EP3394038A4 - Gezielte auswahl von patienten zur behandlung mit spezifischen cortistatinderivaten - Google Patents

Gezielte auswahl von patienten zur behandlung mit spezifischen cortistatinderivaten Download PDF

Info

Publication number: EP3394038A4
Authority: EP; European Patent Office
Prior art keywords: cortistantide; derivatives; treatment; specific; patient selection
Prior art date: 2015-12-23
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP16880061.3A

Other languages

English (en)

French (fr)

Other versions

EP3394038A1 (de

Inventor

Matthew D. Shair

Henry Efrem Pelish

Ioana Llinca NITULESCU

Jae Young Ahn

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Harvard University

Original Assignee

Harvard University

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2015-12-23

Filing date

2016-12-21

Publication date

2019-08-21

2016-12-21 Application filed by Harvard University filed Critical Harvard University

2018-10-31 Publication of EP3394038A1 publication Critical patent/EP3394038A1/de

2019-08-21 Publication of EP3394038A4 publication Critical patent/EP3394038A4/de

Status Withdrawn legal-status Critical Current

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/08—Bridged systems
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Oncology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Hematology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

EP16880061.3A 2015-12-23 2016-12-21 Gezielte auswahl von patienten zur behandlung mit spezifischen cortistatinderivaten Withdrawn EP3394038A4 (de)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US201562387246P	2015-12-23	2015-12-23
US201662297494P	2016-02-19	2016-02-19
US201662298357P	2016-02-22	2016-02-22
PCT/US2016/068137 WO2017112823A1 (en)	2015-12-23	2016-12-21	Targeted selection of patients for treatment with specific cortistatin derivatives

Publications (2)

Publication Number	Publication Date
EP3394038A1 EP3394038A1 (de)	2018-10-31
EP3394038A4 true EP3394038A4 (de)	2019-08-21

Family

ID=59091224

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP16880061.3A Withdrawn EP3394038A4 (de)	2015-12-23	2016-12-21	Gezielte auswahl von patienten zur behandlung mit spezifischen cortistatinderivaten

Country Status (3)

Country	Link
US (1)	US20180369230A1 (de)
EP (1)	EP3394038A4 (de)
WO (1)	WO2017112823A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN107847763A (zh) *	2015-05-08	2018-03-27	哈佛学院院长等	靶向选择适合于用皮质抑素衍生物治疗的患者
EP3541408B1 (de)	2016-11-15	2024-11-13	The Schepens Eye Research Institute, Inc.	Zusammensetzungen und verfahren zur behandlung von aberrierender angiogene
JP7657440B2 (ja)	2017-06-12	2025-04-07	ブルーフィンバイオメディシン，インコーポレイテッド	抗－ｉｌ１ｒａｐ抗体および抗体薬物コンジュゲート
JP7416700B2 (ja)	2017-11-14	2024-01-17	ザスキーペンズアイリサーチインスティチュートインコーポレイテッド	増殖性硝子体網膜症および上皮間葉転換と関連付けられる状態の治療のためのｒｕｎｘ１阻害の方法
CN109337907B (zh) *	2018-11-15	2021-04-20	南通大学附属医院	一种用于抑制TCF12基因的siRNA分子

Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2016182904A1 (en) *	2015-05-08	2016-11-17	President And Fellows Of Harvard College	Targeted selection of patients for treatment with cortistatin derivatives

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20110190323A1 (en) *	2008-08-28	2011-08-04	President And Fellows Of Harvard College	Cortistatin analogues and syntheses thereof
WO2013122609A1 (en) *	2012-02-17	2013-08-22	Genentech, Inc.	Methods of using cdk8 antagonists
SG11201605178WA (en) *	2013-12-24	2016-07-28	Harvard College	Cortistatin analogues and syntheses and uses thereof

2016
- 2016-12-21 EP EP16880061.3A patent/EP3394038A4/de not_active Withdrawn
- 2016-12-21 WO PCT/US2016/068137 patent/WO2017112823A1/en active Application Filing
2018
- 2018-06-22 US US16/016,242 patent/US20180369230A1/en not_active Abandoned

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2016182904A1 (en) *	2015-05-08	2016-11-17	President And Fellows Of Harvard College	Targeted selection of patients for treatment with cortistatin derivatives

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
HENRY E. PELISH ET AL: "Mediator kinase inhibition further activates super-enhancer-associated genes in AML", NATURE, vol. 526, no. 7572, 28 September 2015 (2015-09-28), London, pages 273 - 276, XP055328581, ISSN: 0028-0836, DOI: 10.1038/nature14904 *
See also references of WO2017112823A1 *

Also Published As

Publication number	Publication date
US20180369230A1 (en)	2018-12-27
EP3394038A1 (de)	2018-10-31
WO2017112823A1 (en)	2017-06-29

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Legal Events

Date	Code	Title	Description
2018-09-28	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2018-10-31	17P	Request for examination filed	Effective date: 20180720
2018-10-31	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
2018-10-31	AX	Request for extension of the european patent	Extension state: BA ME
2019-04-03	DAV	Request for validation of the european patent (deleted)
2019-04-03	DAX	Request for extension of the european patent (deleted)
2019-08-21	A4	Supplementary search report drawn up and despatched	Effective date: 20190718
2019-08-21	RIC1	Information provided on ipc code assigned before grant	Ipc: A61K 31/4725 20060101AFI20190712BHEP Ipc: C07D 239/72 20060101ALI20190712BHEP Ipc: C07D 493/08 20060101ALI20190712BHEP Ipc: A61P 35/02 20060101ALI20190712BHEP
2020-07-17	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
2020-08-19	18D	Application deemed to be withdrawn	Effective date: 20200218