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EP2332651A3 - Interactive transparent individual cells biochip processor - Google Patents

Interactive transparent individual cells biochip processor Download PDF

Info

Publication number
EP2332651A3
EP2332651A3 EP10183774A EP10183774A EP2332651A3 EP 2332651 A3 EP2332651 A3 EP 2332651A3 EP 10183774 A EP10183774 A EP 10183774A EP 10183774 A EP10183774 A EP 10183774A EP 2332651 A3 EP2332651 A3 EP 2332651A3
Authority
EP
European Patent Office
Prior art keywords
individual cells
transparent individual
wells
interactive transparent
biochip processor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP10183774A
Other languages
German (de)
French (fr)
Other versions
EP2332651A2 (en
Inventor
Mordechai Deutsch
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bar Ilan University
Original Assignee
Bar Ilan University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bar Ilan University filed Critical Bar Ilan University
Publication of EP2332651A2 publication Critical patent/EP2332651A2/en
Publication of EP2332651A3 publication Critical patent/EP2332651A3/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/46—Means for regulation, monitoring, measurement or control, e.g. flow regulation of cellular or enzymatic activity or functionality, e.g. cell viability
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/12—Well or multiwell plates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/06—Plates; Walls; Drawers; Multilayer plates
    • C12M25/08—Plates; Walls; Drawers; Multilayer plates electrically charged
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1429—Signal processing
    • G01N15/1433—Signal processing using image recognition
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1484—Optical investigation techniques, e.g. flow cytometry microstructural devices
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/34—Microscope slides, e.g. mounting specimens on microscope slides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00315—Microtiter plates
    • B01J2219/00317—Microwell devices, i.e. having large numbers of wells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00702—Processes involving means for analysing and characterising the products
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0681—Filter
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0877—Flow chambers
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N2015/1006—Investigating individual particles for cytology
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1468—Optical investigation techniques, e.g. flow cytometry with spatial resolution of the texture or inner structure of the particle
    • G01N2015/1472—Optical investigation techniques, e.g. flow cytometry with spatial resolution of the texture or inner structure of the particle with colour
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N2015/1497—Particle shape
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • G01N2035/00099—Characterised by type of test elements
    • G01N2035/00158—Elements containing microarrays, i.e. "biochip"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G01N2035/0401—Sample carriers, cuvettes or reaction vessels
    • G01N2035/0429—Sample carriers adapted for special purposes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Sustainable Development (AREA)
  • Genetics & Genomics (AREA)
  • Pathology (AREA)
  • Dispersion Chemistry (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Molecular Biology (AREA)
  • Clinical Laboratory Science (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Optics & Photonics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Signal Processing (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Optical Measuring Cells (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)

Abstract

The present invention concerns a device for holding a plurality of living cells, comprising:
a transparent element defining a multiplicity of optically transparent wells, wherein the size of said wells is configured to hold a single cell, any defined number of cells, or other defined particles; and characterized by a plurality of said wells including an integral biosensor component.
EP10183774A 2001-10-25 2001-10-25 Interactive transparent individual cells biochip processor Ceased EP2332651A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01982673A EP1438385A1 (en) 2001-10-25 2001-10-25 Interactive transparent individual cells biochip processor
PCT/IL2001/000992 WO2003035824A1 (en) 2001-10-25 2001-10-25 Interactive transparent individual cells biochip processor

Related Parent Applications (2)

Application Number Title Priority Date Filing Date
WOPCT/IL01/00992 Previously-Filed-Application 2001-10-25
EP01982673.4 Division 2001-10-25

Publications (2)

Publication Number Publication Date
EP2332651A2 EP2332651A2 (en) 2011-06-15
EP2332651A3 true EP2332651A3 (en) 2011-08-31

Family

ID=11043107

Family Applications (2)

Application Number Title Priority Date Filing Date
EP10183774A Ceased EP2332651A3 (en) 2001-10-25 2001-10-25 Interactive transparent individual cells biochip processor
EP01982673A Ceased EP1438385A1 (en) 2001-10-25 2001-10-25 Interactive transparent individual cells biochip processor

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP01982673A Ceased EP1438385A1 (en) 2001-10-25 2001-10-25 Interactive transparent individual cells biochip processor

Country Status (4)

Country Link
US (3) US20050014201A1 (en)
EP (2) EP2332651A3 (en)
JP (1) JP4192097B2 (en)
WO (1) WO2003035824A1 (en)

