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EP2162725A4 - Apparatus and methods for automatic insertion, debubbling, cleaning and calibration of a spectral probe during dissolution testing - Google Patents

Apparatus and methods for automatic insertion, debubbling, cleaning and calibration of a spectral probe during dissolution testing

Info

Publication number
EP2162725A4
EP2162725A4 EP08771330A EP08771330A EP2162725A4 EP 2162725 A4 EP2162725 A4 EP 2162725A4 EP 08771330 A EP08771330 A EP 08771330A EP 08771330 A EP08771330 A EP 08771330A EP 2162725 A4 EP2162725 A4 EP 2162725A4
Authority
EP
European Patent Office
Prior art keywords
debubbling
calibration
cleaning
methods
automatic insertion
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP08771330A
Other languages
German (de)
French (fr)
Other versions
EP2162725A2 (en
Inventor
Laurence Dwayne Chin
Archibald Williams
Martin Schwalm
Brett Andrew Feeney
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Agilent Technologies Inc
Original Assignee
Varian Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Varian Inc filed Critical Varian Inc
Publication of EP2162725A2 publication Critical patent/EP2162725A2/en
Publication of EP2162725A4 publication Critical patent/EP2162725A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/15—Preventing contamination of the components of the optical system or obstruction of the light path
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N13/00—Investigating surface or boundary effects, e.g. wetting power; Investigating diffusion effects; Analysing materials by determining surface, boundary, or diffusion effects
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/84—Systems specially adapted for particular applications
    • G01N21/85—Investigating moving fluids or granular solids
    • G01N21/8507—Probe photometers, i.e. with optical measuring part dipped into fluid sample
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/15—Medicinal preparations ; Physical properties thereof, e.g. dissolubility
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N13/00—Investigating surface or boundary effects, e.g. wetting power; Investigating diffusion effects; Analysing materials by determining surface, boundary, or diffusion effects
    • G01N2013/006—Dissolution of tablets or the like
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/15—Preventing contamination of the components of the optical system or obstruction of the light path
    • G01N2021/154—Ultrasonic cleaning
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/84—Systems specially adapted for particular applications
    • G01N21/85—Investigating moving fluids or granular solids
    • G01N21/8507—Probe photometers, i.e. with optical measuring part dipped into fluid sample
    • G01N2021/8528—Immerged light conductor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/27—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection ; circuits for computing concentration
    • G01N21/274—Calibration, base line adjustment, drift correction

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Optical Measuring Cells (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
EP08771330A 2007-06-20 2008-06-18 Apparatus and methods for automatic insertion, debubbling, cleaning and calibration of a spectral probe during dissolution testing Withdrawn EP2162725A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US93625707P 2007-06-20 2007-06-20
PCT/US2008/067302 WO2008157584A2 (en) 2007-06-20 2008-06-18 Apparatus and methods for automatic insertion, debubbling, cleaning and calibration of a spectral probe during dissolution testing

Publications (2)

Publication Number Publication Date
EP2162725A2 EP2162725A2 (en) 2010-03-17
EP2162725A4 true EP2162725A4 (en) 2010-06-09

Family

ID=40156950

Family Applications (1)

Application Number Title Priority Date Filing Date
EP08771330A Withdrawn EP2162725A4 (en) 2007-06-20 2008-06-18 Apparatus and methods for automatic insertion, debubbling, cleaning and calibration of a spectral probe during dissolution testing

Country Status (8)

