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EP3775163A4 - METHOD OF INDUCING OR ENHANCEMENT OF THE WOUND HEALING PROPERTIES OF MESENCHYMAL STEM CELLS - Google Patents

METHOD OF INDUCING OR ENHANCEMENT OF THE WOUND HEALING PROPERTIES OF MESENCHYMAL STEM CELLS Download PDF

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Publication number
EP3775163A4
EP3775163A4 EP19784508.4A EP19784508A EP3775163A4 EP 3775163 A4 EP3775163 A4 EP 3775163A4 EP 19784508 A EP19784508 A EP 19784508A EP 3775163 A4 EP3775163 A4 EP 3775163A4
Authority
EP
European Patent Office
Prior art keywords
enhancement
inducing
stem cells
wound healing
mesenchymal stem
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP19784508.4A
Other languages
German (de)
French (fr)
Other versions
EP3775163A1 (en
Inventor
Toan Thang Phan
Gavin TAN
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CellResearch Corp Pte Ltd
Original Assignee
CellResearch Corp Pte Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CellResearch Corp Pte Ltd filed Critical CellResearch Corp Pte Ltd
Publication of EP3775163A1 publication Critical patent/EP3775163A1/en
Publication of EP3775163A4 publication Critical patent/EP3775163A4/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0068—General culture methods using substrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0665—Blood-borne mesenchymal stem cells, e.g. from umbilical cord blood
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0668—Mesenchymal stem cells from other natural sources
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/11—Epidermal growth factor [EGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/33—Insulin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/38—Hormones with nuclear receptors
    • C12N2501/395—Thyroid hormones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2509/00—Methods for the dissociation of cells, e.g. specific use of enzymes
    • C12N2509/10—Mechanical dissociation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Developmental Biology & Embryology (AREA)
  • Cell Biology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Rheumatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
EP19784508.4A 2018-04-12 2019-04-12 METHOD OF INDUCING OR ENHANCEMENT OF THE WOUND HEALING PROPERTIES OF MESENCHYMAL STEM CELLS Pending EP3775163A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862656531P 2018-04-12 2018-04-12
PCT/SG2019/050204 WO2019199234A1 (en) 2018-04-12 2019-04-12 A method of inducing or improving wound healing properties of mesenchymal stem cells

Publications (2)

Publication Number Publication Date
EP3775163A1 EP3775163A1 (en) 2021-02-17
EP3775163A4 true EP3775163A4 (en) 2022-03-09

Family

ID=68163253

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19784508.4A Pending EP3775163A4 (en) 2018-04-12 2019-04-12 METHOD OF INDUCING OR ENHANCEMENT OF THE WOUND HEALING PROPERTIES OF MESENCHYMAL STEM CELLS

Country Status (12)

Country Link
EP (1) EP3775163A4 (en)
JP (2) JP7541730B2 (en)
KR (1) KR20200143399A (en)
CN (1) CN112262211A (en)
AU (1) AU2019250653A1 (en)
BR (1) BR112020020092A2 (en)
CA (1) CA3095490A1 (en)
PH (1) PH12020551658A1 (en)
SG (1) SG11202009687PA (en)
TW (1) TW202012618A (en)
WO (1) WO2019199234A1 (en)
ZA (1) ZA202005967B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH12022550639A1 (en) * 2019-10-08 2023-03-27 Cellresearch Corp Pte Ltd A method of assessing wound healing potency of a mesenchymal stem population and related methods of selecting mesenchymal stem cells and identifying tissue as starting material for producing a mesenchymal stem cell population
WO2021257073A1 (en) * 2020-06-17 2021-12-23 Joy Kong Method for producing mesenchymal stem cells from neonatal stem cells
WO2022004938A1 (en) * 2020-06-30 2022-01-06 주식회사 미래셀바이오 Method for preparing mesenchymal-like stem cells
CN114196626A (en) * 2022-02-16 2022-03-18 北京国卫生物科技有限公司 Umbilical cord mesenchymal stem cells and isolated culture and amplification method thereof
WO2024107102A1 (en) * 2022-11-17 2024-05-23 Cellresearch Corporation Pte. Ltd. Use of conditioned medium derived from cultivation of mesenchymal stem cells of the umbilical cord for inducing, stimulating and promoting hair growth and regeneration
WO2024123237A1 (en) * 2022-12-09 2024-06-13 Cellresearch Corporation Pte. Ltd. Use of conditioned medium of cord lining mesenchymal stem cells for healing and/or preventing the formation and/or recurrence of a wound or a damaged skin area

