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EP3814326A4 - Dihydropyrimidine derivatives and uses thereof in the treatment of hbv infection or of hbv-induced diseases - Google Patents

Dihydropyrimidine derivatives and uses thereof in the treatment of hbv infection or of hbv-induced diseases Download PDF

Info

Publication number
EP3814326A4
EP3814326A4 EP19825897.2A EP19825897A EP3814326A4 EP 3814326 A4 EP3814326 A4 EP 3814326A4 EP 19825897 A EP19825897 A EP 19825897A EP 3814326 A4 EP3814326 A4 EP 3814326A4
Authority
EP
European Patent Office
Prior art keywords
hbv
treatment
induced diseases
dihydropyrimidine derivatives
infection
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19825897.2A
Other languages
German (de)
French (fr)
Other versions
EP3814326A1 (en
Inventor
Gang Deng
Yimin Jiang
Qian Liu
Chao Liang
Zhao-Kui Wan
Wing Shun CHEUNG
Zhanling CHENG
Yanping Xu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Sciences Ireland ULC
Original Assignee
Janssen Sciences Ireland ULC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Sciences Ireland ULC filed Critical Janssen Sciences Ireland ULC
Publication of EP3814326A1 publication Critical patent/EP3814326A1/en
Publication of EP3814326A4 publication Critical patent/EP3814326A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP19825897.2A 2018-06-26 2019-06-25 Dihydropyrimidine derivatives and uses thereof in the treatment of hbv infection or of hbv-induced diseases Withdrawn EP3814326A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2018092875 2018-06-26
US201862716823P 2018-08-09 2018-08-09
PCT/CN2019/092857 WO2020001448A1 (en) 2018-06-26 2019-06-25 Dihydropyrimidine derivatives and uses thereof in the treatment of hbv infection or of hbv-induced diseases

Publications (2)

Publication Number Publication Date
EP3814326A1 EP3814326A1 (en) 2021-05-05
EP3814326A4 true EP3814326A4 (en) 2022-03-16

Family

ID=68984711

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19825897.2A Withdrawn EP3814326A4 (en) 2018-06-26 2019-06-25 Dihydropyrimidine derivatives and uses thereof in the treatment of hbv infection or of hbv-induced diseases

Country Status (8)

Country Link
EP (1) EP3814326A4 (en)
JP (1) JP2021529188A (en)
KR (1) KR20210025596A (en)
CN (1) CN112513017A (en)
AU (1) AU2019296117A1 (en)
CA (1) CA3099605A1 (en)
MA (1) MA53023A (en)
WO (1) WO2020001448A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3558363A1 (en) 2016-12-21 2019-10-30 Amgen Inc. Anti-tnf alpha antibody formulations
EP3645516A4 (en) 2017-06-27 2021-07-07 Janssen Pharmaceutica NV Heteroaryldihydropyrimidine derivatives and methods of treating hepatitis b infections
US11053235B2 (en) * 2018-08-09 2021-07-06 Janssen Sciences Ireland Unlimited Company Substituted 1,4-dihydropyrimidines for the treatment of HBV infection or HBV-induced diseases
CN114989097A (en) * 2022-05-20 2022-09-02 无锡捷化医药科技有限公司 Preparation method of 5-amino-6-chloropyrimidine-4-carboxylic acid ethyl ester

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014029193A1 (en) * 2012-08-24 2014-02-27 Sunshine Lake Pharma Co., Ltd. Dihydropyrimidine compounds and their application in pharmaceuticals

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10179131B2 (en) * 2015-07-13 2019-01-15 Enanta Pharmaceuticals, Inc. Hepatitis B antiviral agents
EP3645516A4 (en) * 2017-06-27 2021-07-07 Janssen Pharmaceutica NV Heteroaryldihydropyrimidine derivatives and methods of treating hepatitis b infections

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014029193A1 (en) * 2012-08-24 2014-02-27 Sunshine Lake Pharma Co., Ltd. Dihydropyrimidine compounds and their application in pharmaceuticals

Also Published As

Publication number Publication date
MA53023A (en) 2021-05-05
EP3814326A1 (en) 2021-05-05
JP2021529188A (en) 2021-10-28
AU2019296117A1 (en) 2020-11-26
KR20210025596A (en) 2021-03-09
CN112513017A (en) 2021-03-16
WO2020001448A1 (en) 2020-01-02
CA3099605A1 (en) 2020-01-02

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