EP3841096A4 - Pyridinylmethylenepiperidine derivatives and uses thereof - Google Patents
Pyridinylmethylenepiperidine derivatives and uses thereof Download PDFInfo
- Publication number
- EP3841096A4 EP3841096A4 EP19851618.9A EP19851618A EP3841096A4 EP 3841096 A4 EP3841096 A4 EP 3841096A4 EP 19851618 A EP19851618 A EP 19851618A EP 3841096 A4 EP3841096 A4 EP 3841096A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- pyridinylmethylenepiperidine
- derivatives
- pyridinylmethylenepiperidine derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- YOWQLUITGNUAHS-UHFFFAOYSA-N 2-(piperidin-2-ylidenemethyl)pyridine Chemical class N1CCCCC1=CC1=CC=CC=N1 YOWQLUITGNUAHS-UHFFFAOYSA-N 0.000 title 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing alicyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Reproductive Health (AREA)
- Addiction (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Gynecology & Obstetrics (AREA)
- Diabetes (AREA)
- Child & Adolescent Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810969837 | 2018-08-24 | ||
| PCT/CN2019/101985 WO2020038435A1 (en) | 2018-08-24 | 2019-08-22 | Pyridinylmethylenepiperidine derivatives and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EP3841096A1 EP3841096A1 (en) | 2021-06-30 |
| EP3841096A4 true EP3841096A4 (en) | 2022-05-18 |
Family
ID=68437065
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP19851618.9A Pending EP3841096A4 (en) | 2018-08-24 | 2019-08-22 | Pyridinylmethylenepiperidine derivatives and uses thereof |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US11858910B2 (en) |
| EP (1) | EP3841096A4 (en) |
| JP (1) | JP7405834B2 (en) |
| CN (1) | CN110437205B (en) |
| AU (1) | AU2019323450A1 (en) |
| CA (1) | CA3107145A1 (en) |
| WO (1) | WO2020038435A1 (en) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111187251B (en) * | 2019-11-22 | 2023-06-09 | 广东东阳光药业有限公司 | Pyridinoylpiperidine derivatives and their use |
| CN111187252B (en) * | 2019-11-22 | 2023-06-09 | 广东东阳光药业有限公司 | Pyridinoyl azaspiroheptane derivatives and their use |
| CN111943930B (en) * | 2020-08-25 | 2022-11-01 | 南京三元阳普医药科技有限公司 | Synthesis process of Lasmidinan |
| CN114685440B (en) * | 2020-12-29 | 2023-07-18 | 广东东阳光药业有限公司 | Salts of pyridyleiperidine derivatives and uses thereof |
| CN114685441B (en) * | 2020-12-29 | 2023-07-18 | 广东东阳光药业有限公司 | Salts of pyridyleiperidine derivatives and uses thereof |
| CN114685443B (en) * | 2020-12-29 | 2023-07-18 | 广东东阳光药业有限公司 | Salts of pyridyleiperidine derivatives and uses thereof |
| CN114685444B (en) * | 2020-12-29 | 2023-07-18 | 广东东阳光药业有限公司 | Salts of pyridyleiperidine derivatives and uses thereof |
| WO2022143622A1 (en) * | 2020-12-29 | 2022-07-07 | Sunshine Lake Pharma Co., Ltd. | Salts of pyridinylmethylenepiperidine derivatives and uses thereof |
| CN112939952A (en) * | 2021-02-02 | 2021-06-11 | 深圳市第二人民医院(深圳市转化医学研究院) | 3-hydroxy chalcone derivative and application thereof |
| CN112898276A (en) * | 2021-02-02 | 2021-06-04 | 深圳市第二人民医院(深圳市转化医学研究院) | Chalcone derivative and application thereof |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA979961B (en) | 1996-11-15 | 1999-05-05 | Lilly Co Eli | 5-HT1F agonists |
| US6133290A (en) | 1998-07-31 | 2000-10-17 | Eli Lilly And Company | 5-HT1F agonists |
| US6777428B1 (en) | 1999-02-10 | 2004-08-17 | Eli Lilly And Company | 5-HT1f agonist |
| TWI263497B (en) | 2002-03-29 | 2006-10-11 | Lilly Co Eli | Pyridinoylpiperidines as 5-HT1F agonists |
| BRPI0409211A (en) * | 2003-04-18 | 2006-03-28 | Lilly Co Eli | compound, pharmaceutical composition, methods for activating 5-ht1f receptors, inhibiting neuronal protein extravasation, and for the treatment or prevention of migraine in a mammal, and, use of a compound |