Country Link
EP (1) EP2162725A4 (en)
JP (1) JP2010530542A (en)
KR (1) KR20100023963A (en)
CN (1) CN101688825A (en)
BR (1) BRPI0813135A2 (en)
DE (1) DE08771330T1 (en)
MX (1) MX2009013778A (en)
WO (1) WO2008157584A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010094341A1 (en) * 2009-02-20 2010-08-26 Erweka Gmbh Decay time measurement device
JP5861010B2 (en) * 2013-12-11 2016-02-16 オリンパス株式会社 Calibrator and calibration device
CN104492365A (en) * 2014-12-29 2015-04-08 常州市龙道电子商务有限公司 Reaction kettle
CN104492364A (en) * 2014-12-29 2015-04-08 常州市龙道电子商务有限公司 Reaction kettle with rotary defoaming device
EP3176565B1 (en) * 2015-12-04 2021-04-28 Atten2 Advanced Monitoring Technologies S.L.U. Fluid monitoring system based on near-infrared spectroscopy
US9945830B2 (en) * 2016-01-21 2018-04-17 Rosemount Inc. Standard solution with cleaning reagent for wet chemistry analyzer
CN113388488B (en) * 2020-03-12 2023-09-29 迪必尔智能科技(深圳)有限公司 Probe type biomass on-line detection device capable of achieving high-temperature sterilization
JP7446614B2 (en) 2020-10-23 2024-03-11 富山産業株式会社 Collapse test basket and collapse detection device
US12350232B2 (en) 2022-10-24 2025-07-08 Thermo Scientific Portable Analytical Instruments Inc. Self centering vial holder for immersion probes

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH636200A5 (en) * 1979-03-20 1983-05-13 Zellweger Uster Ag Method and device for removing gas bubbles and other deposits from cuvettes (cells)
US6174497B1 (en) * 1997-06-04 2001-01-16 Euro-Celtique, S.A. Detection systems and methods for predicting the dissolution curve of a drug from a pharmaceutical dosage form
WO2003098199A1 (en) * 2002-05-17 2003-11-27 Delphian Technology, Inc. In situ methods for measuring the release of a substance from a dosage form

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6762841B1 (en) * 2000-02-22 2004-07-13 Spectraalliance, Inc. Method of performing spectral analysis in a pharmaceutical dissolution process
DE60137599D1 (en) * 2000-03-10 2009-03-19 Textron Systems Corp OPTICAL PROBES AND METHODS FOR SPECTRAL ANALYSIS
US6580506B2 (en) * 2001-02-10 2003-06-17 Leap Technologies, Inc. Fiber optic probes apparatus for spectrophotometry
US6962674B2 (en) * 2001-02-28 2005-11-08 Varian, Inc. Dissolution test apparatus
US6764651B2 (en) * 2001-11-07 2004-07-20 Varian, Inc. Fiber-optic dissolution systems, devices, and methods

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH636200A5 (en) * 1979-03-20 1983-05-13 Zellweger Uster Ag Method and device for removing gas bubbles and other deposits from cuvettes (cells)
US6174497B1 (en) * 1997-06-04 2001-01-16 Euro-Celtique, S.A. Detection systems and methods for predicting the dissolution curve of a drug from a pharmaceutical dosage form
WO2003098199A1 (en) * 2002-05-17 2003-11-27 Delphian Technology, Inc. In situ methods for measuring the release of a substance from a dosage form

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
P. ROGERS ET AL.: "A Comprehensive and Flexible Approach to the Automated-Dissolution Testing of Pharmaceutical Drug Products Incorporating Direct UV-Vis Fiber-Optic Analysis, On-Line Fluorescence Analysis, and Off-Line Storage Options", LABORATORY ROBOTICS AND AUTOMATION, vol. 12, no. 1, 1 January 2000 (2000-01-01), pages 12 - 22, XP002580026 *
P.K. ALDRIDGE ET AL.: "A Robotic Dissolution System with On-Line Fiber-Optic UV Analysis", JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 84, no. 8, 1 August 1995 (1995-08-01), pages 909 - 914, XP002580025 *

Also Published As

Publication number Publication date
EP2162725A2 (en) 2010-03-17
BRPI0813135A2 (en) 2014-12-23
JP2010530542A (en) 2010-09-09
WO2008157584A2 (en) 2008-12-24
MX2009013778A (en) 2010-02-17
WO2008157584A3 (en) 2009-03-05
CN101688825A (en) 2010-03-31
DE08771330T1 (en) 2010-09-30
KR20100023963A (en) 2010-03-04

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Legal Events

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Effective date: 20100512

EL Fr: translation of claims filed
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Owner name: AGILENT TECHNOLOGIES, INC.

STAA Information on the status of an ep patent application or granted ep patent

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Effective date: 20120103