. Process of preparing esters and ethers of probucol and derivatives thereof
US20070260087A1 (en) 2004-04-20 2007-11-08 Atherogenics, Inc. Process of Preparing Esters and Ethers of Probucol and Derivatives Thereof
US7271274B2 (en) 2004-04-20 2007-09-18 Ahterogenics, Inc. Phenolic antioxidants for the treatment of disorders including arthritis, asthma and coronary artery disease
CN103259027A (zh) 2005-04-28 2013-08-21 普罗透斯数字保健公司 药物信息系统
EP2063905B1 (en) 2006-09-18 2014-07-30 Raptor Pharmaceutical Inc Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates
US8252840B2 (en) * 2007-03-26 2012-08-28 Salutria Pharmaceuticals Llc Methods of derivatives of probucol for the treatment of type II diabetes
US20080280985A1 (en) * 2007-03-27 2008-11-13 Scott Robert A D Methods and Compositions Using Certain Phenolic Derivatives for the Treatment of Diabetes
CN102316902B (zh) 2009-02-20 2014-09-24 to-BBB控股股份有限公司 基于谷胱甘肽的药物递送系统
CN110075069A (zh) 2009-05-06 2019-08-02 实验室护肤股份有限公司 包含活性剂-磷酸钙颗粒复合物的皮肤递送组合物及其应用
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
US12161632B2 (en) 2014-05-16 2024-12-10 Cumberland Pharmaceuticals Inc. Compositions and methods of treating cardiac fibrosis with ifetroban
ES2848348T3 (es) 2014-05-16 2021-08-06 Cumberland Pharmaceuticals Inc Composiciones y métodos de tratamiento con ifetroban de la fibrosis cardíaca
US20170000771A1 (en) 2015-06-30 2017-01-05 Cumberland Pharmaceuticals, Inc. Thromboxane Receptor Antagonists in AERD/Asthma
CN115624549A (zh) 2016-05-11 2023-01-20 坎伯兰医药品股份有限公司 用血栓烷-a2受体拮抗剂治疗肌营养不良的组合物和方法
CN113754570B (zh) * 2020-06-02 2024-10-25 河北圣泰材料股份有限公司 一种2-丙腈磺酰基乙腈的合成方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB971700A (en) * 1961-02-02 1964-09-30 Boots Pure Drug Co Ltd Anti-Inflammatory Agents
US3600437A (en) * 1969-05-28 1971-08-17 Lilly Co Eli Substituted phenylalkanoic acids and derivatives thereof
US3880916A (en) * 1969-09-17 1975-04-29 Ciba Geigy Corp Cycloaliphatic acids
US3825587A (en) * 1970-05-05 1974-07-23 Rorer Inc William H Substituted phenylacetic acid compounds
SE377113B (es) * 1971-05-15 1975-06-23 Ciba Geigy Ag
US3845089A (en) * 1972-07-27 1974-10-29 Zoecon Corp Phenylheptadienoates
US4074057A (en) * 1973-12-12 1978-02-14 Takeda Chemical Co., Ltd. 2-Halopropionic acid and its derivatives
DE2809377A1 (de) * 1978-03-04 1979-09-13 Boehringer Mannheim Gmbh Phenoxyalkylcarbonsaeure-derivate, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel
DE3000377A1 (de) * 1980-01-07 1981-07-09 Boehringer Mannheim Gmbh, 6800 Mannheim Neue sulfonamide, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel
DE3169761D1 (en) * 1981-01-09 1985-05-09 Fisons Plc Phenoxy- and thiophenoxy compounds, methods for their preparation and pharmaceutical formulations containing them
US4780558A (en) * 1985-02-15 1988-10-25 Ciba-Geigy Corporation Sulfone compounds

Also Published As

Publication number Publication date
US4752616A (en) 1988-06-21
DE3863857D1 (de) 1991-08-29
JPS6426548A (en) 1989-01-27
GR3003015T3 (en) 1993-02-17
EP0297768A1 (en) 1989-01-04
ATE65500T1 (de) 1991-08-15
EP0297768B1 (en) 1991-07-24

Similar Documents

Publication Publication Date Title
ES2029885T3 (es) Metodo para preparar acidos ariltioalquilfenil-carboxilicos.
ATE44954T1 (de) Carbostyrilderivat und verfahren zu seiner herstellung.
ES483767A1 (es) Procedimiento para producir n-arilsulfonil-l-argininamidas
FI874570A0 (fi) Antibakteriska medel -ii.
DK0454651T3 (da) Hidtil ukendte blodpladeaggregeringsinhibitorer
BG34615A3 (en) Method for preparing 1- oxides of penicillanic acid
ATE10831T1 (de) Herstellung von aromatischen ketonen.
ATE57699T1 (de) Pyridoncarbonsauere-derivate und verfahren zu ihrer herstellung.
ATE29719T1 (de) Hydroxyalkinyl-azolyl-derivate, verfahren zu ihrer herstellung sowie ihre verwendung als fungizide.
IT7829639A0 (it) Processo per la preparazione dell'acido tereftalico.
BG51251A3 (bg) Метод за получаване на тетрахидроимидазо (1,4)- бензодиазепин-2-кетони
ATE34574T1 (de) 1-azolyl-3-pyrazolyl-2-propanol-derivate, verfahren zu ihrer herstellung und ihre verwendung als fungizide.
ATE21694T1 (de) Heterozyklische verbindungen mit pestizider wirksamkeit und verfahren zu ihrer herstellung.
ATE36318T1 (de) Verfahren zur herstellung von azetidinderivaten und zwischenprodukte.
ATE57183T1 (de) Herstellung von substituierten gammabutyrolactonen, verwendbar als zwischenprodukte zur herstellung von fungiziden imidazolen und triazolen.
DE3677838D1 (de) Verfahren zur herstellung von alkylestern von 3,4-epoxybuttersaeure.
ATE106397T1 (de) Verfahren zur herstellung von 3,3- diarylacrylsäureamiden.
HUT35930A (en) Fungicides containing hydroxy-ethyl-azolile-oxym-derivatives as agent and process for the production of hydroxy-ethyl-azolile-oxym-derivatives
EP0205857A3 (en) 5,6-epoxy-7-oxabicycloheptane substituted prostaglandin analogs
IT8025223A0 (it) Procedimento per la produzione di derivati dell'acido penicillanico.
ATE3035T1 (de) Azolyl-alkenole, verfahren zu ihrer herstellung sowie ihre verwendung als fungizide.
ATE166048T1 (de) Verfahren zur herstellung von prostaglandin e
IT7921809A0 (it) Metodo per la produzione di derivati dell'acido 6-beta-amidino-penicillanico.
IT8722693A0 (it) Sintesi elettrochimica dell'acido 2 metil 5 pirazinoico.
ES8600759A1 (es) Procedimiento para preparar 2-(fenetil)-5-((3, 4-metilendioxi)- -hidroxibencil)-pirrolidina

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 297768

Country of ref document: ES