ES2012129A6 - Un metodo para la obtencion de fragmentos de cd4 humana biologicamenteactivos. - Google Patents
Un metodo para la obtencion de fragmentos de cd4 humana biologicamenteactivos.Info
- Publication number
- ES2012129A6 ES2012129A6 ES8803064A ES8803064A ES2012129A6 ES 2012129 A6 ES2012129 A6 ES 2012129A6 ES 8803064 A ES8803064 A ES 8803064A ES 8803064 A ES8803064 A ES 8803064A ES 2012129 A6 ES2012129 A6 ES 2012129A6
- Authority
- ES
- Spain
- Prior art keywords
- fragments
- soluble human
- uses therefor
- hiv
- lymphocytes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000012634 fragment Substances 0.000 title abstract 4
- 101710091045 Envelope protein Proteins 0.000 abstract 1
- 101100005713 Homo sapiens CD4 gene Proteins 0.000 abstract 1
- 101710188315 Protein X Proteins 0.000 abstract 1
- 102100021696 Syncytin-1 Human genes 0.000 abstract 1
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 1
- 230000003449 preventive effect Effects 0.000 abstract 1
- 230000035755 proliferation Effects 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70514—CD4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Toxicology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Veterinary Medicine (AREA)
- Virology (AREA)
- Cell Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
UN METODO PARA LA OBTENCION DE FRAGMENTOS DE CD4 HUMANA BIOLOGICAMENTE ACTIVOS, CARACTERIZADO PORQUE COMPRENDE LAS ETAPAS DE: A) CONSTRUIR UN PLASMIDO RECOMBINANTE QUE PRODUCE CD4 HUMANA SOLUBLE; B) CONTRASFECTAR EL DNA PLASMIDO RECOMBINANTE CON DNA DE VIRUS DE POLIHEDROSIS NUCLEAR AUTOGRAPHA CALIFORNICA (ACNPV) EN CELULAS DE SPODOPTERA FRUGIPERDA (SF9), LO CUAL SE TRADUCE EN LA RECOMBINACION ENTRE LA SECUENCIA RECOMBINANTE DEL PLASMIDO RECOMBINANTE Y LA SECUENCIA GENETICA DE POLIHEDRINA DE ACNPV; C) SELECCIONAR PLACAS NEGATIVAS A LA OCLUSION; D) CULTIVAR LAS PLACAS NEGATIVAS A LA OCLUSION; Y E) RECOGER EL POLIPEPTIDO PRECIPITADO.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10618587A | 1987-10-08 | 1987-10-08 | |
US14431388A | 1988-01-14 | 1988-01-14 | |
US20658588A | 1988-06-14 | 1988-06-14 | |
US07/217,475 US5109123A (en) | 1988-06-14 | 1988-07-11 | Alteration of ability of soluble CD4 fragments to bind HIV |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2012129A6 true ES2012129A6 (es) | 1990-03-01 |
Family
ID=27493499
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES8803064A Expired - Lifetime ES2012129A6 (es) | 1987-10-08 | 1988-10-07 | Un metodo para la obtencion de fragmentos de cd4 humana biologicamenteactivos. |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP0400010A1 (es) |
JP (1) | JPH03504234A (es) |
AU (1) | AU2614888A (es) |
DK (1) | DK87490A (es) |
ES (1) | ES2012129A6 (es) |
GR (1) | GR1000850B (es) |
IL (1) | IL87902A0 (es) |
NZ (1) | NZ226475A (es) |
WO (1) | WO1989003222A1 (es) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5637677A (en) | 1987-07-16 | 1997-06-10 | The Trustees Of The University Of Pennsylvania | Biologically active compounds and methods of constructing and using the same |
ZA887365B (en) * | 1987-10-02 | 1990-05-30 | Genentech Inc | Adheson variants |
US5206353A (en) * | 1988-07-23 | 1993-04-27 | The United States Of America As Represented By The Department Of Health And Human Services | CD-4/cytotoxic gene fusions |
AU623924B2 (en) * | 1988-07-22 | 1992-05-28 | United States of America, as represented by the Secretary, U.S. Department of Commerce, The | Cytotoxic agent against specific virus infection |
EP0408372A1 (en) * | 1989-07-13 | 1991-01-16 | Smithkline Beecham Corporation | Anti-viral therapy |
JPH05500611A (ja) * | 1989-08-23 | 1993-02-12 | ザ・ジェネラル・ホスピタル・コーポレーション | 非ヒト霊長類cd4ポリペプチド、グリコシル化可能なヒトcd4分子、その断片、その融合タンパク質、その遺伝子配列および使用 |
