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ES2015349A6 - Metodo para producir anticuerpos inmunologicamente reactivos con angiogenina. - Google Patents

Metodo para producir anticuerpos inmunologicamente reactivos con angiogenina.

Info

Publication number
ES2015349A6
ES2015349A6 ES888802642A ES8802642A ES2015349A6 ES 2015349 A6 ES2015349 A6 ES 2015349A6 ES 888802642 A ES888802642 A ES 888802642A ES 8802642 A ES8802642 A ES 8802642A ES 2015349 A6 ES2015349 A6 ES 2015349A6
Authority
ES
Spain
Prior art keywords
antibody
antibodies
angiogenin
determination
immunotherapeutic agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES888802642A
Other languages
English (en)
Inventor
James W Fett
Bert L Vallee
Edward M Alderman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Harvard University
Original Assignee
Harvard University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harvard University filed Critical Harvard University
Publication of ES2015349A6 publication Critical patent/ES2015349A6/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/808—Materials and products related to genetic engineering or hybrid or fused cell technology, e.g. hybridoma, monoclonal products
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/808—Materials and products related to genetic engineering or hybrid or fused cell technology, e.g. hybridoma, monoclonal products
    • Y10S530/809—Fused cells, e.g. hybridoma
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/828—Cancer
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/868—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving autoimmunity, allergy, immediate hypersensitivity, delayed hypersensitivity, immunosuppression, or immunotolerance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

METODO PARA PRODUCIR ANTICUERPOS INMUNOLOGICAMENTE REACTIVOS CON ANGIONENINA. CONSISTE EN INMUNIZAR UN ANIMAL CON UN PREPARADO INMUNOLOGICO DE ANGIOGENINA PURIFICADA O UN FRAGMENTO DE LA MISMA, RECOGER DESPUES DE LA INMUNIZACION FLUIDOS CORPORALES QUE CONTIENEN ANTICUERPOS, SOMETER A ENSAYO DICHOS FLUIDOS PARA DETERMINAR LA PRESENCIA DE UN ANTICUERPO ESPECIFICO PARA ANGIOGENINA, Y SEPARAR DICHO ANTICUERPO DE DICHOS FLUIDOS PARA PURIFICARLO. LOS ANTICUERPOS OBTENIDOS, UNA VEZ PURIFICADOS, SE PUEDEN INCORPORAR EN VEHICULOS FARMACEUTICAMENTE ACEPTABLES ADECUADOS PARA INYECCION, SIENDO UTILES PARA INHIBIR LA ANGIOGENESIS EN MAMIFEROS.
ES888802642A 1987-08-06 1988-08-26 Metodo para producir anticuerpos inmunologicamente reactivos con angiogenina. Expired - Lifetime ES2015349A6 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/083,231 US4853219A (en) 1987-08-06 1987-08-06 Antibodies to angiogenin: immunotherapeutic agents
PCT/US1988/002590 WO1989000862A1 (en) 1987-08-06 1988-08-05 Antibodies to angiogenin: immunotherapeutic agents

Publications (1)

Publication Number Publication Date
ES2015349A6 true ES2015349A6 (es) 1990-08-16

Family

ID=22177021

Family Applications (1)

Application Number Title Priority Date Filing Date
ES888802642A Expired - Lifetime ES2015349A6 (es) 1987-08-06 1988-08-26 Metodo para producir anticuerpos inmunologicamente reactivos con angiogenina.

Country Status (13)

Country Link
US (1) US4853219A (es)
EP (1) EP0436526B1 (es)
JP (1) JPH02504512A (es)
KR (1) KR920005691B1 (es)
AT (1) ATE133075T1 (es)
AU (1) AU618024B2 (es)
CA (1) CA1341425C (es)
DE (1) DE3854926T2 (es)
DK (1) DK29490A (es)
ES (1) ES2015349A6 (es)
GR (1) GR1000430B (es)
PT (1) PT88314A (es)
WO (1) WO1989000862A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5520914A (en) * 1987-08-06 1996-05-28 President And Fellows Of Harvard College Antibodies to angiogenin: immunotherapeutic agents
FR2623509B1 (fr) * 1987-11-19 1990-04-20 Centre Nat Rech Scient Proteine de 17 kd a action angiogenique, son procede d'isolement a partir de lait de mammiferes, compositions therapeutiques la contenant, procede de detection et/ou de dosage et reactifs immunologiques de detection et de dosage des angiogenines de mammiferes, de leurs homologues et de leurs fragments
US6929907B2 (en) * 1999-12-31 2005-08-16 North Carolina State University Methods and compositions for determining the purity of chemically synthesized nucleic acids
EP1399186B1 (de) 2001-06-13 2009-11-18 Armbruster Biotechnology GmbH Arzneimittel zur behandlung von tumoren und deren metastasen unter verwendung eines bindemoleküls gegen das bone-sialoprotein
WO2007033187A2 (en) * 2005-09-12 2007-03-22 The Regents Of The University Of Michigan Recurrent gene fusions in prostate cancer
EP2010570B8 (en) * 2006-04-10 2015-01-21 Fusion Antibodies Limited Therapy against cathepsin s

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4229531A (en) * 1978-12-29 1980-10-21 Monsanto Company Production of tumor angiogenesis factor by cell culture
US4229532A (en) * 1978-12-29 1980-10-21 Monsanto Company Production of tumor angiogenesis factor by cell culture
US4273871A (en) * 1980-03-03 1981-06-16 Monsanto Company Production of angiogenic factor by cell culture
DE3110560A1 (de) * 1981-03-18 1982-10-14 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen "angiotropine der leukozyten und des entzuendungsgewebes: eine neue klasse natuerlicher chemotropischer mitogene fuer das richtungswachstum von blutgefaessen und zur neovaskularisierung von geweben"
DE3381236D1 (de) * 1982-11-30 1990-04-05 Univ Manchester Produktion von angiogenen faktoren.
US4529590A (en) * 1982-12-27 1985-07-16 Leveen Robert F Production of angiogenetic factor
US4503038A (en) * 1983-02-25 1985-03-05 The Regents Of The University Of California Extracellular nonmitogenic angiogenesis factor and method of isolation thereof from wound fluid
US4699788A (en) * 1984-08-20 1987-10-13 Trustees Of Boston University Angiogenic factor methods of extraction and method for producing angiogenesis
US4727137A (en) * 1985-04-17 1988-02-23 President And Fellows Of Harvard College Purified protein having angiogenic activity and methods of preparation
EP0234545A3 (en) * 1986-02-24 1989-05-24 Clemens Prof. Dr. Sorg Purified human angiogenic factor, method for its preparation and pharmaceutical preparations

Also Published As

Publication number Publication date
DE3854926T2 (de) 1996-05-30
DK29490A (da) 1990-03-30
PT88314A (pt) 1989-06-30
ATE133075T1 (de) 1996-02-15
AU618024B2 (en) 1991-12-12
JPH02504512A (ja) 1990-12-20
DK29490D0 (da) 1990-02-05
EP0436526A1 (en) 1991-07-17
GR1000430B (el) 1992-07-30
US4853219A (en) 1989-08-01
EP0436526B1 (en) 1996-01-17
KR890701130A (ko) 1989-12-19
DE3854926D1 (de) 1996-02-29
WO1989000862A1 (en) 1989-02-09
CA1341425C (en) 2003-03-18
KR920005691B1 (ko) 1992-07-13
EP0436526A4 (en) 1990-08-20
AU2316688A (en) 1989-03-01

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20001102