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EP4045013A4 - Extracellular vesicle-based agents and methods for the treatment of neuropathic disorders - Google Patents

Extracellular vesicle-based agents and methods for the treatment of neuropathic disorders Download PDF

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Publication number
EP4045013A4
EP4045013A4 EP20877525.4A EP20877525A EP4045013A4 EP 4045013 A4 EP4045013 A4 EP 4045013A4 EP 20877525 A EP20877525 A EP 20877525A EP 4045013 A4 EP4045013 A4 EP 4045013A4
Authority
EP
European Patent Office
Prior art keywords
treatment
methods
extracellular vesicle
based agents
neuropathic disorders
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP20877525.4A
Other languages
German (de)
French (fr)
Other versions
EP4045013A1 (en
Inventor
Deok-Ho Kim
Changho CHUN
Alexander Smith
Minjae DO
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Washington
Johns Hopkins University
Original Assignee
University of Washington
Johns Hopkins University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Washington, Johns Hopkins University filed Critical University of Washington
Publication of EP4045013A1 publication Critical patent/EP4045013A1/en
Publication of EP4045013A4 publication Critical patent/EP4045013A4/en
Pending legal-status Critical Current

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    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0619—Neurons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K38/18—Growth factors; Growth regulators
    • A61K38/185—Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
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    • C12N5/0618—Cells of the nervous system
    • C12N5/0622—Glial cells, e.g. astrocytes, oligodendrocytes; Schwann cells
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    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/08—Coculture with; Conditioned medium produced by cells of the nervous system
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
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  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Neurosurgery (AREA)
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  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
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  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
EP20877525.4A 2019-10-16 2020-10-16 Extracellular vesicle-based agents and methods for the treatment of neuropathic disorders Pending EP4045013A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962916208P 2019-10-16 2019-10-16
PCT/US2020/056092 WO2021076973A1 (en) 2019-10-16 2020-10-16 Extracellular vesicle-based agents and methods for the treatment of neuropathic disorders

Publications (2)

Publication Number Publication Date
EP4045013A1 EP4045013A1 (en) 2022-08-24
EP4045013A4 true EP4045013A4 (en) 2024-02-21

Family

ID=75538393

Family Applications (1)

Application Number Title Priority Date Filing Date
EP20877525.4A Pending EP4045013A4 (en) 2019-10-16 2020-10-16 Extracellular vesicle-based agents and methods for the treatment of neuropathic disorders

Country Status (5)

Country Link
US (1) US20230075630A1 (en)
EP (1) EP4045013A4 (en)
JP (1) JP2022552408A (en)
KR (1) KR20220131513A (en)
WO (1) WO2021076973A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021505193A (en) * 2017-12-04 2021-02-18 ザ アドミニストレイターズ オブ ザ テューレイン エデュケイショナル ファンド Cellular systems using spheroids and their manufacturing and usage methods
US20230050813A1 (en) 2020-01-13 2023-02-16 Carmine Therapeutics Pte. Ltd. Nucleic acid loaded red blood cell extracellular vesicles
CN117320733A (en) * 2021-05-04 2023-12-29 Se生物制药股份有限公司 Composition for promoting nerve regeneration containing extracellular vesicles derived from three-dimensional spheroidal cell aggregates
WO2024025809A1 (en) * 2022-07-23 2024-02-01 Carmine Therapeutics Pte. Ltd. Cns delivery
JP7406059B1 (en) 2022-10-20 2023-12-27 防衛装備庁長官 How to generate data for acute stress assessment
AR130856A1 (en) * 2022-10-26 2025-01-29 Consejo Nacional De Investigaciones Cientificas Y Tecn Conicet COMPOSITION OF EXTRACELLULAR VESICLES
US20240269189A1 (en) * 2022-12-19 2024-08-15 FUJIFILM Holdings America Corporation Extracellular vesicle-enriched secretome composition derived from induced pluripotent stem cell derived-microglia and methods of use thereof

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EP2885414B1 (en) * 2012-08-15 2020-09-23 The University of Chicago Exosome-based therapeutics against neurodegenerative disorders
WO2016187717A1 (en) * 2015-05-26 2016-12-01 Exerkine Corporation Exosomes useful for genome editing
ITUB20155765A1 (en) * 2015-11-20 2017-05-20 Braindtech S R L Methods for diagnosis, prognosis and therapeutic monitoring of neurological, neurodegenerative and inflammatory pathologies based on microRNA contained in microglia microscopy
US20200341011A1 (en) * 2017-11-17 2020-10-29 Edward J. Goetzl Astrocyte exosome complement-based assay for neuroinflammation in alzheimer's disease and uses thereof

