EP4037980A1

EP4037980A1 - Equipment for the preparation of functionalised carriers

Info

Publication number: EP4037980A1
Application number: EP20797658.0A
Authority: EP
Inventors: Jan Kavalírek; Petr BRATKA
Original assignee: Grade Medical sro
Current assignee: Grade Medical sro
Priority date: 2019-10-02
Filing date: 2020-09-29
Publication date: 2022-08-10
Also published as: CZ2019613A3; CZ308744B6; WO2021063428A1

Abstract

An equipment for the preparation of functionalised carriers, in particular equipment (10) for the preparation of functionalised carriers for medical, and/or cosmetic and/or veterinary usage by applying an active substance (14) from a reservoir (2) to a carrier (4) arranged in a capsule (3) containing at least one application plate (1) with at least one opening (9) arranged between the reservoir (2) of the active substance (14) and the capsule (3), and means (21) for creating a pressure drop between the reservoir (2) of the active substance (14) and the capsule (3), to cause the active substance (14) to pass from the reservoir (2), through the opening (9) of the application plate (1), to the carrier (4) arranged in the capsule (3), the reservoir (2) having an underside (15) formed on at least a part of its surface of the material adapted to penetrate the contents of the reservoir (2) from this reservoir (2) and/or the capsule (3), has an upper side (13) formed on at least part of its surface of a material modified to penetrate the released contents of the reservoir (2) into the capsule (3).

Description

Equipment for the preparation of functionalised carriers

Technical Field

The invention relates to medical, and/or cosmetic and/or veterinary equipment, which is equipment for the preparation of functionalised carriers for medical, and/or cosmetic and/or veterinary usage, in particular equipment for the preparation of functionalised carriers by applying an active substance from a reservoir to a carrier arranged in a capsule.

State of the Art

From the current state of technology, a number of devices, aids or systems for introducing a liquid, possibly a gel, etc., into a package are known. A mandrel or a hollow mandrel, typically in the form of a hollow needle, for use in incorporating fluid into a package is known in many variations and uses. To achieve this goal, many devices are known in a wide range of complexity and variability of functions. From amore general point of view, at present the application of the active substance, usually liquid, gel-like or pasty, to a carrier, usually fibrous, but also of a different nature, is carried out by pouring, dipping or rubbing such a carrier, or substrate. In the field of medicine, such an operation is most often performed manually, just before the use of such an activated substrate, or carriers. The disadvantage in such cases is the risk of inaccurate dosing or at least the risk of inaccurate, or uneven distribution of the active substance on the substrate, as well as a greater degree of exposure of the substrate to environmental conditions and thus an increased risk of its contamination.

However, there are also already activated substrates, delivered from the factory in an activated state, in a sterile package. In many situations, it is technically and economically disadvantageous to manufacture or supply and store, both at the supplier and customer, an extremely wide range of such prepackages, which would respect the requirements to cover a wide range of substrate types, combined with a wide range of active ingredients, and also in combination with a wide range of substrate sizes.

From the patent document CZ PV22015-438 a technical solution is known, which enables local finalisation of substrates, or carriers, provided with the active substance, with the possibility of finalisation at the consumer. It is a system for applying an active substance from a disposable reservoir to an encapsulated carrier, the system comprising a disposable active substance reservoir, a capsule with a carrier and an application unit consisting of at least a shaped action plate and a base with a shaped section adapted to hold a capsule with an encapsulated carrier; for cooperation with this action board. The disposable reservoir has a bottom side shaped in accordance with the shaping of the functional surface of the action plate, the action plate being equipped on its functional surface with application ports formed in the form of double-ended needle-tipped tubes or hollow needles the carrier has a bottom side, in the form of a tray, shaped for contact abutment in a recess in the shaped section of the base, the bottom side of the disposable reservoir and the top side of the capsule with the carrier being. The disadvantage of this technical solution is that the used needles or tubes irreversibly destroy the reservoir with the active substance, while the needles or tubes themselves are essentially disposable, with the whole system being relatively difficult to handle.

A number of disadvantages are known from the above-mentioned state of the art, the most significant disadvantage being that there is no simple technical solution that is easy and repeatable to use for precise and medical application of the active substance to the carrier on the patient.

The object of the invention is to provide a technical solution which will easily and cheaply solve a highly precise application of the active substance to a carrier arranged in a capsule, with the possibility of preparing a carrier with the active substance.

