[go: up one dir, main page]

EP2007909A4 - Steroid responsive nucleic acid expression and prediction of disease activity - Google Patents

Steroid responsive nucleic acid expression and prediction of disease activity

Info

Publication number
EP2007909A4
EP2007909A4 EP07861283A EP07861283A EP2007909A4 EP 2007909 A4 EP2007909 A4 EP 2007909A4 EP 07861283 A EP07861283 A EP 07861283A EP 07861283 A EP07861283 A EP 07861283A EP 2007909 A4 EP2007909 A4 EP 2007909A4
Authority
EP
European Patent Office
Prior art keywords
prediction
nucleic acid
disease activity
acid expression
steroid responsive
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP07861283A
Other languages
German (de)
French (fr)
Other versions
EP2007909A2 (en
Inventor
Steven Rosenberg
Preeti Lal
Tod M Klingler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CareDx Inc
Original Assignee
XDx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by XDx Inc filed Critical XDx Inc
Publication of EP2007909A2 publication Critical patent/EP2007909A2/en
Publication of EP2007909A4 publication Critical patent/EP2007909A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
EP07861283A 2006-04-07 2007-04-09 Steroid responsive nucleic acid expression and prediction of disease activity Withdrawn EP2007909A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US79047406P 2006-04-07 2006-04-07
PCT/US2007/008909 WO2008051290A2 (en) 2006-04-07 2007-04-09 Steroid responsive nucleic acid expression and prediction of disease activity

Publications (2)

Publication Number Publication Date
EP2007909A2 EP2007909A2 (en) 2008-12-31
EP2007909A4 true EP2007909A4 (en) 2011-01-26

Family

ID=39325074

Family Applications (1)

Application Number Title Priority Date Filing Date
EP07861283A Withdrawn EP2007909A4 (en) 2006-04-07 2007-04-09 Steroid responsive nucleic acid expression and prediction of disease activity

Country Status (5)

Country Link
US (2) US20070248978A1 (en)
EP (1) EP2007909A4 (en)
AU (1) AU2007309726A1 (en)
CA (1) CA2648580A1 (en)
WO (1) WO2008051290A2 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6905827B2 (en) 2001-06-08 2005-06-14 Expression Diagnostics, Inc. Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases
US7235358B2 (en) 2001-06-08 2007-06-26 Expression Diagnostics, Inc. Methods and compositions for diagnosing and monitoring transplant rejection
US7026121B1 (en) 2001-06-08 2006-04-11 Expression Diagnostics, Inc. Methods and compositions for diagnosing and monitoring transplant rejection
US7892745B2 (en) 2003-04-24 2011-02-22 Xdx, Inc. Methods and compositions for diagnosing and monitoring transplant rejection
US7645575B2 (en) 2004-09-08 2010-01-12 Xdx, Inc. Genes useful for diagnosing and monitoring inflammation related disorders
US7993832B2 (en) 2006-08-14 2011-08-09 Xdx, Inc. Methods and compositions for diagnosing and monitoring the status of transplant rejection and immune disorders
US8148067B2 (en) 2006-11-09 2012-04-03 Xdx, Inc. Methods for diagnosing and monitoring the status of systemic lupus erythematosus
CA2708267C (en) 2007-12-14 2016-05-10 Index Pharmaceuticals Ab Method for predicting the response to a therapy
EP2274444A4 (en) * 2008-04-10 2011-10-05 Univ British Columbia METHOD FOR DIAGNOSING A CHRONIC EXHAUSTION OF ALLOGENIC HEART TRANSPLANTS
DE102009021734B4 (en) * 2009-05-12 2012-02-02 Eberhard-Karls-Universität Tübingen Universitätsklinikum Diagnostic markers for the determination of the predisposition of cervical cancer development and for the determination of oligonucleotides used
CN102854305B (en) * 2011-12-23 2013-08-07 中国人民解放军第三〇九医院 Prewarning kit for transplant kidney rejection and use method thereof
CN102854323B (en) * 2011-12-23 2013-08-07 中国人民解放军第三〇九医院 Transplant kidney rejection reaction early diagnosis kit and use method of kit
CN102854306B (en) * 2011-12-23 2013-08-07 中国人民解放军第三〇九医院 Kit for early warning rejection reaction after kidney transplant and use method of kit
WO2019178364A2 (en) * 2018-03-14 2019-09-19 Elstar Therapeutics, Inc. Multifunctional molecules and uses thereof
EP4515548A1 (en) * 2022-04-29 2025-03-05 CareDx, Inc. Systems and methods for classifying the status of a transplant

