EP2268278A4 - Pharmaceutical composition - Google Patents

Pharmaceutical composition

Info

Publication number: EP2268278A4
Authority: EP; European Patent Office
Prior art keywords: pharmaceutical composition; pharmaceutical; composition
Prior art date: 2008-04-04
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP08742562A

Other languages

German (de)

French (fr)

Other versions

EP2268278A1 (en

Inventor

Paul Bingham

Lakmal W Boteju

Zuzana Zachar

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Individual

Original Assignee

Individual

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-04-04

Filing date

2008-04-04

Publication date

2011-11-09

2008-04-04 Application filed by Individual filed Critical Individual

2011-01-05 Publication of EP2268278A1 publication Critical patent/EP2268278A1/en

2011-11-09 Publication of EP2268278A4 publication Critical patent/EP2268278A4/en

Status Withdrawn legal-status Critical Current

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/385—Heterocyclic compounds having sulfur as a ring hetero atom having two or more sulfur atoms in the same ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

EP08742562A 2008-04-04 2008-04-04 Pharmaceutical composition Withdrawn EP2268278A4 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PCT/US2008/004410 WO2009123597A1 (en)	2008-04-04	2008-04-04	Pharmaceutical composition

Publications (2)

Publication Number	Publication Date
EP2268278A1 EP2268278A1 (en)	2011-01-05
EP2268278A4 true EP2268278A4 (en)	2011-11-09

Family

ID=41135840

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP08742562A Withdrawn EP2268278A4 (en)	2008-04-04	2008-04-04	Pharmaceutical composition

Country Status (10)

Country	Link
EP (1)	EP2268278A4 (en)
JP (1)	JP2011516473A (en)
KR (1)	KR20110025168A (en)
CN (1)	CN102056605A (en)
AU (1)	AU2008354009A1 (en)
BR (1)	BRPI0821894A2 (en)
CA (1)	CA2720396A1 (en)
IL (1)	IL208387A0 (en)
MX (1)	MX2010010867A (en)
WO (1)	WO2009123597A1 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN103037853B (en)	2010-07-08	2015-05-13	Wm.雷格利Jr.公司	Chewing gum containing a cross-linked gelatin matrix gum base
US9421234B2 (en) *	2011-05-20	2016-08-23	Nutramax Laboratories, Inc.	Orally administrable compositions comprising avocado/soybean unsaponifiables and lipoic acid and methods of administration
WO2013123305A1 (en) *	2012-02-16	2013-08-22	The Penn State Research Foundation	Modulators of acyl-coa lysocardiolipin acyltransferase 1 ( alcat1) and uses thereof
MX2015007885A (en) *	2012-12-19	2016-04-28	Cornerstone Pharmaceuticals Inc	Pharmaceutical compounds.
WO2015195070A1 (en)	2014-06-19	2015-12-23	Robert Shorr	Pharmaceutical compounds
ES2747702T3 (en)	2014-06-19	2020-03-11	Rafael Pharmaceuticals Inc	Pharmaceutical compounds
CN110590624B (en) *	2019-09-26	2021-02-26	苏州富士莱医药股份有限公司	Preparation method of lipoic acid derivative 8- (ethyl disulfide) -6- (phenyl disulfide) caprylic acid
WO2023012305A1 (en) *	2021-08-04	2023-02-09	Cytacoat Ab	Disulfide compounds as medicaments
CN118236491A (en) *	2022-12-23	2024-06-25	中国科学院上海营养与健康研究所	PDK4 as cell senescence intervention target and application thereof in chemotherapy and anticancer

Citations (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2789991A (en) *	1954-05-20	1957-04-23	American Cyanamid Co	Substituted disulfones
US2853497A (en) *	1953-12-04	1958-09-23	Merck & Co Inc	6, 8-bis (hydrocarbon substituted mercapto) 5-hydroxycaprylic acids and delta-lactones thereof
JPS61198148A (en) *	1985-01-29	1986-09-02	Fuji Photo Film Co Ltd	Silver halide photographic sensitive material
EP0947503A1 (en) *	1998-04-01	1999-10-06	Galderma Research & Development, S.N.C.	6,8-Dimethylmercaptooctanoic acid derivatives substituted on 6-S and/or 8-S by the 3-methylthiopropanoyl radical and pharmaceutical compositions for the treatment of cancerous tumours
WO2000059899A1 (en) *	1999-04-02	2000-10-12	Societe De Conseil De Recherches Et D'applications Scientifiques (S.C.R.A.S.)	Novel lipoic acid derivatives, their preparation, and pharmaceutical compositions containing them
WO2000061143A1 (en) *	1999-04-09	2000-10-19	Antibioticos S.P.A.	The use of alpha lipoic acid in the antimetastatic treatment
WO2008131114A2 (en) *	2007-04-18	2008-10-30	Cornerstone Pharmaceuticals, Inc.	Pharmaceutical formulations containing lipoic acid derivatives
WO2008131117A1 (en) *	2007-04-18	2008-10-30	Cornerstone Pharmaceuticals, Inc.	Lipoic acid derivatives
WO2009110859A1 (en) *	2008-03-04	2009-09-11	Robert Shorr	Modulation of enzymatic structure, activity, and/or expression level