Principle of the Invention

The above-mentioned disadvantages are largely eliminated and the objects of the invention are fulfilled by equipment for the preparation of functionalised carriers, specifically equipment for the preparation of functionalised carriers for medical, and/or cosmetic and/or veterinary usage by applying the active substance from a reservoir to a carrier arranged in a capsule, which according to the invention, is characterised by that it comprises at least one application plate with at least one opening arranged between the active substance reservoir and the capsule, and means for creating a pressure drop between the active substance reservoir and the capsule to cause the active substance to pass from the reservoir through the application plate opening to a carrier arranged in the capsule, while having an underside forming on at least a portion of its surface of a material adapted to penetrate the contents of the reservoir from the reservoir and/or capsule and having an upper side forming on at least a portion of its surface of a material adapted to penetrate the released contents of the reservoir into the capsule. The advantage is a very simple design, which allows the production of a personalised wound covering exactly according to the specific requirements of a particular patient in virtually any environment. The means for inducing pressure can be, for example, the manual pressing of the serving personnel. Another advantage is the possibility of making a connection tight to the environment under the action of the pressures in the reservoir and the capsule, such as are necessary to achieve the penetration of the dosing substance from the reservoir through the application plate into the capsule with the carrier.

According to a first variant, it is advantageous if the means for creating a pressure drop between the active substance reservoir and the capsule is means for inducing pressure in the active substance reservoir.

According to a second variant, it is advantageous if the means for creating a pressure drop between the active substance reservoir and the capsule is a means for inducing a vacuum in the capsule. This variant has the same advantages as the first variant.

It is to advantage when the arrangement for penetrating the contents of the reservoir into the capsule is formed in such a way that the form and the material of at least part of the underside of the reservoir and the form and material of at least part of the top of the capsule form at least one penetration bridge between the reservoir and the capsule, with the penetration bridge being formed to completely close at the moment of equalised or limitedly differing pressures in the reservoir and capsule, or at least to reduce by 90% its full penetration area, with the pressure difference in the reservoir and capsule exceeding a set value when the pressure in the reservoir exceeds pressure in the capsule, the penetration bridge is designed to open, thus allowing the active substance to be released from the reservoir and to be transferred to the capsule with the carrier. The advantage is the creation of a hygienically safe and accurate transfer of the active substance from the reservoir to the carrier located in the capsule. It is to further advantage if the at least one penetrating bridge is formed in such a way that the upper side of the capsule and the underside of the reservoir are formed on at least part of the surface as a flexible foil or foil of shape memory material, with at least one micro-opening impermeable at a pressure drop of to 30 kPa for gel and liquid. The advantage is the simplicity of design, while maintaining excellent functionality.

According to a further advantageous variant, it is to advantage if the at least one penetrating bridge is formed in such a way that the upper side of the capsule and the underside of the reservoir are formed on at least part of the surface as a flexible foil or a foil of shape memory material, on which foil every space for penetrating bridges be designed as a point attenuation that resists rupture to a pressure drop not in excess of 30 kPa. This design is advantageous in the case of active substances whose entire dose is applied in one.

It is also to advantage if the application plate is part of the underside of the reservoir or itself, together with the flexible film and/or the film of shape memory material forming such an underside of the reservoir. This variant is advantageous for use especially in more hygienically difficult application conditions.

Furthermore, it is also advantageous if the application plate is part of the upper side of the capsule or, together with the flexible foil and/or the foil of shape memory material, forms such an upper side of the capsule.

Alternatively, it may be to advantage if the application plate is located below the top of the capsule and at the same time above the carrier.

It may also be to advantage if the capsule has an upper side which is formed by a pre-stressed flexible film, while in an advantageous design the pre-stressed flexible film is coated with a layer of polytetrafluoroethylene (PTFE) on the contact side with the dosing substance.

The material of the upper side of the capsule is preferably silicone or rubber or fluoroelastomer (Viton) or polypropylene or polyethylene.

It is further to advantage that the reservoir has an underside shaped consistent with the shaping of the functional surface of the application plate.

In an advantageous design, the reservoir has an underside which has a shape which is consistent with the shape of the applicator plate and the upper side of the capsule, the effect of their mutual pressure or the effect of their mutual attachment forming a tight sealing to prevent leakage of the active substance outside the capsule. The advantage is the creation of a substantially safe transfer of the active substance to the carrier.

