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ES2029019T3 - Procedimiento para preparar intermedios para antagonistas de leucotrienos. - Google Patents

Procedimiento para preparar intermedios para antagonistas de leucotrienos.

Info

Publication number
ES2029019T3
ES2029019T3 ES198888305444T ES88305444T ES2029019T3 ES 2029019 T3 ES2029019 T3 ES 2029019T3 ES 198888305444 T ES198888305444 T ES 198888305444T ES 88305444 T ES88305444 T ES 88305444T ES 2029019 T3 ES2029019 T3 ES 2029019T3
Authority
ES
Spain
Prior art keywords
antagonists
leukotrene
procedure
preparing intermediates
intermediates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198888305444T
Other languages
English (en)
Inventor
Winston Stanley Marshall
Sandra Kay Sigmund
Celia Ann Whitesitt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Application granted granted Critical
Publication of ES2029019T3 publication Critical patent/ES2029019T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/82—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups
    • C07C49/825—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups all hydroxy groups bound to the ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/82—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups
    • C07C49/83—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups polycyclic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

SE ACILAN 1,3-DIALCOXIBENCENOS Y SE DESPROTEGEN EN UNA MEZCLA DE ACIDO ACETICO O PROPIONICO Y ACIDO BROMHIDRICO. LAS DIHIDROXIFENONAS ASI PRODUCIDAS SON PRODUCTOS INTERMEDIOS PARA LA SINTESIS DE ANTAGONISTAS DE LEUCOTRIENO.
ES198888305444T 1987-06-19 1988-06-15 Procedimiento para preparar intermedios para antagonistas de leucotrienos. Expired - Lifetime ES2029019T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US6490087A 1987-06-19 1987-06-19

Publications (1)

Publication Number Publication Date
ES2029019T3 true ES2029019T3 (es) 1992-07-16

Family

ID=22058969

Family Applications (1)

Application Number Title Priority Date Filing Date
ES198888305444T Expired - Lifetime ES2029019T3 (es) 1987-06-19 1988-06-15 Procedimiento para preparar intermedios para antagonistas de leucotrienos.

Country Status (10)

Country Link
EP (1) EP0295882B1 (es)
JP (1) JPS6416740A (es)
KR (1) KR960002601B1 (es)
AT (1) ATE66453T1 (es)
CA (1) CA1300170C (es)
DE (1) DE3864324D1 (es)
ES (1) ES2029019T3 (es)
GR (1) GR3002593T3 (es)
HU (1) HU202814B (es)
IL (1) IL86748A (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100383215B1 (ko) * 2000-09-25 2003-05-12 한국생명공학연구원 신균주 ｍｔ90049(ｋｃｔｃ 18043ｐ)와 이 균주로부터생산된 신규 화합물과 신규 화합물의 용도

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4661505A (en) * 1982-11-03 1987-04-28 Eli Lilly And Company Leukotriene antagonists
EP0167286A1 (en) * 1984-06-04 1986-01-08 Celanese Corporation Process for producing 4-hydroxyacetophenone

Also Published As

Publication number Publication date
CA1300170C (en) 1992-05-05
IL86748A0 (en) 1988-11-30
HU202814B (en) 1991-04-29
EP0295882A1 (en) 1988-12-21
KR890000390A (ko) 1989-03-14
HUT47235A (en) 1989-02-28
IL86748A (en) 1992-06-21
ATE66453T1 (de) 1991-09-15
KR960002601B1 (ko) 1996-02-23
EP0295882B1 (en) 1991-08-21
GR3002593T3 (en) 1993-01-25
DE3864324D1 (de) 1991-09-26
JPS6416740A (en) 1989-01-20

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