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EP3283882A4 - BLOOD BIOMARKERS FROM SENSITIVITY OF TUMOR TO PD-1 ANTAGONISTS - Google Patents

BLOOD BIOMARKERS FROM SENSITIVITY OF TUMOR TO PD-1 ANTAGONISTS Download PDF

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Publication number
EP3283882A4
EP3283882A4 EP16780526.6A EP16780526A EP3283882A4 EP 3283882 A4 EP3283882 A4 EP 3283882A4 EP 16780526 A EP16780526 A EP 16780526A EP 3283882 A4 EP3283882 A4 EP 3283882A4
Authority
EP
European Patent Office
Prior art keywords
antagonists
tumor
sensitivity
blood biomarkers
biomarkers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP16780526.6A
Other languages
German (de)
French (fr)
Other versions
EP3283882A1 (en
EP3283882B2 (en
EP3283882B1 (en
Inventor
Mark Ayers
Jared LUNCEFORD
Andrey Loboda
Michael Nebozhyn
Terrill K. Mcclanahan
Heather Hirsch
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Merck Sharp and Dohme LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=57125998&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EP3283882(A4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Sharp and Dohme LLC filed Critical Merck Sharp and Dohme LLC
Priority to EP20212713.0A priority Critical patent/EP3839510A3/en
Publication of EP3283882A1 publication Critical patent/EP3283882A1/en
Publication of EP3283882A4 publication Critical patent/EP3283882A4/en
Application granted granted Critical
Publication of EP3283882B1 publication Critical patent/EP3283882B1/en
Publication of EP3283882B2 publication Critical patent/EP3283882B2/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Oncology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Hospice & Palliative Care (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
EP16780526.6A 2015-04-17 2016-04-12 Blood-based biomarkers of tumor sensitivity to pd-1 antagonists Active EP3283882B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP20212713.0A EP3839510A3 (en) 2015-04-17 2016-04-12 Blood-based biomarkers of tumor sensitivity to pd-1 antagonists

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562149333P 2015-04-17 2015-04-17
PCT/US2016/027014 WO2016168133A1 (en) 2015-04-17 2016-04-12 Blood-based biomarkers of tumor sensitivity to pd-1 antagonists

Related Child Applications (2)

Application Number Title Priority Date Filing Date
EP20212713.0A Division EP3839510A3 (en) 2015-04-17 2016-04-12 Blood-based biomarkers of tumor sensitivity to pd-1 antagonists
EP20212713.0A Division-Into EP3839510A3 (en) 2015-04-17 2016-04-12 Blood-based biomarkers of tumor sensitivity to pd-1 antagonists

Publications (4)

Publication Number Publication Date
EP3283882A1 EP3283882A1 (en) 2018-02-21
EP3283882A4 true EP3283882A4 (en) 2019-01-09
EP3283882B1 EP3283882B1 (en) 2020-12-16
EP3283882B2 EP3283882B2 (en) 2024-10-16

Family

ID=57125998

Family Applications (2)

Application Number Title Priority Date Filing Date
EP20212713.0A Pending EP3839510A3 (en) 2015-04-17 2016-04-12 Blood-based biomarkers of tumor sensitivity to pd-1 antagonists
EP16780526.6A Active EP3283882B2 (en) 2015-04-17 2016-04-12 Blood-based biomarkers of tumor sensitivity to pd-1 antagonists

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EP20212713.0A Pending EP3839510A3 (en) 2015-04-17 2016-04-12 Blood-based biomarkers of tumor sensitivity to pd-1 antagonists

Country Status (4)

Country Link
US (1) US11326211B2 (en)
EP (2) EP3839510A3 (en)
ES (1) ES2844799T5 (en)
WO (1) WO2016168133A1 (en)

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SG11201909955XA (en) * 2017-05-02 2019-11-28 Merck Sharp & Dohme Formulations of anti-lag3 antibodies and co-formulations of anti-lag3 antibodies and anti-pd-1 antibodies
WO2019094352A1 (en) * 2017-11-07 2019-05-16 Memorial Sloan Kettering Cancer Center Inhibition of ctla-4 and/or pd-1 for regulation of t cells
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KR102084196B1 (en) * 2018-08-29 2020-03-03 연세대학교 산학협력단 Methods for providing information about responses to cancer immunotherapy and kits using the same
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KR20220016155A (en) * 2019-05-30 2022-02-08 브리스톨-마이어스 스큅 컴퍼니 Methods of Identifying Suitable Subjects for Immuno-Oncology (I-O) Therapy
EP3799057A1 (en) * 2019-09-25 2021-03-31 Koninklijke Philips N.V. Prediction tool for patient immune response to a therapy
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US20220380854A1 (en) * 2019-11-04 2022-12-01 Merck Sharp & Dohme Corp. ANGIOGENESIS AND mMDSC GENE EXPRESSION BASED BIOMARKER OF TUMOR RESPONSE TO PD-1 ANTAGONISTS
CN111321228B (en) * 2020-03-13 2021-03-05 中国医学科学院肿瘤医院 Anti-PD-1 Therapy Sensitivity Related Gene and Its Application
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Also Published As

Publication number Publication date
US11326211B2 (en) 2022-05-10
ES2844799T5 (en) 2025-01-16
EP3283882A1 (en) 2018-02-21
EP3839510A3 (en) 2021-08-25
ES2844799T3 (en) 2021-07-22
EP3839510A2 (en) 2021-06-23
WO2016168133A1 (en) 2016-10-20
US20180148790A1 (en) 2018-05-31
EP3283882B2 (en) 2024-10-16
EP3283882B1 (en) 2020-12-16

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