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EP4676956A2 - Anti-stammzellenfaktor (scf)- und anti-thymische stromalymphopoietin (tslp)-antikörper und bispezifische konstrukte - Google Patents

Anti-stammzellenfaktor (scf)- und anti-thymische stromalymphopoietin (tslp)-antikörper und bispezifische konstrukte

Info

Publication number
EP4676956A2
EP4676956A2 EP24716533.5A EP24716533A EP4676956A2 EP 4676956 A2 EP4676956 A2 EP 4676956A2 EP 24716533 A EP24716533 A EP 24716533A EP 4676956 A2 EP4676956 A2 EP 4676956A2
Authority
EP
European Patent Office
Prior art keywords
seq
nos
antibody
amino acid
set forth
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP24716533.5A
Other languages
English (en)
French (fr)
Inventor
Tibor Keler
Diego ALVARADO
Joel Goldstein
Laura A. Vitale
Michael Murphy
Lawrence J. Thomas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Celldex Therapeutics Inc
Original Assignee
Celldex Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celldex Therapeutics Inc filed Critical Celldex Therapeutics Inc
Publication of EP4676956A2 publication Critical patent/EP4676956A2/de
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
EP24716533.5A 2023-03-03 2024-03-01 Anti-stammzellenfaktor (scf)- und anti-thymische stromalymphopoietin (tslp)-antikörper und bispezifische konstrukte Pending EP4676956A2 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US202363488388P 2023-03-03 2023-03-03
US202363452326P 2023-03-15 2023-03-15
US202363465970P 2023-05-12 2023-05-12
PCT/US2024/018068 WO2024186635A2 (en) 2023-03-03 2024-03-01 Anti-stem cell factor (scf) and anti-thymic stromal lymphopoietin (tslp) antibodies and bispecific constructs

Publications (1)

Publication Number Publication Date
EP4676956A2 true EP4676956A2 (de) 2026-01-14

Family

ID=90718280

Family Applications (1)

Application Number Title Priority Date Filing Date
EP24716533.5A Pending EP4676956A2 (de) 2023-03-03 2024-03-01 Anti-stammzellenfaktor (scf)- und anti-thymische stromalymphopoietin (tslp)-antikörper und bispezifische konstrukte

Country Status (7)

Country Link
EP (1) EP4676956A2 (de)
KR (1) KR20250167153A (de)
CN (1) CN121219315A (de)
AU (1) AU2024233763A1 (de)
IL (1) IL323100A (de)
MX (1) MX2025010335A (de)
WO (1) WO2024186635A2 (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN120399078A (zh) * 2025-05-08 2025-08-01 上海天泽云泰生物医药有限公司 靶向cd117的纳米抗体及其应用

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Also Published As

Publication number Publication date
CN121219315A (zh) 2025-12-26
KR20250167153A (ko) 2025-11-28
MX2025010335A (es) 2025-10-01
WO2024186635A2 (en) 2024-09-12
AU2024233763A1 (en) 2025-10-16
IL323100A (en) 2025-11-01
WO2024186635A3 (en) 2024-10-24

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