EP2985292A4 - Epidermal growth factor receptor antibody - Google Patents
Epidermal growth factor receptor antibodyInfo
- Publication number
- EP2985292A4 EP2985292A4 EP13881974.3A EP13881974A EP2985292A4 EP 2985292 A4 EP2985292 A4 EP 2985292A4 EP 13881974 A EP13881974 A EP 13881974A EP 2985292 A4 EP2985292 A4 EP 2985292A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- growth factor
- factor receptor
- epidermal growth
- receptor antibody
- antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 102000001301 EGF receptor Human genes 0.000 title 1
- 108060006698 EGF receptor Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1027—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against receptors, cell-surface antigens or cell-surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/515—Complete light chain, i.e. VL + CL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Oncology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/CN2013/073811 WO2014166029A1 (en) | 2013-04-07 | 2013-04-07 | Epidermal growth factor receptor antibody |
Publications (2)
Publication Number | Publication Date |
---|---|
EP2985292A1 EP2985292A1 (en) | 2016-02-17 |
EP2985292A4 true EP2985292A4 (en) | 2016-12-21 |
Family
ID=51688811
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP13881974.3A Withdrawn EP2985292A4 (en) | 2013-04-07 | 2013-04-07 | Epidermal growth factor receptor antibody |
Country Status (6)
Country | Link |
---|---|
US (1) | US9644031B2 (en) |
EP (1) | EP2985292A4 (en) |
BR (1) | BR112015025549A2 (en) |
RU (1) | RU2652880C2 (en) |
WO (1) | WO2014166029A1 (en) |
ZA (1) | ZA201508035B (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109195993B (en) | 2016-02-06 | 2022-05-10 | 岸迈生物科技有限公司 | Tandem FAB immunoglobulins and uses thereof |
MX2020011588A (en) | 2018-05-03 | 2020-12-07 | Shanghai Epimab Biotherapeutics Co Ltd | High affinity antibodies to pd-1 and lag-3 and bispecific binding proteins made therefrom. |
US20220017617A1 (en) * | 2018-07-09 | 2022-01-20 | Shanghai Epimab Biotherapeutics Co., Ltd. | Efficiently expressed egfr and pd-l1 bispecific binding proteins |
WO2020084608A1 (en) * | 2018-10-22 | 2020-04-30 | Explore Bio 1 Ltd | Precursor bispecific antibody constructs and methods of use thereof |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6235883B1 (en) * | 1997-05-05 | 2001-05-22 | Abgenix, Inc. | Human monoclonal antibodies to epidermal growth factor receptor |
WO2002100348A2 (en) * | 2001-06-13 | 2002-12-19 | Genmab A/S | Human monoclonal antibodies to epidermal growth factor receptor (egfr) |
WO2005090407A1 (en) * | 2004-03-19 | 2005-09-29 | Imclone Systems Incorporated | Human anti-epidermal growth factor receptor antibody |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR061171A1 (en) * | 2006-06-02 | 2008-08-06 | Aveo Pharmaceuticals Inc | PROTEINS OF UNION TO THE GROWTH FACTOR OF HEPATOCITS (FCH) |
SG190572A1 (en) * | 2008-04-29 | 2013-06-28 | Abbott Lab | Dual variable domain immunoglobulins and uses thereof |
BRPI0913366A8 (en) * | 2008-06-03 | 2017-07-11 | Abbott Lab | DUAL VARIABLE DOMAIN IMMUNOGLOBULINS AND THEIR USES |
SG192489A1 (en) * | 2008-07-08 | 2013-08-30 | Abbott Lab | Prostaglandin e2 dual variable domain immunoglobulins and uses thereof |
RU2012112550A (en) * | 2009-09-01 | 2013-10-10 | Эбботт Лэборетриз | IMMUNOGLOBULINS WITH TWO VARIABLE DOMAINS AND THEIR APPLICATION |
JP6014596B2 (en) * | 2010-11-09 | 2016-10-25 | メディミューン,エルエルシー | Antibody scaffold for homogeneous conjugation |
CN103619881B (en) * | 2011-04-07 | 2017-07-28 | 安姆根有限公司 | New EGFR associated proteins |
CN103172741B (en) * | 2011-12-20 | 2018-04-27 | 智翔(上海)医药科技有限公司 | Full people source anti-egfr antibodies |
-
2013
- 2013-04-07 BR BR112015025549A patent/BR112015025549A2/en not_active Application Discontinuation
- 2013-04-07 WO PCT/CN2013/073811 patent/WO2014166029A1/en active Application Filing
- 2013-04-07 RU RU2015147913A patent/RU2652880C2/en not_active IP Right Cessation