US5614612A (en) * | 1990-03-09 | 1997-03-25 | Haigwood; Nancy L. | Purified gp120 compositions retaining natural conformation |
JPH0725794B2 (ja) * | 1990-03-23 | 1995-03-22 | 呉羽化学工業株式会社 | 新規なペプチド |
EP0551440B1 (en) * | 1990-09-14 | 2002-12-18 | The Trustees Of The University Of Pennsylvania | Design of bioactive peptides based on immunoglobulin structure |
AU1438592A (en) * | 1991-02-08 | 1992-09-07 | Progenics Pharmaceuticals, Inc. | Cd4-gamma1 and cd4-igg1 chimeras |
US7070991B2 (en) | 1991-02-08 | 2006-07-04 | Progenics Pharmaceuticals, Inc. | Cells expressing a CD4-IgG2 chimeric heterotetramer |
WO1992013947A1 (en) | 1991-02-08 | 1992-08-20 | Progenics Pharmaceuticals, Inc. | CD4-GAMMA2 AND CD4-IgG2 CHIMERAS |
US5234905A (en) * | 1991-02-22 | 1993-08-10 | University Of Colorado Foundation, Inc. | Soluble CD4 molecules modified to prolong circulating half-life |
EP0510483A1 (en) * | 1991-04-22 | 1992-10-28 | Boehringer Ingelheim Pharmaceuticals Inc. | Method for the detection of viruses |
US7935805B1 (en) | 1998-12-31 | 2011-05-03 | Novartis Vaccines & Diagnostics, Inc | Polynucleotides encoding antigenic HIV Type C polypeptides, polypeptides and uses thereof |
AU2487300A (en) | 1998-12-31 | 2000-07-31 | Chiron Corporation | Polynucleotides encoding antigenic hiv type c polypeptides, polypeptides and uses thereof |
AU2596600A (en) | 1998-12-31 | 2000-07-31 | Chiron Corporation | Modified hiv env polypeptides |
US6602705B1 (en) | 1998-12-31 | 2003-08-05 | Chiron Corporation | Expression of HIV polypeptides and production of virus-like particles |
US7211659B2 (en) | 2001-07-05 | 2007-05-01 | Chiron Corporation | Polynucleotides encoding antigenic HIV type C polypeptides, polypeptides and uses thereof |
WO2003020876A2 (en) | 2001-08-31 | 2003-03-13 | Chiron Corporation | Polynucleotides encoding antigenic hiv type b polypeptides, polypeptides and uses thereof |
US20030170614A1 (en) | 2001-08-31 | 2003-09-11 | Megede Jan Zur | Polynucleotides encoding antigenic HIV type B polypeptides, polypeptides and uses thereof |
US20160039904A1 (en) | 2013-03-15 | 2016-02-11 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Serv | Stabilized single human cd4 domains and fusion proteins |
WO2017055522A1 (en) | 2015-09-29 | 2017-04-06 | Academisch Medisch Centrum | Stabilized env proteins of hiv |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0280710B1 (en) * | 1986-08-21 | 1996-03-20 | The Trustees Of Columbia University In The City Of New York | Dna encoding the t cell surface protein t4 and use of fragments of t4 in the treatment of aids |
NZ226414A (en) * | 1987-10-02 | 1992-07-28 | Genentech Inc | Cd4 peptide adhesion variants and their preparation and use |
-
1988
- 1988-10-04 IL IL87902A patent/IL87902A0/xx unknown
- 1988-10-05 AU AU26148/88A patent/AU2614888A/en not_active Abandoned
- 1988-10-05 JP JP63508932A patent/JPH03504234A/ja active Pending
- 1988-10-05 EP EP88909683A patent/EP0400010A1/en not_active Withdrawn
- 1988-10-05 WO PCT/US1988/003454 patent/WO1989003222A1/en not_active Application Discontinuation
- 1988-10-06 NZ NZ226475A patent/NZ226475A/en unknown
- 1988-10-07 GR GR880100675A patent/GR1000850B/el unknown
- 1988-10-07 ES ES8803064A patent/ES2012129A6/es not_active Expired - Lifetime
-
1990
- 1990-04-06 DK DK087490A patent/DK87490A/da not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
GR1000850B (el) | 1993-02-17 |
NZ226475A (en) | 1991-03-26 |
WO1989003222A1 (en) | 1989-04-20 |
JPH03504234A (ja) | 1991-09-19 |
IL87902A0 (en) | 1989-03-31 |
DK87490D0 (da) | 1990-04-06 |
EP0400010A1 (en) | 1990-12-05 |
DK87490A (da) | 1990-06-08 |
AU2614888A (en) | 1989-05-02 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
SA6 | Expiration date (snapshot 920101) |
Free format text: 2008-10-07 |