It is also to advantage if the reservoir has an upper side which is made of a flexible and/or pliable film. The advantage is the possibility of simple deformation to create pressure in the reservoir.

It may also be to advantage if the reservoir is divided by at least one partition into at least two chambers. Such a design of the reservoir advantageously allows the storage and subsequent use of several active substances or excipients simultaneously.

Preferably, the capsule has a tray-shaped underside.

Furthermore, it is also advantageous if the reservoir contains a filling of application substance which takes up 20 to 100% of its total volume.

It is to advantage from the point of view of preserving and ensuring hygienic safety if the capsule, in the state in which the carrier is provided with the active substance, is provided on the outer surface of its upper side with a gas-tight cover film.

According to a first advantageous variant, it is to advantage if the means for inducing pressure in the active substance reservoir is a pressing device. According to a second advantageous variant, it is to advantage if the means for inducing pressure in the active substance reservoir is a pressure device. It may also be to advantage according to a third variant if the means for inducing a vacuum in the capsule is a vacuum pump. The advantage is the possibility of creating a cheap construction of a high-production device for the application of the substance.

In certain cases, it may be to advantage for the substance delivery device to be assembled as to be single-use, with the reservoir, application plate and capsules being made as one piece.

In an advantageous design, the reservoir is designed to be interchangeable, and when the capsule is also designed to be interchangeable. The advantage is that it allows one to minimise the overall cost.

The main advantage of the device for the preparation of functionalised carriers for medical, and/or cosmetic and/or veterinary usage, according to the invention, is that it enables the preparation of functionalised or activated medical, and/or cosmetic and/or veterinary means, specifically wound coverings, with such effects that cannot be achieved with mass-produced medical, and/or cosmetic and/or veterinary means or aids, e.g. due to the short expiry date of such a product or means or aids, after their activation, and also allows the preparation of such aids so-called personalised, i.e. according to the needs of a particular patient and a particular therapy, specific wounds, in the case of designs where the volume of the dosed substance can be regulated. Another advantage in the case of a fixed connection is the speed and simplicity of application in difficult, especially outpatient or field conditions, where the carrier and the dosed substance cannot be interchanged and the actual activation can take place while maintaining the sterility of the carrier even by the force of the human hand on the reservoir against a solid support. Another advantage is the possibility of design with a defined or a standard assembly of a reservoir and a capsule, where the action plate can be inserted separately and optionally reusable or can form an integral part of the noted single-use elements. This makes it possible to combine carriers and dosing substances from available stocks, for example according to the composition or volume of the dosing substance and also according to the composition or volume of the carrier, while in the case of an action plate made separately, these different designs can also be used to facilitate the application of e.g. dosing substances of different viscosities. It is also to advantage that the possible simple preparation of medical, and/or cosmetic and/or veterinary means devices, specifically e.g. wound coverings, which require activation before use in order to achieve their effect, consisting in the application of a solution with the active substance or solution, which is the active substance, to a carrier. Specifically, it is a matter of creating such a system in which, while maintaining a high degree of cleanliness or sterility of the carrier in the capsule, the carrier is activated by a dosing substance of controlled volume by creating different pressures in the dosing reservoir and in the capsule with the carrier, separately or integrally connected to the reservoir or capsule. The advantage is also that in a certain design of the capsule and the reservoir it is possible to use, conversely, applications using automated or semi- automated mechanical devices, which allows higher accuracy of dosing of an active substance or substances and also ensuring an accurate time interval between these doses, in case of the need for a specific application or methods for preparing a personalised covering. Overview of the Figures

The invention will be further elucidated using drawings, in which fig. 1 shows equipment for preparing functionalised carriers with a means for inducing pressure, which is a pressing device; fig. 2 shows equipment for preparing functionalised carriers with means for inducing pressure, which is a pressure device fig. 3 shows an apparatus for preparing functionalised carriers with means for inducing a vacuum in a capsule, which is a vacuum pump, and fig. 4 shows a capsule provided with a gas-tight cover foil.

