EP4043004A1 - Hygienic gel with skin care effect and antimicrobial effect - Google Patents

Abstract

Hygiene gel with skin-care effect and antimicrobial activity, containing- 5 to 35% by weight alcohol, the alcohol having 1 to 4 carbon atoms;- at least 0.3% by weight humectant, the humectant being selected from the group consisting of glycerol , propylene glycol, butane-1,2-diol, butane-1,3-diol, and combinations thereof; and- a moisturizing system containing isopropyl palmitate, myristyl alcohol and 2-octyldodecanol as compounds with moisturizing properties;wherein the hygiene gel has a viscosity of 115 mPa s to 450 mPa s, measured with a DIN measuring system 33 according to ISO 53019 at a temperature of 293.15 K and with a speed of 500 r/min.

Description

The invention relates to a hygiene gel with a skin care effect and antimicrobial activity. Furthermore, the invention also relates to a method for cleaning skin and the use of the hygiene gel for cleaning skin.

Especially nowadays, when our lives are shaped in so many areas by the COVID-19 pandemic, it has become a habit for a large part of the population to eat several times a day, for example after visiting public facilities, shopping in the supermarket or Disinfect your hands with disinfectant when using public transport. Disinfectants effectively eliminate pathogens on the skin and surfaces, thereby minimizing the risk of infection. However, frequent or regular use of disinfectants on the skin also has the disadvantage that the skin's natural protective layer is attacked.

In this respect, it is important to care for the skin attacked by disinfectants through regular use of skin care products and thus to rebuild a damaged protective layer.

In order to also protect the skin, it is also important to only use disinfectants when their use is really necessary or sensible. For example, in the private sphere, e.g. when changing a child's diaper, it is of course important that the hands are as free as possible of pathogenic germs. However, there is no indication for the use of hard disinfectants, this would be disproportionate as the skin would be unnecessarily damaged, especially if used regularly.

the EP 1 056 338 A1 describes disinfectant gels with a low alcohol content, which also contain biocidal active ingredients such as triclosan (Irgasan ^® DP-300 (Ciba)), phenoxyethanol, chlorhexidine gluconate, povidone iodine, iodophor, benzalkonium chloride, benzethonium chloride and cresol.

the CN111050552A describes antimicrobial compositions containing 18% by weight alcohol as well as organic acids and parabens, which are no longer desirable today.

the DE 10 2018 120 717 A1 describes a composition with a disinfecting effect which contains at least 45% by weight alcohol, at least 0.3% by weight humectant and preferably a moisturizing system made from isopropyl palmitate, myristyl alcohol and octyldodecanol.

Other disinfectants with a significantly higher alcohol content are in the DE 10 2016 113 210 A1 , in the EP 3 205 211 A1 as well as in the U.S. 4,956,170 disclosed.

object of the invention

It is the object of the present invention to provide an alternative biocide-free hygiene gel, in particular for use in the private sector, which is characterized by a skin-care effect and good antimicrobial effectiveness, which is preferably directed against viruses, bacteria and fungi.

General Description of the Invention

• 5 bis 35 Gew.-% Alkohol, wobei der Alkohol 1 bis 4 Kohlenstoffatome aufweist;
• zumindest 0,3 Gew.-% Feuchthaltemittel, wobei das Feuchthaltemittel aus der Gruppe ausgewählt ist, die Glycerin, Propylenglycol, Butan-1,2-diol, Butan-1,3-diol und Kombinationen dieser umfasst; und
• ein Rückfettersystem, das Isopropylpalmitate, Myristylalkohol und 2-Octyldodecanol als Verbindungen mit rückfettenden Eigenschaften enthält.

The invention solves this problem with the features of the claims and in particular with a hygiene gel with a skin-care effect and antimicrobial activity, which contains the following ingredients:

• 5 to 35% by weight alcohol, the alcohol having 1 to 4 carbon atoms;
• at least 0.3% by weight humectant, wherein the humectant is selected from the group consisting of glycerin, propylene glycol, butane-1,2-diol, butane-1,3-diol, and combinations thereof; and
• a moisturizing system containing isopropyl palmitate, myristyl alcohol and 2-octyldodecanol as components with moisturizing properties.