Families Citing this family (113)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7485454B1 (en) 2000-03-10 2009-02-03 Bioprocessors Corp. Microreactor
IL136232A0 (en) * 2000-05-18 2001-05-20 Bar Ilan University Res Author Measurements of enzymatic activity in a single, individual cell in population
US20050014201A1 (en) * 2001-10-25 2005-01-20 Mordechai Deuthsch Interactive transparent individual cells biochip processor
FR2832079B1 (en) * 2001-11-14 2004-07-30 Valois Sa DISPENSING HEAD AND FLUID PRODUCT DISPENSER COMPRISING SUCH A DISPENSING HEAD
EP1509593B1 (en) * 2002-06-05 2007-08-15 Bioprocessors Corporation Method comprising reactor systems having a light-interacting component
US7190449B2 (en) * 2002-10-28 2007-03-13 Nanopoint, Inc. Cell tray
IL154677A0 (en) * 2003-02-27 2003-09-17 Univ Bar Ilan A method and apparatus for manipulating an individual cell
WO2004113492A1 (en) * 2003-06-26 2004-12-29 Molecular Cytomics Ltd. Improved materials for constructing cell-chips, cell-chip covers, cell-chip coats, processed cell-chips and uses thereof
US8597597B2 (en) * 2003-06-26 2013-12-03 Seng Enterprises Ltd. Picoliter well holding device and method of making the same
US9200245B2 (en) 2003-06-26 2015-12-01 Seng Enterprises Ltd. Multiwell plate
US7888110B2 (en) 2003-06-26 2011-02-15 Seng Enterprises Ltd. Pico liter well holding device and method of making the same
WO2005008626A1 (en) * 2003-07-11 2005-01-27 University Of North Carolina At Chapel Hill Methods and systems for controlling a computer using a video image and for combining the video image with a computer desktop
EP1664265A4 (en) 2003-07-21 2009-11-25 Seng Entpr Ltd MULTIFUNCTION PLATEAU IMPROVED
US20050064524A1 (en) * 2003-08-11 2005-03-24 Mordechai Deutsch Population of cells utilizable for substance detection and methods and devices using same
NZ548873A (en) * 2004-02-03 2010-04-30 Chemagis Ltd Stable amorphous forms of montelukast sodium
JP2005253412A (en) * 2004-03-15 2005-09-22 Masayasu Suzuki Microwell array chip, method for producing the same and method for assaying specimen
EP1735428A4 (en) 2004-04-12 2010-11-10 Univ California OPTOELECTRONIC CLAMPS FOR HANDLING MICROPARTICLES AND CELLS
US7951580B2 (en) 2004-04-21 2011-05-31 The Regents Of The University Of California Automated, programmable, high throughput, multiplexed assay system for cellular and biological assays
US7403647B2 (en) 2004-09-13 2008-07-22 Seng Enterprises Ltd. Method for identifying an image of a well in an image of a well-bearing component
US20080063251A1 (en) * 2004-07-07 2008-03-13 Mordechai Deutsch Method and Device for Identifying an Image of a Well in an Image of a Well-Bearing
EP1781404A2 (en) * 2004-08-25 2007-05-09 Seng Enterprises Limited Method and device for isolating cells
US7695954B2 (en) 2004-10-04 2010-04-13 The Regents Of The University Of California Micropatterned plate with micro-pallets for addressable biochemical analysis
US8038964B2 (en) 2005-01-25 2011-10-18 Seng Enterprises Ltd. Device for studying individual cells
DE102005034043B4 (en) * 2005-07-18 2019-12-12 Südzucker Aktiengesellschaft Mannheim/Ochsenfurt Mixture containing L-carnitine and trehalulose and product containing the mixture
US7776553B2 (en) * 2005-09-16 2010-08-17 Presidents And Fellows Of Harvard College Screening assays and methods
EP1772722A1 (en) * 2005-10-07 2007-04-11 Micronas Holding GmbH Reaction chamber
US20070141555A1 (en) * 2005-10-11 2007-06-21 Mordechai Deutsch Current damper for the study of cells
US7759635B2 (en) 2005-10-11 2010-07-20 Ecole Polytechnique Federale De Lausanne (Epfl) Miniaturized optical tweezer array
WO2007052245A1 (en) * 2005-11-03 2007-05-10 Seng Enterprises Ltd. Method and device for studying floating, living cells
JP4844161B2 (en) * 2006-02-23 2011-12-28 パナソニック株式会社 Cell electrophysiological sensor, measuring method using the same, and manufacturing method thereof
KR101087809B1 (en) * 2006-04-10 2011-11-29 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 System for the collection of single cells and colonies
US20060223999A1 (en) * 2006-05-10 2006-10-05 Chemagis Ltd. Process for preparing montelukast and precursors thereof
US7968839B2 (en) * 2006-07-26 2011-06-28 Ecole Polytechnique Federale De Lausanne (Epfl) Miniaturized optical tweezers based on high-NA micro-mirrors
US20080220169A1 (en) * 2006-10-16 2008-09-11 The Brigham And Women's Hospital, Inc. Parylene-C Stencils
WO2008078831A1 (en) * 2006-12-22 2008-07-03 Fujirebio, Inc. Biosensor, biosensor chip and method for producing the biosensor chip for sensing a target molecule
US8748085B2 (en) 2007-07-25 2014-06-10 The Regents Of The University Of California Use of photosensitized Epon epoxy resin 1002F for MEMS and bioMEMS applications
US9487745B2 (en) 2007-07-27 2016-11-08 The Regents Of The University Of California Micro-patterned plate composed of an array of releasable elements surrounded with solid or gel walls