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040197786A1 (en) * 2001-04-05 2004-10-07 Yuji Sugita Method of examining steroid resnponsiveness
WO2006122295A2 (en) * 2005-05-11 2006-11-16 Expression Diagnostics, Inc. Methods of monitoring functional status of transplants using gene panels
US20070037167A1 (en) * 2001-06-08 2007-02-15 Expression Diagnostics, Inc. Methods and compositions for diagnosing or monitoring autoimmune and chronic inflammatory diseases

Family Cites Families (95)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US624527A (en) * 1899-05-09 Marius otto
US5212071A (en) * 1988-04-01 1993-05-18 The Johns Hopkins University Nucleic acids encoding a human C3b/C4b receptor (CR1)
US4190535A (en) * 1978-02-27 1980-02-26 Corning Glass Works Means for separating lymphocytes and monocytes from anticoagulated blood
US4215051A (en) * 1979-08-29 1980-07-29 Standard Oil Company (Indiana) Formation, purification and recovery of phthalic anhydride
US4376110A (en) * 1980-08-04 1983-03-08 Hybritech, Incorporated Immunometric assays using monoclonal antibodies
US4582789A (en) * 1984-03-21 1986-04-15 Cetus Corporation Process for labeling nucleic acids using psoralen derivatives
US4751001A (en) * 1984-09-24 1988-06-14 Becton Dickinson And Company Blood partitioning apparatus
US4818418A (en) * 1984-09-24 1989-04-04 Becton Dickinson And Company Blood partitioning method
US4683202A (en) * 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US6197563B1 (en) * 1985-03-28 2001-03-06 Roche Molecular Systems, Inc. Kits for amplifying and detecting nucleic acid sequences
US4683195A (en) * 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US6040166A (en) * 1985-03-28 2000-03-21 Roche Molecular Systems, Inc. Kits for amplifying and detecting nucleic acid sequences, including a probe
US4800159A (en) * 1986-02-07 1989-01-24 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences
US5604099A (en) * 1986-03-13 1997-02-18 Hoffmann-La Roche Inc. Process for detecting specific nucleotide variations and genetic polymorphisms present in nucleic acids
US5310652A (en) * 1986-08-22 1994-05-10 Hoffman-La Roche Inc. Reverse transcription with thermostable DNA polymerase-high temperature reverse transcription
US5618711A (en) * 1986-08-22 1997-04-08 Hoffmann-La Roche Inc. Recombinant expression vectors and purification methods for Thermus thermophilus DNA polymerase
US5322770A (en) * 1989-12-22 1994-06-21 Hoffman-Laroche Inc. Reverse transcription with thermostable DNA polymerases - high temperature reverse transcription
US5374553A (en) * 1986-08-22 1994-12-20 Hoffmann-La Roche Inc. DNA encoding a thermostable nucleic acid polymerase enzyme from thermotoga maritima
US5079352A (en) * 1986-08-22 1992-01-07 Cetus Corporation Purified thermostable enzyme
US5405774A (en) * 1986-08-22 1995-04-11 Hoffmann-La Roche Inc. DNA encoding a mutated thermostable nucleic acid polymerase enzyme from thermus species sps17
US5407800A (en) * 1986-08-22 1995-04-18 Hoffmann-La Roche Inc. Reverse transcription with Thermus thermophilus polymerase
US4908318A (en) * 1987-09-04 1990-03-13 Integrated Genetics, Inc. Nucleic acid extraction methods
US4843155A (en) * 1987-11-19 1989-06-27 Piotr Chomczynski Product and process for isolating RNA
US5120525A (en) * 1988-03-29 1992-06-09 Immunomedics, Inc. Radiolabeled antibody cytotoxic therapy of cancer
US5693760A (en) * 1988-04-14 1997-12-02 Incyte Pharmaceuticals, Inc. Method of causing selective immunosuppression using HL-60 related lectins
US5091310A (en) * 1988-09-23 1992-02-25 Cetus Corporation Structure-independent dna amplification by the polymerase chain reaction
US5389512A (en) * 1988-10-07 1995-02-14 Hoffman-La Roche Inc. Method for determining the relative amount of a viral nucleic acid segment in a sample by the polymerase chain reaction
US6040138A (en) * 1995-09-15 2000-03-21 Affymetrix, Inc. Expression monitoring by hybridization to high density oligonucleotide arrays
US5183973A (en) * 1989-08-14 1993-02-02 Santa Barbara Research Center Flexible cable for interconnecting electronic components
US5219727A (en) * 1989-08-21 1993-06-15 Hoffmann-Laroche Inc. Quantitation of nucleic acids using the polymerase chain reaction
US5215882A (en) * 1989-11-30 1993-06-01 Ortho Diagnostic Systems, Inc. Method of immobilizing nucleic acid on a solid surface for use in nucleic acid hybridization assays
