EP2035001A4 - Préparations de laquinimod stables - Google Patents

Préparations de laquinimod stables

Info

Publication number: EP2035001A4
Authority: EP; European Patent Office
Prior art keywords: preparations; stable; stable laquinimod; laquinimod preparations; laquinimod
Prior art date: 2006-06-12
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

EP07809468A

Other languages

German (de)

English (en)

Other versions

EP2035001A2 (fr

EP2035001B1 (fr

Inventor

Shulamit Patashnik

Daniella Licht

Adrian Gilbert

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Teva Pharmaceutical Industries Ltd

Original Assignee

Teva Pharmaceutical Industries Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-06-12

Filing date

2007-06-12

Publication date

2009-09-23

2007-06-12 Application filed by Teva Pharmaceutical Industries Ltd filed Critical Teva Pharmaceutical Industries Ltd

2007-06-12 Priority to PL07809468T priority Critical patent/PL2035001T3/pl

2009-03-18 Publication of EP2035001A2 publication Critical patent/EP2035001A2/fr

2009-09-23 Publication of EP2035001A4 publication Critical patent/EP2035001A4/fr

2011-11-09 Application granted granted Critical

2011-11-09 Publication of EP2035001B1 publication Critical patent/EP2035001B1/fr

2012-02-07 Priority to CY20121100127T priority patent/CY1113003T1/el

Status Active legal-status Critical Current

2027-06-12 Anticipated expiration legal-status Critical

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4704—2-Quinolinones, e.g. carbostyril
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurology (AREA)
Oil, Petroleum & Natural Gas (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Immunology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Composite Materials (AREA)
Mechanical Engineering (AREA)

EP07809468A 2006-06-12 2007-06-12 Préparations de laquinimod stables Active EP2035001B1 (fr)

Priority Applications (2)

Application Number	Priority Date	Filing Date	Title
PL07809468T PL2035001T3 (pl)	2006-06-12	2007-06-12	Stabilne preparaty lakwinimodu
CY20121100127T CY1113003T1 (el)	2006-06-12	2012-02-07	Ευσταθη παρασκευασματα laquinimod

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US81324706P	2006-06-12	2006-06-12
PCT/US2007/013721 WO2007146248A2 (fr)	2006-06-12	2007-06-12	Préparations de laquinimod stables

Publications (3)

Publication Number	Publication Date
EP2035001A2 EP2035001A2 (fr)	2009-03-18
EP2035001A4 true EP2035001A4 (fr)	2009-09-23
EP2035001B1 EP2035001B1 (fr)	2011-11-09

Family

ID=38832466

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP07809468A Active EP2035001B1 (fr)	2006-06-12	2007-06-12	Préparations de laquinimod stables

Country Status (28)