JP4148367B1 (en) 2007-08-02 2008-09-10 富山県 Cell screening method
US20090042737A1 (en) * 2007-08-09 2009-02-12 Katz Andrew S Methods and Devices for Correlated, Multi-Parameter Single Cell Measurements and Recovery of Remnant Biological Material
WO2009081409A2 (en) 2007-12-26 2009-07-02 Seng Enterprises Ltd. Device for the study of living cells
US9145540B1 (en) 2007-11-15 2015-09-29 Seng Enterprises Ltd. Device for the study of living cells
US9086400B2 (en) * 2007-11-29 2015-07-21 Cornell Research Foundation, Inc. Amplifier and array for measuring small current
JP5295733B2 (en) * 2007-11-30 2013-09-18 キヤノン株式会社 Living body holding method, living body testing method, living body growth method, living body holding sheet, and living body processing apparatus
EP2113941B1 (en) * 2008-05-02 2013-02-13 STMicroelectronics (Research & Development) Limited Reference data encoding in image sensors
GB0809486D0 (en) * 2008-05-23 2008-07-02 Iti Scotland Ltd Triple function elctrodes
CN101614729B (en) * 2008-06-27 2013-04-24 博奥生物有限公司 Microelectrode array device and special device for cell manipulation and electrophysiological signal detection
GB2464300A (en) * 2008-10-10 2010-04-14 Univ Dublin City Microfluidic multiplexed cellular and molecular analysis device and method
US9404924B2 (en) 2008-12-04 2016-08-02 Massachusetts Institute Of Technology Method of performing one-step, single cell RT-PCR
US9244080B2 (en) 2008-12-04 2016-01-26 Massachussetts Institute Of Technology Method for diagnosing allergic reactions
JP2010200679A (en) * 2009-03-04 2010-09-16 Kuraray Co Ltd Cell culture container, method for performing cell culture, and method for evaluating cell
FR2946157B1 (en) * 2009-06-02 2015-03-27 Commissariat Energie Atomique MICROLENTILIC IMAGING SYSTEM AND ASSOCIATED DEVICE FOR DETECTING A SAMPLE.
GB0909923D0 (en) * 2009-06-09 2009-07-22 Oxford Gene Tech Ip Ltd Picowell capture devices for analysing single cells or other particles
CA2776039A1 (en) * 2009-09-30 2011-04-07 Healthwatch Ltd. Continuous non-interfering health monitoring and alert system
WO2011054961A1 (en) 2009-11-09 2011-05-12 Oenfelt Bjoern System and method for detecting and quantifying active t-cells or natural killer cells
EP2522716B1 (en) * 2010-01-08 2019-08-28 Sumitomo Bakelite Company Limited Culture vessel for formation of aggregated cell mass
WO2011083478A2 (en) 2010-01-11 2011-07-14 Seng Enterprises Ltd. Methods of loading cells
GB2477506B (en) * 2010-02-03 2013-10-30 Dna Electronics Ltd Integrated electrochemical and optical sensor with inductor
WO2011108454A1 (en) * 2010-03-05 2011-09-09 コニカミノルタホールディングス株式会社 Cell detection method and cell detection system
DE102010016818A1 (en) * 2010-03-16 2011-09-22 Leica Microsystems Cms Gmbh Method and apparatus for performing multipoint FCS
DE102010024964B4 (en) * 2010-06-24 2012-01-26 Siemens Aktiengesellschaft Cell monitoring by means of scattered light measurement
US10247656B2 (en) * 2010-09-09 2019-04-02 Children's Hospital & Research Center At Oakland Single-cell microchamber array
WO2012125906A1 (en) * 2011-03-16 2012-09-20 Solidus Biosciences, Inc. Apparatus and method for analyzing data of cell chips
JP5487152B2 (en) * 2011-04-11 2014-05-07 株式会社日立製作所 Cell collection system
WO2013011962A1 (en) * 2011-07-15 2013-01-24 独立行政法人科学技術振興機構 Cell culture device, device for long-term monitoring of cell culture, method for long-term cell culture, and method for long-term monitoring of cell culture
US10466160B2 (en) 2011-08-01 2019-11-05 Celsee Diagnostics, Inc. System and method for retrieving and analyzing particles
US9404864B2 (en) 2013-03-13 2016-08-02 Denovo Sciences, Inc. System for imaging captured cells
ES2797448T3 (en) 2011-08-01 2020-12-02 Bio Rad Laboratories Cell capture system
TWI452997B (en) * 2011-10-05 2014-09-21 Univ Kun Shan Biosensor chip with nano-structures
US10274487B2 (en) * 2012-02-06 2019-04-30 Nri R&D Patent Licensing, Llc Microprocessor-controlled microfluidic platform for pathogen, toxin, biomarker, and chemical detection with removable updatable sensor array for food and water safety, medical, and laboratory applications
CA2867636A1 (en) * 2012-03-29 2013-10-03 Centre National De La Recherche Scientifique Immobilizing a plurality of oblong shaped cells or invertebrate embryos on a device
EP2871232B1 (en) 2012-07-03 2021-05-05 Konica Minolta, Inc. Method for detecting rare cell
US10866169B2 (en) * 2012-10-17 2020-12-15 Konica Minolta, Inc. Method for recovering rare cells and method for detecting rare cells
US20140132274A1 (en) * 2012-11-13 2014-05-15 Awareness Technology Inc. Method and apparatus for providing information in an electrolyte measurment system
US9606102B2 (en) 2013-01-26 2017-03-28 Denovo Sciences, Inc. System and method for capturing and analyzing cells
US9707562B2 (en) 2013-03-13 2017-07-18 Denovo Sciences, Inc. System for capturing and analyzing cells
