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EP3724708A4 - SYSTEMS, DEVICES AND METHODS FOR SIMULTANEOUS IMAGING OF MULTIPLE LEVELS - Google Patents

SYSTEMS, DEVICES AND METHODS FOR SIMULTANEOUS IMAGING OF MULTIPLE LEVELS Download PDF

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Publication number
EP3724708A4
EP3724708A4 EP18889118.8A EP18889118A EP3724708A4 EP 3724708 A4 EP3724708 A4 EP 3724708A4 EP 18889118 A EP18889118 A EP 18889118A EP 3724708 A4 EP3724708 A4 EP 3724708A4
Authority
EP
European Patent Office
Prior art keywords
systems
methods
devices
multiple levels
simultaneous imaging
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP18889118.8A
Other languages
German (de)
French (fr)
Other versions
EP3724708B1 (en
EP3724708A1 (en
Inventor
Dmitri Tsyboulski
Natalia ORLOVA
Jérôme Anthony LECOQ
Peter Saggau
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Allen Institute
Original Assignee
Allen Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allen Institute filed Critical Allen Institute
Publication of EP3724708A1 publication Critical patent/EP3724708A1/en
Publication of EP3724708A4 publication Critical patent/EP3724708A4/en
Application granted granted Critical
Publication of EP3724708B1 publication Critical patent/EP3724708B1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0052—Optical details of the image generation
    • G02B21/0076—Optical details of the image generation arrangements using fluorescence or luminescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6402—Atomic fluorescence; Laser induced fluorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • G01N21/6458—Fluorescence microscopy
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0032—Optical details of illumination, e.g. light-sources, pinholes, beam splitters, slits, fibers
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/36—Microscopes arranged for photographic purposes or projection purposes or digital imaging or video purposes including associated control and data processing arrangements
    • G02B21/365—Control or image processing arrangements for digital or video microscopes
    • G02B21/367—Control or image processing arrangements for digital or video microscopes providing an output produced by processing a plurality of individual source images, e.g. image tiling, montage, composite images, depth sectioning, image comparison
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B27/00—Optical systems or apparatus not provided for by any of the groups G02B1/00 - G02B26/00, G02B30/00
    • G02B27/28—Optical systems or apparatus not provided for by any of the groups G02B1/00 - G02B26/00, G02B30/00 for polarising
    • G02B27/283—Optical systems or apparatus not provided for by any of the groups G02B1/00 - G02B26/00, G02B30/00 for polarising used for beam splitting or combining
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B2207/00—Coding scheme for general features or characteristics of optical elements and systems of subclass G02B, but not including elements and systems which would be classified in G02B6/00 and subgroups
    • G02B2207/114—Two photon or multiphoton effect

Landscapes

  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Health & Medical Sciences (AREA)
  • Multimedia (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Microscoopes, Condenser (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
EP18889118.8A 2017-12-12 2018-12-11 Systems, apparatuses, and methods for simultaneous multi-plane imaging Active EP3724708B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762597864P 2017-12-12 2017-12-12
US201862754722P 2018-11-02 2018-11-02
PCT/US2018/064909 WO2019118433A1 (en) 2017-12-12 2018-12-11 Systems, apparatuses, and methods for simultaneous multi-plane imaging

Publications (3)

Publication Number Publication Date
EP3724708A1 EP3724708A1 (en) 2020-10-21
EP3724708A4 true EP3724708A4 (en) 2021-08-25
EP3724708B1 EP3724708B1 (en) 2024-03-27

Family

ID=66820638

Family Applications (1)

Application Number Title Priority Date Filing Date
EP18889118.8A Active EP3724708B1 (en) 2017-12-12 2018-12-11 Systems, apparatuses, and methods for simultaneous multi-plane imaging

Country Status (6)

Country Link
US (1) US11307143B2 (en)
EP (1) EP3724708B1 (en)
JP (1) JP7287961B2 (en)
CN (1) CN111615657B (en)
CA (1) CA3083287C (en)
WO (1) WO2019118433A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111175263B (en) * 2020-01-15 2021-08-20 广州市凯佳光学科技有限公司 Multi-photon fluorescence microscopic imaging system and imaging method
JP2023106641A (en) * 2020-06-10 2023-08-02 浜松ホトニクス株式会社 Observation device and observation method
EP4214562A4 (en) * 2020-09-20 2024-11-20 The Regents Of The University Of California TRANSVERSAL FILM ILLUMINATION MICROSCOPY (TRANSIM)
CN112711130B (en) * 2020-10-31 2022-02-11 浙江大学 Phase-modulated fluorescence differential microscopy imaging method and device based on electro-optic modulation technology
US11994661B2 (en) 2021-02-05 2024-05-28 Meadowlark Optics, Inc. Simultaneous focusing of an optical system to multiple focal planes using liquid crystal polarization lenses
CN113835211B (en) * 2021-08-20 2023-06-30 中国科学院光电技术研究所 Method for improving field duty ratio of field-of-view gating imaging system
DE102022209236A1 (en) 2021-09-06 2023-03-09 Universitätsklinikum Hamburg-Eppendorf, Körperschaft des öffentlichen Rechts Passive device for generating light in an output beam with a first light component and a second light component, the first light component being polarized essentially orthogonally to the second light component, and uses for this device
CN114812443B (en) * 2022-04-24 2024-08-02 合肥工业大学 Straightness and roll angle error simultaneous measurement system

