Classifications

• • G—PHYSICS
  • G09—EDUCATION; CRYPTOGRAPHY; DISPLAY; ADVERTISING; SEALS
  • G09B—EDUCATIONAL OR DEMONSTRATION APPLIANCES; APPLIANCES FOR TEACHING, OR COMMUNICATING WITH, THE BLIND, DEAF OR MUTE; MODELS; PLANETARIA; GLOBES; MAPS; DIAGRAMS
  • G09B23/00—Models for scientific, medical, or mathematical purposes, e.g. full-sized devices for demonstration purposes
  • G09B23/28—Models for scientific, medical, or mathematical purposes, e.g. full-sized devices for demonstration purposes for medicine
  • G09B23/30—Anatomical models
• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
  • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
  • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
  • B01F31/55—Mixers with shaking, oscillating, or vibrating mechanisms the materials to be mixed being contained in a flexible bag submitted to periodical deformation
• • G—PHYSICS
  • G09—EDUCATION; CRYPTOGRAPHY; DISPLAY; ADVERTISING; SEALS
  • G09B—EDUCATIONAL OR DEMONSTRATION APPLIANCES; APPLIANCES FOR TEACHING, OR COMMUNICATING WITH, THE BLIND, DEAF OR MUTE; MODELS; PLANETARIA; GLOBES; MAPS; DIAGRAMS
  • G09B23/00—Models for scientific, medical, or mathematical purposes, e.g. full-sized devices for demonstration purposes
  • G09B23/28—Models for scientific, medical, or mathematical purposes, e.g. full-sized devices for demonstration purposes for medicine
  • G09B23/30—Anatomical models
  • G09B23/32—Anatomical models with moving parts

