EP3773747A4 - Utilisation d'exosomes pour l'administration ciblée d'agents thérapeutiques - Google Patents

Utilisation d'exosomes pour l'administration ciblée d'agents thérapeutiques Download PDF

Info

Publication number: EP3773747A4
Authority: EP; European Patent Office
Prior art keywords: exosomes; therapeutic agents; targeted delivery; targeted; delivery
Prior art date: 2018-03-28
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Pending

Application number

EP19776678.5A

Other languages

German (de)

English (en)

Other versions

EP3773747A1 (fr

Inventor

Raghu Kalluri

Valerie LEBLEU

Pedro CORREA DE SAMPAIO

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

University of Texas System

University of Texas at Austin

Original Assignee

University of Texas System

University of Texas at Austin

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2018-03-28

Filing date

2019-03-28

Publication date

2022-02-23

2019-03-28 Application filed by University of Texas System, University of Texas at Austin filed Critical University of Texas System

2021-02-17 Publication of EP3773747A1 publication Critical patent/EP3773747A1/fr

2022-02-23 Publication of EP3773747A4 publication Critical patent/EP3773747A4/fr

Status Pending legal-status Critical Current

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/45—Transferases (2)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/111—General methods applicable to biologically active non-coding nucleic acids
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C12N2320/32—Special delivery means, e.g. tissue-specific

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Chemical & Material Sciences (AREA)
Biomedical Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Wood Science & Technology (AREA)
General Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Zoology (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Epidemiology (AREA)
Physics & Mathematics (AREA)
Biophysics (AREA)
Plant Pathology (AREA)
Microbiology (AREA)
Biochemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Immunology (AREA)
Gastroenterology & Hepatology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Medicinal Preparation (AREA)
Peptides Or Proteins (AREA)

EP19776678.5A 2018-03-28 2019-03-28 Utilisation d'exosomes pour l'administration ciblée d'agents thérapeutiques Pending EP3773747A4 (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US201862649057P	2018-03-28	2018-03-28
PCT/US2019/024603 WO2019191444A1 (fr)	2018-03-28	2019-03-28	Utilisation d'exosomes pour l'administration ciblée d'agents thérapeutiques

Publications (2)

Publication Number	Publication Date
EP3773747A1 EP3773747A1 (fr)	2021-02-17
EP3773747A4 true EP3773747A4 (fr)	2022-02-23

Family

ID=68060505

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP19776678.5A Pending EP3773747A4 (fr)	2018-03-28	2019-03-28	Utilisation d'exosomes pour l'administration ciblée d'agents thérapeutiques

Country Status (7)

Country	Link
EP (1)	EP3773747A4 (fr)
JP (1)	JP7813099B2 (fr)
KR (1)	KR20200136978A (fr)
CN (1)	CN112533643A (fr)
AU (1)	AU2019243179B2 (fr)
CA (1)	CA3095136A1 (fr)
WO (1)	WO2019191444A1 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2019242912B2 (en)	2018-03-28	2025-07-17	Board Of Regents, The University Of Texas System	Identification of epigenetic alterations in DNA isolated from exosomes
IT201900007785A1 (it) *	2019-05-31	2020-12-01	Univ Degli Studi Milano	Vescicole extracellulari per veicolare farmaci terapeutici o diagnostici
KR20220124170A (ko) *	2019-12-05	2022-09-13	더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템	간 섬유증 및 섬유증 관련 기타 질환에 대한 엑소좀 기반 치료요법
US12311053B2 (en)	2019-12-13	2025-05-27	Lawrence Livermore National Security, Llc	Nanotube-vesicle compositions and uses thereof
WO2021119552A1 (fr) *	2019-12-13	2021-06-17	Lawrence Livermore National Security, Llc	Compositions de vésicule à nanotubes et utilisations associées
CN117860902B (zh) *	2021-11-17	2024-07-16	中国人民解放军空军军医大学	一种前列腺癌分子靶向系统及其构建方法和应用
CN114774471A (zh) *	2022-05-10	2022-07-22	厦门星际诺康细胞科技有限公司	一种呈现il27稳转细胞及其构建方法、呈现il27工程化外泌体及其制备方法和应用
WO2026002276A1 (fr) *	2024-06-28	2026-01-02	艾码生物科技(南京)有限公司	Procédé d'interférence d'arn ciblant tgfb, acide nucléique et application associée

Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2015085096A1 (fr) *	2013-12-04	2015-06-11	Board Of Regents, The University Of Texas System	Analyse d'adn génomique, d'arn et de protéines dans des exosomes pour le diagnostic et la thérapie
WO2016201323A1 (fr) *	2015-06-10	2016-12-15	Board Of Regents, The University Of Texas System	Utilisation d'exosomes pour le traitement de maladies

Family Cites Families (7)

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Publication number	Priority date	Publication date	Assignee	Title
US7473678B2 (en) *	2004-10-14	2009-01-06	Biomimetic Therapeutics, Inc.	Platelet-derived growth factor compositions and methods of use thereof
US9085778B2 (en) *	2006-05-03	2015-07-21	VL27, Inc.	Exosome transfer of nucleic acids to cells
GB201121069D0 (en) *	2011-12-07	2012-01-18	Isis Innovation	Delivery system
US9856477B2 (en) *	2012-11-13	2018-01-02	Codiak Biosciences, Inc.	Delivery of therapeutic agent
US20150290233A1 (en) *	2012-11-29	2015-10-15	Yeda Research And Development Co.Ltd. At The Weizmann Institute Of Science	Methods of preventing tumor metastasis, treating and prognosing cancer and identifying agents which are putative metastasis inhibitors
AU2016381513A1 (en) *	2015-12-30	2018-07-19	The Regents Of The University Of California	Methods for enhanced production and isolation of cell-derived vesicles
TWI601741B (zh) *	2016-07-11	2017-10-11	財團法人國家衛生研究院	利用前列腺素受體ｅｐ４－拮抗劑誘導幹細胞製造含有高囊泡含物之外泌體囊泡的方法及其應用

2019
- 2019-03-28 JP JP2020551798A patent/JP7813099B2/ja active Active
- 2019-03-28 KR KR1020207030993A patent/KR20200136978A/ko not_active Ceased
- 2019-03-28 EP EP19776678.5A patent/EP3773747A4/fr active Pending
- 2019-03-28 AU AU2019243179A patent/AU2019243179B2/en active Active
- 2019-03-28 CN CN201980034058.9A patent/CN112533643A/zh active Pending
- 2019-03-28 CA CA3095136A patent/CA3095136A1/fr active Pending
- 2019-03-28 WO PCT/US2019/024603 patent/WO2019191444A1/fr not_active Ceased

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2015085096A1 (fr) *	2013-12-04	2015-06-11	Board Of Regents, The University Of Texas System	Analyse d'adn génomique, d'arn et de protéines dans des exosomes pour le diagnostic et la thérapie
WO2016201323A1 (fr) *	2015-06-10	2016-12-15	Board Of Regents, The University Of Texas System	Utilisation d'exosomes pour le traitement de maladies

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
See also references of WO2019191444A1 *
SHIN-ICHIRO OHNO ET AL: "Systemically Injected Exosomes Targeted to EGFR Deliver Antitumor MicroRNA to Breast Cancer Cells", MOLECULAR THERAPY, vol. 21, no. 1, 1 January 2013 (2013-01-01), US, pages 185 - 191, XP055501314, ISSN: 1525-0016, DOI: 10.1038/mt.2012.180 *

Also Published As

Publication number	Publication date
EP3773747A1 (fr)	2021-02-17
WO2019191444A1 (fr)	2019-10-03
KR20200136978A (ko)	2020-12-08
JP7813099B2 (ja)	2026-02-12
CA3095136A1 (fr)	2019-10-03
AU2019243179A1 (en)	2020-11-12
JP2021519296A (ja)	2021-08-10
CN112533643A (zh)	2021-03-19
AU2019243179B2 (en)	2025-09-18

