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EP2930180A4 - Doppelsträngige ribonukleinsäure zur adjuvantien - Google Patents

Doppelsträngige ribonukleinsäure zur adjuvantien

Info

Publication number
EP2930180A4
EP2930180A4 EP13861352.6A EP13861352A EP2930180A4 EP 2930180 A4 EP2930180 A4 EP 2930180A4 EP 13861352 A EP13861352 A EP 13861352A EP 2930180 A4 EP2930180 A4 EP 2930180A4
Authority
EP
European Patent Office
Prior art keywords
adjuvants
double stranded
ribonucleic acid
stranded ribonucleic
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP13861352.6A
Other languages
English (en)
French (fr)
Other versions
EP2930180B1 (de
EP2930180A1 (de
Inventor
Tetsuo Nakano
Eitora Yamamura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kyowa Hakko Bio Co Ltd
Original Assignee
Kyowa Hakko Bio Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Bio Co Ltd filed Critical Kyowa Hakko Bio Co Ltd
Publication of EP2930180A1 publication Critical patent/EP2930180A1/de
Publication of EP2930180A4 publication Critical patent/EP2930180A4/de
Application granted granted Critical
Publication of EP2930180B1 publication Critical patent/EP2930180B1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/17—Immunomodulatory nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
    • C12N2310/533—Physical structure partially self-complementary or closed having a mismatch or nick in at least one of the strands
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C12N2320/31—Combination therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Mycology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
EP13861352.6A 2012-12-06 2013-12-06 Doppelsträngige ribonukleinsäure zur adjuvantien Active EP2930180B1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2012267012 2012-12-06
JP2013145471 2013-07-11
PCT/JP2013/082774 WO2014088087A1 (ja) 2012-12-06 2013-12-06 アジュバント用二重鎖リボ核酸

Publications (3)

Publication Number Publication Date
EP2930180A1 EP2930180A1 (de) 2015-10-14
EP2930180A4 true EP2930180A4 (de) 2016-08-03
EP2930180B1 EP2930180B1 (de) 2021-11-10

Family

ID=50883499

Family Applications (1)

Application Number Title Priority Date Filing Date
EP13861352.6A Active EP2930180B1 (de) 2012-12-06 2013-12-06 Doppelsträngige ribonukleinsäure zur adjuvantien

Country Status (4)

Country Link
US (2) US9816095B2 (de)
EP (1) EP2930180B1 (de)
JP (2) JP6446269B2 (de)
WO (1) WO2014088087A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5762307B2 (ja) 2009-03-31 2015-08-12 国立感染症研究所長 経鼻投与用ワクチンを用いるインフルエンザの予防方法
JP6446269B2 (ja) * 2012-12-06 2018-12-26 協和発酵バイオ株式会社 アジュバント用二重鎖リボ核酸
SG10201911695SA (en) 2014-05-14 2020-01-30 Targimmune Therapeutics Ag Improved polyethyleneimine polyethyleneglycol vectors
JP2016113388A (ja) * 2014-12-12 2016-06-23 国立大学法人北海道大学 ロッド型ナノ粒子及び核酸からなる組成物
WO2017043490A1 (ja) * 2015-09-07 2017-03-16 協和発酵バイオ株式会社 自然免疫誘導効果が増強した二重鎖リボ核酸
JP6805095B2 (ja) * 2017-08-01 2020-12-23 株式会社日清製粉グループ本社 食品中の物質が受けた加熱処理の強度の判定方法
CA3145628A1 (en) * 2019-07-02 2021-01-07 Na Vaccine Institute Novel ribonucleic acid and pharmaceutical composition based on the same
EP4023244A4 (de) * 2019-08-28 2023-11-01 NA Vaccine Institute Influenza-impfstoffzusammensetzung auf der grundlage einer neuartigen nukleinsäure

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2207138A (en) * 1987-07-03 1989-01-25 Nippon Shinyaku Co Ltd Preparation of nucleic acid derivatives

