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EP2941421A4 - Coumestan, coumestrol, coumestan derivatives and processes of making the same and uses of same - Google Patents

Coumestan, coumestrol, coumestan derivatives and processes of making the same and uses of same

Info

Publication number
EP2941421A4
EP2941421A4 EP14735430.2A EP14735430A EP2941421A4 EP 2941421 A4 EP2941421 A4 EP 2941421A4 EP 14735430 A EP14735430 A EP 14735430A EP 2941421 A4 EP2941421 A4 EP 2941421A4
Authority
EP
European Patent Office
Prior art keywords
same
coumestan
coumestrol
processes
making
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP14735430.2A
Other languages
German (de)
French (fr)
Other versions
EP2941421A1 (en
Inventor
Doron Pappo
Regev Parnes
Kshirsagar Umesh Achyutrao
Rivka Ofir
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BG Negev Technologies and Applications Ltd
Original Assignee
BG Negev Technologies and Applications Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BG Negev Technologies and Applications Ltd filed Critical BG Negev Technologies and Applications Ltd
Publication of EP2941421A1 publication Critical patent/EP2941421A1/en
Publication of EP2941421A4 publication Critical patent/EP2941421A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/34—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 3 only
    • C07D311/36—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 3 only not hydrogenated in the hetero ring, e.g. isoflavones

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP14735430.2A 2013-01-07 2014-01-05 Coumestan, coumestrol, coumestan derivatives and processes of making the same and uses of same Withdrawn EP2941421A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361749443P 2013-01-07 2013-01-07
US201361749439P 2013-01-07 2013-01-07
PCT/IL2014/050009 WO2014106848A1 (en) 2013-01-07 2014-01-05 Coumestan, coumestrol, coumestan derivatives and processes of making the same and uses of same

Publications (2)

Publication Number Publication Date
EP2941421A1 EP2941421A1 (en) 2015-11-11
EP2941421A4 true EP2941421A4 (en) 2016-09-21

Family

ID=51062192

Family Applications (1)

Application Number Title Priority Date Filing Date
EP14735430.2A Withdrawn EP2941421A4 (en) 2013-01-07 2014-01-05 Coumestan, coumestrol, coumestan derivatives and processes of making the same and uses of same

Country Status (3)

Country Link
US (1) US20150336977A1 (en)
EP (1) EP2941421A4 (en)
WO (1) WO2014106848A1 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104710394B (en) * 2015-03-12 2017-09-19 中国药科大学 Coumestrol ring-opened analogs and their medicinal uses
KR20180012853A (en) 2015-06-16 2018-02-06 지앙수 헨그루이 메디슨 컴퍼니 리미티드 Piperidine derivatives, their preparation methods and their pharmaceutical uses
MX2018007844A (en) 2015-12-22 2019-01-21 Jiangsu Hengrui Medicine Co Benzopiperidine derivative, preparation method thereof and medical use thereof.
CN107540678B (en) * 2016-06-24 2021-12-07 中国科学院上海药物研究所 Method for preparing coumarin heteroaromatic ring compound and derivative thereof through intramolecular cross dehydrogenation coupling
CN106565733B (en) * 2016-09-28 2018-07-24 广州中大南沙科技创新产业园有限公司 A kind of synthetic method of polyhydroxy substitution coumestrol class natural products
AU2018369091B2 (en) 2017-11-14 2021-02-18 Kind Pharmaceutical Heterocyclic compound and application thereof in medicine
CN109020912B (en) * 2018-07-26 2020-08-18 南京昊绿生物科技有限公司 Synthesis process of C-Fos/AP-1 inhibitor
CN108822121A (en) * 2018-08-10 2018-11-16 王培战 A kind of noval chemical compound and preparation method thereof and inhibit gynecological tumor and breast cancer application
CN111349076B (en) * 2018-12-20 2022-07-26 江苏恒瑞医药股份有限公司 Crystal form of L-lysine salt of benzopiperidine derivative and preparation method thereof
CN110396097B (en) * 2019-09-03 2021-09-21 河南中医药大学 Prenylated flavonoid compound sinopodone U as well as preparation method and application thereof
EP4089094A4 (en) 2020-01-10 2023-08-02 Jiangsu Hengrui Pharmaceuticals Co., Ltd. Tricyclic tetrahydroisoquinoline derivative, preparation method therefor and application thereof in medicine
CN117642405A (en) 2021-07-09 2024-03-01 江苏恒瑞医药股份有限公司 Salt form of tricyclic tetrahydroisoquinoline derivative
US11802130B1 (en) 2023-02-22 2023-10-31 King Faisal University Benzofuro[3,2-c]chromen-6-one compounds as antibacterial agents

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10394175T5 (en) * 2003-03-06 2006-08-03 The Medical Research and Education Trust, San Diego Composition with a botanical extract having anti-cancer or phytoestrogenic activity containing prenyflavonoids
CN102264716B (en) * 2008-11-06 2016-08-31 科学与工业研究委员会 For preventing and treat the substituted benzofuran of bone related disease chromene and related compound

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CHUANG CHUANG LI ET AL: "Total Synthesis of Wedelolactone", THE JOURNAL OF ORGANIC CHEMISTRY, vol. 68, no. 22, 1 October 2003 (2003-10-01), US, pages 8500 - 8504, XP055266136, ISSN: 0022-3263, DOI: 10.1021/jo030228f *
LINA TANG ET AL: "Synthesis of Coumestan Derivatives via FeCl 3 -Mediated Oxidative Ring Closure of 4-Hydroxy Coumarins", THE JOURNAL OF ORGANIC CHEMISTRY, vol. 76, no. 8, 15 April 2011 (2011-04-15), US, pages 2744 - 2752, XP055266511, ISSN: 0022-3263, DOI: 10.1021/jo2000644 *
See also references of WO2014106848A1 *

Also Published As

Publication number Publication date
WO2014106848A1 (en) 2014-07-10
US20150336977A1 (en) 2015-11-26
EP2941421A1 (en) 2015-11-11

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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Effective date: 20150806

AK Designated contracting states

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Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

AX Request for extension of the european patent

Extension state: BA ME

DAX Request for extension of the european patent (deleted)
RIC1 Information provided on ipc code assigned before grant

Ipc: C07D 493/04 20060101ALI20160422BHEP

Ipc: A61P 19/10 20060101ALI20160422BHEP

Ipc: C07D 311/36 20060101AFI20160422BHEP

Ipc: A61K 31/353 20060101ALI20160422BHEP

Ipc: A61K 31/352 20060101ALI20160422BHEP

Ipc: A61P 35/00 20060101ALI20160422BHEP

A4 Supplementary search report drawn up and despatched

Effective date: 20160822

RIC1 Information provided on ipc code assigned before grant

Ipc: C07D 493/04 20060101ALI20160816BHEP

Ipc: A61K 31/353 20060101ALI20160816BHEP

Ipc: A61K 31/352 20060101ALI20160816BHEP

Ipc: C07D 311/36 20060101AFI20160816BHEP

Ipc: A61P 35/00 20060101ALI20160816BHEP

Ipc: A61P 19/10 20060101ALI20160816BHEP

STAA Information on the status of an ep patent application or granted ep patent

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17Q First examination report despatched

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Effective date: 20170802