CN103808922B (en) * 2013-04-27 2015-09-09 无锡国盛生物工程有限公司 A kind of screening technique of hybridoma supernatant stage trace antibody
US9856535B2 (en) 2013-05-31 2018-01-02 Denovo Sciences, Inc. System for isolating cells
US10391490B2 (en) 2013-05-31 2019-08-27 Celsee Diagnostics, Inc. System and method for isolating and analyzing cells
WO2015028528A1 (en) 2013-09-02 2015-03-05 Koninklijke Philips N.V. Transparent computer structure
US9567630B2 (en) 2013-10-23 2017-02-14 Genia Technologies, Inc. Methods for forming lipid bilayers on biochips
WO2015087369A1 (en) * 2013-12-12 2015-06-18 ヤマハ発動機株式会社 Well plate and subject selection device provided with well plate
US10073091B2 (en) 2014-08-08 2018-09-11 Ortho-Clinical Diagnostics, Inc. Lateral flow assay device
US10036739B2 (en) 2015-01-27 2018-07-31 Genia Technologies, Inc. Adjustable bilayer capacitance structure for biomedical devices
WO2016140327A1 (en) * 2015-03-04 2016-09-09 国立研究開発法人産業技術総合研究所 Microchamber array plate
EP3278166A2 (en) 2015-03-31 2018-02-07 Samantree Medical SA Systems and methods for in-operating-theatre imaging of fresh tissue resected during surgery for pathology assessment
RU2614926C2 (en) * 2015-07-06 2017-03-30 Российская Федерация, от имени которой выступает Государственная корпорация по атомной энергии "Росатом" Multiprocessor system
US10809243B2 (en) 2015-08-31 2020-10-20 Roche Sequencing Solutions, Inc. Small aperture large electrode cell
US11041848B2 (en) * 2016-01-19 2021-06-22 The University Of Tokyo Method and system for cell collection based on information regarding change over time
CN108779427A (en) * 2016-03-30 2018-11-09 索尼公司 Cell observation device, the method for assessing immunologic cellular activity level and the method for controlling immunocyte quality
WO2017170994A1 (en) * 2016-03-31 2017-10-05 古河電気工業株式会社 Cell-containable chip
JP2018000134A (en) * 2016-07-06 2018-01-11 大日本印刷株式会社 Cell culture container
EP3505489B1 (en) * 2016-08-23 2020-03-25 Sony Corporation Single-particle capturing apparatus, single-particle capturing system, and method for capturing single-particle
JP6218199B1 (en) * 2016-10-06 2017-10-25 日本航空電子工業株式会社 Electrochemical measuring device and transducer
US11067535B2 (en) 2016-10-27 2021-07-20 Sharp Kabushiki Kaisha Fluorescent testing system, dielectrophoresis device, and molecular testing method
WO2019046307A1 (en) 2017-08-29 2019-03-07 Celsee Diagnostics, Inc. System and method for isolating and analyzing cells
JP2021501322A (en) * 2017-10-26 2021-01-14 エッセンリックス コーポレーション High-speed measurement of platelets
US10539776B2 (en) 2017-10-31 2020-01-21 Samantree Medical Sa Imaging systems with micro optical element arrays and methods of specimen imaging
US11747603B2 (en) 2017-10-31 2023-09-05 Samantree Medical Sa Imaging systems with micro optical element arrays and methods of specimen imaging
US10928621B2 (en) 2017-10-31 2021-02-23 Samantree Medical Sa Sample dishes for use in microscopy and methods of their use
WO2019209346A1 (en) * 2018-04-27 2019-10-31 Hewlett-Packard Development Company, L.P. Cellular object growth platform
BR102019006678A2 (en) * 2019-04-02 2020-10-06 Universidade Federal de Uberlândia PROCESS OF MODIFICATION OF THE SURFACE OF ELECTRODES FOR THE CONSTRUCTION OF ELECTROCHEMICAL BIOSSENSORS
US10633693B1 (en) 2019-04-16 2020-04-28 Celsee Diagnostics, Inc. System and method for leakage control in a particle capture system
US11273439B2 (en) 2019-05-07 2022-03-15 Bio-Rad Laboratories, Inc. System and method for target material retrieval from microwells
CN114072490B (en) 2019-05-07 2024-12-27 伯乐实验室有限公司 Systems and methods for automated single cell processing
US11927520B2 (en) 2019-05-30 2024-03-12 Hewlett-Packard Development Company, L.P. Rotating levitated particle imaging
CN112689751A (en) 2019-05-31 2021-04-20 伊鲁米那股份有限公司 Flow cell with one or more barrier features
CA3143241A1 (en) 2019-06-14 2020-12-17 Bio-Rad Laboratories, Inc. System and method for automated single cell processing and analyses
US11504719B2 (en) 2020-03-12 2022-11-22 Bio-Rad Laboratories, Inc. System and method for receiving and delivering a fluid for sample processing
GB2593194B (en) * 2020-03-18 2022-09-07 Refeyn Ltd Methods and apparatus for optimised interferometric scattering microscopy
CN111563550B (en) * 2020-04-30 2023-08-25 北京百度网讯科技有限公司 Sperm morphology detection method and device based on image technology
TWI854167B (en) * 2020-12-14 2024-09-01 國立中央大學 Integrated microfluidic chip for cell imaging and biochemical detection and method using the same
WO2023073701A1 (en) * 2021-10-26 2023-05-04 Micha Zimmermann System and method for optical detection and identification of pathogens in a thin layer of fluid
EP4257046A1 (en) * 2022-04-06 2023-10-11 Leibniz-Institut für Neurobiologie Object carrier for microscopy, method of making same and method of measuring therewith