For the purposes of the invention, a “hygiene level” is a liquid composition with a viscosity of 115 mPas to 450 mPas, measured with a DIN measuring system 33 according to ISO 53019 at a temperature of 293.15 K and with a number of revolutions of 500 r/min, the composition having a hygienic effect, in particular an antimicrobial effect.

An antimicrobial activity is understood to mean, in particular, an activity against viruses, bacteria and/or fungi.

According to the invention, the hygiene gel has a viscosity of 115 mPas to 450 mPas, preferably 200 mPas to 400 mPas and particularly preferably 250 mPas to 350 mPas, measured in each case with a DIN measuring system 33 according to ISO 53019 at a temperature of 293.15 K and with a speed of 500 r/min. Due to its gel-like consistency, the hygiene gel is particularly pleasant to use, because it can be easily applied to the skin, especially the hands, and rubbed in there without the addition of water or cloths until the drying time. Unlike disinfectants, which have a lower viscosity and where a small proportion is often lost during use, since the low-viscosity agent easily runs off the hands, the hygiene gel according to the invention remains on the skin surface even when the hand is tilted due to its higher viscosity, so that the All of the hygiene gel applied to the skin surface can be used to clean hands without wasting it.

In contrast to conventional disinfectants, the hygiene gel according to the invention is also characterized by its low alcohol content, which makes a significant contribution to the skin not drying out excessively, even with regular use. While other compositions known from the prior art, which also have a low alcohol content, achieve sufficient effectiveness only with the addition of biocidal ingredients, it was surprisingly found that a completely biocide-free hygiene gel with a low alcohol content according to the invention in combination with a moisturizing system made from isopropyl palmitate, myristyl alcohol and 2-octyldodecanol and at least one humectant has both excellent skin care properties and good antimicrobial effectiveness. The antimicrobial effectiveness is expressed in a very good reduction in the number of germs, which does not correspond to a reduction in the number of germs achieved by classic disinfectants, but is completely sufficient for areas in which this is not even necessary, especially in the private sector. The application of the hygiene gel according to the invention, which preferably has a drying time of a few seconds when rubbed on the skin, therefore enables hygienic cleaning and simultaneous care of the skin to which it is applied.

The alcohol contained in the hygiene gel according to the invention is preferably selected from the group comprising methanol, ethanol, propanol, isopropanol, butanol, isobutanol and mixtures of these. According to the invention, the proportion of alcohol in the hygiene gel is 5 to 35% by weight, in particular 10 to 30% by weight, preferably 10 to 25% by weight and particularly preferably 10 to 20% by weight.

For the purposes of the invention, a humectant is understood as meaning compounds which increase the moisture content of the skin. At least 0.3% by weight of humectants are contained in the hygiene gel according to the invention. In particular, the proportion of humectant in the hygiene gel is 0.3 to 3.5% by weight, preferably 0.4 to 3.0% by weight, more preferably 0.5 to 2.0% by weight and particularly preferably 0 .5 to 1.2% by weight. One or more compounds in any combination from the group comprising glycerol, propylene glycol, butane-1,2-diol and butane-1,3-diol can be contained as humectants in the hygiene gel according to the invention.

The hygiene gel according to the invention also contains a moisturizing system which contains isopropyl palmitate, myristyl alcohol and 2-octyldodecanol as compounds with moisturizing properties. A "moisturizing system" is understood to mean a combination of different compounds with moisturizing properties, a compound with moisturizing properties being understood for the purposes of the invention as meaning a compound which counteracts the degreasing character of a formulation.

The above-mentioned moisturizing system made from isopropyl palmitate, myristyl alcohol and 2-octyldodecanol has proven to be optimal for providing a hygiene gel that also contains a humectant, even with a comparatively low alcohol content antimicrobial effectiveness on the one hand and a good skin care effect on the other hand.

In addition to the aforementioned moisturizing system, the hygiene gel according to the invention can optionally contain one or more other compounds with moisturizing properties selected from the group consisting of PEG-7 glyceryl cocoate, dicaprylyl ether, lanolin, sorbitan sesquicaprylate, isopropyl myristate, polyglyceryl-4 comprises or consists of caprate, caprylic/capric triglyceride, cetearyl ethylhexanoate, glyceryl laurate and combinations thereof.

