EP4234566A4 - Modifiziertes nukleosid oder nukleotid - Google Patents
Modifiziertes nukleosid oder nukleotid Download PDFInfo
- Publication number
- EP4234566A4 EP4234566A4 EP21882101.5A EP21882101A EP4234566A4 EP 4234566 A4 EP4234566 A4 EP 4234566A4 EP 21882101 A EP21882101 A EP 21882101A EP 4234566 A4 EP4234566 A4 EP 4234566A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- nucleotide
- modified nucleoside
- nucleoside
- modified
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000002777 nucleoside Substances 0.000 title 1
- 150000003833 nucleoside derivatives Chemical class 0.000 title 1
- 239000002773 nucleotide Chemical class 0.000 title 1
- 125000003729 nucleotide group Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2535/00—Reactions characterised by the assay type for determining the identity of a nucleotide base or a sequence of oligonucleotides
- C12Q2535/122—Massive parallel sequencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
- C12Q2563/107—Nucleic acid detection characterized by the use of physical, structural and functional properties fluorescence
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Saccharide Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202011134947 | 2020-10-21 | ||
PCT/CN2021/125262 WO2022083686A1 (zh) | 2020-10-21 | 2021-10-21 | 修饰的核苷或核苷酸 |
Publications (2)
Publication Number | Publication Date |
---|---|
EP4234566A1 EP4234566A1 (de) | 2023-08-30 |
EP4234566A4 true EP4234566A4 (de) | 2024-12-11 |
Family
ID=81289694
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP21882101.5A Pending EP4234566A4 (de) | 2020-10-21 | 2021-10-21 | Modifiziertes nukleosid oder nukleotid |
Country Status (8)
Country | Link |
---|---|
US (1) | US20240067673A1 (de) |
EP (1) | EP4234566A4 (de) |
JP (1) | JP2023546741A (de) |
KR (1) | KR20230107259A (de) |
CN (1) | CN116507736A (de) |
AU (1) | AU2021363336A1 (de) |
CA (1) | CA3199278A1 (de) |
WO (1) | WO2022083686A1 (de) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN115197290B (zh) * | 2021-04-01 | 2025-03-07 | 深圳华大生命科学研究院 | 用于测序的核苷酸类似物 |
WO2024123866A1 (en) * | 2022-12-09 | 2024-06-13 | Illumina, Inc. | Nucleosides and nucleotides with 3´ blocking groups and cleavable linkers |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1994023064A1 (fr) * | 1993-03-26 | 1994-10-13 | Institut Pasteur | Nouveaux derives utilisables en sequençage d'acides nucleiques |
WO1996007669A1 (en) * | 1994-09-02 | 1996-03-14 | Rose-Hiatt Biotechnology Partnership | Compositions for enzyme catalyzed template-independent creation of phosphodiester bonds using protected nucleotides |
WO2002029003A2 (en) * | 2000-10-06 | 2002-04-11 | The Trustees Of Columbia University In The City Of New York | Massive parallel method for decoding dna and rna |
WO2020159447A1 (en) * | 2019-01-31 | 2020-08-06 | Agency For Science, Technology And Research | Method of synthesizing single-stranded nucleotide sequence, blocked nucleoside triphosphates and related methods |
WO2021067970A1 (en) * | 2019-10-04 | 2021-04-08 | Centrillion Technologies, Inc. | Reversible terminators for dna sequencing and methods of using the same |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008037568A2 (en) * | 2006-09-04 | 2008-04-03 | Quiatech Ab | Reversible terminators for efficient sequencing by synthesis |
US8603741B2 (en) * | 2010-02-18 | 2013-12-10 | Pacific Biosciences Of California, Inc. | Single molecule sequencing with two distinct chemistry steps |
KR102230831B1 (ko) * | 2013-03-15 | 2021-03-22 | 일루미나 케임브리지 리미티드 | 변형된 뉴클레오사이드 또는 뉴클레오타이드 |
CN109983136B (zh) * | 2016-12-13 | 2022-07-22 | 深圳华大智造科技股份有限公司 | 提纯可逆阻断脱氧核糖核苷三磷酸的方法和测序方法 |