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4072578A (en) * 1975-11-19 1978-02-07 Bactomatic Corporation Multi-chambered module for use in monitoring growth of microorganisms
WO1999066329A1 (en) * 1998-06-12 1999-12-23 Cenes Limited High throughput screen
WO2002008748A2 (en) * 2000-07-10 2002-01-31 Aurora Biosciences Corporation Ion channel assay methods

Family Cites Families (123)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US646500A (en) * 1897-08-27 1900-04-03 Gen Electric Electric transformer.
US655365A (en) * 1899-11-14 1900-08-07 Henry M Johnson Hernial truss.
US3558387A (en) * 1966-06-10 1971-01-26 Sun Chemical Corp Radiation-curable compositions
US4207554A (en) * 1972-08-04 1980-06-10 Med-El Inc. Method and apparatus for automated classification and analysis of cells
US5310674A (en) * 1982-05-10 1994-05-10 Bar-Ilan University Apertured cell carrier
IL68507A (en) * 1982-05-10 1986-01-31 Univ Bar Ilan System and methods for cell selection
US4684538A (en) * 1986-02-21 1987-08-04 Loctite Corporation Polysiloxane urethane compounds and adhesive compositions, and method of making and using the same
US5681718A (en) * 1986-03-14 1997-10-28 Celltech Limited Methods for enhanced production of tissue plasminogen activator in cell culture using alkanoic acids or salts thereof
JP2662215B2 (en) * 1986-11-19 1997-10-08 株式会社日立製作所 Cell holding device
US5079600A (en) * 1987-03-06 1992-01-07 Schnur Joel M High resolution patterning on solid substrates
US4839280A (en) * 1987-05-04 1989-06-13 Banes Albert J Apparatus for applying stress to cell cultures
JP2559760B2 (en) * 1987-08-31 1996-12-04 株式会社日立製作所 Cell delivery method
US5153136A (en) * 1988-07-22 1992-10-06 Vandenburgh Herman H Apparatus for growing tissue specimens in vitro
US5043082A (en) * 1988-12-15 1991-08-27 Hermann Jr William J Collection device and method of use thereof for the concentration, transport and processing of cellular components to determine the presence or absence of biomarkers
GB8927742D0 (en) * 1989-12-07 1990-02-07 Diatec A S Process and apparatus
US5204055A (en) * 1989-12-08 1993-04-20 Massachusetts Institute Of Technology Three-dimensional printing techniques
US5650323A (en) * 1991-06-26 1997-07-22 Costar Corporation System for growing and manipulating tissue cultures using 96-well format equipment
WO1993003179A1 (en) * 1991-07-30 1993-02-18 Bio-Technical Resources Device for detecting aqueous contaminants
US5744366A (en) * 1992-05-01 1998-04-28 Trustees Of The University Of Pennsylvania Mesoscale devices and methods for analysis of motile cells
GB9215834D0 (en) * 1992-07-24 1992-09-09 Celltech Ltd Cell culture
US5395588A (en) * 1992-12-14 1995-03-07 Becton Dickinson And Company Control of flow cytometer having vacuum fluidics
US6206672B1 (en) * 1994-03-31 2001-03-27 Edward P. Grenda Apparatus of fabricating 3 dimensional objects by means of electrophotography, ionography or a similar process
DE69509650T2 (en) * 1994-04-21 1999-12-30 Medtronic, Inc. TREATMENT OF ATRIAL FIBRILLATIONS
US5527345A (en) * 1994-05-17 1996-06-18 Infinger; Kenneth R. Implantable atrial defibrillator having an intermittenly activated pacing modality
US5707869A (en) * 1994-06-28 1998-01-13 Wolf; Martin L. Compartmentalized multiple well tissue culture plate
US5824536A (en) * 1994-08-23 1998-10-20 St. Jude Children's Research Hospital Influenza virus replicated in mammalian cell culture and vaccine production
SE9402865D0 (en) * 1994-08-29 1994-08-29 Siemens Elema Ab Implantable cardiac defibrillator
US5525800A (en) * 1994-10-31 1996-06-11 The United States Of America As Represented By The Secretary Of The Navy Selective multi-chemical fiber optic sensor
US5627045A (en) * 1995-04-12 1997-05-06 Biolog, Inc. Multi-test format with gel-forming matrix for characterization of microorganisms
US6117612A (en) * 1995-04-24 2000-09-12 Regents Of The University Of Michigan Stereolithography resin for rapid prototyping of ceramics and metals
US6025129A (en) * 1995-04-25 2000-02-15 Irori Remotely programmable matrices with memories and uses thereof
US5905031A (en) * 1995-05-18 1999-05-18 Coulter International Corp. Identification of blast cells in a leukocyte cell preparation