The total proportion of the moisturizing system of isopropyl palmitate, myristyl alcohol and 2-octyldodecanol and optionally other compounds with moisturizing properties in the hygiene gel according to the invention is preferably 0.3 to 10.0% by weight, in particular 0.5 to 5.0% by weight and more preferably 2.0 to 3.5% by weight.

In the particularly preferred embodiment, in which the total proportion of the moisturizing system of isopropyl palmitate, myristyl alcohol and 2-octyldodecanol and optionally other compounds with moisturizing properties is 2.0 to 3.5% by weight, it is preferred that isopropyl palmitate, myristyl alcohol and 2 -Octyldodecanol are each contained at least 0.5 wt .-% in the hygiene gel according to the invention.

A humectant that is preferably contained in the hygiene gel according to the invention is glycerin, the content of which is largely responsible for the skin care properties of the hygiene gel. While from the prior art, such as in the WO 2018/015182 A1 mentioned, it is known that glycerin should weaken the antimicrobial properties of a composition, it was found within the scope of the present invention that the use of a combination of glycerin, the moisturizing system of isopropyl palmitate, myristyl alcohol and 2-octyldodecanol and the low compared to classic disinfectants Alcohol content provides a hygiene gel with high antimicrobial effectiveness and skin care effect.

According to a particularly preferred embodiment, the hygiene gel according to the invention therefore comprises or consists of glycerol, isopropyl palmitate, 2-octyldodecanol, myristyl alcohol, water and one or more alcohols having 1 to 4 carbon atoms, preferably ethanol.

Optionally, the hygiene gel according to the invention also contains one or more thickeners, for example xanthan gum and/or konjac gum. Film formers, e.g. Amorphophallus Konjac Root Extract, preservatives, e.g. citric acid, and/or perfume can be contained in the hygiene gel according to the invention as further possible ingredients.

The composition also optionally contains additional skin care agents, such as urea, dexpanthenol, witch hazel, bisabolol and/or allantoin, with these additional skin care agents in particular having a content of up to 0.9% by weight in the hygiene gel according to the invention.

The invention also relates to a method for cleansing skin, in which the skin is contacted with the hygiene gel according to the invention, which is preferably distributed on the skin surface by rubbing until it dries. Due to the good skin care effect and antimicrobial effectiveness, the hygiene gel according to the invention is particularly suitable for use in the private sector, for example in the context of baby and toddler care.

Accordingly, the invention also relates to the use of the hygiene gel according to the invention for cleaning skin, especially hands.

Detailed description of the invention

The invention will now be described in more detail using exemplary embodiments.

Example 1 Production of a hygiene gel according to the invention with a skin care and antimicrobial effect

For the production of a first hygiene gel according to the invention with a skin-care and antimicrobial effect, the following ingredients listed in Table 1 were mixed in the weight proportions also indicated to form a homogeneous liquid composition (hygiene gel A). Tab. 1: Ingredients of the hygiene gel according to the invention (hygiene gel A) ingredient Proportion /[% by weight] water ad 100 glycerin 0.70 isopropyl palmitates 1.00 myristyl alcohol 1.00 2-octyldodecanol 0.80 alcohol denat. 10.00 - 20.00 Xanthan Gum 1.0 Amorphophallus Konjac Root Extract 0.1 Citric Acid Monohydrate 0.05

For the production of a second hygiene gel according to the invention with a skin-care and antimicrobial effect, the following ingredients listed in Table 2 were mixed in the proportions by weight also indicated to form a homogeneous liquid composition (hygiene gel B). Tab. 2: Ingredients of the hygiene gel according to the invention (hygiene gel B) ingredient Proportion /[% by weight] water ad 100 glycerin 0.70 isopropyl palmitates 1.00 myristyl alcohol 1.00 2-octyldodecanol 0.80 alcohol denat. 10.00-20.00 Xanthan Gum 1.0 Amorphophallus Konjac Root Extract 0.1 Citric Acid Monohydrate 0.05 Perfume 0.1