IL267836B2 (en) | 2017-01-04 | 2023-09-01 | Complete Genomics Inc | Stepwise sequence determination by unlabeled reversible terminations or natural nucleotides |
WO2019071474A1 (zh) * | 2017-10-11 | 2019-04-18 | 深圳华大智造科技有限公司 | 修饰的核苷或核苷酸 |
-
2021
- 2021-10-21 EP EP21882101.5A patent/EP4234566A4/de active Pending
- 2021-10-21 CA CA3199278A patent/CA3199278A1/en active Pending
- 2021-10-21 KR KR1020237017194A patent/KR20230107259A/ko active Pending
- 2021-10-21 WO PCT/CN2021/125262 patent/WO2022083686A1/zh active Application Filing
- 2021-10-21 US US18/033,037 patent/US20240067673A1/en active Pending
- 2021-10-21 AU AU2021363336A patent/AU2021363336A1/en active Pending
- 2021-10-21 JP JP2023548993A patent/JP2023546741A/ja active Pending
- 2021-10-21 CN CN202180071993.XA patent/CN116507736A/zh active Pending
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1994023064A1 (fr) * | 1993-03-26 | 1994-10-13 | Institut Pasteur | Nouveaux derives utilisables en sequençage d'acides nucleiques |
WO1996007669A1 (en) * | 1994-09-02 | 1996-03-14 | Rose-Hiatt Biotechnology Partnership | Compositions for enzyme catalyzed template-independent creation of phosphodiester bonds using protected nucleotides |
WO2002029003A2 (en) * | 2000-10-06 | 2002-04-11 | The Trustees Of Columbia University In The City Of New York | Massive parallel method for decoding dna and rna |
WO2020159447A1 (en) * | 2019-01-31 | 2020-08-06 | Agency For Science, Technology And Research | Method of synthesizing single-stranded nucleotide sequence, blocked nucleoside triphosphates and related methods |
WO2021067970A1 (en) * | 2019-10-04 | 2021-04-08 | Centrillion Technologies, Inc. | Reversible terminators for dna sequencing and methods of using the same |
Non-Patent Citations (2)
Title |
---|
CANARD BRUNO ET AL: "DNA polymerase fluorescent substrates with reversible 3'-tags", GENE 148 (1994), 2 June 1994 (1994-06-02), pages 1 - 6, XP093216361, DOI: https://doi.org/10.1016/0378-1119(94)90226-7 * |
See also references of WO2022083686A1 * |
Also Published As
Publication number | Publication date |
---|---|
US20240067673A1 (en) | 2024-02-29 |
KR20230107259A (ko) | 2023-07-14 |
CN116507736A (zh) | 2023-07-28 |
JP2023546741A (ja) | 2023-11-07 |
CA3199278A1 (en) | 2022-04-28 |
AU2021363336A9 (en) | 2024-09-05 |
WO2022083686A1 (zh) | 2022-04-28 |
AU2021363336A1 (en) | 2023-05-18 |
EP4234566A1 (de) | 2023-08-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE |
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PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
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STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE |
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17P | Request for examination filed |
Effective date: 20230516 |
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AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR |
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DAV | Request for validation of the european patent (deleted) | ||
DAX | Request for extension of the european patent (deleted) | ||
RIC1 | Information provided on ipc code assigned before grant |
Ipc: C12Q 1/68 20180101ALI20240522BHEP Ipc: C07H 19/10 20060101AFI20240522BHEP |
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A4 | Supplementary search report drawn up and despatched |
Effective date: 20241111 |
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RIC1 | Information provided on ipc code assigned before grant |
Ipc: C12Q 1/68 20180101ALI20241105BHEP Ipc: C07H 19/20 20060101ALI20241105BHEP Ipc: C07H 19/10 20060101AFI20241105BHEP |