Country	Link
US (3)	US7989473B2 (fr)
EP (1)	EP2035001B1 (fr)
JP (1)	JP5226678B2 (fr)
KR (4)	KR20160013273A (fr)
CN (1)	CN101466379B (fr)
AR (1)	AR061348A1 (fr)
AT (1)	ATE532515T1 (fr)
AU (1)	AU2007258366B2 (fr)
BR (1)	BRPI0713694A2 (fr)
CA (2)	CA2899472C (fr)
CY (1)	CY1113003T1 (fr)
DK (1)	DK2035001T3 (fr)
EA (1)	EA018031B1 (fr)
ES (1)	ES2377149T3 (fr)
HK (1)	HK1121971A1 (fr)
HR (1)	HRP20120093T1 (fr)
IL (1)	IL195724A (fr)
MX (1)	MX2008015808A (fr)
NO (1)	NO342485B1 (fr)
NZ (1)	NZ573846A (fr)
PL (1)	PL2035001T3 (fr)
PT (1)	PT2035001E (fr)
RS (1)	RS52169B (fr)
SI (1)	SI2035001T1 (fr)
TW (1)	TWI400073B (fr)
UA (1)	UA96449C2 (fr)
WO (1)	WO2007146248A2 (fr)
ZA (1)	ZA200810790B (fr)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US8314124B2 (en)	2004-02-06	2012-11-20	Active Biotech Ab	Crystalline salts of quinoline compounds and methods for preparing them
RS53666B1 (en) *	2005-10-19	2015-04-30	Teva Pharmaceutical Industries Ltd	CRYSTALS OF SODIUM LAKVINIMOD AND THE PROCESS FOR OBTAINING THEM
ZA200810790B (en)	2006-06-12	2010-03-31	Teva Pharma	Stable laquinimod preparations
EP2682120B1 (fr) *	2007-12-20	2016-08-03	Teva Pharmaceutical Industries, Ltd.	Préparations de laquinimod stables
ES2633658T3 (es) *	2008-09-03	2017-09-22	Teva Pharmaceutical Industries Ltd.	Moduladores 2-oxo-1,2-dihidro-quinolina de la función inmunitaria
DE102010048788A1 (de)	2009-02-13	2011-05-19	Amw Gmbh	Transdermales System mit Immunmodulator
DE102009008851A1 (de)	2009-02-13	2010-08-19	Amw Gmbh	Transdermales System mit Immunmodulator
EA201270041A1 (ru)	2009-06-19	2012-06-29	Тева Фармасьютикал Индастриз Лтд.	Лечение рассеянного склероза лаквинимодом
EP2458992B1 (fr) *	2009-07-30	2015-12-16	Teva Pharmaceutical Industries Ltd.	Traitement de la maladie de crohn au moyen de laquinimod
PL2467372T3 (pl)	2009-08-10	2017-04-28	Teva Pharmaceutical Industries Ltd.	Leczenie zaburzeń związanych z BDNF z zastosowaniem lakwinimodu
DE102010026879A1 (de)	2010-02-11	2011-08-11	AMW GmbH, 83627	Transdermales System mit Immunmodulator
PH12012501740A1 (en) *	2010-03-03	2012-11-12	Teva Pharma	Treatment of rheumatoid arthritis with a combination of laquinimod and methotrexate
JP2013521305A (ja) *	2010-03-03	2013-06-10	テバファーマシューティカルインダストリーズリミティド	ラキニモドを用いるループス関節炎の治療
US8889661B2 (en) *	2010-03-03	2014-11-18	Teva Pharmaceutical Industries, Ltd.	Treatment of lupus nephritis using laquinimod
MX2013000332A (es) *	2010-07-09	2013-02-26	Teva Pharma	5-cloro-4-hidroxi-1-metil-2-oxo-n-fenil-1,2-dihidroquinolina-3-ca rboxamida, sales y usos de la misma.
EP2597954A4 (fr)	2010-07-09	2014-01-01	Teva Pharma	N-éthyl-n-phényl-1,2-dihydro-4-hydroxy-5-chloro-1-méthyl-2-oxoquinoléine-3-carboxamide deutéré, sels de ce composé et utilisations correspondantes
EP2648732A4 (fr) *	2010-12-07	2014-04-30	Teva Pharma	Utilisation de laquinimod pour la réduction de la fatigue, l'amélioration de l'état fonctionnel, et l'amélioration de la qualité de vie chez des patients atteints de sclérose en plaques
CA2843432A1 (fr) *	2011-07-28	2013-01-31	Teva Pharmaceutical Industries Ltd.	Traitement de la sclerose en plaques faisant appel a une combinaison de laquinimod et d'interferon-beta
JP2014521658A (ja) *	2011-07-28	2014-08-28	テバファーマシューティカルインダストリーズリミティド	ラキニモドおよび酢酸グラチラマーを組み合わせた多発性硬化症の治療
EP2766020A4 (fr) *	2011-10-12	2015-04-01	Teva Pharma	Traitement de la sclérose en plaques par combinaison de laquinimod et de fingolimod
EP2811832A4 (fr)	2012-02-03	2015-09-23	Teva Pharma	Utilisation de laquinimod pour le traitement de patients souffrant de la maladie de crohn pour lesquels la thérapie anti-tnf de première intention a échoué
CA2863409A1 (fr)	2012-02-16	2013-08-22	Teva Pharmaceutical Industries Ltd.	N-ethyl-n-phenyl-1,2-dihydro-4,5-di-hydroxy-1-methyl-2-oxo-3-quinoleine carboxamide, sa preparation et son utilisation
US20130259856A1 (en)	2012-03-27	2013-10-03	Teva Pharmaceutical Industries, Ltd.	Treatment of multiple sclerosis with combination of laquinimod and dimethyl fumarate
TW201350467A (zh)	2012-05-08	2013-12-16	Teva Pharma	Ｎ－乙基－４－羥基－１－甲基－５－（甲基（２，３，４，５，６－五羥基己基）胺基）－２－側氧－ｎ－苯基－１，２－二氫喹啉－３－甲醯胺
TW201400117A (zh)	2012-06-05	2014-01-01	Teva Pharma	使用拉喹莫德治療眼發炎疾病
US20130345257A1 (en) *	2012-06-26	2013-12-26	The Regents Of The University Of California	Composition for lupus nephritis and methods of making and using the same
AR091706A1 (es) *	2012-07-11	2015-02-25	Teva Pharma	Formulaciones de laquinimod sin agentes alcalinizantes
TW201410243A (zh) *	2012-08-13	2014-03-16	Teva Pharma	用於治療大麻素受體型１（ｃｂ１）媒介之疾病之拉喹莫德（ｌａｑｕｉｎｉｍｏｄ）
TW201410244A (zh) *	2012-08-13	2014-03-16	Teva Pharma	用於治療ｇａｂａ媒介之疾病之拉喹莫德（ｌａｑｕｉｎｉｍｏｄ）
BR112015010193A2 (pt) *	2012-11-07	2017-07-11	Teva Pharma	sais de amina de laquinimod
MX2015010296A (es) *	2013-02-15	2016-05-05	Teva Pharma	Tratamiento de formas progresivas de esclerosis multiple con laquinimod.
US20160038435A1 (en)	2013-03-14	2016-02-11	Teva Pharmaceutical Industries Ltd.	Transdermal formulations of laquinimod
KR20150143499A (ko) *	2013-03-14	2015-12-23	테바 파마슈티컬 인더스트리즈 리미티드	라퀴니모드 나트륨의 결정 및 이의 개선된 제조방법
CN105848653A (zh) *	2013-09-27	2016-08-10	梯瓦制药工业有限公司	用于治疗多发性硬化症的拉喹莫德联合治疗
AR098832A1 (es) *	2013-12-20	2016-06-15	Teva Pharma	Uso de laquinimod para retrasar la progresión de la enfermedad de huntington
US20160331742A1 (en) *	2014-01-17	2016-11-17	Teva Pharmaceutical Industries, Ltd.	Treatment of crohn's disease using low doses of laquinimod
UY36099A (es)	2014-04-29	2016-02-29	Teva Pharma	Laquinimod para el tratamiento de pacientes con esclerosis múltiple remitente recurrente (rrms) con un alto grado de discapacidad
CN110193014B (zh) *	2019-06-06	2021-05-11	温州医科大学	一种注射用拉喹莫德胶束冻干制剂及制备方法、拉喹莫德注射制剂