Examples of the Performance of the Invention

The equipment 10 for the preparation of functionalised carriers for medical, and/or cosmetic and/or veterinary applications (fig. 1, fig. 2, fig. 3) of active substances 14 from a reservoir 2 to a carrier 4 arranged in a capsule 3, comprises an application plate with a number of openings 9 arranged between the reservoir 2 of the active substance 14 and the capsule 3, and means 21 for creating a pressure drop between the reservoir 2 of the active substance 14 and the capsule 3, to cause the active substance 14 to pass from the reservoir 2 through the opening 9 of the applicator plate 1 to the carrier 4 arranged in the capsule 3.

The means 21 for creating a pressure drop can be means 6 for inducing pressure in the reservoir 2 of the active substance 14. which according to the first variant (fig. 1) is a pressing device 7, which according to the second variant is a pressure device 8.

The means 21 for creating a pressure drop can also be means 19 for inducing a vacuum in the capsule 3, which is a vacuum pump 20 (fig. 3).

The reservoir 2 (fig. 1, fig. 2, fig. 3) has an underside 15 made of a material adapted to penetrate the contents of the reservoir 2, at a certain pressure difference between the interior of the reservoir and its surroundings, from this reservoir 2.

The capsule 3 (fig. 1, fig. 2, fig. 3) has an upper side 13 made of a material adapted to penetrate the released contents of the reservoir 2 into the capsule 3.

The arrangement for the penetration of the contents of the reservoir 2 into the capsule 3 is formed in such a way that the design and material of the underside 15 of the reservoir 2 and the design and material of the top 13 of the capsule 3 form in coaction with the openings 9 of the application plate 1 a number of penetrating bridges H between the reservoir 2 and the capsule 3.

The penetrating bridges H (fig. 1 , fig. 2, fig. 3) are designed to be completely closed at the moment of balanced or limit-different pressures in the reservoir 2 and the capsule 3, or at least to reduce by 90% their full penetrating area with pressures in the reservoir 2 and the capsule 3 above a set value, when the pressure in the reservoir 2 exceeds the pressure in the capsule 3, the penetrating bridges H are formed to open and thus allow the active substance 14 to be released from the reservoir 2 and transferred to the capsule 3 with the carrier 4.

According to a first variant (fig. 1, fig. 2, fig. 3), the penetrating bridges H are formed such that the upper side 13 of the capsule 3 and the underside 15 of the reservoir 2 are formed as a flexible foil or foil of shape memory material with micro-openings, impermeable at a pressure drop up to 30 kPa for both gel and liquid.

According to a second variant (fig. 1, fig. 2, fig. 3), the penetrating bridges H are formed in such a way that the upper side 13 of the capsule 3 and the underside 15 of the reservoir 2 are formed as a flexible foil or foil of shape memory material, on which film each point for the penetrating bridges 1_1 is formed as a point attenuation which resists rupture to a pressure drop not in excess of 30 kPa.

According to the first variant, the application plate can be either part of the underside 15 of the reservoir 2 or alone, together with the flexible foil and/or the foil of shape memory material forming such an underside 15 of the reservoir 2.

According to the second variant, the application plate 1 can either be part of the upper side 13 of the capsule 3 or, together with the flexible foil and/or the foil of shape memory material, form such an upper side 13 of the capsule 3.

According to a third variant, the application plate can be placed below the upper side 13 of the capsule 3 and at the same time above the carrier 4.

The capsule 3 may have an upper side 13 formed by a pre-stressed flexible film which is coated on the contact side with the dosing substance with a layer of polytetrafluoroethylene (PTFE), the upper side material 13 being silicone, or in other variants it may be rubber or fluoroelastomer (Viton) or polypropylene or polyethylene.

The reservoir 2 has an underside 15 shaped consistent with the shaping of the functional surface of the application plate .

The reservoir 2 has an underside 15 which has a shape which is consistent with the shape of the applicator plate and the top side 3 of the capsule 3, the action of their mutual pressure or alternatively the effect of their mutual attachment forming a tight connection to prevent the escape of the active substances from the capsule 3.

The reservoir 2 has an upper side 16, which is made of a flexible material which is a flexible and pliable film.

The reservoir 2 (fig. 2) is divided by one partition 17 into two chambers 18.

The capsule 3 has a tray-shaped underside 12.

The reservoir 2 contains a filling of the active substance 14, which occupies 100% of its total volume.

The capsule 3 (fig. 4) is, in the state where the carrier 4 is provided with the active substance 14, provided on the outer surface of its upper side 13 with a gas-tight cover foil 5.

According to the first variant, the reservoir 2, the application plate 1 and the capsule 3 are made as a single unit.