Publication	Publication Date	Title
EP3773747A4 (fr)	2022-02-23	Utilisation d'exosomes pour l'administration ciblée d'agents thérapeutiques
EP3813853A4 (fr)	2022-04-06	Compositions pour l'administration de médicaments et leurs méthodes d'utilisation
EP3840730A4 (fr)	2021-12-22	Compositions pour l'administration d'agents thérapeutiques et leurs méthodes d'utilisation et leurs procédés de préparation
EP3634506A4 (fr)	2021-03-10	Pansement pour surveillance de plaie et administration d'agent thérapeutique
MA51796A (fr)	2020-12-16	Procédés et compositions pour l'administration de protéines thérapeutiques
EP3817696A4 (fr)	2022-03-30	Dispositifs d'administration oculaire topique et leurs procédés d'utilisation
EP3826589A4 (fr)	2022-04-20	Dispositif ophtalmique pour l'administration de médicaments
EP3512554A4 (fr)	2020-06-17	Compositions plaquettaires et procédés pour l'administration d'agents thérapeutiques
EP3817747A4 (fr)	2022-07-06	Administration ciblée d'agents thérapeutiques à des adipocytes humains
MA50557A (fr)	2020-09-16	Pistons pour dispositifs d'administration de médicament
EP3740272A4 (fr)	2021-10-20	Orifice d'injection pour administration thérapeutique
EP3256149A4 (fr)	2019-08-14	Formulations pour administration orale d'agents actifs
EP3697481A4 (fr)	2021-07-14	Appareil d'administration de médicaments par voie nasale et procédés d'utilisation
EP3310343A4 (fr)	2019-02-20	Compositions implantables pour administration de médicaments et méthodes d'utilisation desdites compositions
EP3836866A4 (fr)	2022-06-15	Systèmes d'administration entérique d'agents thérapeutiques
EP3921420A4 (fr)	2022-11-16	Compositions d'administration de médicament pour l'administration oculaire d'agents thérapeutiques et leurs méthodes d'utilisation
EP3324944A4 (fr)	2019-04-03	Systèmes d'administration de médicaments intravitréens pour le traitement d'états oculaires
EP3498280A4 (fr)	2020-03-18	Administration et dosage d'un agent thérapeutique pour l'endométriose
EP3509573A4 (fr)	2020-04-29	Compositions pharmaceutiques pour l'administration d'un peptide
EP3852655A4 (fr)	2022-06-22	Dispositifs d'exosquelette extensibles pour administration de médicaments
EP3672587A4 (fr)	2021-05-19	Compositions pharmaceutiques destinées au traitement d'affections ophtalmiques
EP3500291A4 (fr)	2020-03-11	Formulations pour l'administration par voie orale d'agents actifs
EP3454868A4 (fr)	2019-12-18	Système d'administration de médicaments pour l'administration d'agents antiviraux
GB201803435D0 (en)	2018-04-18	Porous scaffold for the delivery of therapeutic agents
EP3471829A4 (fr)	2020-01-15	Système d'administration de médicaments pour l'administration d'agents antiviraux

Legal Events

Date	Code	Title	Description
2019-10-05	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE
2021-01-15	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2021-01-15	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE
2021-02-17	17P	Request for examination filed	Effective date: 20200930
2021-02-17	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
2021-02-17	AX	Request for extension of the european patent	Extension state: BA ME
2021-07-07	DAV	Request for validation of the european patent (deleted)
2021-07-07	DAX	Request for extension of the european patent (deleted)
2022-02-23	A4	Supplementary search report drawn up and despatched	Effective date: 20220124
2022-02-23	RIC1	Information provided on ipc code assigned before grant	Ipc: C12N 15/113 20100101ALI20220118BHEP Ipc: C12N 15/87 20060101ALI20220118BHEP Ipc: A61K 48/00 20060101AFI20220118BHEP