CA2033692A1 (en) * 1990-01-25 1991-07-26 Wilhelm Bannwarth Energy transfer systems
ES2141088T3 (en) * 1990-02-16 2000-03-16 Hoffmann La Roche IMPROVEMENTS IN THE SPECIFICITY AND CONVENIENCE OF THE REACTION IN THE POLYMERASE CHAIN.
US5215727A (en) * 1990-03-02 1993-06-01 Occidental Chemical Corporation Method of making chromic oxide
US5344755A (en) * 1990-04-21 1994-09-06 The United States Of America As Represented By The Department Of Health And Human Services Method for detecting immune system dysfunction in asymptomatic, HIV-scropositive individuals
US5130423A (en) * 1990-07-13 1992-07-14 Microprobe Corporation Non-corrosive compositions and methods useful for the extraction of nucleic acids
CA2087724C (en) * 1990-07-24 2003-09-16 John J. Sninsky Reduction of non-specific amplification during in vitro nucleic acid amplification using modified nucleic acid bases
US5210015A (en) * 1990-08-06 1993-05-11 Hoffman-La Roche Inc. Homogeneous assay system using the nuclease activity of a nucleic acid polymerase
DE4034036C2 (en) * 1990-10-26 1994-03-03 Diagen Inst Molekularbio Device and method for isolating nucleic acids from cell suspensions
CA2101166C (en) * 1991-01-22 2003-05-20 Walther Jacobus Van Venrooij Method for detection of anti-rna-antibodies
US5994056A (en) * 1991-05-02 1999-11-30 Roche Molecular Systems, Inc. Homogeneous methods for nucleic acid amplification and detection
DK0519338T3 (en) * 1991-06-20 1996-10-28 Hoffmann La Roche Improved Methods for Nucleic Acid Amplification
US5487970A (en) * 1992-06-17 1996-01-30 Arch Development Corp. Compositions and methods for detecting gene rearrangements and translocations
GB2268935B (en) * 1992-06-24 1996-10-23 Nat Heart & Lung Inst Diagnosis of rejection of transplanted organs
DE69332852T2 (en) * 1992-09-11 2003-12-04 F. Hoffmann-La Roche Ag, Basel Detection of nucleic acids in the blood
JP3615545B2 (en) * 1993-02-01 2005-02-02 キアゲン・エヌ・ブイ Quaternary ammonium salt surfactant and its RNA isolator
US6403304B1 (en) * 1993-04-06 2002-06-11 Forsyth Dental Infirmary For Children Human osteoclast-specific and -related DNA sequences
US5491086A (en) * 1993-05-14 1996-02-13 Hoffmann-La Roche Inc. Purified thermostable nucleic acid polymerase and DNA coding sequences from pyrodictium species
US5426039A (en) * 1993-09-08 1995-06-20 Bio-Rad Laboratories, Inc. Direct molecular cloning of primer extended DNA containing an alkane diol
US6045996A (en) * 1993-10-26 2000-04-04 Affymetrix, Inc. Hybridization assays on oligonucleotide arrays
US5538848A (en) * 1994-11-16 1996-07-23 Applied Biosystems Division, Perkin-Elmer Corp. Method for detecting nucleic acid amplification using self-quenching fluorescence probe
AU1513495A (en) * 1993-12-14 1995-07-03 University Of Pittsburgh Systemic gene treatment of connective tissue diseases
US5512462A (en) * 1994-02-25 1996-04-30 Hoffmann-La Roche Inc. Methods and reagents for the polymerase chain reaction amplification of long DNA sequences
US6190872B1 (en) * 1994-05-06 2001-02-20 Gus J. Slotman Method for identifying and monitoring patients at risk for systemic inflammatory conditions and apparatus for use in this method
US5491063A (en) * 1994-09-01 1996-02-13 Hoffmann-La Roche Inc. Methods for in-solution quenching of fluorescently labeled oligonucleotide probes
US5506145A (en) * 1994-12-02 1996-04-09 Bull; Brian S. Determination of an individual's inflammation index from whole blood fibrinogen and hematocrit or hemoglobin measurements
US5834248A (en) * 1995-02-10 1998-11-10 Millennium Pharmaceuticals Inc. Compositions and methods using rchd534, a gene uregulated by shear stress
US6066322A (en) * 1995-03-03 2000-05-23 Millennium Pharmaceuticals, Inc. Methods for the treatment of immune disorders
EP0735144B1 (en) * 1995-03-28 2002-06-05 Japan Science and Technology Corporation Method for molecular indexing of genes using restriction enzymes
US6251597B1 (en) * 1996-03-29 2001-06-26 Millennium Pharmaceuticals, Inc. Methods for detecting fohy030
US5635365A (en) * 1995-08-07 1997-06-03 Emory University Noninvasive diagnosis for allograft rejection
US5773258A (en) * 1995-08-25 1998-06-30 Roche Molecular Systems, Inc. Nucleic acid amplification using a reversibly inactivated thermostable enzyme