According to other variants, the reservoir 2 can be designed as interchangeable and/or even the capsule 3 can be designed as interchangeable.

The equipment for the preparation of functionalised carriers for medical, and/or cosmetic and/or veterinary usage works in such a way that the pressure in the reservoir 2 with the active substance 14 or the vacuum created in the capsule 3 with carrier 4 creates a pressure drop between the reservoir 2 and the capsule 3 which overcomes the passage resistance of the liquid or gel active substance while passing through the penetrating bridges 1± and subsequently the active substance thus transported under pressure is applied to the carrier 4, with, at the moment when the formation of the pressure drop between the reservoir 2 and the capsule 3 is completed, the penetrating bridges 1± are closed. Subsequently, the upper side 13 of the capsule 3 is covered with a gas-tight cover foil 5.

Industrial Application

Equipment for the preparation of functionalised carriers according to the invention can be used in particular in medical, cosmetic or veterinary field, for example for the preparation of functionalised wound dressings requiring one-step activation before application on a patient. List of Reference Marks

1 application plate

2 reservoir

3 capsule

4 carrier

5 cover foil

6 means for inducing pressure

7 pressing device

8 pressure device

9 application plate opening

10 equipment for application

11 penetrating bridge

12 underside of the capsule

13 upper side of the capsule

14 active substance

15 underside of the reservoir

16 upper side of the reservoir

17 reservoir partition

18 reservoir chamber

19 means for inducing a vacuum

20 vacuum pump

21 means for creating a pressure drop

Claims

Patent Claims

1. An equipment for the preparation of functionalised carriers, in particular equipment (10) for preparing functionalised carriers for medical, and/or cosmetic and/or veterinary usage, by applying the active substance (14) from a reservoir (2) to a carrier (4) arranged in a capsule (3), characterised in that it comprises at least one application plate (1) with at least one opening (9) arranged between the reservoir (2) of the active substance (14) and the capsule (3), and the means (21) to create a pressure drop between the reservoir (2) of the active substance (14) and the capsule (3), to cause the active substance (14) to pass from the reservoir (2), through the opening (9) of the application plate (1), to the carrier (4) arranged in a capsule (3), with the reservoir (2) having an underside (15) formed on at least part of its surface of a material adapted to penetrate the contents of the reservoir (2) from this reservoir (2) and/or the capsule (3) having an upper side (13) formed on at least part of its surface of a material adapted to penetrate the released contents of the reservoir (2) into the capsule (3).

2. The equipment for the preparation of functionalised carriers, according to claim 1, characterised in that the means (21) for creating a pressure drop between the reservoir (2) of active substance (14) and capsule (3) is a means (6) for inducing pressure in the reservoir (2) of active substance (14).

3. The equipment for the preparation of functionalised carriers, according to claim 1, characterised in that the means (21) for creating a pressure drop between the reservoir (2) of active substance (14) and capsule (3) is a means (19) for inducing a vacuum in the capsule (3).

4. The equipment for the preparation of functionalised carriers, according to any one of the preceding claims, characterised in that the arrangement for penetrating the contents of the reservoir (2) into the capsule (3) is designed in such a way that that the design and the material of at least a part of the underside (15) of the reservoir (2) as well as the design and the material of at least a part of the upper side (13) of the capsule (3) form with at least one opening (9) of the application plate (1) at least one penetrating bridge (11) between the reservoir (2) and the capsule (3).

5. The equipment for the preparation of functionalised carriers, according to claim 4, characterised in that the penetrating bridge (11) is designed to be completely closed at the moment of equilibrated or limit-different pressures in the reservoir (2) and the capsule (3), or at least to reduce by 90% of its full penetration area, where the pressure difference in the reservoir (2) and the capsule (3) exceeds a set value, when the pressure in the reservoir (2) exceeds the pressure in the capsule (3) the penetration bridge (11) is designed to open and thus to allow the release of the active substance (14) from the reservoir (2) and its transfer to the capsule (3) with the carrier (4).

6. The equipment for the preparation of functionalised carriers, according to any one of claims 4 and 5, characterised in that the at least one penetrating bridge (11) is formed in such a way that the upper side (13) of the capsule (3) and the underside (15) of the reservoir (2) are formed on at least part of the surface as a flexible foil or foil of shape memory material, with at least one micro-hole, impermeable at a pressure drop not in excess of 30 kPa for both gel and liquid.