Patent Citations (1)

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US20170073382A1 (en) * 2015-09-11 2017-03-16 Nomadogen Biotechnologies Inc. Methods and Compositions For The Packaging of Nucleic Acids Into Microglial Exosomes For The Targeted Expression of Polypeptides in Neural Cells

Non-Patent Citations (9)

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Title
AMRITA DATTA CHAUDHURI ET AL: "Stimulus-dependent modifications in astrocyte-derived extracellular vesicle cargo regulate neuronal excitability", GLIA, WILEY-LISS, INC, US, vol. 68, no. 1, 30 August 2019 (2019-08-30), pages 128 - 144, XP071753066, ISSN: 0894-1491, DOI: 10.1002/GLIA.23708 *
FRÖHLICH DOMINIK ET AL: "Multifaceted effects of oligodendroglial exosomes on neurons: impact on neuronal firing rate, signal transduction and gene regulation", PHILOSOPHICAL TRANSACTIONS. ROYAL SOCIETY OF LONDON. B: BIOLOGICAL SCIENCES., vol. 369, no. 1652, 26 September 2014 (2014-09-26), GB, pages 20130510, XP093086974, ISSN: 0962-8436, Retrieved from the Internet <URL:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142031/pdf/rstb20130510.pdf> DOI: 10.1098/rstb.2013.0510 *
HONGQI XIN ET AL: "Secondary Release of Exosomes from Astrocytes Contributes to the Increase in Neural Plasticity and Improvement of Functional Recovery after Stroke in Rats Treated with Exosomes Harvested from MicroRNA 133b-Overexpressing Multipotent Mesenchymal Stromal Cells", CELL TRANSPLANTATION, vol. 26, no. 2, 1 February 2017 (2017-02-01), US, pages 243 - 257, XP055649765, ISSN: 0963-6897, DOI: 10.3727/096368916X693031 *
KATHRIN GUITART ET AL: "Improvement of neuronal cell survival by astrocyte-derived exosomes under hypoxic and ischemic conditions depends on prion protein", GLIA, WILEY-LISS, INC, US, vol. 64, no. 6, 16 March 2016 (2016-03-16), pages 896 - 910, XP071740230, ISSN: 0894-1491, DOI: 10.1002/GLIA.22963 *
LAFOURCADE CARLOS ET AL: "MIRNAS in Astrocyte-Derived Exosomes as Possible Mediators of Neuronal Plasticity : Supplementary Issue: Brain Plasticity and Repair", JOURNAL OF EXPERIMENTAL NEUROSCIENCE, vol. 10s1, 1 January 2016 (2016-01-01), XP093086849, ISSN: 1179-0695, Retrieved from the Internet <URL:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4978198/pdf/jen-suppl.1-2016-001.pdf> DOI: 10.4137/JEN.S39916 *
MURPHY DANIEL E. ET AL: "Extracellular vesicle-based therapeutics: natural versus engineered targeting and trafficking", EXPERIMENTAL & MOLECULAR MEDICINE, vol. 51, no. 3, 1 March 2019 (2019-03-01), pages 32, XP055844692, Retrieved from the Internet <URL:https://www.nature.com/articles/s12276-019-0223-5.pdf> DOI: 10.1038/s12276-019-0223-5 *
NECKLES VICTORIA N. ET AL: "A transgenic inducible GFP extracellular-vesicle reporter (TIGER) mouse illuminates neonatal cortical astrocytes as a source of immunomodulatory extracellular vesicles", SCIENTIFIC REPORTS, vol. 9, no. 1, 28 February 2019 (2019-02-28), XP093087398, Retrieved from the Internet <URL:https://www.nature.com/articles/s41598-019-39679-0> DOI: 10.1038/s41598-019-39679-0 *
See also references of WO2021076973A1 *
YOU YANG ET AL: "Emerging roles of extracellular vesicles in neurodegenerative disorders", NEUROBIOLOGY OF DISEASE, ELSEVIER, AMSTERDAM, NL, vol. 130, 20 June 2019 (2019-06-20), XP085795864, ISSN: 0969-9961, [retrieved on 20190620], DOI: 10.1016/J.NBD.2019.104512 *

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Publication number Publication date
JP2022552408A (en) 2022-12-15
KR20220131513A (en) 2022-09-28
EP4045013A1 (en) 2022-08-24
WO2021076973A1 (en) 2021-04-22
US20230075630A1 (en) 2023-03-09

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