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EP1968559A4 - BOTANICAL ANTI-INFLAMMATORY PRODUCTS FOR THE TREATMENT OF METABOLIC SYNDROME AND DIABETES - Google Patents

BOTANICAL ANTI-INFLAMMATORY PRODUCTS FOR THE TREATMENT OF METABOLIC SYNDROME AND DIABETES

Info

Publication number
EP1968559A4
EP1968559A4 EP06844984.2A EP06844984A EP1968559A4 EP 1968559 A4 EP1968559 A4 EP 1968559A4 EP 06844984 A EP06844984 A EP 06844984A EP 1968559 A4 EP1968559 A4 EP 1968559A4
Authority
EP
European Patent Office
Prior art keywords
diabetes
treatment
metabolic syndrome
inflammatory products
botanical anti
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP06844984.2A
Other languages
German (de)
French (fr)
Other versions
EP1968559A2 (en
Inventor
Matthew L Tripp
John G Babish
Jeff Bland
Amy Jennae Hall
Veera Konda
Linda Pacioretty
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MetaProteomics LLC
Original Assignee
MetaProteomics LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MetaProteomics LLC filed Critical MetaProteomics LLC
Priority to EP14000382.3A priority Critical patent/EP2737897A3/en
Publication of EP1968559A2 publication Critical patent/EP1968559A2/en
Publication of EP1968559A4 publication Critical patent/EP1968559A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/348—Cannabaceae
    • A61K36/3486—Humulus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/282—Artemisia, e.g. wormwood or sagebrush
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/01—Hydrocarbons
    • A61K31/015—Hydrocarbons carbocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/235—Foeniculum (fennel)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/80—Scrophulariaceae (Figwort family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)
EP06844984.2A 2005-12-09 2006-12-07 BOTANICAL ANTI-INFLAMMATORY PRODUCTS FOR THE TREATMENT OF METABOLIC SYNDROME AND DIABETES Withdrawn EP1968559A4 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP14000382.3A EP2737897A3 (en) 2005-12-09 2006-12-07 Anti-inflammatory botanical products for the treatment of metabolic syndrome and diabetes

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US74890705P 2005-12-09 2005-12-09
PCT/US2006/046770 WO2007070355A2 (en) 2005-12-09 2006-12-07 Anti-inflammatory botanical products for the treatment of metabolic syndrome and diabetes

Related Child Applications (1)

Application Number Title Priority Date Filing Date
EP14000382.3A Division EP2737897A3 (en) 2005-12-09 2006-12-07 Anti-inflammatory botanical products for the treatment of metabolic syndrome and diabetes

Publications (2)

Publication Number Publication Date
EP1968559A2 EP1968559A2 (en) 2008-09-17
EP1968559A4 true EP1968559A4 (en) 2013-08-07

Family

ID=38163414

Family Applications (2)

Application Number Title Priority Date Filing Date
EP06844984.2A Withdrawn EP1968559A4 (en) 2005-12-09 2006-12-07 BOTANICAL ANTI-INFLAMMATORY PRODUCTS FOR THE TREATMENT OF METABOLIC SYNDROME AND DIABETES
EP14000382.3A Withdrawn EP2737897A3 (en) 2005-12-09 2006-12-07 Anti-inflammatory botanical products for the treatment of metabolic syndrome and diabetes

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP14000382.3A Withdrawn EP2737897A3 (en) 2005-12-09 2006-12-07 Anti-inflammatory botanical products for the treatment of metabolic syndrome and diabetes

Country Status (5)