US5840565A (en) * 1995-08-22 1998-11-24 The Regents Of The University Of California Methods for enhancing the production of viral vaccines in PKR-deficient cell culture
US6103479A (en) * 1996-05-30 2000-08-15 Cellomics, Inc. Miniaturized cell array methods and apparatus for cell-based screening
US6890426B2 (en) * 1996-06-07 2005-05-10 Immunivest Corporation Magnetic separation apparatus and methods
US6046426A (en) * 1996-07-08 2000-04-04 Sandia Corporation Method and system for producing complex-shape objects
US5854684A (en) * 1996-09-26 1998-12-29 Sarnoff Corporation Massively parallel detection
US6692961B1 (en) * 1996-10-11 2004-02-17 Invitrogen Corporation Defined systems for epithelial cell culture and use thereof
WO1998022819A1 (en) * 1996-11-16 1998-05-28 Nmi Naturwissenschaftliches Und Medizinisches Institut An Der Universität Tübingen In Reutlingen Stiftung Bürgerlichen Rechts Array of microelements, method of contacting cells in a liquid environment and method for the production of an array of microelements
US6383810B2 (en) * 1997-02-14 2002-05-07 Invitrogen Corporation Dry powder cells and cell culture reagents and methods of production thereof
US5910287A (en) * 1997-06-03 1999-06-08 Aurora Biosciences Corporation Low background multi-well plates with greater than 864 wells for fluorescence measurements of biological and biochemical samples
KR100266448B1 (en) * 1997-06-26 2000-09-15 박종헌 Mass production of taxol by changing temperature during the plant cell culture
AU8846498A (en) * 1997-08-07 1999-03-01 Imaging Research, Inc. A digital imaging system for assays in well plates, gels and blots
US6048723A (en) * 1997-12-02 2000-04-11 Flexcell International Corporation Flexible bottom culture plate for applying mechanical load to cell cultures
US6066285A (en) * 1997-12-12 2000-05-23 University Of Florida Solid freeform fabrication using power deposition
US6413680B1 (en) * 1998-02-26 2002-07-02 Kabushiki Kaisha Toyota Chuo Kenkyusho Optical recording method, optical recording medium, and optical recording system
US6210910B1 (en) * 1998-03-02 2001-04-03 Trustees Of Tufts College Optical fiber biosensor array comprising cell populations confined to microcavities
US7236888B2 (en) * 1998-03-06 2007-06-26 The Regents Of The University Of California Method to measure the activation state of signaling pathways in cells
DE69903800T2 (en) * 1998-03-18 2003-10-02 Massachusetts Institute Of Technology, Cambridge VASCULARIZED PERFUNDED ARRANGEMENTS FOR MICRO TISSUE AND MICROORGANES
US6027695A (en) * 1998-04-01 2000-02-22 Dupont Pharmaceuticals Company Apparatus for holding small volumes of liquids
US6378527B1 (en) * 1998-04-08 2002-04-30 Chondros, Inc. Cell-culture and polymer constructs
US6528286B1 (en) * 1998-05-29 2003-03-04 Genentech, Inc. Mammalian cell culture process for producing glycoproteins
FR2779443B1 (en) * 1998-06-08 2000-08-04 Claude Hanni ORGANIC CELL CULTURE AND STUDY OF THEIR ELECTROPHYSIOLOGICAL ACTIVITY AND MEMBRANE DEVICE USED IN SUCH A DEVICE
US6521182B1 (en) * 1998-07-20 2003-02-18 Lifescan, Inc. Fluidic device for medical diagnostics
KR100271208B1 (en) * 1998-08-13 2000-12-01 윤덕용 Selective infiltration manufacturing method and apparatus
CA2351545C (en) * 1998-08-19 2010-06-15 University Health Network The use of high frequency ultrasound imaging to detect and monitor the process of apoptosis in living tissues, ex-vivo tissues and cell-culture
US6342384B1 (en) * 1998-08-21 2002-01-29 The University Of Va Patent Foundation Production of adenoviral vectors using serum-free suspension cell culture in a hollow fiber system
US6228437B1 (en) * 1998-12-24 2001-05-08 United Technologies Corporation Method for modifying the properties of a freeform fabricated part
US6416642B1 (en) * 1999-01-21 2002-07-09 Caliper Technologies Corp. Method and apparatus for continuous liquid flow in microscale channels using pressure injection, wicking, and electrokinetic injection
US6492148B1 (en) * 1999-03-05 2002-12-10 Akzo Nobel Nv Genetically engineered cell culture adapted infectious bursal disease virus (IBDV) mutants
US6410309B1 (en) * 1999-03-23 2002-06-25 Biocrystal Ltd Cell culture apparatus and methods of use
US6193647B1 (en) * 1999-04-08 2001-02-27 The Board Of Trustees Of The University Of Illinois Microfluidic embryo and/or oocyte handling device and method