- 2013-04-07 EP EP13881974.3A patent/EP2985292A4/en not_active Withdrawn
-
2015
- 2015-10-06 US US14/876,053 patent/US9644031B2/en not_active Expired - Fee Related
- 2015-10-29 ZA ZA2015/08035A patent/ZA201508035B/en unknown
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6235883B1 (en) * | 1997-05-05 | 2001-05-22 | Abgenix, Inc. | Human monoclonal antibodies to epidermal growth factor receptor |
WO2002100348A2 (en) * | 2001-06-13 | 2002-12-19 | Genmab A/S | Human monoclonal antibodies to epidermal growth factor receptor (egfr) |
WO2005090407A1 (en) * | 2004-03-19 | 2005-09-29 | Imclone Systems Incorporated | Human anti-epidermal growth factor receptor antibody |
Non-Patent Citations (6)
Title |
---|
B. KUENEN ET AL: "A Phase I Pharmacologic Study of Necitumumab (IMC-11F8), a Fully Human IgG1 Monoclonal Antibody Directed Against EGFR in Patients with Advanced Solid Malignancies", CLINICAL CANCER RESEARCH, vol. 16, no. 6, 2 March 2010 (2010-03-02), pages 1915 - 1923, XP055173595, ISSN: 1078-0432, DOI: 10.1158/1078-0432.CCR-09-2425 * |
FERNANDO RIVERA ET AL: "Current situation of Panitumumab, Matuzumab, Nimotuzumab and Zalutumumab", ACTA ONCOLOGICA., vol. 47, no. 1, 1 January 2008 (2008-01-01), GB, pages 9 - 19, XP055317119, ISSN: 0284-186X, DOI: 10.1080/02841860701704724 * |
PATEL D; GUO X; NG S; MELCHIOR M; BALDERES P; BURTRUM D; PERSAUD K; LUNA X; LUDWIG DL; KANG X: "IgG isotype, glycosylation, and EGFR expression determine the induction of antibody-dependent cellular cytotoxicity in vitro by cetuximab", HUM ANTIBODIES, vol. 19, 2010, pages 89 - 99, XP009172959 * |
See also references of WO2014166029A1 * |
STEPLEWSKI Z ET AL: "BIOLOGICAL ACTIVITY OF HUMAN-MOUSE IGG1, IGG2, IGG3, AND IGG4 CHIMERIC MONOCLONAL ANTIBODIES WITH ANTITUMOR SPECIFICITY", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, US, vol. 85, no. 13, 1 July 1988 (1988-07-01), pages 4852 - 4856, XP001007415, ISSN: 0027-8424, DOI: 10.1073/PNAS.85.13.4852 * |
T. SCHNEIDER-MERCK ET AL: "Human IgG2 Antibodies against Epidermal Growth Factor Receptor Effectively Trigger Antibody-Dependent Cellular Cytotoxicity but, in Contrast to IgG1, Only by Cells of Myeloid Lineage", THE JOURNAL OF IMMUNOLOGY, vol. 184, no. 1, 30 November 2009 (2009-11-30), US, pages 512 - 520, XP055270382, ISSN: 0022-1767, DOI: 10.4049/jimmunol.0900847 * |
Also Published As
Publication number | Publication date |
---|---|
ZA201508035B (en) | 2018-05-30 |
US20160017045A1 (en) | 2016-01-21 |
US9644031B2 (en) | 2017-05-09 |
BR112015025549A2 (en) | 2017-10-10 |
EP2985292A1 (en) | 2016-02-17 |
WO2014166029A1 (en) | 2014-10-16 |
RU2015147913A (en) | 2017-05-15 |
RU2652880C2 (en) | 2018-05-03 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20151103 |
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AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR |
|
AX | Request for extension of the european patent |
Extension state: BA ME |
|
DAX | Request for extension of the european patent (deleted) | ||
A4 | Supplementary search report drawn up and despatched |
Effective date: 20161123 |
|
RIC1 | Information provided on ipc code assigned before grant |
Ipc: C07K 16/08 20060101AFI20161117BHEP Ipc: A61K 39/395 20060101ALI20161117BHEP Ipc: A61P 35/00 20060101ALI20161117BHEP Ipc: A61K 39/44 20060101ALI20161117BHEP Ipc: C12N 15/13 20060101ALI20161117BHEP Ipc: A61K 51/10 20060101ALI20161117BHEP |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: EXAMINATION IS IN PROGRESS |
|
17Q | First examination report despatched |
Effective date: 20171006 |
|
GRAP | Despatch of communication of intention to grant a patent |
Free format text: ORIGINAL CODE: EPIDOSNIGR1 |
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STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: GRANT OF PATENT IS INTENDED |
|
INTG | Intention to grant announced |
Effective date: 20180420 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20180831 |