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ES2004734A6 - Procedimiento de obtencion de conjugados biologicamente activos de metaloproteina-albumina o metaloproteina-albumina-anticuerpos - Google Patents

Procedimiento de obtencion de conjugados biologicamente activos de metaloproteina-albumina o metaloproteina-albumina-anticuerpos

Info

Publication number
ES2004734A6
ES2004734A6 ES8701587A ES8701587A ES2004734A6 ES 2004734 A6 ES2004734 A6 ES 2004734A6 ES 8701587 A ES8701587 A ES 8701587A ES 8701587 A ES8701587 A ES 8701587A ES 2004734 A6 ES2004734 A6 ES 2004734A6
Authority
ES
Spain
Prior art keywords
conjugates
albumin
metalloproteins
derivatives
metalloprotein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8701587A
Other languages
English (en)
Inventor
Romano Deghenghi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Debiopharm SA
Original Assignee
Debiopharm SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Debiopharm SA filed Critical Debiopharm SA
Publication of ES2004734A6 publication Critical patent/ES2004734A6/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0089—Oxidoreductases (1.) acting on superoxide as acceptor (1.15)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1075—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of amino acids or peptide residues
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Public Health (AREA)
  • Toxicology (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

PROCEDIMIENTO DE OBTENCION DE CONJUGADOS BIOLOGICAMENTE ACTIVOS DE METALOPROTEINA-ALBUMINA O METALOPROTEINA-ALBUMINA-ANTICUERPOS, QUE COMPRENDE RETICULAR UNA APOPROTEINA LIBRE DE METALES POR MEDIO DE UN AGENTE RETICULANTE EN PRESENCIA DE ALBUMINA HUMANA Y FACULTATIVAMENTE UN FRAGMENTO DE ANTICUERPO, PURIFICAR DICHOS CONJUGADOS LIBRES DE METALES Y RECONSTITUIR LA ACTIVIDAD BIOLOGICA AÑADIENDO LOS METALES DESEADOS A DICHOS CONJUGADOS. EL PROCEDIMIENTO PERMITE LA OBTENCION DE LOS MENCIONADOS CONJUGADOS CON ELEVADO RENDIMIENTO Y SIN PERDIDA DE ACTIVIDAD BIOLOGICA. LOS CONJUGADOS NUEVOS OBTENIDOS CON EL PROCEDIMIENTO SON PARTICULARMENTE UTILES PARA DIRIGIR LA METALOPROTEINA A UN TEJIDO U ORGANO ESPECIFICO, CON FINES TERAPEUTICOS.
ES8701587A 1986-06-02 1987-05-29 Procedimiento de obtencion de conjugados biologicamente activos de metaloproteina-albumina o metaloproteina-albumina-anticuerpos Expired ES2004734A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8613315A GB2191200B (en) 1986-06-02 1986-06-02 Process for preparing conjugates of metalloproteins and novel derivatives thereof

Publications (1)

Publication Number Publication Date
ES2004734A6 true ES2004734A6 (es) 1989-02-01

Family

ID=10598769

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8701587A Expired ES2004734A6 (es) 1986-06-02 1987-05-29 Procedimiento de obtencion de conjugados biologicamente activos de metaloproteina-albumina o metaloproteina-albumina-anticuerpos

Country Status (10)

Country Link
JP (1) JPS62292800A (es)
BE (1) BE1002130A3 (es)
CH (1) CH674939A5 (es)
DE (1) DE3718476A1 (es)
DK (1) DK280187A (es)
ES (1) ES2004734A6 (es)
FR (1) FR2603287B1 (es)
GB (1) GB2191200B (es)
IT (1) IT1207805B (es)
NL (1) NL8701254A (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014133377A3 (es) * 2013-02-27 2014-11-27 Universidad Autonoma Del Estado De Morelos Composiciones que comprenden immp para coadyuvar al desarrollo, crecimiento y mejora de los parámetros productivos de animales de interés zootécnico, y uso de las mismas

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1317895B1 (it) * 2000-08-10 2003-07-15 Univ Napoli Federico Ii Pseudo-metalloproteine, loro preparazione e loro uso.

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1168150A (en) * 1981-12-18 1984-05-29 The Governors Of The University Of Alberta Targeting conjugates of albumin and therapeutic agents

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014133377A3 (es) * 2013-02-27 2014-11-27 Universidad Autonoma Del Estado De Morelos Composiciones que comprenden immp para coadyuvar al desarrollo, crecimiento y mejora de los parámetros productivos de animales de interés zootécnico, y uso de las mismas

Also Published As

Publication number Publication date
FR2603287B1 (fr) 1991-02-08
DE3718476A1 (de) 1987-12-03
GB2191200A (en) 1987-12-09
DK280187A (da) 1987-12-03
IT8705187A0 (it) 1987-06-01
CH674939A5 (es) 1990-08-15
FR2603287A1 (fr) 1988-03-04
JPS62292800A (ja) 1987-12-19
GB8613315D0 (en) 1986-07-09
IT1207805B (it) 1989-06-01
NL8701254A (nl) 1988-01-04
DK280187D0 (da) 1987-06-01
BE1002130A3 (fr) 1990-07-24
GB2191200B (en) 1990-07-11

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Legal Events

Date Code Title Description
SA6 Expiration date (snapshot 920101)

Free format text: 2007-05-29

FD1A Patent lapsed

Effective date: 19981103