EP3694515A4 - ZINCIONOPHORS AND THEIR USES - Google Patents

ZINCIONOPHORS AND THEIR USES Download PDF

Info

Publication number: EP3694515A4
Authority: EP; European Patent Office
Prior art keywords: zincionophors
Prior art date: 2017-10-13
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Pending

Application number

EP18867181.2A

Other languages

German (de)

French (fr)

Other versions

EP3694515A1 (en

Inventor

Mark Walker

Christopher MCDEVITT

Mark Von Itzstein

Alastair Mcewan

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

University of Adelaide

University of Queensland UQ

Griffith University

Original Assignee

University of Adelaide

University of Queensland UQ

Griffith University

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2017-10-13

Filing date

2018-10-12

Publication date

2021-04-21

2017-10-13 Priority claimed from AU2017904135A external-priority patent/AU2017904135A0/en

2018-10-12 Application filed by University of Adelaide, University of Queensland UQ, Griffith University filed Critical University of Adelaide

2020-08-19 Publication of EP3694515A1 publication Critical patent/EP3694515A1/en

2021-04-21 Publication of EP3694515A4 publication Critical patent/EP3694515A4/en

Status Pending legal-status Critical Current

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/30—Zinc; Compounds thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Immunology (AREA)
Inorganic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Gastroenterology & Hepatology (AREA)
Engineering & Computer Science (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

EP18867181.2A 2017-10-13 2018-10-12 ZINCIONOPHORS AND THEIR USES Pending EP3694515A4 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
AU2017904135A AU2017904135A0 (en)		2017-10-13	Compositions and their uses
PCT/AU2018/051116 WO2019071325A1 (en)	2017-10-13	2018-10-12	Zinc ionophores and uses thereof

Publications (2)

Publication Number	Publication Date
EP3694515A1 EP3694515A1 (en)	2020-08-19
EP3694515A4 true EP3694515A4 (en)	2021-04-21

Family

ID=66100161

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP18867181.2A Pending EP3694515A4 (en)	2017-10-13	2018-10-12	ZINCIONOPHORS AND THEIR USES

Country Status (6)

Country	Link
US (1)	US20200261440A1 (en)
EP (1)	EP3694515A4 (en)
JP (2)	JP7514763B2 (en)
CN (1)	CN111787921A (en)
AU (1)	AU2018348796B2 (en)
WO (1)	WO2019071325A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR3114742A1 (en) *	2020-10-04	2022-04-08	Bruno Eto	Pharmaceutical or dietetic composition for blocking the synthesis of peptides by ribosomes.
CA3237199A1 (en)	2021-11-02	2023-05-11	Flare Therapeutics Inc.	Pparg inverse agonists and uses thereof
CN116726145A (en) *	2022-03-04	2023-09-12	海南普利制药股份有限公司	Stable ester peptide pharmaceutical composition
AU2023319130A1 (en) *	2022-08-01	2025-03-13	Griffith University	Antibacterial compound pbt2

Citations (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5696083A (en) *	1992-11-10	1997-12-09	Olin Corporation	Personal care composition containing pyrithione and polymyxin
WO2009140215A2 (en) *	2008-05-11	2009-11-19	Geraghty, Erin	Method for treating drug-resistant bacterial and other infections with clioquinol, phanquinone, and related compounds
WO2009155088A1 (en) *	2008-05-30	2009-12-23	University Of Cincinnati	Use of zinc chelators to inhibit biofilm formation
WO2014172435A1 (en) *	2013-04-16	2014-10-23	University Of Cincinnati	Antimicrobial compositions of aminoglycosidic antibiotics and zinc ion chelators
WO2015049546A1 (en) *	2013-10-04	2015-04-09	Universitetet I Oslo	Inhibitors of metallo-beta-lactamase (mbl) comprising a zinc chelating moiety
WO2016207183A1 (en) *	2015-06-23	2016-12-29	Janssen Pharmaceutica Nv	Antimicrobial compositions comprising food approved antimicrobials and zinc pyrithione

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2002950217A0 (en) *	2002-07-16	2002-09-12	Prana Biotechnology Limited	8- Hydroxy Quinoline Derivatives
DK1898909T3 (en) *	2005-06-28	2017-02-06	Janssen Pharmaceutica Nv	QUINOLIN DERIVATIVES AS ANTIBACTERIAL AGENTS
US11008290B2 (en)	2015-09-24	2021-05-18	University Of Florida Research Foundation, Incorporated	Halogenated quinoline derivatives as antimicrobial agents

2018
- 2018-10-12 JP JP2020541834A patent/JP7514763B2/en active Active
- 2018-10-12 EP EP18867181.2A patent/EP3694515A4/en active Pending
- 2018-10-12 AU AU2018348796A patent/AU2018348796B2/en active Active
- 2018-10-12 US US16/755,328 patent/US20200261440A1/en active Pending
- 2018-10-12 WO PCT/AU2018/051116 patent/WO2019071325A1/en unknown
- 2018-10-12 CN CN201880076537.2A patent/CN111787921A/en active Pending
2024
- 2024-03-14 JP JP2024040061A patent/JP2024073569A/en not_active Withdrawn