Country Link
EP (2) EP1968559A4 (en)
JP (1) JP2009518429A (en)
AU (1) AU2006326658A1 (en)
CA (1) CA2632607A1 (en)
WO (1) WO2007070355A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008115163A (en) * 2006-10-10 2008-05-22 Kikkoman Corp Adiponectin production enhancer and stimulator
JP5669729B2 (en) * 2008-05-13 2015-02-12 ジェンメディカ・セラピューティックス・ソシエダッド・リミターダＧｅｎｍｅｄｉｃａ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｓｌ Salicylate conjugates useful for treating metabolic disorders
TWI492755B (en) * 2009-12-30 2015-07-21 Metal Ind Res & Dev Ct Extract of toona sinensis from supercritical fluid extraction for treating diabetes and metabolic diseases, the preparation method and the use thereof
JP6259287B2 (en) 2010-10-30 2018-01-10 カインデックス ファーマシューティカルズ インコーポレイテッド 3,4-dihydroxy-2- (3-methylbutanoyl) -5- (3-methylbutyl) -4- (4-methylpentanoyl) cyclopent-2-en-1-one derivative, substantially pure mirror image Isomeric compositions and related applications
CN102821771B (en) * 2010-12-28 2015-01-14 高雄医学大学 Toon supercritical extract for anti-diabetes and anti-metabolic disease, preparation method and application
SG11202100264YA (en) 2018-08-10 2021-02-25 Suntory Holdings Ltd Composition and method for suppressing increase in blood glucose level
KR20220118504A (en) * 2019-12-20 2022-08-25 주식회사 다이셀 composition for suppressing obesity

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002003996A1 (en) * 2000-07-12 2002-01-17 RAJKUMAR, Sujatha Use of dammarane-type tritepenoid saporins
US6451355B1 (en) * 2000-07-17 2002-09-17 Howard M. Reisner Composition to treat diabetes
US6511683B1 (en) * 1999-09-30 2003-01-28 Factors R & D Technologies Ltd. Enchinacea supplement and method of manufacture
JP2005047822A (en) * 2003-07-30 2005-02-24 Japan Research & Development Association For New Functional Foods Hyperglycemia inhibitor
US20050074447A1 (en) * 2003-10-01 2005-04-07 Papas Andreas M. Treatment for diabetic microvascular and macrovascular complications
CN1608644A (en) * 2003-10-21 2005-04-27 陈钟 Medicine capsule for treating diabetes

Family Cites Families (15)

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JP4497566B2 (en) * 1998-09-02 2010-07-07 株式会社 日本薬用食品研究所 Aldose reductase inhibitors and novel saponins and novel sapogenols
US6586438B2 (en) * 1999-11-03 2003-07-01 Bristol-Myers Squibb Co. Antidiabetic formulation and method
US20040115290A1 (en) * 2001-06-20 2004-06-17 Tripp Matthew L. Modulation of inflammation by hops fractions and derivatives
US7205151B2 (en) * 2001-06-20 2007-04-17 Metaproteomics, Llc Complex mixtures exhibiting selective inhibition of cyclooxygenase-2
US7279185B2 (en) * 2001-10-26 2007-10-09 Metaproteonics, Llc Curcuminoid compositions exhibiting synergistic inhibition of the expression and/or activity of cyclooxygenase-2
WO2003057232A1 (en) * 2002-01-10 2003-07-17 Biosynergen, Inc. A pharmaceutical composition and functional foods for prevention and treatment of diabetes millitus
JPWO2003068205A1 (en) * 2002-02-14 2005-06-02 麒麟麦酒株式会社 Obesity treatment agent and food for preventing or improving obesity
NZ539642A (en) * 2002-10-21 2007-01-26 Metaproteomics Llc Compositions containing extracts from hops in combination with a second component for treating inflammatory response
JPWO2004045632A1 (en) * 2002-11-12 2006-03-16 株式会社カネカ Peroxisome proliferator-responsive receptor ligand agent
CN100560076C (en) * 2003-02-26 2009-11-18 尤尼根制药公司 Composition for prevention and treatment of diseases and conditions induced by sugar
CN1805738A (en) * 2003-06-16 2006-07-19 兰贝克赛实验室有限公司 Extended-release tablets of metformin
EP1510208A1 (en) * 2003-08-22 2005-03-02 Fournier Laboratories Ireland Limited Pharmaceutical composition comprising a combination of metformin and statin
US20050192356A1 (en) * 2004-02-27 2005-09-01 Babish John G. Synergistic anti-inflammatory pharmaceutical compositions and methods of use
KR100772980B1 (en) * 2004-04-01 2007-11-02 한미약품 주식회사 Sustained-release preparations for oral administration of metformin
EP2248532A1 (en) * 2005-08-09 2010-11-10 Metaproteomics, LLP Protein kinase modulation by hops and acacia products cross-reference to related applications