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9638909B2 (en) * 2006-12-22 2017-05-02 Isis Innovation Limited Focusing apparatus and method

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2312114B (en) * 1996-04-09 2000-03-29 Icg Ltd Apparatus for and method of controlling an image recording device
KR100325687B1 (en) * 1999-12-21 2002-02-25 윤덕용 A low-cost WDM source with an incoherent light injected Fabry-Perot semiconductor laser diode
US7170598B2 (en) * 2002-10-17 2007-01-30 Direvo Biotech Ag Multi-parameter fluorimetric analysis in a massively parallel multi-focal arrangement and the use thereof
KR100955129B1 (en) * 2003-05-30 2010-04-28 정보통신연구진흥원 Implementation Method of Wavelength Division Multiplexing Passive Network Using Incoherent Wideband Light Source
US7092595B2 (en) * 2004-05-18 2006-08-15 Novera Optics, Inc. Multiple-wavelength pulsed light source for a wavelength division multiplexed passive optical network
KR100680815B1 (en) * 2004-11-09 2007-02-08 한국과학기술원 Optical modulation method of wavelength-fixed FPD-LD by injecting broadband incoherent light source using mutual injection of FPD-LD
WO2006127967A2 (en) * 2005-05-25 2006-11-30 Massachusetts Institute Of Technology Multifocal scanning microscopy systems and methods
US8571410B2 (en) * 2006-10-11 2013-10-29 Novera Optics, Inc. Mutual wavelength locking in WDM-PONS
JP2008286736A (en) * 2007-05-21 2008-11-27 Nippon Sheet Glass Co Ltd Method and apparatus for detecting feeble signal
US8259212B2 (en) * 2009-01-05 2012-09-04 Applied Quantum Technologies, Inc. Multiscale optical system
US8488919B1 (en) * 2009-01-07 2013-07-16 Alliance Fiber Optic Products, Inc. Apparatus for combining multiple signals as depolarized output
FR2941787B1 (en) * 2009-02-04 2011-04-15 Ecole Polytech METHOD AND DEVICE FOR ACQUIRING SIGNALS IN LASER SCANNING MICROSCOPY.
JP5525882B2 (en) * 2010-03-24 2014-06-18 オリンパス株式会社 Light source device and scanning microscope
DE102011013613A1 (en) * 2010-10-01 2012-04-05 Carl Zeiss Microimaging Gmbh Microscope and microscopy method
US9103721B2 (en) * 2011-04-07 2015-08-11 Uwm Research Foundation, Inc. High speed microscope with spectral resolution
US9250128B2 (en) * 2012-03-02 2016-02-02 Beihang University Method and apparatus for optical asynchronous sampling signal measurements
DE102012010207B4 (en) * 2012-05-15 2024-02-29 Carl Zeiss Microscopy Gmbh Microscope and microscopy methods
DE102012009836A1 (en) * 2012-05-16 2013-11-21 Carl Zeiss Microscopy Gmbh Light microscope and method for image acquisition with a light microscope
JP6116142B2 (en) * 2012-06-21 2017-04-19 オリンパス株式会社 Scanning confocal laser microscope
US10180564B2 (en) * 2013-07-02 2019-01-15 Nanyang Technological University Methods and systems for transport-of-intensity imaging

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9638909B2 (en) * 2006-12-22 2017-05-02 Isis Innovation Limited Focusing apparatus and method

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
JAMES NICHOLAS SOFRONIEW ET AL: "A large field of view two-photon mesoscope with subcellular resolution for in vivo imaging", ELIFE, 14 June 2016 (2016-06-14), pages 1 - 20, XP055590448, DOI: 10.7554/eLife.14472 *
JEFFREY N STIRMAN ET AL: "Wide field-of-view, multi-region, two-photon imaging of neuronal activity in the mammalian brain", NATURE BIOTECHNOLOGY, vol. 34, no. 8, 27 June 2016 (2016-06-27), New York, pages 857 - 862, XP055590489, ISSN: 1087-0156, DOI: 10.1038/nbt.3594 *
STIRMAN, JEFFREY N ET AL: "Wide field-of-view, multi-region, two-photon imaging of neuronal activity in the mammalian brain - supplementary information", NATURE BIOTECHNOLOGY, vol. 34, no. 8, 1 August 2016 (2016-08-01), New York, pages 857 - 862, XP055826098, ISSN: 1087-0156, Retrieved from the Internet <URL:https://static-content.springer.com/esm/art:10.1038/nbt.3594/MediaObjects/41587_2016_BFnbt3594_MOESM9_ESM.pdf> DOI: 10.1038/nbt.3594 *

Also Published As

Publication number Publication date
EP3724708B1 (en) 2024-03-27
US20200309701A1 (en) 2020-10-01
US11307143B2 (en) 2022-04-19
WO2019118433A1 (en) 2019-06-20
CN111615657B (en) 2022-10-18
CA3083287C (en) 2024-02-20
JP7287961B2 (en) 2023-06-06
EP3724708A1 (en) 2020-10-21
JP2021507211A (en) 2021-02-22
CN111615657A (en) 2020-09-01
CA3083287A1 (en) 2019-06-20

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