CA2247246A1 (en) * 1996-02-16 1997-08-21 Millennium Pharmaceuticals, Inc. Compositions and methods for the treatment and diagnosis of cardiovascular disease
US6060240A (en) * 1996-12-13 2000-05-09 Arcaris, Inc. Methods for measuring relative amounts of nucleic acids in a complex mixture and retrieval of specific sequences therefrom
US6190857B1 (en) * 1997-03-24 2001-02-20 Urocor, Inc. Diagnosis of disease state using MRNA profiles in peripheral leukocytes
US6010853A (en) * 1997-05-29 2000-01-04 Dana-Farber Cancer Institute Siva genes, novel genes involved in CD27-mediated apoptosis
US6228628B1 (en) * 1997-07-09 2001-05-08 Roche Molecular Systems Mutant chimeric DNA polymerase
WO1999010536A1 (en) * 1997-08-22 1999-03-04 Yale University A process to study changes in gene expression in granulocytic cells
US6187534B1 (en) * 1997-09-24 2001-02-13 Cornell Research Foundation, Inc. Methods of evaluating transplant rejection
ATE291097T1 (en) * 1997-10-31 2005-04-15 Affymetrix Inc A Delaware Corp EXPRESSION PROFILES IN ADULT AND FETAL ORGANS
US6248528B1 (en) * 1998-04-06 2001-06-19 Millennium Pharmaceuticals, Inc. Methods and compositions for the diagnosis and treatment of neuropsychiatric disorders
US6048695A (en) * 1998-05-04 2000-04-11 Baylor College Of Medicine Chemically modified nucleic acids and methods for coupling nucleic acids to solid support
US6218122B1 (en) * 1998-06-19 2001-04-17 Rosetta Inpharmatics, Inc. Methods of monitoring disease states and therapies using gene expression profiles
US6410319B1 (en) * 1998-10-20 2002-06-25 City Of Hope CD20-specific redirected T cells and their use in cellular immunotherapy of CD20+ malignancies
US6248527B1 (en) * 1998-10-21 2001-06-19 Millennium Pharmaceuticals, Inc. Method of detecting risk of type II diabetes based on mutations found in carboxypeptidase E
US6203987B1 (en) * 1998-10-27 2001-03-20 Rosetta Inpharmatics, Inc. Methods for using co-regulated genesets to enhance detection and classification of gene expression patterns
US6194158B1 (en) * 1998-11-12 2001-02-27 Nyxis Neurotherapies, Inc. Diagnostic assay for cancer
US6177254B1 (en) * 1998-12-15 2001-01-23 Jerome Bernard Rattner Nucleolus autoantigenic marker for systemic lupus erthyematosus
US6222093B1 (en) * 1998-12-28 2001-04-24 Rosetta Inpharmatics, Inc. Methods for determining therapeutic index from gene expression profiles
US6087112A (en) * 1998-12-30 2000-07-11 Oligos Etc. Inc. Arrays with modified oligonucleotide and polynucleotide compositions
US6242185B1 (en) * 1999-04-01 2001-06-05 Incyte Genomics, Inc. Purified nucleic acid encoding transcription factor regulatory protein
US6245526B1 (en) * 1999-05-26 2001-06-12 Incyte Pharmaceuticals, Inc. Lipid metabolism transcription factor
US6168933B1 (en) * 1999-06-08 2001-01-02 Incyte Pharmaceuticals, Inc. Phospholipid transfer protein
US6245527B1 (en) * 1999-06-30 2001-06-12 Millennium Pharmaceuticals, Inc. Nucleic acid molecules encoding glycoprotein VI and recombinant uses thereof
US6225093B1 (en) * 1999-09-07 2001-05-01 Decode Genetics Ehf. Detection of C4A deletion by long range PCR
US20020168711A1 (en) * 2000-01-31 2002-11-14 Rosen Craig A. Nucleic acids, proteins, and antibodies
US6900015B2 (en) * 2000-04-24 2005-05-31 Beth Israel Deaconess Medical Center, Inc. Measurement of protective genes in allograft rejection
US20070037144A1 (en) * 2000-10-20 2007-02-15 Jay Wohlgemuth Leukocyte expression profiling
US7235358B2 (en) * 2001-06-08 2007-06-26 Expression Diagnostics, Inc. Methods and compositions for diagnosing and monitoring transplant rejection
US7026121B1 (en) * 2001-06-08 2006-04-11 Expression Diagnostics, Inc. Methods and compositions for diagnosing and monitoring transplant rejection
PT1410011E (en) * 2001-06-18 2011-07-25 Rosetta Inpharmatics Llc Diagnosis and prognosis of breast cancer patients
EP1319717A1 (en) * 2001-12-11 2003-06-18 Roche Diagnostics GmbH Method for detection of inflammatory processes
AU2003212822A1 (en) * 2002-01-22 2003-09-02 Trustees Of The University Of Pennsylvania Methods for determining drug responsiveness
US7645575B2 (en) * 2004-09-08 2010-01-12 Xdx, Inc. Genes useful for diagnosing and monitoring inflammation related disorders
US7993832B2 (en) * 2006-08-14 2011-08-09 Xdx, Inc. Methods and compositions for diagnosing and monitoring the status of transplant rejection and immune disorders