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9618934D0 (en) *	1996-09-11	1996-10-23	Univ London	Inositol phosphoglycans for therapeutic use in the treatment of diabetes and obesity
AU743316C (en) *	1998-03-20	2005-09-15	Commonwealth Scientific And Industrial Research Organisation	Control of gene expression
ES2340488T3 (en) *	1998-10-26	2010-06-04	The Research Foundation Of State University Of New York	SALTS DERIVED FROM LIPOIC ACID AND ITS USE FOR THE TREATMENT OF DISEASES.
DE19904794A1 (en) *	1999-02-05	2000-08-10	Biotechnolog Forschung Gmbh	Methods for improving the primary metabolism of mammalian cell lines
US6284786B1 (en) *	1999-02-16	2001-09-04	The Center For The Improvement Of Human Functioning, Int'l., Inc.	Treatment of cancer using lipoic acid in combination with ascorbic acid
WO2001090353A1 (en) *	2000-05-19	2001-11-29	F.Hoffmann-La Roche Ag	A process for determining the tumoricidal potential of a sample by the use of a nucleic acid which is downregulated in human tumor cells
WO2006119355A2 (en) *	2005-05-03	2006-11-09	Albert Einstein College Of Medicine Of Yeshiva University	Mammalian hypothalamic nutrient modulation of glucose metabolism
US20070077583A1 (en) *	2005-09-21	2007-04-05	Aurelium Biopharma, Inc.	Alpha enolase-directed diagnostics and therapeutics for cancer and chemotherapeutic drug resistance
US20070212360A1 (en) *	2006-01-17	2007-09-13	Denko Nicholas C	Modulation of mitochondrial oxygen consumption for therapeutic purposes

2008
- 2008-04-04 BR BRPI0821894-3A patent/BRPI0821894A2/en not_active IP Right Cessation
- 2008-04-04 KR KR1020107024775A patent/KR20110025168A/en not_active Ceased
- 2008-04-04 WO PCT/US2008/004410 patent/WO2009123597A1/en active Application Filing
- 2008-04-04 JP JP2011502908A patent/JP2011516473A/en active Pending
- 2008-04-04 CA CA2720396A patent/CA2720396A1/en not_active Abandoned
- 2008-04-04 EP EP08742562A patent/EP2268278A4/en not_active Withdrawn
- 2008-04-04 MX MX2010010867A patent/MX2010010867A/en not_active Application Discontinuation
- 2008-04-04 AU AU2008354009A patent/AU2008354009A1/en not_active Abandoned
- 2008-04-04 CN CN2008801296335A patent/CN102056605A/en active Pending
2010
- 2010-10-03 IL IL208387A patent/IL208387A0/en unknown

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2853497A (en) *	1953-12-04	1958-09-23	Merck & Co Inc	6, 8-bis (hydrocarbon substituted mercapto) 5-hydroxycaprylic acids and delta-lactones thereof
US2789991A (en) *	1954-05-20	1957-04-23	American Cyanamid Co	Substituted disulfones
JPS61198148A (en) *	1985-01-29	1986-09-02	Fuji Photo Film Co Ltd	Silver halide photographic sensitive material
EP0947503A1 (en) *	1998-04-01	1999-10-06	Galderma Research & Development, S.N.C.	6,8-Dimethylmercaptooctanoic acid derivatives substituted on 6-S and/or 8-S by the 3-methylthiopropanoyl radical and pharmaceutical compositions for the treatment of cancerous tumours
WO2000059899A1 (en) *	1999-04-02	2000-10-12	Societe De Conseil De Recherches Et D'applications Scientifiques (S.C.R.A.S.)	Novel lipoic acid derivatives, their preparation, and pharmaceutical compositions containing them
WO2000061143A1 (en) *	1999-04-09	2000-10-19	Antibioticos S.P.A.	The use of alpha lipoic acid in the antimetastatic treatment
WO2008131114A2 (en) *	2007-04-18	2008-10-30	Cornerstone Pharmaceuticals, Inc.	Pharmaceutical formulations containing lipoic acid derivatives
WO2008131117A1 (en) *	2007-04-18	2008-10-30	Cornerstone Pharmaceuticals, Inc.	Lipoic acid derivatives
WO2009110859A1 (en) *	2008-03-04	2009-09-11	Robert Shorr	Modulation of enzymatic structure, activity, and/or expression level