7. The equipment for the preparation of functionalised carriers, according to any one of claims 4 and 5, characterised in that the at least one penetrating bridge (11) is formed in such a way that the upper side (13) the capsule (3) and the underside (15) of the reservoir (2) are formed on at least part of the surface as a flexible film or a film of shape memory material, on which film each penetration bridge site (11) is formed as an attenuation point, which resists rupture to a pressure drop not in excess of 30 kPa.

8. The equipment for the preparation of functionalised carriers, according to any one of the preceding claims, characterised in that the application plate (1) is part of the underside (15) of the reservoir (2) or itself, together with the flexible film and/or the film of shape memory material, forms such a underside (15) of the reservoir (2).

9. The equipment for the preparation of functionalised carriers, according to any one of the preceding claims, characterised in that the application plate (1) is part of the upper side (13) of the capsule (3) or, together with the flexible foil and/or the foil of shape memory material, forms such an upper side (13) of the capsule (3).

10. The equipment for the preparation of functionalised carriers, according to any one of the preceding claims, characterised in that the application plate (1) is located below the upper side (13) of the capsule (3) and at the same time above the carrier (4).

11. The equipment for the preparation of functionalized carriers, according to any one of the preceding claims, characterised in that the capsule (3) has an upper side (13) which is formed by a pre-stressed flexible film.

12.The equipment for the preparation of functionalised carriers, according to any one of the preceding claims, characterised in that the capsule (3) has an upper side (13) which is formed by a pre-stressed flexible film, which is coated with a layer of polytetrafluoroethylene (PTFE) on the side of contact with the dosing substance.

13. The equipment for the preparation of functionalized carriers, according to any one of the preceding claims, characterised in that the capsule (3) has an upper side (13) which is formed by a material which is silicone or rubber or fluoroelastomer or polypropylene or polyethylene.

14. The equipment for the preparation of functionalised carriers, according to any one of the preceding claims, characterised in that the reservoir (2) has an underside (15) shaped consistent with the shaping of the functional surface application plate (1).

15. The equipment for the preparation of functionalized carriers, according to any one of the preceding claims, characterised in that the reservoir (2) has an underside (15) which has a shape which is consistent with the shape of the application plate (1) and the upper side (13) of the capsule (3), the action of their mutual pressure or the effect of their mutual attachment forming a tight connection to prevent leakage of the active substance (14) outside the capsule (3).

16. The equipment for the preparation of functionalised carriers, according to any one of the preceding claims, characterised in that the reservoir (2) has an upper side (16) which is formed of a flexible and/or flexible film.

17. The equipment for the preparation of functionalised carriers, according to any one of the preceding claims, characterised in that the reservoir (2) is divided by at least one partition (17) into at least two chambers (18).

18. The equipment for the preparation of functionalised carriers, according to any one of the preceding claims, characterised in that the capsule (3) has an underside (12) in the shape of a tray.

19. The equipment for the preparation of functionalised carriers, according to any one of the preceding claims, characterised in that the reservoir (2) contains a dose of application substance (14) which occupies 20 to 100 % of its total volume.

20. The equipment for the preparation of functionalised carriers, according to any one of the preceding claims, characterised in that the capsule (3) is in a state where the carrier (4) is provided with an active substance (14), on the outer surface of its upper side (13) provided with a gas-tight cover foil (5).

21. The equipment for the preparation of functionalised carriers, according to claim 1, characterised in that the means (6) for inducing pressure in the reservoir (2) of active substance (14) is a pressing device (7).

22. The equipment for the preparation of functionalised carriers, according to claim 2, characterised in that the means (6) for inducing pressure in the reservoir (2) of active substance (14) is a pressure device (8).

23. The equipment for the preparation of functionalised carriers, according to claim 3, characterised in that the means (19) for inducing a vacuum in the capsule (3) is a vacuum pump (20).

24. The equipment for the preparation of functionalised carriers, according to any one of the preceding claims, characterised in that the reservoir (2), the application plate (1) and the capsules (3) are made as a single unit.

25. The equipment for the preparation of functionalised carriers, according to any one of claims 1 to 23, characterised in that the reservoir (2) is designed to be interchangeable.

26. The equipment for the preparation of functionalised carriers, according to any one of claims 1 to 23 and 25, characterised in that the capsule (3) is designed to be interchangeable.