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040197786A1 (en) * 2001-04-05 2004-10-07 Yuji Sugita Method of examining steroid resnponsiveness
US20070037167A1 (en) * 2001-06-08 2007-02-15 Expression Diagnostics, Inc. Methods and compositions for diagnosing or monitoring autoimmune and chronic inflammatory diseases
WO2006122295A2 (en) * 2005-05-11 2006-11-16 Expression Diagnostics, Inc. Methods of monitoring functional status of transplants using gene panels

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
CARGO INVESTIGATORS MEHRA ET AL: "Transcriptional Signals of T-cell and Corticosteroid-sensitive Genes Are Associated With Future Acute Cellular Rejection in Cardiac Allografts", JOURNAL OF HEART AND LUNG TRANSPLANTATION, MOSBY-YEAR BOOK, INC., ST LOUIS, MO, US, vol. 26, no. 12, 26 November 2007 (2007-11-26), pages 1255 - 1263, XP022392425, ISSN: 1053-2498, DOI: 10.1016/J.HEALUN.2007.09.009 *
DENG M C ET AL: "Noninvasive discrimination of rejection in cardiac allograft recipients using gene expression profiling", AMERICAN JOURNAL OF TRANSPLANTATION, BLACKWELL MUNKSGAARD, DK, vol. 6, no. 1, 1 January 2006 (2006-01-01), pages 150 - 160, XP002578025, ISSN: 1600-6135, [retrieved on 20051213], DOI: 10.1111/J.1600-6143.2005.01175.X *
GARRAWAY L A ET AL: "Array-based approaches to cancer genome analysis", DRUG DISCOVERY TODAY: DISEASE MECHANISMS, ELSEVIER, vol. 2, no. 2, 1 January 2005 (2005-01-01), pages 171 - 177, XP004978867, ISSN: 1740-6765, DOI: 10.1016/J.DDMEC.2005.05.020 *
GORCZYNSKI R M ET AL: "CORRELATION OF PERIPHERAL BLOOD LYMPHOCYTE AND INTRAGRAFT CYTOKINE MRNA EXPRESSION WITH REJECTION IN ORTHOTOPIC LIVER TRANSPLANTATION", SURGERY, C.V. MOSBY CO., ST. LOUIS, US, vol. 120, no. 3, 1 September 1996 (1996-09-01), pages 496 - 502, XP008005398, ISSN: 0039-6060, DOI: 10.1016/S0039-6060(96)80069-9 *
HAYASHI ET AL: "Effects of glucocorticoids on gene transcription", EUROPEAN JOURNAL OF PHARMACOLOGY, ELSEVIER BV, NL, vol. 500, no. 1-3, 1 October 2004 (2004-10-01), pages 51 - 62, XP005480403, ISSN: 0014-2999, DOI: 10.1016/J.EJPHAR.2004.07.011 *
KESHAVJEE S ET AL: "Immunoregulatory influences on peripheral blood gene expression in lung transplant patients: the lung allograft rejection gene expression observational (LARGO) study", JOURNAL OF HEART AND LUNG TRANSPLANTATION, MOSBY-YEAR BOOK, INC., ST LOUIS, MO, US, vol. 25, no. 2, 1 February 2006 (2006-02-01), pages S78, XP022702679, ISSN: 1053-2498, [retrieved on 20060201], DOI: 10.1016/J.HEALUN.2005.11.105 *
MEHRA ET AL: "131: Gene expression and prediction of early cardiac allograft rejection: Discovery of a gene-based corticosteroid efficacy measure", JOURNAL OF HEART AND LUNG TRANSPLANTATION, MOSBY-YEAR BOOK, INC., ST LOUIS, MO, US, vol. 26, no. 2, 1 February 2007 (2007-02-01), pages S106 - S107, XP022060492, ISSN: 1053-2498 *
MEHRA MANDEEP ET AL: "The role of IL1R2 and FLT3 gene expression in cardiac allograft rejection: A precise measure of corticosteroid effect?", CIRCULATION, vol. 114, no. 18, Suppl. S, October 2006 (2006-10-01), & 79TH ANNUAL SCIENTIFIC SESSION OF THE AMERICAN-HEART-ASSOCIATION; CHICAGO, IL, USA; NOVEMBER 12 -15, 2006, pages 709, XP002614049, ISSN: 0009-7322 *
See also references of WO2008051290A2 *
VERMEER HARRY ET AL: "An in vitro bioassay to determine individual sensitivity to glucocorticoids: induction of FKBP51 mRNA in peripheral blood mononuclear cells", MOLECULAR AND CELLULAR ENDOCRINOLOGY, ELSEVIER IRELAND LTD, IE, vol. 218, 1 January 2004 (2004-01-01), pages 49 - 55, XP003025130, ISSN: 0303-7207, DOI: 10.1016/J.MCE.2003.12.011 *