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RS53666B1 (en)	2005-10-19	2015-04-30	Teva Pharmaceutical Industries Ltd	CRYSTALS OF SODIUM LAKVINIMOD AND THE PROCESS FOR OBTAINING THEM
ZA200810790B (en)	2006-06-12	2010-03-31	Teva Pharma	Stable laquinimod preparations
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EP2682120B1 (fr)	2007-12-20	2016-08-03	Teva Pharmaceutical Industries, Ltd.	Préparations de laquinimod stables
ES2633658T3 (es)	2008-09-03	2017-09-22	Teva Pharmaceutical Industries Ltd.	Moduladores 2-oxo-1,2-dihidro-quinolina de la función inmunitaria
EA201270041A1 (ru)	2009-06-19	2012-06-29	Тева Фармасьютикал Индастриз Лтд.	Лечение рассеянного склероза лаквинимодом
EP2458992B1 (fr)	2009-07-30	2015-12-16	Teva Pharmaceutical Industries Ltd.	Traitement de la maladie de crohn au moyen de laquinimod
PL2467372T3 (pl)	2009-08-10	2017-04-28	Teva Pharmaceutical Industries Ltd.	Leczenie zaburzeń związanych z BDNF z zastosowaniem lakwinimodu
US8889661B2 (en)	2010-03-03	2014-11-18	Teva Pharmaceutical Industries, Ltd.	Treatment of lupus nephritis using laquinimod
PH12012501740A1 (en)	2010-03-03	2012-11-12	Teva Pharma	Treatment of rheumatoid arthritis with a combination of laquinimod and methotrexate
JP2013521305A (ja)	2010-03-03	2013-06-10	テバファーマシューティカルインダストリーズリミティド	ラキニモドを用いるループス関節炎の治療
MX2013000332A (es)	2010-07-09	2013-02-26	Teva Pharma	5-cloro-4-hidroxi-1-metil-2-oxo-n-fenil-1,2-dihidroquinolina-3-ca rboxamida, sales y usos de la misma.
EP2597954A4 (fr)	2010-07-09	2014-01-01	Teva Pharma	N-éthyl-n-phényl-1,2-dihydro-4-hydroxy-5-chloro-1-méthyl-2-oxoquinoléine-3-carboxamide deutéré, sels de ce composé et utilisations correspondantes

2007
- 2007-06-12 ZA ZA200810790A patent/ZA200810790B/xx unknown
- 2007-06-12 KR KR1020167001876A patent/KR20160013273A/ko not_active Ceased
- 2007-06-12 RS RS20120039A patent/RS52169B/en unknown
- 2007-06-12 TW TW096121085A patent/TWI400073B/zh not_active IP Right Cessation
- 2007-06-12 NZ NZ573846A patent/NZ573846A/en unknown
- 2007-06-12 AT AT07809468T patent/ATE532515T1/de active
- 2007-06-12 SI SI200730834T patent/SI2035001T1/sl unknown
- 2007-06-12 KR KR1020157014257A patent/KR20150065951A/ko not_active Ceased
- 2007-06-12 AU AU2007258366A patent/AU2007258366B2/en active Active
- 2007-06-12 EA EA200870599A patent/EA018031B1/ru not_active IP Right Cessation
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2011
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Also Published As