Definitions

• the invention relates to the simulation of the human digestive system, consisting of a set of at least two deformable chambers kept at constant temperature during operation and formed by interconnected elastic bags.
• Each of the bags is equipped by outlets for hydraulic interconnection, as well as by outlets for measuring probes connection and by outlets for sample withdrawal and refilling of titration solvent into bags respectively.
• This apparatus includes the unit, consisting of at least two pressurized chambers, each of them containing the elastic tube. Each end of this tube is tightly connected to the wall of pressure chamber, so the space between the wall of chamber and the tube is hermetically closed.
• the unit has a connecting hardware for inlet and outlet of gas or liquid into (and out of, respectively) the spaces between walls of pressure chamber and tubes, as well as the hydraulic hardware for connection of chambers together or to terminal or intermediate pieces.
• the unit has also connecting systems in terminal and intermediate pieces for introduction of working medium components into tubes or removal of them respectively. Medium present in spaces between walls of pressure chamber and the tube can be exploited also for heating of components taking part in a reaction within the tube.
• controlling systems and regulating units are used for increasing and decreasing the inner pressure between the tube ⁇ ⁇ 2010/000123 and wall of the chamber. These units utilize pumps controlled by the computer.
• the purpose for designing the human digestive system simulator according to this invention was to eliminate drawbacks of improve upon the above mentioned apparatuses, possibly using readily commercially available components.
• the human digestive system simulator which uses a unique system for modulation of hydraulically interconnected elastic bags, kept at constant temperature.
• the bags represent a stomach and a small intestine.
• the subject matter of the invention is the fact that the heating source is represented by a heated plate, having two levers swinging around a common axis and arranged in an axial distance over its working surface intended for the placing of elastic bags.
• a bent wing having working arms opened in a wide angle in direction away from the working surface, is mounted to these levers on the side near to heating plate. The wing is placed in parallel with the heating plate, whereas at least one of levers is connected to the pendulum engine with adjustable motion.
• Elastic bags are in an operating state situated side by side and symmetrically across at the axis of levers between the working surface of the heating plate and the wing. Each of them is equipped by an air cock and an input and output pipe channel for working medium, connecting bags together via tubing coupled through peristaltic pump.
• the deflected (bent) wing can be advantageously divided so it's one part works with the elastic bag, which represents a stomach, while the second part works with the bags representing a small intestine.
• Each of the levers is operated by its own pendulum engine. ⁇ ⁇
• At least one of elastic bags is equipped by a filler hole with a plug for inserting the solid form of drug and cleaning solvent, by a socket for pH probe, by inputs of titration components of working solution, by the inlet for a temperature probe, by an input for a digestive juice and finally by an output for sample collection.
• the next advantage of the human digestive simulator according to the invention consists in the fact that the assembly of the heating plate with elastic bags, the tiltable steering deflected wing on levers connected to pendulum motion engine(s) and with the peristaltic pumps is placed in a closeable box which is heated by an air heater and equipped with at least two linear dosing equipments of working medium components.
• the system is connected to computer controlling unit.
• Fig. 1 shows the view of the assembly of the main part of the simulator in accordance with the invention.
• Fig. 2 shows the view of overall configuration of the digestive tract simulator, including the closeable box in which it is placed.
• Fig. 3 shows the view of the possible realization of the semi-product of elastic bag representing stomach.
• Fig.4 shows the side view of the elastic bag for the small intestine simulation.
• Fig. 5 shows the ground plan view of the elastic bag from the figure 4.
• Fig. 6 shows an axonometric view of the bag from figures 4 and 5.
• the main part of this equipment forms the main unit, which consists of the heating resp. temperature regulating plate 2, on which elastic bags 12 ⁇ ⁇ ⁇ are placed during operating state.
• These bags are advantageously realized by readily available bags for infusion solutions, which are modified by adding air cock 127, inlet and outlet sockets 126 for inputs of working solutions as acids or alkalis for automatic titration of their content, as well as by adding hydraulic cross connection 12 of bags, output for sample collection and pH probes.
• Swing levers 7 with gimbal are assembled to the ends of heating plate 2, heated by flat resistor body.
• the levers 7 are removably connected with parts of divided, longitudinally deflected wing 3 which are arranged over all bags 12 and touching on filled bags 12 by a part of their working surface.
• Each of levers 7 is operated by the common pendulum pneumatic motor 4 with adjustable speed.
• Peristaltic pumps 5 for pumping of each bag 12 volume from one bag 12 to the next or outward of the apparatus, are placed under the temperature regulating plate 2.
• the first (or left) elastic bag 12 representing stomach is equipped by the filler hole 121 with a plug for inserting the solid form of the drug and perhaps even for inserting the cleaning solution or gas purging input.
• the volume of which is with advantage larger than the inner volume of bags 12 representing parts of the small intestine, see Figures 3, 4 and 5.
• the pH probe 122 is loaded into the bag 12 through an independent socket.
• the bag 12 is equipped by inlets 124 for titration components, by the outlet 125 for sample collection and by the inlet for a temperature probe 123.
• Heating plate 2 is manufactured advantageously as metallic board equipped with temperature probes, which are not displayed on figures.
• the central unit mentioned above is placed inside the closeable box, containing also air heating unit 1 1 and at least two linear dosing equipments 10 connected to computerized control unit.
• the softened, flattened, buckled or truncated lower rim of deflected wing 3 doesn't push flanks of elastic bags 12 to one another, but it is set to the level allowing during operation, it means during swinging motion of wing, the transit of working liquid together with solid form of drug ⁇ ⁇ between one part of the bag 12 from which a liquid is squeezed out into its second part which is not pressed.
• stomach 12 While the stomach 12 is represented by a unique bag, a small intestine in which the final stage of digestion is performed as well as absorption of nutrients happens is represented by three bags linearly ordered on the heating plate 2 across the direct-axis of it and of the deflected wing 3 too. These bags 12 represent jejunum, duodenum and ileum.
• the transit of liquids between discrete elastic bags 12 of the digestive tract simulator according to the invention is provided by peristaltic pumps 5, whose action is controlled, as well as the action of the air heating unit 1 1, the linear dosing equipments 10, the temperature regulating plate 2 heating, and speed of the pneumatic pendulum motor 4, by the computer control unit placed outside of closeable box 1 of the simulator.
• the digestive tract simulator imitates the human digestive tract very accurately. Moreover, the individual parts of the simulator are easily removable and replaceable.
• the volume of each elastic bag 12 is periodically mixed during the operation by periodically compressing upper side of the bag 12 by parallel surface of bent wing 3. At the same time the pH value and the temperature of inner volume are measured.

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• Engineering & Computer Science (AREA)
• General Physics & Mathematics (AREA)
• Physics & Mathematics (AREA)
• Chemical & Material Sciences (AREA)
• Medical Informatics (AREA)
• Mathematical Analysis (AREA)
• Medicinal Chemistry (AREA)
• Health & Medical Sciences (AREA)
• Algebra (AREA)
• Computational Mathematics (AREA)
• Theoretical Computer Science (AREA)
• General Health & Medical Sciences (AREA)
• Mathematical Optimization (AREA)
• Mathematical Physics (AREA)
• Pure & Applied Mathematics (AREA)
• Business, Economics & Management (AREA)
• Educational Administration (AREA)
• Educational Technology (AREA)
• Chemical Kinetics & Catalysis (AREA)
• Infusion, Injection, And Reservoir Apparatuses (AREA)

Applications Claiming Priority (2)

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• 2009
  • 2009-12-08 CZ CZ20090818A patent/CZ2009818A3/cs not_active IP Right Cessation
• 2010
  • 2010-12-06 EP EP10809131A patent/EP2510511A1/de not_active Withdrawn
  • 2010-12-06 WO PCT/CZ2010/000123 patent/WO2011069472A1/en active Application Filing

Non-Patent Citations (2)

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