Also Published As

Publication number Publication date
EP2007909A2 (en) 2008-12-31
AU2007309726A1 (en) 2008-05-02
WO2008051290A3 (en) 2008-10-30
US20100136564A1 (en) 2010-06-03
WO2008051290A2 (en) 2008-05-02
US20070248978A1 (en) 2007-10-25
CA2648580A1 (en) 2008-05-02

Similar Documents

Publication Publication Date Title
EP2007909A4 (en) Steroid responsive nucleic acid expression and prediction of disease activity
HK1256238A1 (en) Methods of treating inflammatory and autoimmune diseases with natalizumab
SG10201508995QA (en) Targeted integration and expression of exogenous nucleic acid sequences
EP1988921A4 (en) Methods of treating inflammatory and autoimmune diseases with natalizumab
EP1999276A4 (en) Methods and means for nucleic acid sequencing
ZA200807341B (en) Fatty acid by-products and methods of using same
EP1991694A4 (en) Element-tagged oligonucleotide gene expression analysis
TWI347935B (en) Isomerisation of pharmaceutical intermediates
IL196480A0 (en) Improvement of arginase levels/activity
ZA200807296B (en) Fatty acid by-products and methods of using same
HRP20130148T1 (en) Delayed-release glucocorticoid treatment of rheumatoid disease
ZA201004144B (en) Fatty acid by-products and methods of using same
IL198286A0 (en) Use of an indazolemethoxyalkanoic acid for reducing triglyceride, cholesterol and glucose levels
EP2046496A4 (en) Hydroprocessing catalyst and process of use
GB0809165D0 (en) Systems and methods of conducting clinical research
GB0709092D0 (en) Diagnosis and method of disease
GB2439562C2 (en) System for analysis of electrograms
EP2452934A4 (en) N-phenyl-1-sulfonyl-2-pyrrolidine carboxamides libraries for the identification of biological and pharmacological activity
GB0617816D0 (en) Nucleic acids and methods of protein expression
PL2029740T3 (en) Use of polysaccharides for promotion of enzymatic activity
FR2898132B1 (en) SYSTEM FOR EXPRESSING A GENE OF INTEREST IN YEAST
GB2427728B (en) Analysis of gene expression data
IL177309A0 (en) Gene profiling of human embryonic stem cells
GB0428166D0 (en) Use of essentially fatty acid molecules
GB2452842B (en) Method of increasing activity

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20081106

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR

AX Request for extension of the european patent

Extension state: AL BA HR MK RS

A4 Supplementary search report drawn up and despatched

Effective date: 20101227

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20110726