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019199230A1 (en) * 2018-04-09 2019-10-17 Cellresearch Corporation Pte. Ltd. A method of transporting mesenchymal stem cells by means of a cell culture medium and a method of administering stem cells to wounds

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI287010B (en) * 2003-06-12 2007-09-21 Euro Celtique Sa Therapeutic agents useful for treating pain
AU2005273077B2 (en) * 2004-08-16 2011-02-24 Cellresearch Corporation Pte Ltd Isolation of stem/progenitor cells from amniotic membrane of umbilical cord.
CN101189341B (en) * 2005-04-04 2016-10-19 纳幕尔杜邦公司 Polynucleotides and methods for producing plants resistant to fungal pathogens
EP1937326B1 (en) * 2005-10-21 2018-09-12 CellResearch Corporation Pte Ltd Isolation and cultivation of stem/progenitor cells from the amniotic membrane of umbilical cord and uses of cells differentiated therefrom
JP4569711B2 (en) * 2006-04-14 2010-10-27 和光純薬工業株式会社 Multiple solution introduction structure, microfluidic device having the structure, and solution introduction method
WO2008123918A1 (en) * 2007-04-02 2008-10-16 The General Hospital Corporation Cellular compositions for the treatment of kidney disease and uses thereof
KR101138091B1 (en) 2011-08-31 2012-04-24 세원셀론텍(주) Method for manufacturing basic culture media for mesenchymal stem cell, basic culture media for mesenchymal stem cell and cell theraphy products cultured and differenciated using the same
WO2013059528A2 (en) * 2011-10-18 2013-04-25 City Of Hope Encapsulated diagnostics and therapeutics in nanoparticles-conjugated to tropic cells and methods for their use
WO2013066721A2 (en) * 2011-11-04 2013-05-10 Dicerna Pharmaceuticals, Inc. Methods and compositions for the specific inhibition of met by double-stranded rna
CN104630142B (en) * 2015-02-06 2018-06-05 广州赛莱拉干细胞科技股份有限公司 A kind of isolation and culture method of ox umbilical cord mesenchymal stem cells
EP3385368B1 (en) * 2015-12-03 2023-03-01 Takara Bio Inc. Method for producing mesenchymal stem cells
WO2017096607A1 (en) * 2015-12-11 2017-06-15 郭镭 Method for separating and extracting huc-msc from outer layer of amniotic membrane tissue of umbilical cord
BR112019005652A2 (en) * 2016-10-05 2019-06-04 Cellresearch Corp Pte Ltd method of isolating mesenchymal stem cells from the umbilical cord amniotic membrane using a cell culture medium

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019199230A1 (en) * 2018-04-09 2019-10-17 Cellresearch Corporation Pte. Ltd. A method of transporting mesenchymal stem cells by means of a cell culture medium and a method of administering stem cells to wounds

Also Published As

Publication number Publication date
ZA202005967B (en) 2021-08-25
PH12020551658A1 (en) 2021-07-26
SG11202009687PA (en) 2020-10-29
AU2019250653A1 (en) 2020-10-15
KR20200143399A (en) 2020-12-23
CA3095490A1 (en) 2019-10-17
EP3775163A1 (en) 2021-02-17
WO2019199234A1 (en) 2019-10-17
TW202012618A (en) 2020-04-01
CN112262211A (en) 2021-01-22
JP2021526125A (en) 2021-09-30
JP7541730B2 (en) 2024-08-29
BR112020020092A2 (en) 2021-02-17
JP2024069365A (en) 2024-05-21

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