For the production of a third hygiene gel according to the invention with a skin-care and antimicrobial effect, which in addition to the moisturizing system according to the invention also contained dicaprylyl ether as a further moisturizing agent, the following ingredients listed in Table 3 were mixed in the proportions by weight also indicated to form a homogeneous liquid composition (hygiene gel C). . Tab. 3: Ingredients of the hygiene gel according to the invention (hygiene gel C) ingredient Proportion /[% by weight] water ad 100 glycerin 0.70 isopropyl palmitates 1.00 myristyl alcohol 1.00 2-octyldodecanol 0.80 dicaprylyl ether 1.00 Ethanol 99% Denatured 1% MEK 20.00 Xanthan Gum 1.0 Konjac Gum 0.1 Citric Acid Monohydrate 0.05

All three hygiene gels A, B and C were produced by first producing two phases A and B each. Phase A contained water and thickener, i.e. xanthan gum in the case of hygiene gel A and B and xanthan gum and konjac gum in the case of hygiene gel C. In all three cases the pH of phase A was adjusted to pH 7 with citric acid.

Phase B, which consisted of the other ingredients, was then stirred into phase A, with the agitation having to be increased more and more over time. A pH between 5 and 6 was adjusted with citric acid. It was then homogenized with stirring and in all three cases an emulsion-like gel was obtained.

The viscosity of all the hygiene gels produced in this way was determined. This was 220 mPa s for hygiene gel A, 150 mPa s for hygiene gel B and 150 mPa s for hygiene gel C, each measured with a DIN measuring system 33 according to ISO 53019 at a temperature of 293.15 K and with a speed of 500 r/min.

All three hygiene gels according to the invention are characterized by good antimicrobial activity, good handling when applied to the skin (due to the gel-like consistency) and a pleasant feeling on the skin.

The features of the invention disclosed in the above description, in the examples and in the claims can be essential both individually and in any combination for the implementation of the invention in its various embodiments.

Claims (10)

Hygiene gel with skin care effect and antimicrobial activity, containing - 5 to 35% by weight of alcohol, the alcohol having from 1 to 4 carbon atoms; - at least 0.3% by weight of humectant, wherein the humectant is selected from the group consisting of glycerin, propylene glycol, butane-1,2-diol, butane-1,3-diol and combinations thereof, and - a moisturizing system containing isopropyl palmitate, myristyl alcohol and 2-octyldodecanol as compounds with moisturizing properties, wherein the hygiene gel has a viscosity of 115 mPas to 450 mPas, measured with a DIN measuring system 33 according to ISO 53019 at a temperature of 293.15 K and with a speed of 500 r/min. Hygiene gel according to claim 1, characterized in that it contains at least one other compound with moisturizing properties selected from the group consisting of PEG-7 glyceryl cocoate, lanolin, dicaprylyl ether, sorbitan sesquicaprylate, isopropyl myristate, polyglyceryl-4-caprate, caprylic /Capric Triglyceride (Caprylic/Capric Triglyceride), Cetearyl Ethylhexanoate, Glyceryl Laurate, and combinations thereof. Hygiene gel according to one of Claims 1 or 2, characterized in that the proportion of alcohol is 10 to 30% by weight and in particular 10 to 25% by weight. Hygiene gel according to one of the preceding claims, characterized in that the alcohol is selected from the group comprising methanol, ethanol, propanol, isopropanol, butanol, isobutanol and mixtures of these. Hygiene gel according to one of the preceding claims, characterized in that the proportion of humectant in the composition is 0.5-3.5% by weight. Hygiene gel according to one of the preceding claims, characterized by a viscosity of 200 mPas to 400 mPas, measured with a DIN measuring system 33 according to ISO 53019 at a temperature of 293.15 K and with a speed of 500 r/min. Hygiene gel according to one of the preceding claims, characterized in that the humectant is glycerol. Hygiene gel according to one of the preceding claims, characterized in that it comprises or consists of glycerol, isopropyl palmitate, 2-octyldodecanol, myristyl alcohol, water and one or more alcohols having 1 to 4 carbon atoms. A method of cleansing skin, characterized in that the skin is contacted with a hygienic gel according to any one of claims 1 to 8. Use of a hygiene gel according to any one of Claims 1 to 8 for cleaning the skin.