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6511683B1 (en) * 1999-09-30 2003-01-28 Factors R & D Technologies Ltd. Enchinacea supplement and method of manufacture
WO2002003996A1 (en) * 2000-07-12 2002-01-17 RAJKUMAR, Sujatha Use of dammarane-type tritepenoid saporins
US6451355B1 (en) * 2000-07-17 2002-09-17 Howard M. Reisner Composition to treat diabetes
JP2005047822A (en) * 2003-07-30 2005-02-24 Japan Research & Development Association For New Functional Foods Hyperglycemia inhibitor
US20050074447A1 (en) * 2003-10-01 2005-04-07 Papas Andreas M. Treatment for diabetic microvascular and macrovascular complications
CN1608644A (en) * 2003-10-21 2005-04-27 陈钟 Medicine capsule for treating diabetes

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Title
AGGARWAL BHARAT B ET AL: "Suppression of the nuclear factor-kappa B activation pathway by spice-derived phytochemicals - Reasoning for seasoning", ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, WILEY-BLACKWELL PUBLISHING, INC, US, vol. 1030, 1 December 2004 (2004-12-01), pages 434 - 441, XP009097664, ISSN: 0077-8923, DOI: 10.1196/ANNALS.1329.054 *
ARORA DEEPA ET AL: "Immunomodulating effects of rasayana drugs in diabetics - a clinical study.", ANCIENT SCIENCE OF LIFE OCT 2002, vol. 22, no. 2, October 2002 (2002-10-01), pages 42 - 48, XP018015455, ISSN: 0257-7941 *
DATABASE WPI Week 200519, Derwent World Patents Index; AN 2005-176026, XP002699141 *
DATABASE WPI Week 200560, Derwent World Patents Index; AN 2005-583447, XP002699140 *
HOU C C ET AL: "Bacopaside III, bacopasaponin G, and bacopasides A, B, and C from Bacopa monniera", MEDICINAL & AROMATIC PLANTS ABSTRACTS, SCIENTIFIC PUBLISHERS, SCIENTIFIC PUBLISHERS, NEW DELHI - INDIA, vol. 25, no. 4, 1 August 2003 (2003-08-01), XP018007587, ISSN: 0250-4367 *
OOMAH B DAVE ET AL: "Characteristics of raspberry (Rubus idaeus L.) seed oil", FOOD CHEMISTRY, vol. 69, no. 2, March 2000 (2000-03-01), pages 187 - 193, XP002699143, ISSN: 0308-8146 *
RANA T S ET AL: "Studies on indigenous herbal remedies for diabetes mellitus in India", BIOSIS,, 15 September 1990 (1990-09-15), XP002572903 *
SUBRAMONIAM A ET AL: "EFFECTS OF ARTEMISIA PALLENS WALL. ON BLOOD GLUCOSE LEVELS IN NORMAL AND ALLOXAN-INDUCED DIABETIC RATS", JOURNAL OF ETHNOPHARMACOLOGY, ELSEVIER SCIENTIFIC PUBLISHERS LTD, IE, vol. 50, no. 1, 1 January 1996 (1996-01-01), pages 13 - 17, XP002038211, ISSN: 0378-8741, DOI: 10.1016/0378-8741(95)01329-6 *
WANG X-S ET AL: "Study on hypoglycemic polysaccharide from Centalla asiatica", CHINESE PHARMACEUTICAL JOURNAL NOVEMBER 2005 CHINESE MEDICAL ASSOCIATION CN, vol. 40, no. 22, November 2005 (2005-11-01), pages 1697 - 1700, XP009170472 *

Also Published As

Publication number Publication date
EP2737897A2 (en) 2014-06-04
WO2007070355A2 (en) 2007-06-21
AU2006326658A1 (en) 2007-06-21
WO2007070355A3 (en) 2008-07-03
JP2009518429A (en) 2009-05-07
CA2632607A1 (en) 2007-06-21
EP2737897A3 (en) 2014-10-01
EP1968559A2 (en) 2008-09-17

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