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5298614A (en) 1986-01-06 1994-03-29 Nippon Shinyaku Co. Ltd. Size limited double stranded poly I poly(cytidylate/4-thiouridylate)
JPH01238597A (ja) 1987-07-03 1989-09-22 Nippon Shinyaku Co Ltd 核酸誘導体
JPH01104094A (ja) * 1987-07-03 1989-04-21 Nippon Shinyaku Co Ltd 核酸誘導体の製法及び製剤法
JPH02227077A (ja) 1988-11-07 1990-09-10 Nippon Shinyaku Co Ltd 固定化酸素及び利用法
TW524693B (en) 1997-10-16 2003-03-21 Nippon Shinyaku Co Ltd Cancer cell nuclease activator
EP1153931B1 (de) * 1999-02-15 2005-07-20 Nippon Shinyaku Co., Ltd. Polynukleotide mit gekürzter kette und verfahren zu ihrer herstellung
EP2323695B1 (de) * 2008-08-19 2018-12-05 Nektar Therapeutics Komplexe von small-interfering nukleinsäuren
KR101224828B1 (ko) * 2009-05-14 2013-01-22 (주)바이오니아 ｓｉＲＮＡ 접합체 및 그 제조방법
WO2012014953A1 (ja) * 2010-07-29 2012-02-02 大日本住友製薬株式会社 光学活性スクシンイミド誘導体の製造方法
CN103068853B (zh) * 2010-08-19 2016-08-10 Peg生物制药公司 协同性生物分子-聚合物轭合物
KR101178947B1 (ko) * 2011-04-29 2012-09-03 한국생명공학연구원 올레아놀린산 아세테이트를 유효성분으로 포함하는 ｔｌｒ 및 ｉｌ-6 매개성 질환 예방 또는 치료용 약학적 조성물
US10172960B2 (en) * 2011-12-15 2019-01-08 Biontech Ag Particles comprising single stranded RNA and double stranded RNA for immunomodulation
JP6446269B2 (ja) * 2012-12-06 2018-12-26 協和発酵バイオ株式会社 アジュバント用二重鎖リボ核酸
WO2015050191A1 (ja) * 2013-10-03 2015-04-09 協和発酵バイオ株式会社 二重鎖リボ核酸の精製方法
EP3083962B1 (de) * 2013-12-16 2021-08-18 RiboxX GmbH Doppelsträngige polyc:poly(g/i)-rna für immunstimulation und krebsbehandlung
EP3231864B1 (de) * 2014-12-11 2024-07-31 Riken Modifizierte immunzellen, verfahren zur herstellung von modifizierter immunzelle und nutzung davon
JP2016113388A (ja) * 2014-12-12 2016-06-23 国立大学法人北海道大学 ロッド型ナノ粒子及び核酸からなる組成物
WO2017043490A1 (ja) * 2015-09-07 2017-03-16 協和発酵バイオ株式会社 自然免疫誘導効果が増強した二重鎖リボ核酸

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2207138A (en) * 1987-07-03 1989-01-25 Nippon Shinyaku Co Ltd Preparation of nucleic acid derivatives

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
HIROKI KATO ET AL: "Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5", THE JOURNAL OF EXPERIMENTAL MEDICINE, vol. 89, no. 7, 7 July 2008 (2008-07-07), US, pages 1601 - 1610, XP055281984, ISSN: 0022-1007, DOI: 10.1016/j.jsb.2005.05.002 *
MILLS JANINE B ET AL: "Origin of the intrinsic rigidity of DNA", NUCLEIC ACIDS RESEARCH, vol. 32, no. 13, 2004, pages 4055 - 4059, XP002484664, ISSN: 0305-1048, DOI: 10.1093/NAR/GKH740 *
See also references of WO2014088087A1 *

Also Published As

Publication number Publication date
JP2019014756A (ja) 2019-01-31
EP2930180B1 (de) 2021-11-10
US9816095B2 (en) 2017-11-14
US20180044678A1 (en) 2018-02-15
US20150307884A1 (en) 2015-10-29
US10370670B2 (en) 2019-08-06
WO2014088087A1 (ja) 2014-06-12
JP6595071B2 (ja) 2019-10-23
EP2930180A1 (de) 2015-10-14
JP6446269B2 (ja) 2018-12-26
JPWO2014088087A1 (ja) 2017-01-05

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