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
COURVOISIER C ET AL: "Synthesis and effects of 3-methylthiopropanoyl thiolesters of lipoic acid, methional metabolite mimics", BIOORGANIC CHEMISTRY, ACADEMIC PRESS INC., NEW YORK, NY, US, vol. 34, no. 1, 1 February 2006 (2006-02-01), pages 49 - 58, XP024896857, ISSN: 0045-2068, [retrieved on 20060201], DOI: 10.1016/J.BIOORG.2005.11.001 *
FELLER DENNIS R ET AL: "Selective PPARgamma versus PPARalpha agonist activity of a novel set of alpha-lipoic acid analogs of thiazolidinediones", FASEB JOURNAL, FED. OF AMERICAN SOC. FOR EXPERIMENTAL BIOLOGY, US, vol. 17, no. 4-5, 1 March 2003 (2003-03-01), pages A1061, XP009133351, ISSN: 0892-6638 *
HYK W ET AL: "The extreme migrational enhancement of faradaic current at microelectrodes: experimental studies on sodium (6,8-diferrocenylmethylthio)octanoate electrooxidation", JOURNAL OF ELECTROANALYTICAL CHEMISTRY AND INTERFACIALELECTRO CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 575, no. 2, 1 February 2005 (2005-02-01), pages 321 - 328, XP025373180, ISSN: 0022-0728, [retrieved on 20050201] *
MARK VAN DE K ET AL: "ALPHA-LIPOIC ACID INDUCES P27KIP-DEPENDENT CELL CYCLE ARREST IN NON-TRANSFORMED CELL LINES AND APOPTOSIS IN TUMOR CELL LINES", JOURNAL OF CELLULAR PHYSIOLOGY, WILEY LISS, NEW YORK, NY, US, vol. 194, no. 3, 1 March 2003 (2003-03-01), pages 325 - 340, XP008037152, ISSN: 0021-9541, DOI: 10.1002/JCP.10205 *
SATOH ET AL: "Simultaneous determination of alpha-lipoic acid and its reduced form by high-performance liquid chromatography with fluorescence detection", JOURNAL OF CHROMATOGRAPHY B: BIOMEDICAL SCIENCES & APPLICATIONS, ELSEVIER, AMSTERDAM, NL, vol. 854, no. 1-2, 25 June 2007 (2007-06-25), pages 109 - 115, XP022127447, ISSN: 1570-0232, DOI: 10.1016/J.JCHROMB.2007.04.003 *
See also references of WO2009123597A1 *

Also Published As

Publication number	Publication date
EP2268278A1 (en)	2011-01-05
IL208387A0 (en)	2010-12-30
CA2720396A1 (en)	2009-10-08
CN102056605A (en)	2011-05-11
KR20110025168A (en)	2011-03-09
BRPI0821894A2 (en)	2015-07-21
MX2010010867A (en)	2011-05-25
WO2009123597A1 (en)	2009-10-08
AU2008354009A1 (en)	2009-10-08
JP2011516473A (en)	2011-05-26

Publication	Publication Date	Title
HUS1800007I1 (en)	2018-03-28	Pharmaceutical composition
IL228817A0 (en)	2013-12-31	Pharmaceutical composition
EP2240022A4 (en)	2012-04-25	Pharmaceutical compositions
GB0814695D0 (en)	2008-09-17	Pharmaceutical compositions
EP2133095A4 (en)	2012-09-26	Pharmaceutical composition
EP2133094A4 (en)	2010-10-13	Pharmaceutical composition
PT2323623T (en)	2016-11-04	Pharmaceutical compositions
IL200125A0 (en)	2010-04-15	Pharmaceutical composition
EP2224805A4 (en)	2013-10-16	Pharmaceutical composition
EP2224915A4 (en)	2014-01-22	Pharmaceutical composition
ZA201102715B (en)	2012-07-25	Solid pharmaceutical composition
IL208387A0 (en)	2010-12-30	Pharmaceutical composition
EP2224808A4 (en)	2013-11-27	Pharmaceutical composition
ZA201100871B (en)	2012-05-30	Solid pharmaceutical composition
ZA201006224B (en)	2011-11-30	Pharmaceutical composition
IL206487A0 (en)	2010-12-30	Pharmaceutical compositions
EP2224806A4 (en)	2014-02-19	Pharmaceutical composition
GB2464200B (en)	2013-05-08	Pharmaceutical composition
GB0817969D0 (en)	2008-11-05	Pharmaceutical composition
IL205975A0 (en)	2010-11-30	Pharmaceutical composition
IL205931A0 (en)	2010-11-30	Pharmaceutical composition
EP2236135A4 (en)	2012-05-02	Stable pharmaceutical composition
GB0800659D0 (en)	2008-02-20	Pharmaceutical Compositions
GB0817974D0 (en)	2008-11-05	Pharmaceutical composition
GB0817566D0 (en)	2008-11-05	Pharmaceutical composition

Legal Events

Date	Code	Title	Description
2010-12-03	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2011-01-05	17P	Request for examination filed	Effective date: 20101015
2011-01-05	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR
2011-01-05	AX	Request for extension of the european patent	Extension state: AL BA MK RS
2011-07-13	DAX	Request for extension of the european patent (deleted)
2011-11-09	A4	Supplementary search report drawn up and despatched	Effective date: 20111012
2011-11-09	RIC1	Information provided on ipc code assigned before grant	Ipc: A61K 31/19 20060101ALI20111006BHEP Ipc: A61K 31/385 20060101AFI20111006BHEP
2014-02-28	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
2014-04-02	18D	Application deemed to be withdrawn	Effective date: 20131101