Publication number	Publication date
KR20090017694A (ko)	2009-02-18
ES2377149T3 (es)	2012-03-22
DK2035001T3 (da)	2012-02-27
PT2035001E (pt)	2012-02-06
IL195724A0 (en)	2009-09-01
TW200815006A (en)	2008-04-01
HK1121971A1 (en)	2009-05-08
NO20090175L (no)	2009-03-11
CN101466379A (zh)	2009-06-24
NZ573846A (en)	2012-01-12
PL2035001T3 (pl)	2012-05-31
EA200870599A1 (ru)	2009-06-30
EP2035001A2 (fr)	2009-03-18
TWI400073B (zh)	2013-07-01
US8383645B2 (en)	2013-02-26
KR101495327B1 (ko)	2015-02-24
US7989473B2 (en)	2011-08-02
US20110251235A1 (en)	2011-10-13
JP5226678B2 (ja)	2013-07-03
US20070293537A1 (en)	2007-12-20
ATE532515T1 (de)	2011-11-15
AU2007258366A1 (en)	2007-12-21
NO342485B1 (no)	2018-05-28
IL195724A (en)	2015-09-24
CN101466379B (zh)	2012-10-31
CY1113003T1 (el)	2016-04-13
CA2654982A1 (fr)	2007-12-21
BRPI0713694A2 (pt)	2012-10-30
KR20160013273A (ko)	2016-02-03
WO2007146248A2 (fr)	2007-12-21
MX2008015808A (es)	2009-02-17
RS52169B (en)	2012-08-31
EP2035001B1 (fr)	2011-11-09
UA96449C2 (en)	2011-11-10
SI2035001T1 (sl)	2012-03-30
CA2899472C (fr)	2019-04-30
ZA200810790B (en)	2010-03-31
WO2007146248A3 (fr)	2008-12-24
HRP20120093T1 (hr)	2012-03-31
US20120302600A1 (en)	2012-11-29
KR20150065951A (ko)	2015-06-15
CA2654982C (fr)	2015-11-10
AU2007258366B2 (en)	2012-10-25
AR061348A1 (es)	2008-08-20
JP2009539984A (ja)	2009-11-19
CA2899472A1 (fr)	2007-12-21
EA018031B1 (ru)	2013-05-30
KR20140091778A (ko)	2014-07-22

Publication	Publication Date	Title
ZA200810790B (en)	2010-03-31	Stable laquinimod preparations
HK1220126A1 (zh)	2017-04-28	穩定的拉喹莫德製劑
IL193265A0 (en)	2009-02-11	Quinoline derivatives
GB2435419B (en)	2008-03-05	Formulations
EP1988922A4 (fr)	2010-06-02	Formulations de protéines
EP2046930A4 (fr)	2012-06-27	Formulations à base de rhamnolipides
IL194367A (en)	2014-12-31	Dihydropyrazolopyrimidinone derivatives
HK1134284A1 (en)	2010-04-23	Pyridizinone derivatives pyridizinone
IL193641A0 (en)	2009-05-04	Spiroindolinone derivatives
HK1137344A1 (en)	2010-07-30	Tape preparation
HK1124233A1 (en)	2009-07-10	Quinoline derivatives as antibacterical agents
GB0605780D0 (en)	2006-05-03	Formulations
IL192401A0 (en)	2008-12-29	Indol-3-yl-carbonyl-spiro-piperidine derivatives
GB0618697D0 (en)	2006-11-01	Formulations
IL193211A0 (en)	2009-02-11	Indazole-heteroaryl derivatives
HK1136276A1 (en)	2010-06-25	5-hydroxymethyl-oxazolidin-2-one derivatives 5---2-
GB0610336D0 (en)	2006-07-05	Formulations
GB0610140D0 (en)	2006-06-28	Protein stability
GB0718346D0 (en)	2007-10-31	Tooth-bleaching preparations
GB0625671D0 (en)	2007-01-31	Protein formulation
GB0718404D0 (en)	2007-10-31	Formulations
ZA200806877B (en)	2009-08-26	Quinoline Derivatives
AU4913P (en)	2014-09-02	KencoralGL Kennedia coccinea
GB0616155D0 (en)	2006-09-20	Food preparations
GB0623791D0 (en)	2007-01-10	Formulations

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