| UA82711C2 (en) | 2003-09-12 | 2008-05-12 | Эли Лилли Энд Компани | Substituted 2-carbonylamino-6-piperidinaminopyridines and substituted 1-carbonylamino-3-piperidinaminobenzenes as 5-ht1f agonists |
| EP1697305B1 (en) | 2003-12-17 | 2007-08-15 | Eli Lilly And Company | Substituted (4-aminocyclohexen-1-yl)phenyl and (4-aminocyclohexen-1-yl)pyridinyl compounds as 5-ht1f agonists |
| ME01308B (en) | 2006-10-18 | 2013-12-20 | Pfizer Prod Inc | Biaryl ether urea compounds |
| CN101602708B (en) | 2008-06-10 | 2012-11-21 | 江苏国华投资有限公司 | Aryl alkanol piperidine derivative and application thereof as antidepressive medicine |
| TW201028421A (en) | 2009-01-15 | 2010-08-01 | Abbott Lab | Novel benzenesulfonamides as calcium channel blockers |
| GB201114448D0 (en) | 2011-08-22 | 2011-10-05 | Takeda Pharmaceutical | Compounds and their use |
| MX2016016488A (en) | 2014-08-27 | 2017-03-30 | Hoffmann La Roche | Substituted azetidine derivatives as taar ligands. |
| GB201416513D0 (en) * | 2014-09-18 | 2014-11-05 | Astex Therapeutics Ltd And Cancer Res Technology Ltd | Pharmaceutical compounds |
-
2019
- 2019-08-22 JP JP2021509988A patent/JP7405834B2/en active Active
- 2019-08-22 WO PCT/CN2019/101985 patent/WO2020038435A1/en unknown
- 2019-08-22 US US17/263,177 patent/US11858910B2/en active Active
- 2019-08-22 AU AU2019323450A patent/AU2019323450A1/en active Pending
- 2019-08-22 CN CN201910778613.0A patent/CN110437205B/en active Active
- 2019-08-22 CA CA3107145A patent/CA3107145A1/en active Pending
- 2019-08-22 EP EP19851618.9A patent/EP3841096A4/en active Pending
Non-Patent Citations (1)
| Title |
|---|
| ZHANG DEYI ET AL: "Discovery of selective N-[3-(1-methylpiperidine-4-carbonyl)phenyl]benzamide-based 5-HT1F receptor agonists: Evolution from bicyclic to monocyclic cores", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 25, no. 19, 2015, pages 4337 - 4341, XP029264226, ISSN: 0960-894X, DOI: 10.1016/J.BMCL.2015.07.042 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CA3107145A1 (en) | 2020-02-27 |
| EP3841096A1 (en) | 2021-06-30 |
| WO2020038435A1 (en) | 2020-02-27 |
| CN110437205B (en) | 2022-07-08 |
| US11858910B2 (en) | 2024-01-02 |
| JP2021536433A (en) | 2021-12-27 |
| AU2019323450A1 (en) | 2021-02-11 |
| JP7405834B2 (en) | 2023-12-26 |
| CN110437205A (en) | 2019-11-12 |
| US20210188803A1 (en) | 2021-06-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE |
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| PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
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| STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE |
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| 17P | Request for examination filed |
Effective date: 20210204 |
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| AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR |
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| DAV | Request for validation of the european patent (deleted) | ||
| DAX | Request for extension of the european patent (deleted) | ||
| A4 | Supplementary search report drawn up and despatched |
Effective date: 20220422 |
|
| RIC1 | Information provided on ipc code assigned before grant |
Ipc: A61P 25/00 20060101ALI20220414BHEP Ipc: A61P 25/06 20060101ALI20220414BHEP Ipc: A61K 31/4545 20060101ALI20220414BHEP Ipc: C07D 401/14 20060101ALI20220414BHEP Ipc: C07D 401/06 20060101AFI20220414BHEP |
|
| P01 | Opt-out of the competence of the unified patent court (upc) registered |
Effective date: 20231228 |