EP3918063A4 - MRNA DISPLAY ANTIBODY LIBRARY AND METHODS - Google Patents

MRNA DISPLAY ANTIBODY LIBRARY AND METHODS Download PDF

Info

Publication number: EP3918063A4
Authority: EP; European Patent Office
Prior art keywords: methods; antibody library; mrna display; display antibody; mrna
Prior art date: 2019-01-31
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Pending

Application number

EP19913048.5A

Other languages

German (de)

French (fr)

Other versions

EP3918063A1 (en

Inventor

Clifford Anders OLSON

Kayvan Niazi

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

NantBio Inc

Original Assignee

NantBio Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2019-01-31

Filing date

2019-01-31

Publication date

2022-12-14

2019-01-31 Application filed by NantBio Inc filed Critical NantBio Inc

2019-01-31 Priority to DE19913048.5T priority Critical patent/DE19913048T1/en

2021-12-08 Publication of EP3918063A1 publication Critical patent/EP3918063A1/en

2022-12-14 Publication of EP3918063A4 publication Critical patent/EP3918063A4/en

Status Pending legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/005—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
- C07K16/248—IL-6
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1062—Isolating an individual clone by screening libraries mRNA-Display, e.g. polypeptide and encoding template are connected covalently
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B30/00—Methods of screening libraries
- C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

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Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Genetics & Genomics (AREA)
Immunology (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
General Health & Medical Sciences (AREA)
Biophysics (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Biotechnology (AREA)
Microbiology (AREA)
Virology (AREA)
Plant Pathology (AREA)
Physics & Mathematics (AREA)
Crystallography & Structural Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Computational Biology (AREA)
Peptides Or Proteins (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

EP19913048.5A 2019-01-31 2019-01-31 MRNA DISPLAY ANTIBODY LIBRARY AND METHODS Pending EP3918063A4 (en)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
DE19913048.5T DE19913048T1 (en)	2019-01-31	2019-01-31	MRNA DISPLAY ANTIBODY LIBRARY AND METHODS

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PCT/US2019/016135 WO2020159524A1 (en)	2019-01-31	2019-01-31	Mrna display antibody library and methods

Publications (2)

Publication Number	Publication Date
EP3918063A1 EP3918063A1 (en)	2021-12-08
EP3918063A4 true EP3918063A4 (en)	2022-12-14

Family

ID=71841195

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP19913048.5A Pending EP3918063A4 (en)	2019-01-31	2019-01-31	MRNA DISPLAY ANTIBODY LIBRARY AND METHODS

Country Status (8)

Country	Link
EP (1)	EP3918063A4 (en)
JP (2)	JP7550770B2 (en)
KR (2)	KR20240166044A (en)
CN (1)	CN113366104B (en)
AU (1)	AU2019427773A1 (en)
CA (1)	CA3124941A1 (en)
DE (1)	DE19913048T1 (en)
WO (1)	WO2020159524A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US11034951B2 (en)	2017-11-20	2021-06-15	Nantbio, Inc.	mRNA display antibody library and methods
KR20230174295A (en)	2017-11-20	2023-12-27	난트바이오 인코포레이티드	mRNA DISPLAY ANTIBODY LIBRARY AND METHODS

Citations (7)

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Publication number	Priority date	Publication date	Assignee	Title
WO2006072773A1 (en) *	2005-01-05	2006-07-13	Cambridge Antibody Technology Limited	Ribosome display or mrna display method with selection for increased stability of the protein
WO2010054007A1 (en) *	2008-11-07	2010-05-14	Fabrus Llc	Combinatorial antibody libraries and uses thereof
WO2012148497A2 (en) *	2011-04-28	2012-11-01	The Board Of Trustees Of The Leland Stanford Junior University	Identification of polynucleotides associated with a sample
US8633139B2 (en) *	2007-12-21	2014-01-21	Abbvie Biotherapeutics Inc.	Methods of screening complex protein libraries to identify altered properties
US9464286B2 (en) *	2002-08-12	2016-10-11	Adimab, Llc	High throughput generation and affinity maturation of humanized antibody
WO2018005559A1 (en) *	2016-06-27	2018-01-04	Juno Therapeutics, Inc.	Method of identifying peptide epitopes, molecules that bind such epitopes and related uses
WO2019099882A2 (en) *	2017-11-20	2019-05-23	Nantbio, Inc.	mRNA DISPLAY ANTIBODY LIBRARY AND METHODS