CA2368797C (en) * 1999-04-26 2010-08-17 Genentech, Inc. Cell culture process
US6338964B1 (en) * 1999-05-07 2002-01-15 Bayer Corporation Process and medium for mammalian cell culture under low dissolved carbon dioxide concentration
US6372494B1 (en) * 1999-05-14 2002-04-16 Advanced Tissue Sciences, Inc. Methods of making conditioned cell culture medium compositions
US6706519B1 (en) * 1999-06-22 2004-03-16 Tecan Trading Ag Devices and methods for the performance of miniaturized in vitro amplification assays
AU784506B2 (en) * 1999-08-25 2006-04-13 Immunex Corporation Compositions and methods for improved cell culture
AU2001251114A1 (en) * 2000-03-28 2001-10-08 Board Of Regents, The University Of Texas System Enhancing contrast in biological imaging
AU2001253147A1 (en) * 2000-04-03 2001-10-15 Phycogen, Inc. Generation of combinatorial synthetic libraries and screening for proadhesins and nonadhesins
AU2001250058A1 (en) * 2000-04-06 2001-10-23 Caliper Technologies Corp. Methods and devices for achieving long incubation times in high-throughput systems
US20030104494A1 (en) * 2001-10-26 2003-06-05 Ilya Ravkin Assay systems with adjustable fluid communication
US6627159B1 (en) * 2000-06-28 2003-09-30 3M Innovative Properties Company Centrifugal filling of sample processing devices
EP1330306A2 (en) * 2000-10-10 2003-07-30 BioTrove, Inc. Apparatus for assay, synthesis and storage, and methods of manufacture, use, and manipulation thereof
JP2004537712A (en) * 2000-10-18 2004-12-16 バーチャル・アレイズ・インコーポレーテッド Multiple cell analysis system
US7033821B2 (en) * 2000-11-08 2006-04-25 Surface Logix, Inc. Device for monitoring cell motility in real-time
US6699665B1 (en) * 2000-11-08 2004-03-02 Surface Logix, Inc. Multiple array system for integrating bioarrays
US6844184B2 (en) * 2000-11-08 2005-01-18 Surface Logix, Inc. Device for arraying biomolecules and for monitoring cell motility in real-time
US7211209B2 (en) * 2000-11-08 2007-05-01 Surface Logix, Inc. Method of making device for arraying biomolecules and for monitoring cell motility in real-time
US6495340B2 (en) * 2000-11-28 2002-12-17 Medis El Ltd. Cell carrier grids
US6555365B2 (en) * 2000-12-07 2003-04-29 Biocrystal, Ltd. Microincubator comprising a cell culture apparatus and a transparent heater
US6588586B2 (en) * 2000-12-08 2003-07-08 Biocrystal Ltd Mailer for cell culture device
JPWO2002055653A1 (en) * 2001-01-09 2004-05-20 松下電器産業株式会社 Extracellular potential measuring device, extracellular potential measuring method using the same, and high-speed drug screening apparatus equipped with the same
US6376148B1 (en) * 2001-01-17 2002-04-23 Nanotek Instruments, Inc. Layer manufacturing using electrostatic imaging and lamination
US6403369B1 (en) * 2001-01-19 2002-06-11 Gary W. Wood Cell culture vessel
US20020106715A1 (en) * 2001-02-02 2002-08-08 Medisel Ltd System and method for collecting data from individual cells
US6544788B2 (en) * 2001-02-15 2003-04-08 Vijay Singh Disposable perfusion bioreactor for cell culture
EP1565747B1 (en) * 2001-03-29 2013-11-27 Cellect Technologies Corp. Method and system for separating and sorting particles
US6830931B2 (en) * 2001-07-12 2004-12-14 Automated Cell, Inc. Method and apparatus for monitoring of proteins and cells
KR100413535B1 (en) * 2001-07-18 2003-12-31 학교법인 포항공과대학교 Absorbance detection system for lab-on-a-chip
EP1421365A1 (en) * 2001-07-19 2004-05-26 Tufts University Optical array device and methods of use thereof for screening, analysis and manipulation of particles
US7285412B2 (en) * 2001-07-27 2007-10-23 Surface Logix Inc. Device for magnetic immobilization of cells
US7169578B2 (en) * 2001-07-27 2007-01-30 Surface Logix, Inc. Cell isolation and screening device and method of using same
EP1423501A4 (en) * 2001-08-06 2008-08-06 Univ Vanderbilt DEVICE AND METHODS FOR MEASURING THE RESPONSE OF AT LEAST ONE CELL FACING A MEDIUM
US20050230272A1 (en) * 2001-10-03 2005-10-20 Lee Gil U Porous biosensing device
US20030087292A1 (en) * 2001-10-04 2003-05-08 Shiping Chen Methods and systems for promoting interactions between probes and target molecules in fluid in microarrays
US20050014201A1 (en) * 2001-10-25 2005-01-20 Mordechai Deuthsch Interactive transparent individual cells biochip processor