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5696083A (en) *	1992-11-10	1997-12-09	Olin Corporation	Personal care composition containing pyrithione and polymyxin
WO2009140215A2 (en) *	2008-05-11	2009-11-19	Geraghty, Erin	Method for treating drug-resistant bacterial and other infections with clioquinol, phanquinone, and related compounds
WO2009155088A1 (en) *	2008-05-30	2009-12-23	University Of Cincinnati	Use of zinc chelators to inhibit biofilm formation
WO2014172435A1 (en) *	2013-04-16	2014-10-23	University Of Cincinnati	Antimicrobial compositions of aminoglycosidic antibiotics and zinc ion chelators
WO2015049546A1 (en) *	2013-10-04	2015-04-09	Universitetet I Oslo	Inhibitors of metallo-beta-lactamase (mbl) comprising a zinc chelating moiety
WO2016207183A1 (en) *	2015-06-23	2016-12-29	Janssen Pharmaceutica Nv	Antimicrobial compositions comprising food approved antimicrobials and zinc pyrithione

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 59, no. 7, July 2015 (2015-07-01), pages 4148 - 4156, ISSN: 0066-4804(print), DOI: 10.1128/AAC.00885-15 *
BLANCHARD CATLYN ET AL: "Zinc Pyrithione Improves the Antibacterial Activity of Silver Sulfadiazine Ointment", MSPHERE, vol. 1, no. 5, September 2016 (2016-09-01), pages - 16, XP002802337, ISSN: 2379-5042 *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; July 2015 (2015-07-01), LI YIJIA ET AL: "Inhibition of Aminoglycoside Acetyltransferase Resistance Enzymes by Metal Salts", Database accession no. PREV201500708381 *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; September 2016 (2016-09-01), BLANCHARD CATLYN ET AL: "Zinc Pyrithione Improves the Antibacterial Activity of Silver Sulfadiazine Ointment", Database accession no. PREV201700224114 *
KEVIN CHIEM ET AL: "Inhibition of Aminoglycoside 6'-N-Acetyltransferase Type lb- Mediated Amikacin Resistance in Klebsiella pneumoniae by Zinc and Copper Pyrithione", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 59, no. 9, 13 July 2015 (2015-07-13), US, pages 5851 - 5853, XP055591249, ISSN: 0066-4804, DOI: 10.1128/AAC.01106-15 *
LI YIJIA ET AL: "Inhibition of Aminoglycoside Acetyltransferase Resistance Enzymes by Metal Salts", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 59, no. 7, July 2015 (2015-07-01), pages 4148 - 4156, XP002802338, ISSN: 0066-4804 *
MSPHERE, vol. 1, no. 5, September 2016 (2016-09-01), pages Article No.: e00194 - 16, ISSN: 2379-5042(print), DOI: 10.1128/MSPHERE.00194-16 *
See also references of WO2019071325A1 *

Also Published As

Publication number	Publication date
CN111787921A (en)	2020-10-16
AU2018348796B2 (en)	2024-09-26
JP2024073569A (en)	2024-05-29
JP2020536966A (en)	2020-12-17
US20200261440A1 (en)	2020-08-20
AU2018348796A1 (en)	2020-05-07
EP3694515A1 (en)	2020-08-19
JP7514763B2 (en)	2024-07-11
WO2019071325A1 (en)	2019-04-18

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Legal Events

Date	Code	Title	Description
2019-04-19	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE
2020-07-17	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2020-07-17	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE
2020-08-19	17P	Request for examination filed	Effective date: 20200512
2020-08-19	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
2020-08-19	AX	Request for extension of the european patent	Extension state: BA ME
2020-12-02	RIC1	Information provided on ipc code assigned before grant	Ipc: A61K 31/47 20060101AFI20201026BHEP Ipc: A61P 31/04 20060101ALI20201026BHEP Ipc: A61K 33/30 20060101ALI20201026BHEP
2021-01-20	DAV	Request for validation of the european patent (deleted)
2021-01-20	DAX	Request for extension of the european patent (deleted)
2021-04-21	A4	Supplementary search report drawn up and despatched	Effective date: 20210323
2021-04-21	RIC1	Information provided on ipc code assigned before grant	Ipc: A61K 31/47 20060101AFI20210316BHEP Ipc: A61K 33/30 20060101ALI20210316BHEP Ipc: A61P 31/04 20060101ALI20210316BHEP
2023-05-18	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: EXAMINATION IS IN PROGRESS
2023-06-21	17Q	First examination report despatched	Effective date: 20230517