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Publication number	Priority date	Publication date	Assignee	Title
WO2006014498A2 (en)	2004-07-06	2006-02-09	Bioren, Inc.	Universal antibody libraries
EP1943332A4 (en)	2005-10-14	2011-04-13	Medimmune Inc	Cell display of antibody libraries
KR100961392B1 (en) *	2008-04-15	2010-06-07	이화여자대학교 산학협력단	Method for producing antibody phage surface presentation library, antibody phage surface presentation library prepared by the method, phagemid vector comprising the antibody phage surface presentation library gene
US9650432B2 (en) *	2010-01-29	2017-05-16	Morphosys Ag	Rodent combinatorial antibody libraries
WO2016114567A1 (en) *	2015-01-13	2016-07-21	이화여자대학교 산학협력단	Method for preparing novel antibody library and library prepared thereby

2019
- 2019-01-31 WO PCT/US2019/016135 patent/WO2020159524A1/en unknown
- 2019-01-31 KR KR1020247038275A patent/KR20240166044A/en active Pending
- 2019-01-31 CN CN201980090819.2A patent/CN113366104B/en active Active
- 2019-01-31 AU AU2019427773A patent/AU2019427773A1/en active Pending
- 2019-01-31 JP JP2021544556A patent/JP7550770B2/en active Active
- 2019-01-31 CA CA3124941A patent/CA3124941A1/en active Pending
- 2019-01-31 DE DE19913048.5T patent/DE19913048T1/en active Pending
- 2019-01-31 EP EP19913048.5A patent/EP3918063A4/en active Pending
- 2019-01-31 KR KR1020217025365A patent/KR102736548B1/en active Active
2024
- 2024-08-30 JP JP2024150043A patent/JP2024167352A/en active Pending

Patent Citations (7)

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Publication number	Priority date	Publication date	Assignee	Title
US9464286B2 (en) *	2002-08-12	2016-10-11	Adimab, Llc	High throughput generation and affinity maturation of humanized antibody
WO2006072773A1 (en) *	2005-01-05	2006-07-13	Cambridge Antibody Technology Limited	Ribosome display or mrna display method with selection for increased stability of the protein
US8633139B2 (en) *	2007-12-21	2014-01-21	Abbvie Biotherapeutics Inc.	Methods of screening complex protein libraries to identify altered properties
WO2010054007A1 (en) *	2008-11-07	2010-05-14	Fabrus Llc	Combinatorial antibody libraries and uses thereof
WO2012148497A2 (en) *	2011-04-28	2012-11-01	The Board Of Trustees Of The Leland Stanford Junior University	Identification of polynucleotides associated with a sample
WO2018005559A1 (en) *	2016-06-27	2018-01-04	Juno Therapeutics, Inc.	Method of identifying peptide epitopes, molecules that bind such epitopes and related uses
WO2019099882A2 (en) *	2017-11-20	2019-05-23	Nantbio, Inc.	mRNA DISPLAY ANTIBODY LIBRARY AND METHODS

Non-Patent Citations (2)

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MARCEL WEBER ET AL: "A Highly Functional Synthetic Phage Display Library Containing over 40 Billion Human Antibody Clones", PLOS ONE, vol. 9, no. 6, 20 June 2014 (2014-06-20), pages e100000, XP055215910, DOI: 10.1371/journal.pone.0100000 *
See also references of WO2020159524A1 *

Also Published As

Publication number	Publication date
AU2019427773A1 (en)	2021-07-15
CA3124941A1 (en)	2020-08-06
JP2022521147A (en)	2022-04-06
CN113366104A (en)	2021-09-07
KR20210106001A (en)	2021-08-27
EP3918063A1 (en)	2021-12-08
JP7550770B2 (en)	2024-09-13
JP2024167352A (en)	2024-12-03
CN113366104B (en)	2024-03-26
KR20240166044A (en)	2024-11-25
KR102736548B1 (en)	2024-12-02
WO2020159524A1 (en)	2020-08-06
DE19913048T1 (en)	2022-01-27

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