US20030082632A1 (en) * 2001-10-25 2003-05-01 Cytoprint, Inc. Assay method and apparatus
US7267958B2 (en) * 2001-11-01 2007-09-11 Rensselaer Polytechnic Institute Biocatalytic solgel microarrays
WO2003039753A1 (en) * 2001-11-05 2003-05-15 President And Fellows Of Harvard College System and method for capturing and positioning particles
WO2003069333A1 (en) * 2002-02-14 2003-08-21 Illumina, Inc. Automated information processing in randomly ordered arrays
JP3818265B2 (en) * 2002-03-04 2006-09-06 株式会社豊田中央研究所 Light immobilization method for minute object, carrier for immobilizing minute object, and observation method for minute object
US7507579B2 (en) * 2002-05-01 2009-03-24 Massachusetts Institute Of Technology Apparatus and methods for simultaneous operation of miniaturized reactors
US20050106714A1 (en) * 2002-06-05 2005-05-19 Zarur Andrey J. Rotatable reactor systems and methods
AU2003277316A1 (en) * 2002-10-08 2004-05-04 Case Western Reserve University Hydrodynamic micromanipulation of individual cells to patterned attachement sites
US7122384B2 (en) * 2002-11-06 2006-10-17 E. I. Du Pont De Nemours And Company Resonant light scattering microparticle methods
US20040091397A1 (en) * 2002-11-07 2004-05-13 Corning Incorporated Multiwell insert device that enables label free detection of cells and other objects
JP2004224627A (en) * 2003-01-22 2004-08-12 Seiko Epson Corp Method for producing potassium niobate single crystal thin film, surface acoustic wave device, frequency filter, frequency oscillator, electronic circuit, and electronic device
CN101128601B (en) * 2003-01-29 2011-06-08 454生命科学公司 Methods of amplifying and sequencing nucleic acids
IL154677A0 (en) * 2003-02-27 2003-09-17 Univ Bar Ilan A method and apparatus for manipulating an individual cell
US7888110B2 (en) * 2003-06-26 2011-02-15 Seng Enterprises Ltd. Pico liter well holding device and method of making the same
US20050026299A1 (en) * 2003-07-31 2005-02-03 Arindam Bhattacharjee Chemical arrays on a common carrier
US20050064524A1 (en) * 2003-08-11 2005-03-24 Mordechai Deutsch Population of cells utilizable for substance detection and methods and devices using same
WO2005075080A1 (en) * 2004-01-30 2005-08-18 Corning Incorporated Multiwell plate and method for making multiwell plate using a low cytotoxicity photocurable adhesive
WO2006119467A2 (en) * 2005-05-04 2006-11-09 Impulse Dynamics Nv Protein activity modification
US7403647B2 (en) * 2004-09-13 2008-07-22 Seng Enterprises Ltd. Method for identifying an image of a well in an image of a well-bearing component
US20080063251A1 (en) * 2004-07-07 2008-03-13 Mordechai Deutsch Method and Device for Identifying an Image of a Well in an Image of a Well-Bearing
EP1781404A2 (en) * 2004-08-25 2007-05-09 Seng Enterprises Limited Method and device for isolating cells
US8038964B2 (en) * 2005-01-25 2011-10-18 Seng Enterprises Ltd. Device for studying individual cells
US20070141555A1 (en) * 2005-10-11 2007-06-21 Mordechai Deutsch Current damper for the study of cells
WO2007052245A1 (en) * 2005-11-03 2007-05-10 Seng Enterprises Ltd. Method and device for studying floating, living cells
US7531140B2 (en) * 2005-12-29 2009-05-12 Corning Incorporated Multiwell plate having transparent well bottoms and method for making the mulitiwell plate
TW200810834A (en) * 2006-04-28 2008-03-01 Univ California Method of manufacture of a plate of releasable elements and its assembly into a cassette
EP4190448A3 (en) * 2006-05-11 2023-09-20 Bio-Rad Laboratories, Inc. Microfluidic devices

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4072578A (en) * 1975-11-19 1978-02-07 Bactomatic Corporation Multi-chambered module for use in monitoring growth of microorganisms
WO1999066329A1 (en) * 1998-06-12 1999-12-23 Cenes Limited High throughput screen
WO2002008748A2 (en) * 2000-07-10 2002-01-31 Aurora Biosciences Corporation Ion channel assay methods

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
GONZALEZ J E ET AL: "CELL-BASED ASSAYS AND INSTRUMENTATION FOR SCREENING ION-CHANNEL TARGETS", DRUG DISCOVERY TODAY, ELSEVIER, RAHWAY, NJ, US, vol. 4, no. 9, 1 September 1999 (1999-09-01), pages 431 - 439, XP001026838, ISSN: 1359-6446, DOI: 10.1016/S1359-6446(99)01383-5 *

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